JamesCOatesMD

Lupus & Related, Rheumatoid Arthritis & Related, Clinical Informatics

Professor of Medicine, Richard M. Silver Endowed Chair, Director of Rheumaotlogy and Immunology, Vice Chair for Research, Department of Medicine, Medical University of South Carolina.

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Office
96 Jonathan Lucas Street
Suite 822, MSC 637
Charleston, SC 29425
Phone+1 843-792-1991

Fax+1 843-792-7121

Summary

My general training is in immunology and autoimmunity, with specific expertise in lupus, lupus nephritis, endothelial dysfunction, biomarkers and predictors of lupus nephritis outcomes and atherosclerosis in lupus, and the role of reactive intermediates in lupus nephritis and atherosclerosis. I have maintained a translational research laboratory and have developed a clinical research program as an integral member of the Medical University of South Carolina Lupus Erythematosus (MUSCLE) clinical research group and the CCCR P30 leadership. I have conducted multiple investigator initiated clinical studies and commercial clinical trials.

I am the Director of the MUSC the NIAMS P30 Core Center for Clinical Research (CCCR) and Vice Chair for Research in the Department of Medicine. As the former Informatics Medical Director of Research and Reporting for the Medical University Hospital Authority, I was in charge of integration of clinical research processes into the electronic health record and governance of research data. Collaborations developed during the time of this Directorship have lead to projects on electronic phenotyping and prediction and outcome tools derived from medical record data.
Finally, I serve as Chair of the Division Directors Committee of the American College of Rheumatology. In this position, I collaborate with colleagues to address the most important issues facing division directors in our subspecialty.

Education & Training

Medical University of South CarolinaFellowship, Rheumatology, 1996 - 1997
Duke University HospitalFellowship, Rheumatology, 1994 - 1996
Duke University HospitalResidency, Internal Medicine, 1991 - 1994
Johns Hopkins University School of MedicineClass of 1991
Bates CollegeB.S., Chemistry, 1982 - 1986

Certifications & Licensure

SC State Medical License 1996 - 2025
NC State Medical License 1993 - 1998
American Board of Internal Medicine Rheumatology

Awards, Honors, & Recognition

Member Americal Clinical and Climatological Association, 2018
Member Henry Kunkel Society, 2018
Fellow Southern Society for Clinical Investigation, 2007
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
Nominated by medical students as "Teacher of the Month" College of Medicine, MUSC, 2012-2013
"America's Top Physicians" Consumers' Research Council of America, 2007
"Best Doctors in America" Best Doctors, Inc., 2007
International Exchange Award Research Education Foundation/European League Against Rheumatism, 2003
Health Sciences Foundation Developing Scholar Award Medical University os South Carolina, 2003
Merck Young Investigator Award 2001
Associate Investigator Award Department of Veterans Affairs, 1997
Four Schools Physician Scientist Training Program Scholar Johns Hopkins University School of Medicine, Duke University Medical Center, 1989
Advanced Research Career Development Award Department of Veterans Affairs
Dana Scholar Bates College
Health Sciences Foundation Developing Scholar Award Medical University of South Carolina
Research Education Foundation/European League Against Rheumatism International Exchange Award ACR/REF
Arthritis Investigator Award Arthritis Foundation
Senior Rheumatology Scholar Award American College of Rheumatology
Four Schools Physician Scientist Training Program Scholar Johns Hopkins University School of Medicine
Phi Beta Kappa Bates College
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Clinical Trials

Long-Term Safety and Efficacy Study of Deucravacitinib in Participants With Systemic Lupus Erythematosus Start of enrollment: 2019 Mar 26
Active, not recruiting
Phase 2
An Investigational Study to Evaluate the Safety and Effectiveness of BMS-986165 With Background Treatment in Participants With Lupus Nephritis Start of enrollment: 2019 Jul 15
Terminated
Phase 2
Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE) Start of enrollment: 2020 Feb 19
Completed
Phase 2
CCCR Lupus Patient Navigator Program Start of enrollment: 2020 Sep 03
Completed
Not Applicable
Vitamin D to Improve Endothelial Function in SLE Start of enrollment: 2011 Jun 01
Completed
Phase 2
Balancing Lupus Experiences With Stress Strategies Start of enrollment: 2010 Aug 01
Completed
Phase 1, Phase 2
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Publications & Presentations

