JamesRichardSpearsMD

PubMed

• 21 citations
  Update on Cardioprotective Strategies for STEMI: Focus on Supersaturated Oxygen Delivery
  Robert A. Kloner, Jeffrey L. Creech, Gregg W. Stone, William W. O’Neil, Daniel Burkhoff
  JACC. Basic to Translational Science. 2021-07-28
• 2 citations
  National Trends of Tobacco, Alcohol, and Drug Use in Patients Admitted With Acute Myocardial Infarction
  Amer N. Kadri, Sara Khodor, Ahmed Ali, Leen Nusairat, Asadullah Mahmood
  Cardiovascular Revascularization Medicine. 2021-05-01
• 8 citations
  Cardiac Catheterization Laboratory Volume Changes During COVID-19-Findings from a Cardiovascular Fellows Consortium.
  Sabeeda Kadavath, Jay Mohan, Said Ashraf, Adnan Kassier, Dalia Hawwass
  The American Journal of Cardiology. 2020-06-11

Journal Articles

• Book review, Coronary Angioscopy by Yasumi Uchida, MD  
  Spears JR, Circulation, 1/1/2001
• Association of left ventricular noncompaction with polycystic kidney disease  
  Katukuri NP, Finger J, Vaitkevicius P, Riba A, Spears JR, Texas Heart J, 1/1/2014
• Vieussens' ring with congenitally hypoplastic left coronary arterial system  
  Atallah PC, Atallah PC, Spears JR, Int J Cardiol, 1/18/2010
• Effect of supersaturated oxygen delivery on infarct size after percutaneous coronary intervention in acute myocardial infarction  
  Stone GW, Martin JL, de Boer M-J, Margheri M, Bramucci E, Blankenship JC, Metzger DC, Gibbons RJ, Lindsay BS, Weiner BH, Lansky AJ, Krucoff MW, Fahy M, Boscardin WJ an..., Circulation: Cardiovasc Intervent, 1/1/2009
• Families and the decision to withhold or withdraw life-sustaining therapy from the critically ill: are pressure tactics ever justified?  
  Dandapantula H, Reddy V, Spears JR, Am J Respir Crit Care Med, 1/1/2008
• Incidence and predictors of vascular complications after invasive coronary procedures: A prospective analysis  
  Penugonda N., Jones J, Spears JR, Schreiber T, Vascular Diseases Management, 1/1/2008
• Acute Myocardial Infarction with Hyperoxemic Therapy (AMIHOT): a prospective, randomized trial of intracoronary hyperoxemic reperfusion after percutaneous coronary int...  
  O�Neill WW, Martin JL, Dixon SR, Bartorelli AL, Trabattoni D, Oemrawsingh PV, Atsma DE, Chang M, Marquardt W, Oh JK, Krucoff MW, Gibbons RJ, Spears JR; AMIHOT Investig..., J Am Coll Cardiol, 1/16/2007
• Unexplained pulmonary hypertension in elderly patients: role of heart failure with normal ejection fraction, Bernheim effect, and reverse Bernheim effect  
  Dandapantula HK, Afonso L, Katkuri H, Chandu L, Spears JR, Chest, 1/1/2007
• Cigarette smoking and myocardial infarction in young men and women-�Let us not forget coronary vasospasm�  
  Dandapantula HK, Spears JR, Chandu L, Katkuri H, Afonso L, Int J Cardiol, 1/1/2007
• Interventional approach to recurrent myocardial infarction in HIV infection  
  Glazier JJ, Spears JR, Murphy MC, J. Intervent Cardiol, 1/1/2006
• Interventional approach to recurrent myocardial infarction in HIV-1 infection  
  Glazier JJ, Spears JR, Murphy MC, J Interven Cardiol, 1/1/2006
• Case report: recurrent heart failure with preserved ejection fraction but markedly elevated BNP in a 51-year-old female on hemodialysis with oversized AV fistula  
  Jin H, Afonso L, Singh A, Migdal S, Spears JR, Int J Cardiol, 1/1/2006
• Intracoronary aqueous oxygen perfusion, performed 24 hrs after the onset of postinfarction reperfusion, experimentally reduces infarct size and improves left ventricul...  
