JamesWhelessMDBScPharm, FAAP, FACP, FAAN, FAES

PubMed

• 251 citations
  History of the ketogenic diet.
  James W. Wheless
  Epilepsia. 2008-11-01
• 102 citations
  Vagus nerve stimulation (VNS) therapy update.
  James W. Wheless, Andrew J. Gienapp, Phillippe Ryvlin
  Epilepsy & Behavior. 2018-11-01
• 147 citations
  A comparison of magnetoencephalography, MRI, and V-EEG in patients evaluated for epilepsy surgery.
  James W. Wheless, L. J. Willmore, Joshua I. Breier, M. Kataki, Joseph R. Smith
  Epilepsia. 1999-07-01

Journal Articles

• Burden of Renal Angiomyolipomas Associated with Tuberous Sclerosis Complex: Results of a Patient and Caregiver Survey  
  James W Wheless, Judith Prestifilippo, Springer Open
• Predicting Seizure Outcome of Vagus Nerve Stimulation Using MEG-Based Network Topology  
  Basanagoud Mudigoudar, James W Wheless, ScienceDirect
• Assessing motor function in young children with transcranial magnetic stimulation  
  Narayana S, Rezaie R, McAfee SS, Choudhri AF, Babajani-Feremi A, Fulton S, Boop FA, Wheless JW, Papanicolaou AC, Pediatric Neurol, 1/1/2015
• Tuberous Sclerosis Complex: A survey of health care resource use and health burden  
  Rentz AM, Skalicky AM, Liu Z, Wheless JW, Dunn DW, Frost MD, Nakagawa J, Magestro M, Prestifilippo J, Pediatr. Neurol, 1/1/2015
• An unusual cause of flaccid paralysis and coma: Baclofen overdose  
  Caron E, Morgan R, Wheless JW, J. Child Neurol, 1/1/2014
• A computerized standard protocol order entry for pediatric inpatient acute seizure emergencies reduces time to treatment  
  Xie Y, Morgan R, Schiff L, Hannah D, Wheless JW, J. Child Neurol., 1/1/2014
• Subependymal giant cell astrocytomas in patients with tuberous sclerosis complex: considerations for surgical or Pharmacotherapeutic intervention  
  Wheless JW, Klimo P Jr, J. Child Neurol, 1/1/2014
• Osteoporsis and Obesity in Epilepsy Patients  
  Volgyi E, Wheless JW, J. Osteopor Phys Act, 1/1/2014
• Safety and effectiveness of long-term treatment with diazepam auto-injector administered by caregivers in an out-patient setting for the treatment of acute repetitive ...  
  Rogin J, Wheless J, Abou-Khalil B, Walter K, Pixton G, Sherman N, Shukla R, Roland C, Sommerville K, Epilepsia, 1/1/2014
• Yes, Neurostimulation has a role in the management of epilepsy  
  Benbadis SR, Helmers S, Hirsch L, Sirven J, Vale F, Wheless J, Neurology, 1/1/2014
• Stable dosages of clobazam for Lennox-Gastaut syndrome are associated with sustained drop-seizure and total-seizure improvements over 3 years  
  Conry JA, Ng YT, Kernitsky L, Mitchell WG, Veidemanis R, Drummond R, Isojarvi J, Lee D, Paolicchi JM, Wheless JW and OV-1004 study investigators, Epilepsia, 1/1/2014
• Clobazam is efficacious for patients across the spectrum of disease severity of Lennox-Gastaut Syndrome: Post hoc analysis of clinical trial results by baseline seizur...  
