JamesTilfordElderMDPhD

PubMed

• 20 citations
  Transethnic analysis of psoriasis susceptibility in South Asians and Europeans enhances fine-mapping in the MHC and genomewide
  Philip E. Stuart, Lam C. Tsoi, Rajan P. Nair, Manju Ghosh, Madhulika Kabra
  HGG Advances. 2022-01-01
• 154 citations
  Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis.
  William R. Swindell, Andrew Johnston, Steve Carbajal, Gangwen Han, Christian Wohn
  Plos One. 2011-04-04
• 1042 citations
  Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways
  Rajan P. Nair, Kristina Callis Duffin, Cynthia Helms, Jun Ding, Philip E. Stuart
  Nature Genetics. 2009-01-25

Journal Articles

• Erlotinib-induced skin inflammation is IL-1 mediated in KC-Tie2 mice and human skin organ culture  
  Ward NL, Bhagathavula N, Johnston A, Dawes SM, Fu W, Lambert S, Gudjonsson JE, Varani J, Elder JT, Journal of Investigative Dermatology, 10/1/2014
• Comparison of molecular signatures from multiple skin diseases identifies mechanisms of immunopathogenesis  
  Inkeles MS, Scumpia PO, Swindell WR, Lopez D, Teles RMB, Graeber TG, Elder JT, Modlin RL, Pellegrini M, Journal of Investigative Dermatology, 9/18/2014
• Fine mapping of eight psoriasis susceptibility loci  
  Das S, Stuart PE, Ding J, Tejasvi T, Li Y, Tsoi LC, Chandran V, Fischer J, Helms C, Callis Duffin K, Voorhees JJ, Bowcock, AM, Krueger GG, Lathrop GM, Nair RP, Rahman ..., European Journal of Human Genetics, 9/3/2014
• Cellular dissection of psoriasis for integration of transcriptome analyses and GWAS data  
  Swindell WR, Stuart PE, Voorhees JJ, Elder JT, Johnston A, Gudjonsson JE, BMC Med Genomics, 5/1/2014
• Fine-mapping major histocompatibility complex associations in psoriasis and its clinical subtypes  
  Okada Y, Han B, Tsoi LC, Stuart PE, Ellinghaus E, Tejasvi T, Chandran V, Pellett F, Pollock R, Bowcock AM, Krueger GG, Weichenthal M, Voorhees JJ, Rahman P, Gregersen ..., American Journal of Human Genetics, 1/1/2014
• Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides new insights into disease mechanisms  
  Li B, Tsoi LC, Swindell WR, Gudjonsson JE, Tejasvi T, Johnston A, Ding J, Stuart PE, Xing X, Voorhees JJ, Kang HM, Nair RP, Abecasis GR, Elder JT, Journal of Investigative Dermatology, 1/1/2014
• Integrative RNA-seq and microarray data analysis reveals GC content and gene length biases in the psoriasis transcriptome  
  Swindell WR, Xing X, Voorhees JJ, Elder JT, Johnston A, Gudjonsson JE, Physiological Genomics, 1/1/2014
• Genetic associations of psoriasis in a Pakistani population  
  Shaiq PA, Stuart PE, Latif A, Schmotzer C, Kazmi AH, Khan MS, Azam M, Tejasvi T, Voorhees JJ, Raja GK, Elder JT, Qamar R, Nair RP, British Journal of Dermatology, 1/1/2013
• Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis  
  Johnston A, Xing X, Swindell WR, Kochkodan J, Riblett M, Nair RP, Stuart PE, Ding J, Voorhees JJ, Elder JT, Gudjonsson JE, Human Molecular Genetics, 1/1/2013
• What can psoriasis teach us about alopecia areata?  