  Spears JR, Prcevski P, Jiang A, Brereton GJ, and Vander Heide R, International J Cardiol, 1/1/2006
• Aqueous oxygen near the homogeneous nucleation limit of water: stabilization with submicron capillaries  
  Spears JR, Prcevski P, Brereton GJ, ASAIO Journal, 1/1/2006
• Angiographic observations ten years following coronary laser balloon angioplasty  
  Glazier JJ, Spears JR, J. Intervent Cardiol, 1/1/2005
• Angiographic observations 10 years following coronary laser balloon angioplasty  
  Glazier JJ, Spears JR, J Intervent Cardiol, 1/1/2005
• Aqueous Oxygen Attenuation of Reperfusion Microvascular Ischemia in a Canine Model of Myocardial Infarction  
  Spears JR, Prcevski P, Xu R, Li L, Brereton G, DiCarli M, Spanta A, Crilly R, Lavine S, and vander Heide R, ASAIO Journal, 1/1/2003
• Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of metastatic lung tumors in a rat model  
  Petre PM, Baciewicz FA, Tigan S, Spears JR, J Cardiovasc Thorac Surg, 1/1/2003
• Early recovery of infarct zone function with intracoronary hyperoxemia reperfusion after primary angioplasty for acute myocardial infarction  
  Dixon SR, O�Neill WW, Bartorelli AL, Spears JR, David S, Grinberg I, Qureshi MA, Pepi M, Trabattoni D, Fabbiocchi F, Montorsi P, Marcovitz PA, JACC, 1/1/2002
• Aqueous Oxygen Hyperbaric Reperfusion in a Porcine Model of Myocardial Infarction  
  Spears JR, Henney C, Prcevski P, Xu R, Li L, Brereton GJ, DiCarli M, Spanta A, Crilly RJ, Sulaiman AM, Hadded S, Lavine S, Patterson WR, Creach J, Vander Heide R, J. Invasive Cardiology, 1/1/2002
• Prominent ECG repolarization changes associated with intracoronary infusion of normal saline: comparisons with alternate coronary catheter flush solutions  
  Romanelli MP, Meissner MD, Fromm BS, Spears JR, Catheter Cardiovasc Inter, 1/1/1999
• Successful redeployment of an unexpanded coronary stent  
  McGinnity JG, Glazier JJ, Spears JR, Rogers C, Turi ZG, Cath Cardiovasc. Diag., 1/1/1998
• Nucleation in small capillary tubes  
  Brereton GJ, Crilly RJ, Spears JR, Chemical Physics, 1/1/1998
• Coronary embolism complicating aortic valve endocarditis: treatment with placement of an intracoronary stent  
  Glazier JJ, McGinnity JG, Spears JR, Clin. Cardiol., 1/1/1997
• Aqueous Oxygen: a highly O2-supersaturated infusate for regional correction of hypoxemia and production of hyperoxemia  
  Spears JR, Wang B, Xu X, Prevski P, Jiang AJ, Spanta A, Crilly R, Brereton GJ, Circulation, 1/1/1997
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Books/Book Chapters

• Urgent Interventional Therapies 
  Chapter: Aqueous Oxygen for Treatment of ST- Segment Elevation Myocardial Infarction 
  Page 502 - 508Neelima Katukuri, Jeffrey L. Creech, James Richard SpearsEditors: Kipshidze N, Serruys P.John Wiley & Sons, Oxford, United Kingdom2015
• Handbook of Cardiovascular Interventions 
  Chapter: Lasers and balloons 
  Page 705 - 714Spears JREditors: Sigwart U, Bertrand M, Serruys P.Churchill Livingstone, London, England, United Kingdom1996
• Optical and Thermal Responses of Laser Irradiation on Tissue 
  Chapter: Laser balloon angioplasty 
  Page 831 - 858Cheong W-F, Crilly RJ, Spears JREditors: Welch AJ, Van Gemert MJC.Plenum Press, New York, NY1995