  Wheless JW, Isojarvi J, Lee D, Drummond R, Benbadis SR, Epilepsy & Behavior, 1/1/2014
• Skepticism should not result in ignoring a treatment option  
  Benbadis S, Helmers S, Hirsch L, Sirven J, Vale F, Wheless J, Neurology, 1/1/2014
• Assessment of hemispheric dominance for receptive language in pediatric patients under sedation using magnetoencephalography  
  Rezaie R, Narayana S, Schiller K, Birg L, Wheless JW, Boop FA, Papanicolaou AC, Frontiers in Human Neuroscience, 1/1/2014
• Long-term safety of perampanel and seizure outcomes in refractory partial-onset seizures and secondarily generalized seizures: results from Phase III extension Study 307  
  Krauss GL, Perucca E, Ben-Menachem E, Kwan P, Shih JJ, Clement J-F, Wang X, Bagul M, Gee M, Zhu J, Squillacote D, Wheless JW and Study 307 Investigators, Epilepsia, 1/1/2014
• Introduction: Recommendations regarding management of patients with Lennox- Gastaut Syndrome  
  Pellock JM, Wheless JW, Epilepsia, 1/1/2014
• The efficacy and tolerability of pharmacologic treatment options for Lennox-Gastaut Syndrome  
  Montouris GD, Wheless JW, Glauser TA, Epilepsia, 1/1/2014
• Variation in the topography of speech production cortex verified by cortical stimulation and high gamma activity  
  Babajani-Feremi A, Rezaie R, Narayana S, Choudhri AF, Fulton SP, Boop FA, Wheless JW, Papanicolaou AC, Neuro Report, 1/1/2014
• Enteral topiramate in a pediatric patient with refractory status epilepticus: a case report and review of the literature  
  Shelton CM. Alford EL, Storgion S, Wheless J, Phelps SJ, J. Pediatr. Pharmacol Ther, 1/1/2014
• Perampanel, a selective noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazole prioponic acid receptor antagonist, as adjunctive therapy for refractory partial-onse...  
  Krauss GL, Perucca E, Ben-Menachem E, Kwan P, Shih JJ, Squillacote D, Yang H, Gee M, Zhu T, Laurenza A, Wheless JW and study 307 Investigators, Epilepsia, 1/1/2013
• Clobazam: A newly approved but well-established drug for the treatment of intractable epilepsy syndromes  
  Wheless JW, Phelps SJ, J. Child Neurol, 1/1/2013
• Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: Initial monotherapy outcomes at 12 months  
  Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Adamson PC, Wheless JW and for the Childhood Absence Epilepsy Study Team, Epilepsia, 1/1/2013
• Functional magnetic resonance imaging of the visual cortex performed in children under sedation to assist in pre-surgical planning  
  Weier LI, Wait SD, Ogg R, Scoggins M, Zou P, Wheless JW, Boop FA, J. of Neurosurg: Pediatrics, 1/1/2013
• Prospective study of two bed alarms for detection of nocturnal seizures  
  Fulton S, VanPoppel K, McGregor A, Ellis M, Patters A, Wheless JW, J. Child Neurol, 1/1/2013
• Prospective study of the Emfit movement monitor  
  VanPoppel K, McGregor A, Fulton SP, Ellis M, Patters A, Wheless JW, J. Child Neurol, 1/1/2013
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Books/Book Chapters

• The Oxford Handbook of Functional Neuroimaging: Systems Neuroscience and Neuropsychology 
  Chapter: Clinical applications of transcranial magnetic stimulation. 
  Narayana S, Salinas F, Boop FA, Wheless JW, Papanicolaou ACEditors: Papanicolaou AC.2014
• The Oxford Handbook of Functional Neuroimaging: Systems Neuroscience and Neuropsychology 
  Chapter: Applications of functional neuroimaging: pre-surgical functional mapping. 
  Papanicolaou AC, Rezaie R, Narayana S, Choudhri AF, Wheless JW, Castillo EM, Baumgartner JE, Boop FAEditors: Papanicolaou AC.Oxford University Press2014
• Wyllies' Treatment of Epilepsy 
  Chapter: Vagus Nerve Stimulation Therapy. 
  Wheless, JWEditors: Wyllie E.Edition 6th,2014
• Pediatric Epilepsy 
  Chapter: Anti-epileptic drug follow-up and withdrawal. 
  Page 381 - 390Wheless JWEditors: Duchowny M, Cross JH, Arzimonoglou A.McGraw-Hill, New York City, NY2013
• Epilepsy in Children and Adolescents 
  Chapter: Pharmacology of Anti-Epileptic Drugs. 
  Page 145 - 158Wheless JWEditors: Wheless JW.Wiley-Blackwell, Oxford, UK2012
• Epilepsy in Children and Adolescents 
  Chapter: Therapeutic Efficacy of Anti-Epileptic Drugs. 
