James Kuang-Jan Liao MD

PubMed

• 1 citations
  Safety and efficacy of atorvastatin for rebleeding in cerebral cavernous malformations (AT CASH EPOC): a phase 1/2a, randomised placebo-controlled trial.
  Issam A Awad, Roberto J Alcazar-Felix, Agnieszka Stadnik, Serena Kinkade, Aditya Jhaveri
  The Lancet. Neurology. 2025-04-01
• ARNT-dependent HIF-2α signaling protects cardiac microvascular barrier integrity and heart function post-myocardial infarction.
  Karim Ullah, Lizhuo Ai, Yan Li, Lifeng Liu, Qin Zhang
  Communications Biology. 2025-03-15
• 2 citations
  Endothelial oestrogen-myocardial cyclic guanosine monophosphate axis critically determines angiogenesis and cardiac performance during pressure overload.
  Nobuaki Fukuma, Hiroyuki Tokiwa, Genri Numata, Kazutaka Ueda, Pang-Yen Liu
  Cardiovascular Research. 2024-12-04

Journal Articles

• Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial  
  Amy L Akers, Kevin J Whitehead, Gregory A Christoforidis, Daniel F Hanley, Kelly D Flemming, Sean P Polster, James K Liao, Matthew Sorrentino, Cornelia Lee, Issam A Aw..., Neurosurgery
• Two functional polymorphisms of ROCK2 enhance arterial stiffening through inhibiting its activity and expression  
  Liao YC, Liu PY, Lin HF, Lin WY, Liao JK, Juo SH, J Mol Cell Cardiol, 1/1/2015
• Effect of aldosterone-producing adenoma on endothelial function and Rho-associated kinase activity in patients with primary aldosteronism  
  Matsumoto T, Oki, K, Kajikawa M, Nakashima A, Maruhashi T, Iwamoto Y, Iwamoto A, Oda N, Hidaka T, Kihara Y, Kohno N, Chayama K, Goto C, Aibara Y, Noma K, Liao JK, Higa..., Hypertension, 1/1/2015
• Exogenous nitric oxide inhibits Rho-associated kinase activity in patients with angina pectoris: a randomized controlled trial  
  Maruhashi T, Noma K, Fujimura N, Kajikawa M, Matsumoto T, Hidaka T, Nakashima A, Kihara Y, Liao JK, Higashi Y, Hypertens Res, 1/1/2015
• ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice  
  Kasahara DI, Mathews JA, Park CY, Cho Y, Hung G, Wumbrand AP, Liao JK, Shore SA, Am J Physiol Lung Cell Mol Physiol, 1/1/2015
• Rho-associated kinase activity is an independent predictor of cardiovascular events in acute coronary syndrome  
  Kajikawa M, Noma K, Nakashima A, aruhashi T, Iwamoto Y, Matsumoto T, Iwamoto A, Oda N, Hidaka T, Kihara Y, Aibara Y, Chayama K, Sasaki S, Kato M, Dote K, Goto C, Liao ..., Hypertension, 1/1/2015
• The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis  
  Knipe RS, Tager AM, Liao JK, Pharmacol Rev, 1/1/2015
• Gene variations of ROCKs and risk of ischaemic stroke: the Women's Genome Health Study  
  Zee RY, Wang QM, Chasman DI, Ridker PM, Liao JK, Clin Sci, 1/1/2014
• Evidence of pleiotropy by statins: leukocyte Rho kinase (ROCK) activity and pretreated statin before percutaneous coronary interventions are clinical vascular outcome ...  
  Liu PY, Lee PT, Chang WT, Tai YL, Chao TH, Lee CH, Li YH, Chen JH, Tsai LM, Liao JK, Int J Cardiol, 1/1/2014
• Critical role of exogenous nitric oxide in ROCK activity in vascular smooth muscle cells  
  Maruhashi T, Noma K, Iwamoto Y, Iwamoto A, Oda N, Jajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Nakashima A, Goto C, Liao JK, Higashi Y, PLoS One, 1/1/2014
• Abrogation of airway hyperresponsiveness but not inflammation by Rho kinase insufficiency  
  Kasahara DI, Ninin FM, Wurmbrand AP, Liao JK, Shore SA, Clin Exp Allergy, 1/1/2014
• Rho/Rho-associated coiled-coil forming kinase pathway as therapeutic targets for statins in atherosclerosis  
  Sawada N, Liao JK, Antioxid Redox Signal, 1/1/2014
• ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression  
  Montalvo J, Spencer C, Hackathorn A, Masterjohn K, Perkins A, Coty C, Arumugam A, Ongusaha PP, Lakshmanaswamy R, Liao JK, Mitchell DC, Bryan BA, Curr Mol Med, 1/1/2013
• Mineralocorticoid receptor blocker eplerenone improves endothelial function and inhibits rho-associated kinase activity in patients with hypertension  
  Fujimura N, Noma K, Hata T, Soga J, Hidaka T, Idei N, Fujii Y, Mikami S, Maruhashi T, Iwamoto Y, Kihara Y, Chayama K, Kato H, Liao JK, Higashi Y, Clin Pharm Ther, 1/1/2012
• ROCK2 deficiency in bone marow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis  
  Zhou Q, Yu M, Shoji T, Han X, Kaminski K, Oh GT, Ongusaha PP, Zhang K, Schmitt H, Moser M, Bode C, Liao JK, Circulation, 1/1/2012
• Notch1 in bone marrow derived cells mediates cardiac repair after myocardial infarction  
  Li Y, Hiroi Y, Ngoy S, Okamoto R, Noma K, Wang CY, Wang HW, Zhou Q, Radtke F, Liao R, Liao JK, Circulation, 1/1/2011
• Measurement of Rho-associate kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil  
  Hata T, Goto C, Soga J, Hidaka T, Fujii Y, Idei N, Fujimura N, Maruhashi T, Mikami S, Kihara Y, Chayama K, Noma K, Liao JK, Higashi Y, Atherosclerosis, 1/1/2011
• Calcium channel blocker and Rhoassociated kinase activity in patients with hypertension  
  Hata T, Soga J, Hidaka T, Idei N, Fujii Y, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Kato H, Noma K, Liao JK, Higashi Y, J Hypertens, 1/1/2011
• Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neurogenesis  
  Reis SA, Thompson MN, Lee JM, Fossale E, Kim HH, Liao JK, Moskowitz MA, Shaw SY, Dong L, Haggarty SJ, MacDonald ME, Seong IS, Human Mol Gen, 1/1/2011
• Role of rho kinase isoforms in murine allergic airway responses  
  Zhu M, Liu PY, Kasahara DI, Williams AS, Verbout NG, Halayko AJ, Fedulov A, Shoji T, Williams ES, Noma K, Shore SA, Liao JK, Eur Resp J, 1/1/2011
• Rho-associated kinase activity, endothelial function, and cardiovascular risk factors  
  Soga J, Noma K, Hata T, Hidaka T, Fujii Y, Idei N, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Kato H, Liao JK, Higashi Y, Arterioscl Thromb Vasc Biol, 1/1/2011
• Rho-associated coiled-coil forming kinase (ROCK): a potential target for the treatment of atherosclerosis and vascular disease  
  Zhou Q, Gensch C, Liao JK, Trends Pharm Sci, 1/1/2011
• Noninvasive method for assessing the human circadian clock using hair follicle cells  
  Akashi M, Soma H, Yamamoto T, Tsugitomi A, Yamashita S, Nishida E, Yasuda A, Liao JK, Node K, Proc Natl Acad Sci, 1/1/2010
• Elevated homocysteine and C-reactive protein levels independently predict worsening prognosis after stroke in Chinese patients  
  Yan J, Liao JK, Wang D, J Huazhong U Sci Tech, 1/1/2010
• Pleiotropic effects of statins - Basic research and clinical perspectives  
  Zhou Q, Liao JK, Circulation Journal, 1/1/2010
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Books/Book Chapters

