JamesL.KirklandMD

PubMed

• 244 citations
  A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues.
  Dominik Saul, Robyn Laura Kosinsky, Elizabeth J Atkinson, Madison L Doolittle, Xu Zhang
  Nature Communications. 2022-08-16
• 102 citations
  Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.
  Anthony B. Lagnado, Jack Leslie, Marie-Hélène Ruchaud-Sparagano, Stella Victorelli, Petra Hirsova
  The EMBO Journal. 2021-05-03
• 944 citations
  Cellular senescence mediates fibrotic pulmonary disease
  Marissa J. Schafer, Thomas A. White, Koji Iijima, Andrew J. Haak, Giovanni Ligresti
  Nature Communications. 2017-02-23

Journal Articles

• Therapeutic Approaches to Aging—Reply  
  James Kirkland, MD, JAMA
• Aging, Cell Senescence, and Chronic DiseaseEmerging Therapeutic Strategies  
  James Kirkland, MD, JAMA
• Senolytics Improve Physical Function and Increase Lifespan in Old Age  
  James L Kirkland, Nathan K LeBrasseur, S John Weroha, Vesna D Garovic, Sundeep Khosla, Allyson K Palmer, Nature
• Clinical strategies and animal models for developing senolytic agents  
  Kirkland JL, Tchkonia T., Exp Gerontol, 10/28/2014
• Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence  
  Tran D, Bergholz J, Zhang H, He H, Wang Y, Zhang Y, Li Q, Kirkland JL, Xiao ZX, Aging Cell, 1/1/2014
• Testosterone plus low-intensity physical training in late life improves functional performance, skeletal muscle mitochondrial biogenesis, and mitochondrial quality con...  
  Guo W, Wong S, Li M, Liang W, Liesa M, Serra C, Jasuja R, Bartke A, Kirkland JL, Shirihai O, Bhasin S, PLoS ONE, 1/1/2012
• 77. Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM. Clearance of p16Ink4a-positive senescent cells delays agei...  
  Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM, Nature, 11/2/2011
• Perspectives on cellular senescence and short term dietary restriction in adults  
  Kirkland JL, Aging-us, 1/1/2010
• Adipokines, regional fat tissue development, and cardiovascular disease (Invited Review)  
  Tchkonia T, Kirkland J, Circulation Frontier, 1/1/2005
• Adipose tissue as an endocrine organ: regional differences in adipocyte endocrine function  
  Kirkland JL, Tchkonia T, Giorgadze N, Pirtskhalava T, Progress in Obesity Research, 1/1/2003
• Current views of the fat cell as an endocrine cell: lipotoxicity  
  Tchkonia T, Corkey BE, Kirkland JL, Endocrine Updates, 1/1/2003
• Interdisciplinary inpatient care for elderly people with hip fracture: a randomized controlled trial  
  Naglie G, Tansey C, Kirkland JL, Ogilvie-Harris DJ, Detsky AS, Etchells E, Tomlinson G, O'Rourke K, Goldlist B, CMAJ 9, 1/1/2002
• Different fat depots are distinct mini-organs  
  Tchkonia T, Karagiannides I, Forse RA, Kirkland JL, Curr Opin Endocrinol Diabetes Obes, 1/1/2001
• Subject recruitment, retention, and protocol feasibility in a prospective study of nutritional risk among urban, frail homebound elders  
  Ewart CV, Fearon NA, Lund M, Martin B, Kirkland JL, Ritchie CS, Quatromoni P, Silliman RA, Millen BE, J Nutr Elder, 1/1/2001
• Commentary: aging, differentiation-dependent gene expression, and fat cell function Discussion  
  Kirkland JL, J Gerontol, 1/1/1999
• Discharges home following intensive inpatient geriatric rehabilitation  
  Straus SE, Kirkland JL, Verwoerd R, Hamilton L, Gottfried M, Naglie G, Can J Rehabil, 1/1/1997
• Cluster deaths in long term care institutions  
  Naglie G, Goldlist B, Wilson B, Kirkland JL, Isenberg Y, Gordon M, Klapecki P, Clark P, Clin Invest Med, 1/1/1991
• Issues in underwriting for the elderly  
  Krinik J, Kirkland JL, Proc Home Off Underwriters Assoc, 1/1/1988
• Itching and neoplastic skin conditions in the elderly (Invited Review)  
  Abouchacra S, Kirkland JL, Diagnosis, 1/1/1987
• Rehabilitating the elderly instead of warehousing them (Invited Review)  
  Kirkland JL, Dimensions, 1/1/1987
• Thyroid disorders in the elderly (Invited Review)  
  Kirkland JL, Diagnosis, 1/1/1986
• Analysis of circadian rhythms by fitting a least squares sine curve  
  Hickey DS, Kirkland JL, Lucas SB, Lye M, Comput Biol Med, 1/1/1984
• Falls in the elderly (Invited Review)  
  Kirkland JL, Ontario Medicine, 1/1/1984
• Plasma arginine vasopressin in dehydrated elderly patients  
  Kirkland J, Lye M, Goddard C, Vargas E, Davies I, Clin Endocrinol (Oxf), 1/1/1984
• Indican excretion in the elderly  
  Kirkland JL, Vargas E, Lye M, Postgrad Med J, 1/1/1983
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Books/Book Chapters