  Elder JT, Journal of Investigative Dermatology Symposium Proceedings, 1/1/2013
• High-density genotyping study identifies four new susceptibility loci for atopic dermatitis  
  Ellinghaus D, Baurecht H, Esparza-Gordillo J, Rodríguez E, Matanovic A, Marenholz I, Hübner N, Schaarschmidt H, Novak N, Michel S, Maintz L, Werfel T, Meyer-Hoffert U,..., Nat Genet, 1/1/2013
• Meta-profiles of gene expression during aging: Limited similarities between mouse and human and an unexpectedly decreased inflammatory signature  
  Swindell WR, Johnston A, Sun L, Xing X, Fisher GJ, Bulyk ML, Elder JT, Gudjonsson JE, PLoS One, 3/1/2012
• Combined analysis of genome-wide association studies for Crohn's disease and psoriasis identifies seven shared susceptibility loci  
  Ellinghaus D, Ellinghaus E, Nair RP, Stuart PE, Esko T, Metspalu A, Debrus S, Raelson JV, Belouchi M, Koks S, Kingo K, Latiano A, Annese V, Gieger C, Wichmann HE, Kab..., American Journal of Human Genetics, 1/1/2012
• Rare and common variants in caspase recruitment domain protein 14 (CARD14) in psoriasis  
  Jordan, CT, Roberson EDO, Cao L, Pierson KC, Yang, CF, Joice, CE, Ryan C, Duan S, Helms, C, Nair RP, Yiu Y, Callis Duffin K, Chen Y, Feng, BJ, Goldgar D, Hwu, W-L, Stu..., American Journal of Human Genetics, 1/1/2012
• Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL  
  Ellinghaus E, Stuart PE, Ellinghaus D, Nair RP, Debrus S, Raelson JV, Belouchi M, Tejasvi T, Li Y, Tsoi LC, Onken AT, Esko T, Metspalu A, Rahman P, Gladman DD, Bowcock..., Journal of Investigative Dermatology, 1/1/2012
• Heparin-binding EGF-like growth factor regulates epithelial-mesenchymal transition in human keratinocytes  
  Stoll SW, Johnson JL, Rittié L, Elder JT, Journal of Investigative Dermatology, 1/1/2012
• Association of beta-defensin copy number and psoriasis in three cohorts of European origin  
  Stuart PE, Huffmeier U, Nair RP, Pala R, Tejasvi T, Schalkwijk J, Elder JT, Reis A, Armour JAL, Journal of Investigative Dermatology, 1/1/2012
• TNFAIP3 gene polymorphisms are associated with response to TNF blockade in psoriasis  
  Tejasvi, T, Stuart PE, Chandran V, Voorhees JJ, Gladman DD, Rahman P, Elder JT, Nair RP, Journal of Investigative Dermatology, 1/1/2012
• Genetics of psoriasis and psoriatic arthritis: A report from the GRAPPA 2010 annual meeting  
  Rahman P, Elder JT, Journal of Rheumatology, 1/1/2012
• Fifteen novel psoriasis susceptibility loci: disease specific signals highlight the role of innate immunity  
  Tsoi LC, West SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T Gudjonsson JE, Kang HM, Weale M, Allen MH, McMannus R, Novelli G, Samuelson L, Sc..., Nature Genetics, 1/1/2012
• Heterogeneity of inflammatory and cytokine networks in chronic plaque psoriasis  
  Swindell W, Xing X, Stuart PE, Chen C, Aphale A, Nair RP, Voorhees JJ, Elder JT, Johnston A, Gudjonsson JE, PLoS One, 1/1/2012
• Pervasive sharing of genetic effects in autoimmune disease  
  Cotsapas C, Voight BF, Rossin E, Lage K, Neale BM, Wallace C, Abecasis G, Barrett JC, Behrens T, Cho JH, de Jager PL, Elder JT, Graham RR, Gregersen P, Klareskog L, Si..., PLoS Genetics, 8/1/2011
• Novel multiplex technology for diagnostic characterization of rheumatoid arthritis  
  Chandra PE, Sokolove J, Hipp BG, Lindstrom TM, Elder JT, Reveille JD, Eberl H, Klause U, Robinson WH, Arthritis Research & Therapy, 1/1/2011
• IL-1F5, F6, F8, and F9: A novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression  
  Johnston A, Xing X, Guzman AM, Riblett M, Matheny CM, Ward NL, Wohn C, Prens EP, Wang F, Maier LE, Voorhees JJ, Elder JT, Gudjonsson JE, Journal of Immunology, 1/1/2011
• EGFR and IL-1 synergistically promote keratinocyte antimicrobial defenses in a differentiation-dependent manner  
  Johnston A, Gudjonsson JE, Aphale A, Guzman AM, Stoll SW, Elder JT, Journal of Investigative Dermatology, 1/1/2011
• Join now to see all

Books/Book Chapters

• Emery and Rimoin's Principles and Practice of Medical Genetics 
  Chapter: Chapter 150: Psoriaisis. 