• Retension of tim ethyl etiopurpurin [SnEt2] by atheromatous plaque, studies in vitro and in vivo rabbit. Proc SPIE 
  Chapter: Diagnostic and Theraputic Cardivascular Intervention 
  Page 30 - 41Cheong WF, Narciso HL, Ali M, Iyer G, Raza SJ, Crilly RJ, Spears JR1994
• Application of the adjoint method to monte carlo studies of fluorescent quantification in turbid media. Proc SPIE 
  Chapter: Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases 
  Crilly RJ, Cheong W-F, Wilson B, Spears JR1994
• Interventional Cardiology: Future Directions 
  Chapter: Laser balloon angioplasty: therapeutic mechanisms and clinical correlations 
  Page 263 - 272Jenkins RD, Spears JREditors: Vogel JHK, King SB III.C.V. Mosby, St. Louis, MOEdition 2nd,1993
• Restenosis after Intervention with New Coronary Devices 
  Chapter: Introduction to assessment of stenosis/restenosis-present and future 
  Page 3 - 9Spears JREditors: Serruys PW, Strauss BH, King SB III.Kluwer Academic Publishers, Dordrecht, The Netherlands1992
• Restenosis after Intervention with New Coronary Devices 
  Chapter: Improved luminal dimensions and local pharmacologic therapy with laser balloon angioplasty for potential mitigation of restenosis 
  Page 347 - 358Spears JREditors: Serruys PW, Strauss BH, King SB III.Kluwer Academic Publishers, Dordrecht, The Netherlands1992
• Coronary Laser Angioplasty 
  Chapter: Laser balloon angioplasty: evolving technology 
  Page 192 - 221Spears JREditors: Litvack F.Blackwell Scientific Pub, Boston, MA1992
• Complications of Coronary Angioplasty 
  Chapter: Treatment of acute closure with laser balloon angioplasty 
  Page 159 - 176Spears JR, Sinclair IN, Jenkins RDEditors: Black AJR, Anderson HV, Ellis SG.Mercel Dekker, Inc., New York, NY1991
• Cardiac Catheterization and Angiography 
  Chapter: The role of lasers in the cardiac catheterization laboratory 
  Page 492 - 510Levine AB, Spears JREditors: Grossman W.Lea and Febiger, Philadelphia, PA1991
• Quantitative Coronary Arteriography 
  Chapter: Laser balloon angioplasty 
  Page 329 - 339Spears JREditors: Reiber JHC, Serruys PW.Kluwer Academic Publishers, Dordrecht, The Netherlands1990
• Lasers in Cardiovascular Medicine and Surgery: Fundamentals and Techniques 
  Chapter: Laser balloon angioplasty: Experimental in vivo and in vitro studie 
  Page 167 - 188Spears JR, Sinclair IN, Jenkins RDEditors: Abela GS.Kluwer Academic Publishers, Nowell, MA1990
• Interventional Cardiology: Future Directions 
  Chapter: Laser balloon angioplasty 
  Page 182 - 193Spears JREditors: Vogel JHK, King SB.C.V. Mosby Co., St. Louis, MO1989
• Endovascular Surgery 
  Chapter: Laser welding as an adjunct to balloon angioplasty 
  Page 278 - 285Jenkins RD, Spears JREditors: Moore WS, Ahn SS.W.B. Saunders Co., Philadelphia, PA1989
• Interventional Cardiology 
  Chapter: Role of laser balloon angioplasty as an adjunct to PTCA 
  Spears JREditors: Topol.W.B. Saunders Co., Philadelphia, PA1989
• Lasers in Cardiovascuar Disease 
  Chapter: Photosensitization 
  Page 107 - 120Spears JREditors: Isner JM, Clarke RH.Matinus Nijhoff Publishers, Boston, MA1989
• Lasers in Cardiovascuar Disease 
  Chapter: Sealing 
  Page 107 - 120Spears JREditors: Isner JM, Clarke RH.Matinus Nijhoff Publishers, Boston, MA1989
• State of the Art in Quantitative Coronary Arteriography 