  Page 159 - 174Wheless JWEditors: Wheless JW.Wiley-Blackwell, Oxford, UK2012
• Epilepsy in Children and Adolescents 
  Chapter: Adverse Effects of Anti-Epileptic Drugs. 
  Page 175 - 192Wheless JWEditors: Wheless JW.Wiley-Blackwell, Oxford, UK2012
• Epilepsy in Children and Adolescents 
  Chapter: Epilepsy Surgery and Vagus Nerve Stimulation. 
  Page 193 - 218Wheless JW, VanPoppel KEditors: Wheless JW.Wiley-Blackwell, Oxford, UK2012
• Epilepsy in Children and Adolescents 
  Chapter: Dietary Therapy for Epilepsy. 
  Page 219 - 242Wheless JWEditors: Wheless JW.Wiley-Blackwell, Oxford, UK2012
• Swaiman's Pediatric Neurology 
  Chapter: The Ketogenic Diet. 
  Page 836 - 853Wheless JWEditors: Swaiman K, Ashwal S, Ferriero DM, Schor NF.Edition 5th,2012
• Extratemporal Lobe Epilepsy Surgery (Progress in Epileptic Disorders, Vol. 10) 
  Chapter: Vagus Nerve Stimulation: Techniques and Outcome. 
  Page 435 - 456Wheless JWEditors: Koubeissi MZ, Maciunas R.John Libbey Eurotext, Montrouge, France2011
• Pharmacotherapy 
  Chapter: Status Epilepticus 
  Page 1007 - 1017Phelps SJ, Hovinga CA, Wheless JWEditors: Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM.McGraw-HillEdition 8th,2011
• Wyllie's Treatment of Epilepsy: Principles and Practice 
  Chapter: Vagus Nerve Stimulation Therapy. 
  Page 797 - 808Wheless JWEditors: Wyllie E, Cascino GD, Gidal BE, Goodkin HP.2011
• Epilepsy: Mechanisms, Models And Translational Perspectives 
  Chapter: Special treatments in Epilepsy. 
  Page 381 - 405Chapman, K, Wheless JWEditors: Rho JM, Sankar R, Stafstrom CE.CRC Press, New York City, NY2010
• The Atlas of Epilepsies 
  Chapter: Vigabatrin. 
  Page 1869 - 1876VanPoppel K, Wheless JWEditors: Panayiotopoulos CP.Springer-Verlag, London, UK2010
• Clinical magnetocephalography and Magnetic Source Imaging 
  Chapter: MEG in Pediatric Non-Lesional Epilepsy Surgery. 
  Page 92 - 101Wheless JW, McManis, MH, Ramachandran Nair R, Otsubo HEditors: Papanicolaou AC.Cambridge University Press, New York City, NY2009
• Advanced Therapy in Epilepsy 
  Chapter: Levetriacetam. 
  Page 320 - 325Wheless JW, Patters ABEditors: Wheless JW, Willmore LJ, Brumback RA.PMPH-USA, Shelton, CT2009
• Advanced Therapy in Epilepsy 
  Chapter: Neurostimulation Therapy for Epilepsy. 
  Page 393 - 401Wheless JWEditors: Wheless JW, Willmore LJ, Brumback RA.PMPH-USA, Shelton, CT2009
• Pediatric Epilepsy Case Studies: From Infancy and Childhood Through Adolescence 
  Chapter: Vagus Nerve Stimulation Therapy. 
  Page 37 - 48Wheless JWEditors: Chapman K, Rho JM.CRC Press, New York City, NY2009
• Current Management in Child Neurology 
  Chapter: Recurrent Seizures 
  Page 159 - 168Wheless JW, Clarke DFEditors: Maria BL.BC Decker, Inc., London, UKEdition 4th,2009
• Encyclopedia of Neuroscience 
  Chapter: Application of Magnetoencephalography (MEG). 
  Wheless JW, McManis MHEditors: Squire LR.Academic Press, Oxford, UK2008
• Puzzling Puzzling 
  Chapter: Dietary Treatment of Seizures from a Hypothalamic Hamartoma. 
  Maggio V, Wheless JWEditors: Schmidt D, Schachter SC.Elsevier, San Diego, CAEdition 2nd,2008
• Pharmacotherapy 
  Chapter: Status Epilepticus. 