• The endothelium: A comprehensive reference 
  Chapter: Diagnosis and treatment: Statins 
  Page 1668 - 1673Liao JKEditors: Aird W.Cambridge University Press, New York, NY2007
• The endothelium: A comprehensive reference 
  Chapter: Steroid hormones 
  Page 1674 - 1681Liao JKCambridge University Press, New York, NY2007
• Statins 
  Chapter: The pleiotropic effects of statins: Relevance to their salutary effects 
  Page 163 - 188Wolfrum S, Liao JKEditors: Mehta J.Elsevier Publishers (Saunders), Philadelphia, PA2004
• Clinical challenges in dyslipidemia management 
  Chapter: Role of statin pleiotropy in cardiovascular risk reduction 
  Page 1438 - 1459Liao JKEditors: Toth P, Sica, D.Atlas Medical Publishing, Ltd., Oxford, UK2003
• Encyclopedia of molecular medicine 
  Chapter: Statins 
  Page 3000 - 3002Liao JK, Moskowitz MAEditors: Creighton TE.John Wiley & Sons, Inc., New York, NY2002
• Milestones in drug therapy 
  Chapter: Pleiotropic effects of HMG-CoA reductase inhibitors on cells of the vascular wall 
  Page 81 - 98Node K, Liao JKEditors: Mehta JL.Birkhauser-Verlag Publishers2002
• Nitric oxide and inflammation 
  Chapter: Anti-inflammatory actions of nitric oxide 
  Page 99 - 116Spiecker M, Liao JKEditors: Billiar TR, Salvemini D.Birkhauser Publishers Ltd., New York, NY2001
• Basic science and clinical applications of nitric oxide 
  Chapter: Endothelial nitric oxide and vascular inflammation 
  Page 119 - 132Liao JKEditors: Cannon RO, Panza JA.Futura Publishing Co., Inc., Armonk, New York1999
• Methods in molecular medicine, vascular disease: Molecular biology and gene therapy protocols 
  Chapter: Nuclear run-on assay to study gene transcription in vascular cells 
  Page 1 - 7Laufs U, Liao JKEditors: Baker AH.Humana Press, Inc., Totowa, NJ1999
• Pathophysiology and clinical applications of nitric oxide 
  Page 99 - 120Liao JK, Libby PEditors: Rubanyi GM.Harwood Academic Publishers, Chur, Switzerland1998
• Pharmacology of cerebral ischemia 
  Chapter: Specific upregulation of endothelial nitric oxide synthase and its potential importance to cerebral ischemia 
  Page 299 - 307Endres M, Laufs U, Liao JK, Moskowitz MAEditors: Krieglstein J.Medpharm Scientific Publishers, Inc., Stuttgart, Germany1998
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Other