  Chapter: Quantitation of coronary artery stenosis severity: Limitations of angiography and computerized information extraction 
  Page 103 - 124Spears JR and Sandor TEditors: Reiber JHC, Serrys PW.Martinus Nijhoff Publishers, Amsterdam, The Netherlands1986
• Cardiac Catheterization and Angiogaphy 
  Chapter: Potential role of lasers in the cardiac catheterization laborator 
  Page 536 - 543Spears JREditors: Grossman W.Lea & Febiger, Philadelphia, PA1986
• Cardiology Update for the Practicing Physician 
  Chapter: The current management of angina pectoris 
  Page 41 - 51Spears JR and Grossman WEditors: Grossman W, Margan JP, Braunwald E.Brigham/Beth Israel Medical Group1984
• Radiological Functional Analysis of the Vascualr System 
  Chapter: Computer aided densitometric evaluation of coronary cineangiograms 
  Page 195 - 205Spears JR, Sandor T, Serur JR, Paulin SEditors: Heuck HW.Springer-Verlag, New York, NY1983
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Abstracts/Posters

• Comparison of Intra-Aortic Aqueous Oxygen (IA-AO) Vs Intravenous Norepinephrine in a Swine Model of Hemodynamic Shock Associated with Acute Isovolemic Critical Anemia
  Lakshmi Muthukumar, Neelima Katukuri, Yazan Khouri, Ibrahim Shaik, Robert Hammond, Salik Jahania, and J. Richard Spears, AHA Scientific Sessions; ReSS (Resuscitation Science Symposium); Circulation, 1/1/2014
• Controlled Nucleation from Oxygen- Supersaturated Solutions (CNOSS): Microbubble Size Modification with Effluent Velocity and Surfactants
  Tiona Stephens, Azmi S. Kumaravelu, Lakshmi Muthukumar, Petar Prcevski, DVM, and James Richard Spears, Michigan ACP meeting, 1/1/2014
• A novel surfactant-free small oxygen microbubble echo contrast agent
  Muthukumar L, Shaik I, Mangalpally K, Katukuri N, Khouri Y, Agarwal S, Spears JR, J Amer Coll Cardiol; ACC Meeting, Washington, DC, 1/1/2014
• Intra-aortic Aqueous Oxygen Infusion in a Swine Model of Acute Isovolemic Anemia
  Yazan Khouri, Lakshmi Muthukumar, Neelima Katukuri, Ibrahim Shaik, Subhashish Agarwal, Kiran Mangalpally, Salik Jahania, Robert Hammond, PhD, Saptarshi Bandyopadhyay, ..., Circulation; AHA Meeting, ReSS (Resuscitation Science Symposium), Dallas, TX, 1/1/2013
• Intracoronary AO hyperbaric perfusion, delayed 24 hrs after the onset of postinfarction reperfusion, reduces infarct size and improves LV function
  Spears JR, Prcevski P, Jiang A, Brereton GJ, Scientific Sessions, American Heart Association; Circulation, New Orleans, LA, 1/1/2004
• Effects of gas diffusion on nucleation of gas-supersaturated liquids
  Brereton GJ, Liu X, Garret S, Spears JR, American Physical Society, Annual APS March Meeting, Indiana Convention Center, Indianapolis, IN, 1/18/2002
• Effects of gas diffusion on nucleation of gas-supersaturated liquids
  Brereton GJ, Liu X, Garett S, Spears JR, Amer Physical Society, Indianapolis, IN, 1/18/2001
• Global and regional left ventricular function after intracoronary hyperoxemic perfusion with the aqueous oxygen system in acute myocardial infarction
  Dixon SR, O�Neill WW, Bartorelli AL, David SW, Spears JR, Qureshi MA, Grinberg I, Pepi M, Tabattoni D, Fabbiocchi F, Motorsi P, Marcovitz P, Circulation, 1/1/2000
• Reperfusion microvascular ischemia: attenuation with aqueous oxygen