  Page 953 - 964Phelps, SJ, Hovinga CA, Wheless JWEditors: Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM.McGraw-HillEdition 7th,2008
• Pediatric Epilepsy: Diagnosis and Therapy 
  Chapter: Vagus Nerve Stimulation Therapy in Pediatric Patients: Use and Effectiveness. 
  Page 811 - 827Wheless JWEditors: Pellock JM, Bourgeois BFD, Dodson WE.Demos Publications, New York City, NYEdition 3rd,2008
• Epilepsy in Women-Care and Management (Series: Current Clinical Neurology) 
  Chapter: The effect of puberty on epilepsy. 
  Clarke DF, Wheless JWEditors: Krishnamur KB, Spencer S.Humana Press Inc., USA2007
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Abstracts/Posters

• Vagus Nerve Stimulation in children with Dravet Syndrome.
  Fulton SP, Van Poppel K, McGregor AL, Mudigoudar B, Wheless JW, Epilepsy Currents, 68th Annual Meeting of the American Epilepsy Society, Seattle, WA, 2014, 1/1/2015
• Improving Long-term management of epilepsy using a wearable multi-modal seizure detection system.
  Sabesan S, Carlson G, Rosea K, Muellera A, Sankar R, Wheless JE, Epilepsy Currents, 68th Annual Meeting of the American Epilepsy Society, Seattle, WA, 2014, 1/1/2015
• Long-term response to clobazam by baseline seizure frequency in patients with Lenox-Gastaut syndrome.
  Lee D, Wheless J, Isojarvi J, 66th Annual Meeting of the American Academy of Neurology, Philadelphia, PA, 1/29/2014
• Validity of determining language laterality using transcranial magnetic stimulation: Comparison with MEG and cortical stimulation.
  Narayana S, Rezaie R, Birg L, Schiller K, Boop FA, Wheless JW, Papanicolaou AC, 19th International Conference on Biomagnetism, Halifax, Nova Scotia, Canada, 1/24/2014
• Chronological evolution of radiological findings in case series of patients with Febrile-infections related epilepsy syndrome (FIRES).
  Rivas-Coppola MS, Choudhri A, Wheless J, Shah NS, Annals of Neurol, 43rd Annual Meeting of the Child Neurology Society, Columbus, OH, 1/23/2014
• Dealing with next generation sequencing data not generated in the TSC context.
  Ekong R, Plagnol V, Migone N, Sparagana S, Wheless J, Futema M, Humphries S, Povey S, 5th Biennial Meeting of the Human Variome Project Consortium, Paris, France, 1/20/2014
• Accuracy of high gamma activity and transcranial magnetic stimulation in language mapping.
  Babajani-Feremi A, Narayana S, Rezaie R, Choudhri AF, Fulton SP, Boop FA, Wheless JW, Papanicolaou AC, 44th Annual Meeting of the Society for Neuroscience, Washington, DC, 1/15/2014
• Improving identification of tuberous sclerosis complex: A model of high-risk patients.
  Johnson JC, Johnson MP, Engel-Nitz N.M., Thayer S, Altan A, Lui Z, Gipson T.T., Roach ES, Wheless J, Annual Meeting of the American Academy of Pediatrics, San Diego, CA, 1/11/2014
• Aberrant topography of language production cortex.
  Babajani-Feremi A, Rezaie R, Narayana S, Choudhri AF, Boop FA, Wheless JW, Papanicolaou AC, International Conference on Functional Mapping of the Human Brain, Hamburg, Germany, 1/8/2014
• Improving identification of tuberous sclerosis complex: A model of high-risk patients.
  Johnson JC, Johnson MP, Engel-Nitz N.M., Thayer S, Altan A, Lui Z, Gipson T.T., Roach ES, Wheless J, World Tuberous Sclerosis Complex Conference, Washington, DC, 1/5/2014
• Language laterality assessment through MEG under sedation.
  Papanicolaou AC, Rezaie R, Narayana S, Wheless J, Epilepsy Currents, 67th Annual Meeting of the American Epilepsy Society, Washington, DC, 2013, 1/1/2014
• Open-label continuation of the effectiveness and safety of diazepam auto-injector administered by caregivers in an out-patient setting to subjects with epilepsy for ep...
