James F Markmann MD

General Surgery•Philadelphia, PA

Transplantation

Professor, Surgery-Massachusetts General Hospital, Harvard Medical School

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3400 Spruce StFl 4Philadelphia, PA 19104
Phone+1 215-615-4949
Fax+1 215-662-2244

Education & Training

University of Pennsylvania Health SystemResidency, Surgery, 1990 - 1996
Perelman School of Medicine at the University of PennsylvaniaClass of 1989

Certifications & Licensure

CA State Medical License 1996 - Present
MA State Medical License 2007 - 2026
PA State Medical License 1992 - 2026
NH State Medical License 2021 - 2025
RI State Medical License 2020 - 2024
VT State Medical License 2013 - 2024
ME State Medical License 2020 - 2021
American Board of Surgery Surgery

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2006-2008, 2011-2014
Boston Magazine Castle Connolly, 2011-2013
Philadelphia Magazine Castle Connolly, 2006-2007
Fellow (FACS) American College of Surgeons
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Clinical Trials

Efficacy of Islet After Kidney Transplantation Start of enrollment: 2007 Jan 01
Completed
Phase 3
Study of Islet Transplantation in Type 1 Diabetic Kidney Transplant Recipients Start of enrollment: 2009 May 01
Completed
Phase 1, Phase 2
Research Study of ATG and Rituximab in Renal Transplantation Start of enrollment: 2011 Jul 25
Terminated
Early Phase 1
Reference Group Trial for The ONE Study Start of enrollment: 2012 Dec 01
Completed
Phase 4
Infusion of T-Regulatory Cells in Kidney Transplant Recipients (The ONE Study) Start of enrollment: 2014 May 01
Completed
Phase 1
Multicenter Trial of the Effect of AAT on Islet Transplant Engraftment and Durability After Renal Transplant Start of enrollment: 2017 Jan 01
Completed
Phase 2
Liver Transplantation With Tregs at MGH Start of enrollment: 2019 Mar 29
ACTIVE_NOT_RECRUITING
PHASE1, PHASE2
OCS Liver PROTECT Continued Access Protocol Start of enrollment: 2020 Feb 03
COMPLETED
NA
OCS Liver DCD Trial Start of enrollment: 2020 Jul 24
TERMINATED
NA
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Publications & Presentations

PubMed

1 citations
The Impact of Over Three Years Commercial Use of Ex Vivo Normothermic Machine Perfusion for Liver Transplantation in the USA: A UNOS/OPTN Database Analysis.
Takayuki Yamamoto, Naoru Koizumi, James F Markmann
Artificial Organs. 2025-02-18
Machine Perfusion in Deceased Donor Kidney Transplantation: Promises of Improved Outcomes but Gaps in Implementation.
Elizabeth M Sonnenberg, James F Markmann
American Journal of Kidney Diseases. 2025-01-30
UW supplementation with AP39 improves liver viability following static cold storage.
McLean Taggart, Saige Holkup, Alexandra Tchir, Mohammadreza Mojoudi, Arnaud Lyon
Scientific Reports. 2025-01-10

Journal Articles

Hepatocellular Carcinoma in Transplantable Child-Pugh A Cirrhotics: Should Cost Affect Resection vs Transplantation?
Theodoros Michelakos, Dimitrios Xourafas, David Berger, James F Markmann, Cristina R Ferrone, Motaz Qadan, Kenneth K Tanabe, Joel T Adler, Nahel Elias, Heidi Yeh, Madh..., Journal of gastrointestinal surgery
Signatures of Tolerance or Immunosuppression?
James Markmann, MD, American journal of transplantation

Press Mentions

Vertex Releases New Data on Potential Cure for Type 1 DiabetesJune 21st, 2022
First Patient Gains Insulin Independence with Novel Stem Cell-Derived Islet Cell TherapyJune 7th, 2022
Stem Cell Transplants Promising so Far in Type 1 DiabetesJune 7th, 2022
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Grant Support

Autologous chimeric antigen receptor engineered T cell immunotherapy for desensitization in patients awaiting kidney transplantationUNIVERSITY OF PENNSYLVANIA2021–2028
Mechanisms of action, optimization and application of BregsUNIVERSITY OF PENNSYLVANIA2006–2027
Mechanisms of action, optimization and application of BregsUNIVERSITY OF PENNSYLVANIA2006–2027
Mechanisms of action, optimization and application of BregsUNIVERSITY OF PENNSYLVANIA2006–2027
Hydrogels for human beta cell survival, function and evasion of immune rejectionGEORGIA INSTITUTE OF TECHNOLOGY2022–2026
Liver Xenotransplantation using CRISPR-modified Porcine OrgansUNIVERSITY OF PENNSYLVANIA2020–2025
Mechanisms Of B Cell-Dependent Transplantation ToleranceNational Institute Of Allergy And Infectious Diseases2011
Regulation And Counter-Regulation In TransplantationNational Institute Of Allergy And Infectious Diseases2010
Regulatory T Cells In Transplantation ToleranceNational Institute Of Allergy And Infectious Diseases2007–2008
Regulatory T Cells In Transplantation ToleranceNational Institute Of Allergy And Infectious Diseases2004–2007
Mechanisms Of Acquired Central Transplantation ToleranceNational Institute Of Allergy And Infectious Diseases2001–2003
Gene Transfer For Autoimmune Beta Cell Damage PreventionNational Institute Of Diabetes And Digestive And Kidney Diseases2000–2002

Professional Memberships

American College of Surgeons - ACS
Member