  Gudjonsson JE, Elder JTEdition 6th,2013
• Fitzpatrick’s Dermatology in General Medicine 
  Chapter: Psoriasis. 
  Page 169 - 193Gudjonsson J, Elder JTEditors: Wolff K, Goldsmith LE, Katz S, Gilchrest B, Paller A, Lefell D.Mc Graw-Hill, New York, NYEdition 7th,2008
• Clinics in Dermatology 
  Chapter: Psoriasis: Epidemiology. 
  Page 535 - 546Gudjonsson JE, Elder JTElsevier, New York, NY2007
• Principles of Molecular Medicine 
  Chapter: Psoriasis. 
  Page 793 - 800Elder JT, Voorhees JJEditors: Jameson L.Humana Press, Totowa, NJ1998
• Advances of Dermatology 
  Chapter: Cytokine and genetic regulation of psoriasis. 
  Page 99 - 133Elder JTEditors: Callen JP, Dahl MV.Mosby-Year Book, Inc., Chicago, IL1995
• Basic Mechanisms of Physiological and Aberrant Lympho-proliferation in the Skin 
  Chapter: Activation of reactive versus malignant T cells in cutaneous T cell lymphoma: Role of abnormal antigen presenting cells and T cell activating molecules. 
  Page 29 - 38Cooper KD, Laurent M, Ho V, Baadsgaard O, Lee M-S, Hansen E, Lisby S, Mehregan D, Allen E, Vejlsgaard GL, Elder JTEditors: Van Vloten WA, Lambert WC.Plenum Publishing, New York, NY1994
• Epidermal Growth Factors and Cytokines 
  Chapter: Transforming growth factor-alpha and related growth factors. 
  Page 205 - 240Elder JTEditors: Luger T, Schwarz T.Marcel Dekker, New York, NY1993
• Retinoids: 10 Years On (Special Edition) 
  Chapter: Topical retinoids - pharmacological, cellular and molecular aspects. 
  Page 152 - 166Fisher GJ, Astrom A, Elder JT, Griffiths CEM, Higley H, Voorhees JJEditors: Karger, Balse.1991
• Physiology, Biochemistry and Molecular Biology of the Skin 
  Chapter: Regulation of keratinocyte growth and differentiation: Interactive signal transduction pathways. 
  Page 266 - 313Elder JT, Fisher GJ, Duell EA, Kragballe K, Voorhees JJEditors: Lowell A Goldsmith.Oxford University Press, New York, NYEdition 2nd,1991
• Encyclopedia of Human Biology 
  Chapter: Growth factors and the regulation of epidermal proliferation. 
  Page 445 - 453Elder JTEditors: R. Dulbecco.Academic Press, New York, NY1991
• Proceedings of the Cold Spring Harbor Symposium: Cancer Cells 
  Chapter: Expression of the transforming growth factor-alpha gene in tumor cells and normal cells. 
  Page 297 - 302Derynck R, Lindquist PB, Bringman TS, Wilcox JN, Elder JT, Fisher GJ, Voorhees JJ, Moses HL, Pittelkow M, Coffey RJEditors: Furth M, Greaves M.Cold Spring Harbor Press, Cold Spring Harbor, NY1989
• Sandimmum Ciclosporin is Psoriasis 
  Chapter: Clinical experience with ciclosporin in psoriasis: Conclusions and perspectives. 
