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James Murrough, MD, Psychiatry, New York, NY

JamesWarrenMurroughMDPhD

Psychiatry New York, NY

Psychopharmacology

Director, Depression and Anxiety Center for Discovery and Treatment; Associate Professor of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai

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  • Office

    1 Gustave L Levy Pl
    Box 1230
    New York, NY 10029
    Phone+1 212-585-4640
    Fax+1 212-241-3354

Summary

  • Dr. James Murrough is Professor of Psychiatry and Neuroscience and Director of the Depression and Anxiety Center for Discovery and Treatment at the Icahn School of Medicine at Mount Sinai. He is a faculty member of the Friedman Brain Institute. Dr. Murrough conducts clinical and translational research aimed at understanding the biological basis of mood and anxiety disorders in order to point the way towards new, more effective treatments. He received his Bachelor of Science in Neuroscience and Behavioral Biology from Emory University in Atlanta and his Medical degree from Tufts University School of Medicine in Boston. He completed residency training in psychiatry, a research fellowship in experimental therapeutics and clinical neuroscience, and a PhD in clinical research from Mount Sinai. Dr. Murrough has received research support from the National Institutes of Health, the Doris Duke Charitable Foundation, the American Foundation for Suicide Prevention, the Dana Foundation and the Brain and Behavior Research Foundation. He is a Member of the American College of Neuropsychopharmacology and an active member of the scientific community. In addition to his research and educational activities, Dr. Murrough oversees a clinical program at Mount Sinai focused on evidence-based treatments for treatment-resistant depression and other refractory forms of mood and anxiety disorders.
  • Depression & Anxiety Center NYC | Icahn School of Medicine

    The Depression and Anxiety Center for Discovery and Treatment (DAC) is a comprehensive research facility and clinical program

Education & Training

  • Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount SinaiFellowship, Research, 2009 - 2011
  • Icahn School of Medicine at Mount Sinai/Mount Sinai Hospital
    Icahn School of Medicine at Mount Sinai/Mount Sinai HospitalResidency, Psychiatry, 2005 - 2009
  • Tufts University School of Medicine
    Tufts University School of MedicineClass of 2005

Certifications & Licensure

  • NY State Medical License
    NY State Medical License 2007 - 2026
  • Psychiatry
    American Board of Psychiatry and Neurology Psychiatry

Clinical Trials

Publications & Presentations

Journal Articles

  • Effects of the KCNQ Channel Opener Ezogabine on Functional Connectivity of the Ventral Striatum and Clinical Symptoms in Patients with Major Depressive Disorder  
    Katherine A Collins, Dan V Iosifescu, James W Murrough, Eric J Nestler, Nisha Chadha, Nature
  • Double-Blind, Placebo-Controlled, Dose-Ranging Trial of Intravenous Ketamine as Adjunctive Therapy in Treatment-Resistant Depression (TRD)  
    Sanjay J Mathew, Madhukar H Trivedi, Lee C Chang, Dan V Iosifescu, Manish K Jha, Maurizio Fava, Marlene P Freeman, Cristina Cusin, James Murrough, George I Papakostas,..., Nature
  • High-Dose Ondansetron Reduces Activation of Interoceptive and Sensorimotor Brain Regions  
    Evan Leibu, Wayne K Goodman, James W Murrough, Barbara J Coffey, Nature
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Authored Content

  • F142. Effect of Treatment Resistance Status on Whole Brain Voxel-Based Morphometry in Major Depressive DisorderApril 2018

Press Mentions

  • Ketamine Beats Shock Therapy in Easing Tough-to-Treat Depression
    Ketamine Beats Shock Therapy in Easing Tough-to-Treat DepressionMay 25th, 2023
  • AAGP Session to Highlight Research on Resilience, Emotional Well-Being in Aging
    AAGP Session to Highlight Research on Resilience, Emotional Well-Being in AgingJanuary 27th, 2023
  • Plastic Surgeons Are Using Ketamine to Make Nose Jobs More Pleasant
    Plastic Surgeons Are Using Ketamine to Make Nose Jobs More PleasantJanuary 18th, 2022
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Grant Support

  • Neural Circuit-Specific Mechanisms of Ketamine's Effect on Anhedonia and Anxiety in Depression Using Ultra-High Field 7-Tesla MRIICAHN SCHOOL OF MEDICINE AT MOUNT SINAI2023–2028
  • Biomarker-Guided Antidepressant Selection for Treatment-Resistant DepressionWEILL MEDICAL COLL OF CORNELL UNIV2024–2026
  • Influence of Dietary Botanical Supplements on Biological and Behavioral ResilienceICAHN SCHOOL OF MEDICINE AT MOUNT SINAI2020–2025
  • Developing Neuronal KCNQ Channel Modulators for Mood DisordersICAHN SCHOOL OF MEDICINE AT MOUNT SINAI2017–2025