  Rogin J, Wheless J, Abou-Khalil B, Wolter K, Pixton GC, Sherman NA< Shukla R, Roland CL, Sommerville K, Goli V, Epilepsy Currents, 67th Annual Meeting of the American Epilepsy Society, Washington, DC, 2013, 1/1/2014
• Long-term response to clobazam in relation to baseline seizure frequency in patients with Lennox-Gastaut Syndrome.
  Wheless J, Epilepsy Currents, 67th Annual Meeting of the American Epilepsy Society, Washington, DC, 2013, 1/1/2014
• Expert opinion on treatment of pediatric status epilepticus in Poland.
  Steinborn B, Dunin-Wasowicz D, Mazurkiewicz-Beldzinska M, Balcerzak M, Jus A, Wheless J, Jazwiak S, Epilepsy Currents, 67th Annual Meeting of the American Epilepsy Society, Washington, DC, 2013, 1/1/2014
• Expert opinion of treatment of idiopathic generalized epilepsy syndromes of childhood and adolescence in Poland.
  Mazurkiewicz-Beldzinska M, Dunin-Wasowicz D, Steinborn B, Balcerzak M, Jus A, Wheless J, Jozwiak S, Epilepsy Currents, 67th Annual Meeting of the American Epilepsy Society, Washington, DC, 2013, 1/1/2014
• Subtraction imaging and MR co-registration to increase diagnostic yield of ictal and interictal SPECT in localization of epileptogenic foci in patients with intractabl...
  Abramson Z, Choudhri AF, Magill HL, Wheless J, 66th Annual Meeting of the American Academy of Neurology, Philadelphia, PA, 1/1/2014
• Developmental and epilepsy follow up of children with duplications of FOXG1 on 14q12.
  Seltzer LE, Sohnee A, Paciorkowski AR, Bertrand M, Blume HK, Opheim KE, Dobyns WB, Wheless J, Annals of Neurol, 42nd Annual Meeting of the Child Neurology Society, Austin, TX, 2013, 1/31/2013
• Health care resource utilization in tuberous sclerosis complex in the United States.
  Wheless JW, Rentz AM, Skalicky AM, Pashos CL, Liu Z, Magestro M, Prestifilippo J, Nakagawa JA, Dunn DW, Frost MD, 2013 International Research Conference on Tuberous Sclerosis Complex, Washington, DC, 1/22/2013
• The economic burden of tuberous sclerosis complex on families in the United States.
  Rentz AM, Skalicky AM, Magestro M, Liu Z, Prestifilippo J, Nakagawa JA, Dunn DW, Wheless JW, Frost MD, Pashos CL, 2013 International Research Conference on Tuberous Sclerosis Complex, Washington, DC, 1/22/2013
• Tuberous Sclerosis Complex in the US: patient-reported physical and mental health burden.
  Skalicky AM, Rentz AM, Magestro M, Liu Z, Prestifilippo J, Wheless JW, Nakagawa JA, Frost MD, Dunn DW, Pashos CL, 2013 International Research Conference on Tuberous Sclerosis Complex, Washington, DC, 1/22/2013
• Humanistic burden in Tuberous Sclerosis Complex (TSC) caregivers in the United States.
  Dunn DW, Rentz AM, Skalicky AM, Pashos CL, Liu Z, Magestro M, Prestifilippo J, Nakagawa JA, Wheless JW, Frost MD, 2013 International Research Conference on Tuberous Sclerosis Complex, Washington, DC, 1/22/2013
• Characteristics and burden of subependymal giant cell astrocytomas (SEGAs) in patients with tuberous sclerosis complex: results of a patient and caregiver survey in th...
  Dunn DW, Rentz AM, Skalicky AM, Pashas CL, Liu Z, Pelletier C, Prestifilippo J, Nakagawa JA, Dunn DW, Frost MD, Wheless JW, 65th Annual Meeting of the American Academy of Neurology, San Diego, CA, 1/21/2013
• A novel topical rapamycin cream for treatment of facial angiofibromas in tuberous sclerosis complex.