  Page 89 - 94Baadsgaard O, Cooper KD, Elder JT, Ellis CN, Esmann J, Fisher GJ, Klein SB, Nickoloff BJ, Talwar H, Voorhees JJEditors: Kragballe K, Lumholtz B.FADL, Copenhagen1989
• Sandimmum Cyclosporin in Psoriasis. 
  Chapter: Pathomechanisms of psoriasis: New developments and summary. 
  Page 28 - 32Baadsgaard O, Cooper KD, Elder JT, Ellis CN, Esmann J, Fisher GJ, Klein SB, Nickoloff BJ, Talwar HS, Voorhees JJEditors: K. Kragballe K, B. Lumholtz B.FADL, Copenhagen1989
• Cellular and Molecular Regulation of Hemoglobin Switching 
  Chapter: Characterization of a human leukemia cell line. 
  Page 241 - 251Hoffman R, Burger B, Tonkonow B, Ibrahim N, Murnane MJ, Elder JT, Mazur E, Scarpa A, Diamond A, Bruno E, Levere RD, Forget BG, and Benz EJ JrEditors: Stamatoyannopolus G, Nienhuis AW.Alan R. Liss, New York, NY1981
• Organization and Expression of Globin Genes 
  Chapter: Structural and functional characterization of cloned beta+-thalassemic globin gene fragments. 
  Page 279 - 286Spritz RA, Jagadeeswaran P, Biro PA, Elder JT, Choudary PV, deRiel JK, Manley JL, Gefter ML, Weissman SM, Forget BGEditors: Stamatoyannopolus G, Nienhuis AW.Alan R. Liss, New York, NY1981
• Annual Review of Genetics 
  Chapter: Simian virus 40 as a eukaryotic cloning vehicle. 
  Page 295 - 340Elder JT, Spritz RA, Weissman SM1981
• Rheumatology 
  Chapter: Psoriasis: Etiopathogenesis. 
  Page 37 - 47Gudjonssson JE, Elder JTEditors: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman, MH.Elsevier, New York, NYEdition 2nd,
• Join now to see all

Abstracts/Posters

• Genome-wide serum miRNA expression profiles identify serum miRNAs as potential biomarkers for human psoriatic arthritis.
  Han L, Weiland M, Yin C, Lu C, Nair RP, Zhou L, Lim HW, Elder JT, Mi Q, J Invest Dermatol, 1/1/2014
• Genome wide association study of psoriasis in India.
  Nair, RP, Tsoi LC, Ghosh M, Kabra M, Tejasvi T, Stuart PE, Zawistowski MS, Voorhees JJ, Abecasis GR, Sharma VK, Elder JT, J Invest Dermatol, 1/1/2014
• Microanatomy of psoriasis: Sebaceous gland atrophy contributes to downregulation of lipid metabolism genes.
  Rittie L, Tejasvi T, Tsoi LC, Swindell WR, Nair RP, Elder JT, J Invest Dermatol, 1/1/2014
• Amphiregulin supports G2/M progression via FoxM1 and inhibits differentiation in human keratinocytes.
  Stoll SW, Swindell WR, Johnston A, Elder JT, J Invest Dermatol, 1/1/2014
• Gene expression signature of TRAF3IP2-silenced keratinocytes reveals unexpected effects on KC differentiation and cytokine responses.
  Lambert S, Swindell WR, Tsoi LC, Drumright BL, Stoll SW, Nair RP, Elder JT, J Invest Dermatol, 1/1/2013
• Amphiregulin increases sebaceous gland size and tail epidermal thickness but not basal or imiquimod-induced skin inflammation.
  Li Y, Talsma C, Stoll SW, Elder JT, J Invest Dermatol, 1/1/2013
• Meta-analysis of psoriasis and psoriatic arthritis identifies three new susceptibility loci.
  Nair RP, Tsoi LC, Stuart PE, Chandran V, Tejasvi T, Ellinghous E, Voorhees JJ, Weichenthal M, Franke A, Abecasis GR, Rahman P, Gladman D, Elder JT, J Invest Dermatol, 1/1/2013
• Amphiregulin cytoplasmic domain regulates G2/M in human keratinocytes.