  Spears JR, Henney C, Prcevski P, Xu R, Li L, Brereton GJ, Dicarli M, Spanta A, Crilly RJ, Sulaiman AM, Hadded S, Lavine S, Patterson WR, Creach J, vander Heide R, Circulation, 1/1/2000
• Reperfusion microvascular ischemia attenuated with aqueous oxygen infusion in a porcine coronary occlusion model
  Spears JR, Henney C, Prcevski P, Wu R, Li L, Brereton G, DiCarli M, Spanta A, Crilly RJ, Sulaiman A, Lavine S, Vander Heide R, Circulation; 72nd Scientific Sessions of the AHA, 1/9/1999
• Subselective intracoronary aqueous oxygen hyperoxemic reperfusion after one hour coronary occlusion in swine restores left ventricular function
  Spears JR, ACC Meeting; JACC, New Orleans, LA, 1/3/1999
• Reperfusion microvascular ischemia attenuated with aqueous oxygen infusion in a porcine coronary occlusion model
  Spears, JR, Henney C, Prcevski P, Wu X, Li L, Brereton G, DiCarli M, Spanta A, Crilly RJ, Sulaiman AM, Lavine S, Vander Heide R, Circulation, 1/1/1999
• Subselective intracoronary aqueous oxygen hyperoxemic reperfusion after one hour coronary occlusion in swine restores left ventricular function
  Spears JR, Prcevski P,Jiang AJ, Wu X, Li L, Spanta A, Henney C, Crilly RJ, JACC, 1/1/1999
• Post MI aqueous oxygen reperfusion acutely improves canine LV function compared to normoxemic reperfusion
  Henney C, Spears JR, Prcevski P, Jiang AJ, Wu X, Spanta A, Lavine S, Am J Cardiol; TCT X, Washington Convention Center, Washington, DC, 1/1/1998
• Nucleation in small capillary tubes
  Brereton GJ, Crilly RJ, Spears JR, Meeting of the American Physical Society, 1/1/1998
• Hyperoxemia reperfusion with aqueous oxygen improves left ventricular function and microvascular flow in the postischemic canine myocardium
  Spears JR, Prcevski P, Jiang AJ, Spanta A, Vander Heide R, DiCarli M, Lavine S, Crilly RJ, JACC, 1/1/1998
• Aqueous oxygen: a highly O2-supersaturated infusate for hyperoxemic treatment of postischemic myocardium
  Spears JR, Prceveski P, Wu X, Jianf AJ, Spanta A, Brereton G, Crilly RJ, Amer J. Cardiol., 1/1/1997
• Intraaortic infusion of oxygen in a rabbit model
  Spears JR, Jiang AJ, Wu X, Prcevski P, Spanta A, Crilly RJ, Brereton GJ, JACC, 1/1/1997
• Hyperoxemic perfusion with aqueous oxygen improves LV function during experimental MI-reperfusion
  Spears JR, Prcrevski P, Wu X, Jiang AJ, Crilly RJ, Circulation, 1/1/1997
• Perturbation in radiation fields due to calcification for isotopes considered for intravascular brachytherapy
  Crilly RJ, Roberts W, Spears JR, Circulation, 1/1/1997
• Laser balloon angioplasty of pulmonary arteries in growing swine: reducing elastic recoil following balloon angioplasty
  Morrow WR, Vincent J, Pebbles K, Tower A, Spears JR, Amer. Acad. Pediatrics, 1/1/1996
• Effect of topical O2-supersaturated normal saline on UV light-induced mouse ear inflammation
  Guttikonda P, Wang B, Prcevski P, Crilly RJ, Spears JR, J. Invest. Med.; AFCR meeting, New Orleans, LA, 1/1/1996
• Myocardial protection with a perfusion guidewire during balloon angioplasty in a canine model
  Spears JR, Wu X, Wang B, Prcevski P, Levin P, Crilly RJ, Spears JR, JACC, 1/1/1996
• Retension of tim ethyl etiopurpurin [SnEt2] by atheromoatic plaquie, studies in vitro and in vivo rabbit