  Wheless JW, Almoazen H, 2013 International Research Conference on Tuberous Sclerosis Complex, Washington, DC, 1/21/2013
• Functional connectivity in tuberous sclerosis complex with autistic spectrum disorder - preliminary findings.
  Rezaie R, Zouridakis G, Choudhri AF, Wheless JW, Volgyi E, VanPoppel K, Clanton NR, Papanicolaou AC, 2013 International Research Conference on Tuberous Sclerosis Complex, Washington, DC, 1/21/2013
• Motor plasticity following complete hemispherectomy: A TMS study.
  Narayana S, McAfee SS, Choudhri AF, Papanicolaou AC, Wheless J, Annual Meeting of the Organization for Human Brain Mapping, Seattle, WA, 1/17/2013
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Other

• Interviewed for story on, "Gene Mutations Linked to Severe Phenytoin-Related Skin Reactions in Epilepsy." 
  Wheless JW, Neurology Today, pp. 49-50
  1/1/2014
• Optimizing treatment of adolescents with partial-onset seizures. 
  Jonas R, Bazil CW, Wheless JW, Neurology Reviews
  1/1/2013
• Appeared on "Healthy Body, Healthy Mind" 
  Wheless JW, PBS-TV, Epilepsy Defined Program won FREDDIE Award for best neurology medical media presentation
  1/1/2007
• Women With Epilepsy: Hormonal Issues from Menarche through Menopause. 
  Cramer JA, Gordon J, Schachter S, Devinsky O, Wheless JW and the Epilepsy Therapy Development Project Women's Issues Work Group, Epilepsy.com
  http://professionals.epilepsy.com/pdfs/discussion_guide.pdf
  1/1/2007
• Treatment of Idiopathic Generalized Epilepsies with Convulsive Seizures: An Evidence-based Medicine Approach. 
  Wheless JW, Epilepsy Network News
  www.minifellow.net
  1/1/2006
• Future in Mind Report: Critical Years Review. 
  Baker G, Brandl U, Cross H, Holmes G, Plouin P, Sanmartini F, Vigevano F, Wheless J, International Bureau for Epilepsy
  www.ibe-epilepsy.org
  1/1/2005
• Early identification and long-term management of Pharmacoresistant epilepsy. 
  Wheless JW, Levisohn PM, Sankar R, Medical Education Systems, Inc.
  Philadelphia, PA - 1/1/2003
• Acute management of seizures in the syndromes of idiopathic generalized epilepsies. 
  Wheless JW, Epilepsy Network News
  www.minifellow.net
  1/1/2003
• Epilepsy: Pathogenesis, clinical recognition and treatment. 
  Wheless JW, Pediatric aspects (CD-ROM), Postgraduate Institute for Medicine
  1/1/2002
• "Appeared on "Houston Medical" 
  Wheless JW, ABC TV
  1/1/2002
• Monotherapy Options for Children with Generalized Seizure Disorders: Topiramate and Lamotrigine. 
  Wheless JW, Clinical Decision Making Clinical Decision Making American Epilepsy Society)
  1/1/2000
• Epilepsy and Sudden Death 
  Wheless JW, Clinical Lessons in Epilepsy
  1/1/1998
• Epilepsy: New Technologies Aid in Diagnosis and Treatment 
  Wheless J, The Neuroscience Research Center Newsletter, University of Texas - Houston Health Science Center, pp
  1/1/1998
• Pediatric Issues in Status Epilepticus 
  Wheless JW, Management of Acute Seizures; Partners in Medical Communications, pp. 11-12
  Clifton, NJ - 1/1/1997
• Seizure Disorder: A Clinical Update. 
  Wheless JW, The Neuroscience Research Center Newsletter, University of Texas - Houston Health Science Center, Vo
  1/1/1995
• Initial Experience with Ictal Injection of Stabilized TC-99m-Exametazime (HMPA0): "Patterns and Pitfalls". 
  Barron B, Curtis V, Lamki L, Ephron V, Wheless JW, Willmore LJ, Radiographics (CD-ROM)
  1/1/1994
• "Ask Dr. Wheless" 
  Wheless JW, Quarterly Column for the Epilepsy Association of Houston/Gulf Coast Newsletter, 1991-1994
  1/1/1990
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