  Stoll SW, Rittie L, Lambert S, Johnston A, Swindell WR, Stuart PE, Elder JT, J Invest Dermatol, 1/1/2013
• Transcriptome analysis reveals that severity of psoriasis is correlated with expression of genes involved in epidermal differentiation and proliferation.
  Tejasvi T, Tsoi LC, Stuart PE, Nair RP, Voorhees JJ, Abecasis G, Elder JT, J Invest Dermatol, 1/1/2013
• Opposing effects of the IL12B and IL23R psoriasis associated risk alleles on Th1 and Th17 responses in psoriatic skin.
  Xing X, Johnston A, Swindell WR, Stuart PR, Nair RP, Voorhees JJ, Elder JT, Gudjonsson JE, J Invest Dermatol, 1/1/2013
• Elevated EphA2 in the psoriatic epidermis provides a molecular target for restoring keratinocyte differentiation.
  Gudjonsson, JE, Blatt H, Gordon K, Kochkodan J, Johnston A, Lin S, Hoover P, Schlosser BJ, Elder JT, Getsios S, J Invest Dermatol, 1/1/2012
• Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis.
  Johnston A, Xing X, Swindell W, Kochkodan J, Nair RP, Stuart PE, Ding J, Voorhees JJ, Elder JT, Gudjonsson JE, J Invest Dermatol, 1/1/2012
• IKKi/IKKe mediates inflammatory induction of DEFB4 in keratinocytes.
  Lambert S, Stoll SW, Uhm M, Saltiel AR, Elder JT, J Invest Dermatol, 1/1/2012
• Genome wide association analysis of psoriatic arthritis.
  Nair RP, Tsoi LC, Chandran V, Stuart PE, Tejasvi T, Voorhees JJ, Abecasis GR, Rahman P, Elder JT, Gladman D, J Invest Dermatol, 1/1/2012
• HB-EGF directly promotes epithelial-mesenchymal transition and invasiveness in human keratinocytes.
  Stoll SW, Rittie L, Elder JT, J Invest Dermatol, 1/1/2012
• Prevalence of comorbidities is lower among HLA-Cw6-positive psoriasis patients.
  Tejasvi T, Stuart PE, Nair RP, Voorhees JJ, Elder JT, J Invest Dermatol, 1/1/2012
• The identification of fifteen novel psoriasis susceptibility loci highlights the skin’s role in innate immune defense.
  Trembath RC, Abecais G, Elder JT, O of Psoriasis, T Association Genetics Extension, T Psoriasis Consortium, A Consortium, J Invest Dermatol, 1/1/2012
• RNASeq reveals new insights into psoriasis biology.
  Tsoi LC, Li B, Nair RP, Ding J, Gudjonsson JE, Stuart PE, Voorhees JJ, Tejasvi T, Kang HM, Abecais GR, Elder JT, J Invest Dermatol, 1/1/2012
• The role of the IL12B associated psoriasis risk allele in the pathoegenesis of psoriasis.
  Xing X, Riblett M, Kochkodan JJ, Nair RP, Voorhees JJ, Elder JT, Johnston A, Gudjonsson JE, J Invest Dermatol, 1/1/2012
• What's New in Molecular Genetics
  Elder JT, World Congress of Dermatology, Seoul, Korea, 5/29/2011
• Replication of 18 psoriasis genetic associations in Caucasians.
  Nair RP, Ellinghaus E, Tsoi LC, Esko T, Stuart PE, Tejasvi T, Chandran V, Pellett F, Peddle L, Weichenthal M, Weidinger S, Mrowietz U, Balschun T, Metspaul A, Voorhees..., Brit J Dermatol, 1/1/2011
• Heterogeneity of Inflammatory and Cytokine Networks in Chronic Plaque Psoriasis.
  Swindell WR, Xing X, Stuart PE, Chen CS, Aphale A, Nair RP, Voorhees JJ, Elder JT, Johnston A, Gudjonsson, Brit J Dermatol, 1/1/2011
• TNFAIP3 polymorphisms and age at onset are associated with response to tumour necrosis factor blockade in psoriasis.