• Handbook of the biology of aging. 
  Chapter: Aging and adipose tissue. 
  Page 119 - 139Florido R, Tchkonia T, Kirkland JLEditors: Masoro EJ; Austad SN.Elsevier/AP, London; BurlingtonEdition 7,2011
• Adipose Tissue in Health and Disease. 
  Chapter: The Cellular, Molecular Basis of Functional Differences Among Fat Depots. 
  Page 21 - 47Thomou T, Tchkonia T, Kirkland JLEditors: Granneman JG, Leff T.Wiley-VCH2010
• Overweight and the metabolic syndrome: from bench to bedside. Volume 26. (Endocrine updates.) 
  Chapter: Current views of the fat cell as an endocrine cell: lipotoxicity. 
  Page 105 - 118Tchkonia T, Corkey BE, Kirkland JL2006
• Ethical and Legal Issues in Alzheimer's Disease Research. 
  Chapter: Ethical and legal guidelines for Alzheimer's disease research: Progress, problems, and current recommendations. 
  Berg JM, Karlinsky HJ, Lowy FH, Kirkland JL, Meier HMREditors: Berg JM, Karlinsky HJ, Lowy, FH.Carswell, Toronto1991
• Geriatric Assessment, the Canadian Experience. 
  Chapter: A broader approach to geriatric assessment. Chapter 4. 
  Page 65 - 84Kirkland JLNational Advisory Council on Aging, Ottawa1989
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Abstracts/Posters