PubMed

18 citations
Antiphospholipid Antibodies and Heart Valve Disease in Systemic Lupus Erythematosus
Daniel Ruiz, Jim C. Oates, Diane L. Kamen
The American Journal of the Medical Sciences. 2017-07-20
877 citations
Efficacy and Safety of Rituximab in Moderately-to-Severely Active Systemic Lupus Erythematosus: The Randomized, Double-Blind, Phase II/III Systemic Lupus Erythematosus...
Joan T. Merrill, C. Michael Neuwelt, Daniel J. Wallace, Joseph C. Shanahan, Kevin Latinis
Arthritis and Rheumatism. 2010-01-01
116 citations
At the Bedside: Neutrophil extracellular traps (NETs) as targets for biomarkers and therapies in autoimmune diseases
April Barnado, Leslie J. Crofford, Jim C. Oates
Journal of Leukocyte Biology. 2016-02-01

Journal Articles

Stress Intervention and Disease in African American Lupus Patients: the Balancing Lupus Experiences with stress strategies (BLESS) study
Williams E, Kamen D, Penfield M, Oates J, Health, 1/1/2014
An Intervention to Reduce Psychosocial and Biological Indicators of stress in African American Lupus Patients: the Balancing Lupus Experiences with stress strategies s...
Williams E, Penfield M, Kamen D, Oates J, Open Journal of Preventive Medicine, 1/1/2014
NADPH oxidase and nitric oxide synthase dependent superoxide production is increased in proliferative lupus nephritis
Oates JC, Mashmoushi AK, Shaftman S, Gilkeson GS, Lupus, 1/1/2013
Differential regulation of cell functions by subdomains of the caveolin-1 scaffolding domain peptide
Reese C, Dyer S, Perry B, Bonner M, Oates J, Hofbauer A, Sessa W, Bernatchez P, Visconti RP, Zhang J, Hatfield CM, Silver RM, Hoffman S, Tourkina E, J Resp Res, 1/1/2013
Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry
Ramos PS, Oates JC, Kamen DL, et al., J Rheumatol, 1/1/2013
Lack of nitric oxide synthases increases lipoprotein immune complex deposition in the aorta and elevates plasma sphingolipid levels in lupus
Al Gadban MM, German J, Truman JP, Soodavar F, Riemer EC, Twal WO, Smith KJ, Heller D, Hofbauer AF, Oates JC, Hammad SM, Cellular immunology, 3/1/2012
Overcoming the Effects of Matrix Interference in the Measurement of Urine Protein Analytes
Taylor TP, Janech MG, Slate EH, Lewis EC, Arthur JM, and Oates JC, Biomarker Insights, 1/1/2012
Premature Atherosclerosis Is Associated With Hypovitaminosis D and Angiotensin-Converting Enzyme Inhibitor Nonuse in Lupus Patients
Ravenell RL, Kamen DL, Spence JD, Hollis BW, Fleury TJ, Janech MG, Almeida, JS, Shaftman, SR, Oates, JC, American Journal of Medical Sciences, 1/1/2012
Altered monocyte and fibrocyte phenotype and function in scleroderma interstitial lung disease: reversal by caveolin-1 scaffolding domain peptide
Tourkina E, Bonner M, Oates J, Hofbauer A, Richard M, Znoyko1 S,. Visconti RP, Zhang J, Hatfield, CM, Silver RM, Hoffman S, Fibrogenesis & Tissue Repair, 1/1/2011
Caveolin-1 Regulates Leucocyte Behaviour in Fibrotic Lung Disease
Tourkina E, Richard M, Oates J, Hofbauer A, Bonner M, Gööz P, Visconti R, Zhang J, Znoyko S, Hatfield CM, Silver RM, and Hoffman S, Ann Rheum Dis, 1/1/2010