• ROCK and Cellular Metabolism 
  Liao JK
  Chicago, IL - 1/1/2015
• Bench to Bedside Research 
  Liao JK
  Chicago, IL - 1/1/2015
• Challenges to Building a Successful Basic Science Program in Academic Cardiology 
  Liao JK
  Chicago, IL - 1/1/2015
• ROCK and Heart Failure 
  Liao JK
  Chicago, IL - 1/1/2015
• ROCK as a Novel Biomarker of CV Disease 
  Liao JK
  Chicago, IL, 2015; Beijing, China, 2015 - 1/1/2015
• Endothelial Function in Vascular Disease 
  Liao JK
  Iowa City, IA - 1/1/2015
• Chinese Cholesterol Education Program 
  Liao JK
  Beijing, China - 1/1/2015
• Cardiovascular Disease: Emerging Science and Therapeutics 
  Liao JK
  Taipei, Taiwan - 1/1/2015
• ROCK and Vascular Aging 
  Liao JK
  Chicago, IL - 1/1/2014
• ROCK: From Bench to Bedside 
  Liao JK
  Chicago, IL - 1/1/2014
• Regulation of eNOS by ROCK 
  Liao JK
  Chicago, IL - 1/1/2014
• Control of Metabolism by ROCK/ 
  Liao JK
  Phoenix, AZ - 1/1/2014
• Pharmacokinetic Properties of Statins: Mechanisms for Pleiotropic Effects 
  Liao JK
  San Diego, CA - 1/1/2014
• ROCK and Aortic Stiffness 
  Liao JK
  Kyoto, Japan - 1/1/2014
• Dyslipidemia 
  Liao JK
  Multiple Locations, 2004, 2008, 2013 - 1/1/2013
• Post-Translational Regulation of eNOS by ROCK2 
  Liao JK
  Chicago, IL - 1/1/2013
• Diagnosis and Treatment of Peripheral Vascular Disease 
  Liao JK
  Chicago, IL - 1/1/2013
• ROCK and Vascular Stiffness 
  Liao JK
  Chicago, IL - 1/1/2013
• Grant Workshop 
  Liao JK
  Chicago, IL - 1/1/2013
• Pleiotropic Effecs of Statins on Endothelial Function is Mediated by ROCK 
  Liao JK
  Chicago, IL - 1/1/2013
• Pathobiology of Atherosclerosis 
  Liao JK
  Chicago, IL, 2013; Hong Kong, China, 2013 - 1/1/2013
• Treatment of Dyslipidemia 
  Liao JK
  New York, NY, 2006; Raleigh, NC, 2013 - 1/1/2013
• Update on Lipid Mangement 
  Liao JK
  Indianapolis, IN - 1/1/2013
• Lipid Treatment Goals 
  Liao JK
  Honolulu, HI - 1/1/2013
• ROCKs and Fibrosis 
  Liao JK
  San Diego, CA - 1/1/2013
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