• Aging, inflammation and skeletal muscle.
  White TA, Zhu Y, Giorgadze N, Tchkonia T, Kirkland JL, LeBrasseur NK, FASEB J, 1/1/2012
• Establishment of an in vitro assay for high-throughput screening of pro-adipogenic agents.
  Kling R, Ravuri S, Lin YC, Bechtel J, Gough A, Philips B, Kirkland J, Marra K, Fernstrom J, Rubin P, Journal Of Tissue Engineering And Regenerative Medicine, 1/1/2012
• Senescent Cells Compromise Fat Tissue Function.
  Xu M, Zhu Y, Pirtskhalava T, Giorgadze N, Baker DJ, Jensen MD, van Deursen J, Tchkonia T, Kirkland JL, J Tissue Eng Regen Med, 1/1/2012
• Inflammation and the fat depot-specific secretome of human fat cell progenitors.
  Zhu Y, Tchkonia T, Giorgadze N, Liang G, Li P, Holtz-Heppelmann CJ, Bergen HR, Jensen MD, Bouloumié A, Kirkland JL, European Congress on Obesity, Istanbul, Turkey, 1/1/2011
• Cellular senescence and an inflammatory senescence-associated secretory phenotype in human preadipocytes
  Kirkland JL, Zhu Y, Tchkonia T, Giorgadze N, Pirtskhalava T, Bergen HR, Li PW, Jensen MD, The Obesity Society, Orlando, FL, 1/1/2011
• Cellular senescence and an inflammatory senescence-associated secretory phenotype in human preadipocytes.
  Kirkland JL, Zhu Y, Tchkonia T, Li PW, Bergen HR, Jensen MD, Obesity, 1/1/2011
• Inflammation and the fat depot-specific secretome of human fat cell progenitors.
  Zhu Y, Tchkonia T, Giorgadze N, Liang G, Li P, Holtz-Heppelmann CJ, Bergen HR, Jensen MD, Bouloumie A, Kirkland JL, Obesity Rev, 1/1/2011
• Aging, adipose tissue, cellular senescence.
  Kirkland JL, Rejuvenation Res, 1/1/2011
• Age-Related Fat Redistribution and Cellular Senescence Are Delayed in GH/IGF-1 Deficient Mice
  Kirkland, J.L., Tchkonia, T., Pirtskhalava, T., Giorgadze, N., Bartke, A., Masternak, M., Miller, R., Kopchick, J., Berryman, D., List, E., Ikeno, Y., Adamo, M., Boney..., Obesity Society Annual Meeting, San Diego, CA, 1/1/2010
• The Inflammatory and Anti-Adipogenic Effects of the Senescent Preadipocytes that Accumulate due to Aging and TNFa Exposure Are Blocked by Inhibiting JAK-2
  Tchkonia, T., Pirtskhalava, T., Thomou, T., Giorgadze, N., von Zglinicki, T., Kirkland, J.L., International Congress on Obesity, Stockholm, Sweden, 1/1/2010
• IGF-I protects human subcutaneous but not omental preadipocytes from FFA-induced JNK activation and TNFa expression.
  Boney CM, Cleveland-Donovan K, Tchkonia T, Kirkland JL, Endocr Rev, 1/1/2010
• Fat and aging.
  Kirkland JL, Diabetes Obesity & Metabolism, 1/1/2010
• Age-related fat redistribution and cellular senescence are delayed in growth hormone/IGF-1 deficient mice.
  Kirkland JL, Tchkonia T, Pirtskhalava T, Giorgadze N, Bartke A, Masternak M, Miller R, Kopchick J, Berryman D, List E, Ikeno Y, Adamo M, Boney C, Cleveland-Donovan K, Obesity, 1/1/2010
• The inflammatory and anti-adipogenic effects of the senescent preadipocytes that accumulate due to aging and TNF-alpha exposure are blocked by inhibiting JAK-2.
  Tchkonia T, Pirtskhalava T, Giorgadze N, von Zglinicki T, Kirkland JL, Obesity Rev, 1/1/2010
• Does Aging Make Fat go MAD?
  Kirkland JL, Karolinska Institute, Stockholm, Sweden, 1/1/2009
• Different thiazolidinediones elicit distinct responses in human preadipocytes.
  Tchkonia, T., Lenburg, M., Giorgadze, N., Thomou, T., Gadua, M., Kirkland, J.L., 3rd International Congress on Prediabetes and the Metabolic Syndrome, Nice, France, 1/1/2009
• Cellular Senescence and Inflammation in Obesity
  Tchkonia, T., Giorgadze, N., Pirtskhalava, T., Thomou, T., Bouloumie, A., von Zglinicki, T., Kirkland, J.L, National Obesity Society Annual Meeting, Washington, DC, 1/1/2009
• Inhibition of acyl CoA synthetase decreases fat storage in human adipocytes and body weight and fat mass in DIO mice.
  Kane A, Bergenhem N, Kirkland JL, Pilch PF, Farmer S, Hamilton JA, McCormack JG, Pan DA, Wong-Kai-In P, Corkey BE, Diabetes, 1/1/2009
• Different thiazolidinediones elicit distinct responses in human preadipocytes.
  Tchkonia T, Lenburg M, Giorgadze N, Thomou T, Gadua M, Kirkland JL, J Diabetes, 1/1/2009
• Cellular senescence and inflammation in obesity.
  Tchkonia T, Giorgadze N, Pirtskhalava T, Thomou T, Villaret A, Bouloumie A, von Zglinicki T, Kirkland JL, Obesity, 1/1/2009
• Retinoids regulate fat depot-specific developmental gene expression.
  Thomou T, Ziouzenkova O, Tchkonia T, Giorgadze N, Kirkland JL, Obesity, 1/1/2009
• Preadipocyte IGF-1 signaling, bioavailability, and responsiveness vary among fat depots.
  Kirkland, J.L., Tchkonia, T., Pirtskhalava, T., Giorgadze, N., Gagua, M., Karagiannides, I., Cleveland-Donovan, K., Conover, C., Boney, B., 16th European Congress on Obesity, Geneva, Switzerland, 1/1/2008
• Preadipocyte igf-1 signaling, bioavailability, and responsiveness vary among fat depots.
  Kirkland JL, Tchkonia T, Pirtskhalava T, Giorgadze N, Gagua M, Karagiannides I, Cleveland-Donovan K, Conover C, Boney B, Int J Obes, 1/1/2008
• IGF-1-mediated adipogenesis varies between human subcutaneous and omental fat depots.
  Boney C, Cleveland-Donovan K, Tchkonia T, Giorgadze N, Gagua M, Kirkland JL, Prog Ann Endo Soc M, 1/1/2008
• Aging, fat depot origin, and preadipocyte expression profiles: setting the stage for fat tissue dysfunction
  Kirkland, J.L., Cartwright, M., Tchkonia, T., Lenburg, M., Schlauch, K., Pirtskhalava, T., Cartwright, A., Lopez, M., Frampton, G, European Congress on Obesity, Budapest, Hungary, 1/1/2007
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Lectures