Upregulation of xCT by KSHV-encoded microRNAs facilitates KSHV dissemination and persistence in an environment of oxidative stress
Qin Z, Freitas E, Sullivan R, Mohan S, Bacelieri R, Branch D, Romano M, Kearney P, Oates JC et al., PLoS Pathog, 1/1/2010
The Place of William Osler in the Description of Systemic Lupus Erythematosus
Scofield RH, Oates JC, Am J Med Sci, 1/1/2009
Inducible nitric oxide synthase inhibitor SD-3651 reduces proteinuria in MRL/lpr mice deficient in the NOS2 gene
Njoku C, Self SE, Ruiz P, Hofbauer AF, Gilkeson GS, Oates JC, J Investig Med, 10/1/2008
Association of serum nitrate and nitrite levels with longitudinal assessments of disease activity and damage in systemic lupus erythematosus and lupus nephritis
Oates JC, Shaftman SR, Self SE, Gilkeson GS, Arthritis Rheum, 1/1/2008
Association of the G-463A myeloperoxidase gene polymorphism with renal disease in African Americans with systemic lupus erythematosus
Bouali H, Nietert P, Nowling TM, Pandey J, Dooley MA, Cooper G, Harley J, Kamen DL, Oates J, Gilkeson G, the Journal of Rheumatology, 10/1/2007
Anti-dsDNA antibody assay: high specificity and sensitivity with a filtration radioassay in comparison to low specificity with the standard ELISA
Yu L, Wang J, O'Dell JR, Oates J, Arend WP, Eisenbarth GS, J Rheumatol, 1/1/2007
The biology of nitric oxide and other reactive intermediates in systemic lupus erythematosus
Oates JC, Gilkeson GS, Clin Immunol., 1/1/2006
Curcumin-Induced Apoptosis in Scleroderma Lung Fibroblasts: Role of Protein Kinase C{epsilon}
Tourkina E, Gooz P, Oates JC, Ludwicka-Bradley A, Silver RM, Hoffman S, Am. J. Respir. Cell Mol. Biol., 1/1/2004
Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in African-Americans
Oates JC, Levesque MC, Hobbs MR, Smith EG, Molano ID, Page GP, et al., J. Rheumatol., 1/1/2003
Oates, JC, Reilly, CM, Crosby, MB, Gilkeson, GS, Arthritis Rheum, 1/1/2002
Prostaglandin J(2) inhibition of mesangial cell iNOS expression
Reilly CM, Oates JC, Sudian J, Crosby MB, Halushka PV, Gilkeson GS, Clinical Immunology, 1/1/2001
Inhibition of mesangial cell nitric oxide in MRL/lpr mice by prostaglandin J2 and proliferator activation receptor-gamma agonists
Reilly CM, Oates JC, Cook JA, Morrow JD, Halushka PV, Gilkeson GS, J. Immunol., 1/1/2000
thrombosis in patients with connective tissue diseases treated with specific cyclooxygenase 2 inhibitors-A report of four cases
Crofford LJ, Oates JC, McCune WJ, Gupta S, Kaplan MJ, Catella-Lawson F, et al., Arthritis Rheum., 1/1/2000
Prospective measure of serum 3-nitrotyrosine levels in systemic lupus erythematosus: Correlation with disease activity
Oates JC, Christensen EF, Reilly CM, Self SE, Gilkeson GS., Proc. Assoc. Am. Physicians, 1/1/1999
Correlation of serum measures of nitric oxide production with lupus disease activity
Gilkeson G, Cannon C, Oates J, Reilly C, Goldman D, Petri M, J. Rheumatol., 1/1/1999
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Books/Book Chapters