  Cheong WF, Narciso HL, Ali M, Iyer G, Raza SJ, Crilly RJ, Spears JR, Proceeding of SPIE; Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, 1/1/1994
• Application of the adjoint method to monte carlo studies of fluorescent qualification in turbid media
  Crilly RJ, Cheong WF, Wilson B, Spears JR, Proceeding of SPIE; Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, 1/1/1994
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Lectures

• Future Technologies: Aqueous Oxygen 
  Washington, DC - 1/1/2008
• Why SSO2 Works 
  Washington, DC - 1/1/2007
• AMIHOT II: update of clinical trial 
  1/1/2006
• Aqueous Oxygen 
  1/1/2005
• Intracoronary AO hyperbaric perfusion, delayed 24 hrs after the onset of postinfarction reperfusion, reduces infarct size and improves LV function 
  New Orleans, LA - 1/1/2004
• Treatment of Reperfusion Microvascular Ischemia with Aqueous Oxygen 
  1/1/2003
• Stem cell therapy for post MI myocardial regeneration 
  1/19/2002
• Reperfusion microvascular ischemia: attenuation with aqueous oxygen 
  1/14/2000
• Advances in anticoagulation and antithrombotic therapy of cardiology patients 
  Dearborn, MI - 1/24/1999
• Bioengineering problems encountered in the development of aqueous oxygen 
  1/22/1999
• Local hyperbaric oxygen therapy for treatment of myocardial infarction/reperfusion 
  1/18/1999
• Novel reperfusion strategies for acute myocardial infarction 
  Hilton Northfield, Troy, MI - 1/13/1999
• The Middle in the Middle: Understanding the Process of New Enterprise Development from Uiversity-Based Discoveries 
  University of Michigan, Ann Arbor, MI - 1/9/1999
• Hyperoxemic perfusion with aqueous oxygen improves left ventricular function and coronary flow in postischemic canine myocardium 
  Florence, Italy - 1/21/1998
• Hyperoxemic reperfusion with aqueous oxygen improves left ventricular function and microvascular flow in the postischemic canine myocardium 
  Atlanta, GA - 1/1/1998
• Hyperoxemic reperfusion with aqueous oxygen in a canine model 
  Washington Convention Center, Washington, DC - 1/24/1997
• Supersaturated oxygen solutions 
  Cambridge, MA - 1/22/1997
• Intraaortic infusion of oxygen in a canine model 
  Anaheim, CA - 1/19/1997
• Hyperoxemic perfusion with aqueous oxygen improves LV function during experimental MI-reperfusion 
  Orlando, FL - 1/11/1997
• Intravascular oxygen delivery 
  1/17/1996
• Potential treatment of myocardial ischemia with intravascualr oxygen 
  Good Samaritan Hospital, Wright State University, Dayton, OH - 1/10/1996
• Transcatheter oxygen delivery: role in high risk and acute MI? 
  Washington Convention Center, Washington, DC - 1/2/1996
• Myocardial protection with a perfusion guidewire during balloon angioplasty in a canine model 
  Orlando, FL - 1/1/1996
• Transcatheter Therapeutics VII, Catheter-based delivery of oxygen 
  Washington, DC - 1/25/1995
• Intravascular oxygenation with oxygen-supersaturated solutions 
  1/6/1995
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Other

• Effects of gas diffusion on nucleation of gas-supersaturated liquids 
  Brereton GJ, Liu X, Garett S, Spears JR, Bulletin American Physical Society
  1/1/2001
• Nucleation in small capillary tubes 
  Brereton GJ, Crilly RJ, Spears JR, Bulletin of the American Physical Society
  1/1/1998