• Translating Advances from the Basic Biology of Aging into Clinical Application: Opportunities and Challenges 
  Basel, Switzerland - 1/1/2014
• Obesity, Weight Loss, Diabetes, and Cellular Senescence in Seniors: Opportunities for Intervention 
  Bethesda, MD - 1/1/2014
• Molecular Basis of Organ Systems Diseases Course (GMSMM-707) 
  Boston University Graduate School, Boston, MA - 1/1/2014
• Cellular Senescence: Implications for Multiple Age-related Disabilities and Diseases 
  Bregenz, Austria - 1/1/2014
• Aging Research: Transformative Advances and challenges 
  Brussels, Belgium - 1/1/2014
• Aging, Chronic Disease, and Cellular Senescence: Therapeutic Opportunities and Challenges 
  CHA University, Bundang Medical Center, Seoul, South Korea - 1/1/2014
• Inflammation, Cellular Senescence, and Aging 
  Halle, Germany - 1/1/2014
• Animal Models of Aging, Chronic Disease, Resilience, Healthspan, and Lifespan: Advantages and Problems 
  Santa Barbara, CA - 1/1/2014
• A Novel Tool for Uncovering How Senescent Cells Cause Age-Related Dysfunction 
  Santa Barbara, CA - 1/1/2014
• Cellular Senescence, Fat Cell Progenitors, and Aging 
  Scripps, FL - 1/1/2014
• Developing Therapeutics for Aging: Transformative Advances and Challenges 
  Scripps, FL - 1/1/2014
• Fat Tissue and Cellular Senescence. Highlights of ENDO 
  Seoul, South Korea - 1/1/2014
• MicroRNA, Aging, And Adipose Tissue Function 
  Seoul, South Korea - 1/1/2014
• Aging, Diabetes, and Cellular Senescence 
  Southern Illinois University, Springfield, IL - 1/1/2014
• Cellular Senescence and Aging Phenotypes 
  St. Jude Children’s Research Hospital, Memphis, TN - 1/1/2014
• Aging, Adipose Tissue, Diabetes, And Cellular Senescence 
  University of Arizona, Tucson, AZ - 1/1/2014
• Translational Aging Research: Challenges and Opportunities for Developing Interventions 
  University of Colorado, Boulder, CO - 1/1/2014
• Cellular Senescence and Adipose Tissue. Adipose Tissue Biology: Targeting the Life Cycle. 
  Atlanta, GA - 1/1/2013
• Cellular Senescence: Causes, Mechanisms, and Consequences 
  Baltimore, MD - 1/1/2013
• Aging and Adipose Tissue Cellular Senescence 
  Barga, Italy - 1/1/2013
• Cellular Senescence and Inflammation 
  Barshop Institute for Experimental Aging Research, San Antonio, TX - 1/1/2013
• Translational Research 
  Barshop Institute for Experimental Aging Research, San Antonio, TX - 1/1/2013
• Cellular Senescence: Contributions to Age-Related Disease 
  Bethesda, MD - 1/1/2013
• Cellular Senescence and Adipose Tissue 
  Keystone, CO - 1/1/2013
• Challenges and Opportunities for Developing Interventions. Translating Recent, Transformational Advances in the Basic Biology of Aging into Clinical Application: Oppor... 
  New Orleans, LA - 1/1/2013
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Other

• Transgenic Animals Capable of Being Induced to Delete Senescent Cells 
  van Deursen J, Kirkland JL, Tchkonia T, Baker D, US 43613
  1/1/2012
• Human preadipocyte cell strains and uses therefore. 
  Kirkland JL, Tchkoniai TT, US 31635
  1/1/2002
• Human adipocyte cell populations and methods for identifying modulators of same. US Provisional Patent 
  Kirkland JL, US 377500
  1/1/2002
• Ageing and adipocyte precursor function. [thesis] 
  Kirkland JL, University of Toronto
  1/1/1990
• Renal circadian rhythms and ageing. M.Sc. Thesis. 
  Kirkland JL, University of Manchester
  1/1/1982
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