Dubois' Lupus Erythematosus and Related Syndromes
Chapter: Tissue Damage in Lupus: Free Radicals and Fibrosis
Page 248 - 260Oates JC, Nowlingn TMEditors: Wallace DJ and Hahn BH.Elsevier, Philadelphia, PAEdition 9th,2019
Lupus. Epigenetics of Autoimmune disease
Chapter: Reactive Intermediates, Inflammation and Epigenetics in Lupus
Page 151 - 164Gilkeson GS, Oates JCEditors: Moncef, Z..John Wiley and Sons, Hoboken, NJ2014
Systemic Lupus Erythematosus
Chapter: The role of reactive intermediates in systemic lupus erythematosus
Page 199 - 2117. Mashmoushi AK, Gilkeson GS, and Oates JCEditors: Lahita R.Elsevier, Philadelphia, PAEdition 5th,2011
Systemic lupus erythematosus : a companion to Rheumatology
Chapter: Nitric Oxide in SLE
Oates JC, Gilkeson GSEditors: Tsokos GC, Gordon C, Smolen JS.Mosby ElsevierEdition 1st,2007
Arthritis and Allied Conditions A Textbook of Rheumatology
Chapter: Nitric oxide and related compounds
Page 541 - 555Oates JC, Gilkeson GS.Editors: Klippel JH, Weyand CM, Wortmann R.Williams & Wilkins, Baltimore, MDEdition 15th,2005
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Press Mentions

Restoring This Enzyme's Function Protects Against Heart Disease in Lupus and BeyondMarch 28th, 2019
Richard M. Silver, MD, in the SpotlightDecember 18th, 2018

Grant Support

Improving Minority Health in Rheumatic Disease (IMHeaRD)NIAMS, NIH2022–2027
Targeting pathogenic endothelial dysfunction in lupus nephritisVA2022–2027
Targeting pathogenic endothelial dysfunction and lupus nephritisLupus Research Alliance2021–2023
Peer Approaches to Lupus Self-Management (PALS)NINR2018–2023
PREDICTIVE BIOMARKERS FOR DISEASE ACTIVITY AND ORGAN DAMAGE IN PATIENTS WITH LUPUSNIAMS2018–2023
EHR-based Longitudinal Cohort to Explore Pregnancy OuTComes in SLE (ELIPTCL)Department of Defense2020–2022
Role of microbiota-TLR7/8 Interaction in systemic lupus erythematosusNIAID2018–2022
Improving Minority Health in Rheumatic Diseases (IaMHeaRD)NIAMS2017–2022
TARGETING PATHOGENIC ENDOTHELIAL DYSFUNCTION IN SYSTEMIC LUPUS ERYTHEMATOSUSVA2016–2020
Role Of Reactive Intermediates In Lupus NephritisNational Institute of Arthritis and Musculoskeletal and Skin Diseases2011–2013
Urine Biomarkers Of Lupus Nephritis Pathology And Response To TherapyVeterans Affairs2011–2012
Role Of Reactive Intermediates In Lupus NephritisNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2008–2011
Biomarkers Of Atherosclerosis In Systemic Lupus Erythematosus (SLE)National Center For Research Resources2008
Proteomic Approach To Urine Biomarkers Of Disease In Lupus NephritisNational Center For Research Resources2007–2008
The Role Of Nitric Oxide And Eicosanoids In Lupus NephritisNational Center For Research Resources2005–2008
The Role Of Nitric Oxide In Systemic SclerosisNational Center For Research Resources2005
Urine Protein Markers Of Disease In Lupus NephritisNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2004–2005
Role Of Nitric Oxide And Eicosanoids In Lupus NepthritisNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2001–2005
The Role Of Nitric Oxide In SLENational Center For Research Resources2004
Role Of Nitric Oxide In LupusNational Center For Research Resources2000–2002
Role Of Nitric Oxide In SLENational Center For Research Resources1998–1999

Professional Memberships

American College of Rheumatology - ACR
Member
Southern Society for Clinical Investigation
Fellow
Henry Kunkel Society
Member
American Clinical and Climatological Association
Member
Royal Society of Medicine
Member

External Links

MUSC profilehttps://education.musc.edu/MUSCApps/facultydirectory/Oates-Jim
MUSC Rheumatologyhttps://medicine.musc.edu/departments/dom/divisions/rheumatology-and-immunology/about/2023-year-in-review
MUSC Rheumatologyhttps://medicine.musc.edu/departments/dom/divisions/rheumatology-and-immunology