  Tejasvi T, Stuart PE, Chandran V, Voorhees JJ, Gladman DD, Rahman P, Elder JT, Nair RP, Brit J Dermatol, 1/1/2011
• Heterogeneity of inflammatory and cytokine Networks in chronic plaque psoriasis.
  Aphale A, Swindell W, Stuart P, Chen C, Xing X, Nair R, Voorhees J, Elder J, Johnston, A, Gudjonsson, J, J Invest Dermatol, 1/1/2011
• IL-17C is overexpressed in psoriasis skin and contributes to cytokine-driven inflammation.
  Chen CS, Al-Attar PM, Fu W, Loyd CM, Riblett MB, Xing X, Voorhees JJ, Elder JT, Ward NL, Gudjonsson JE, Johnston A, J Invest Dermatol, 1/1/2011
• Join now to see all

Lectures

• Genetics of Psoriasis and Psoriatic Arthritis: What's at the End of the Rainbow? 
  Detroit, MI - 10/2/2014
• Genetics of Skin Disease: From EGF Receptors to Psoriasis and Back 
  Valdecilla Hospital, Santander, Spain - 9/23/2014
• Omics: From Genomics to Skinomics 
  Paris, France - 9/20/2014
• Molecular Biology of Psoriasis: A Common, Chronic, Inflammatory Skin Disorder 
  Christian-Albrechts University, Kiel, Germany - 9/8/2014
• Psoriasis Genetics – State of the Art: Identification of Populations at Risk 
  New York, NY - 5/2/2014
• Translational Research in Psoriasis: From Genetics to Immunology 
  4/2/2014
• Genetics and Skin. Plenary Lecture 
  12/5/2013
• Architecture of the Psoriatic Transcriptome 
  Bangalore Medical College, Bangalore, India - 12/2/2013
• Autoimmunity in Dermatology: Any Skin in the Game? 
  University of Michigan - 6/22/2013
• Autocrine Regulation of Keratinocyte Growth and Differentiation 
  Punta del Este, Uruguay - 4/27/2013
• Genetics of Psoriasis and Psoriatic Arthritis 
  American Academy of Dermatology, Miami, FL - 3/4/2013
• Psoriasis Bench to Bedside: Genetics Meets Immunology 
  Delhi, India - 1/29/2013
• Advances in Psoriasis Genetics. Invited Speaker 
  Bethesda, MD - 11/29/2012
• Genetics of Psoriasis and Psoriatic Arthritis. Invited Speaker 
  Asilomar, CA - 11/16/2012
• Genetics of psoriasis. Invited Speaker 
  Lausanne, Switzerland - 11/1/2012
• Advances in the Genetics of Psoriasis and Psoriatic Arthritis. Invited Speaker 
  Beijing, China - 6/15/2012
• RNASeq Reveals New Insights Into Skin Biology. Guest Lecturer 
  Beijing, China - 6/13/2012
• Functional Genomics of Psoriasis and Psoriatic Arthritis. Guest Lecturer 
  Northwestern University Feinberg School of Medicine - 3/7/2012
• Completing the Genetic Map of Psoriasis and its Future Implications", Keynote Lecture 
  London, England - 12/1/2011
• Genetic Dissection of Psoriasis and Psoriatic Arthritis 
  University of Cape Town, Cape Town, South Africa - 11/21/2011
• Genetics of Psoriasis: Which Road to Follow? 
  Barcelona, Spain - 9/10/2011
• Functional Genomics of TRAF31P2 in Psoriasis. Invited Lecturer 
  Cleveland Clinic, Cleveland, OH - 6/29/2011
• Genome-wide Association Scans Identify Novel Susceptibility Loci for Psoriasis and Psoriatic Arthritis 
  Seoul, Korea - 5/29/2011
• Erlotinib-stimulated epidermal hyperplasia is mediated by IL-1 
  Phoenix, AZ - 5/7/2011
• Linking Bench to Bedside: Establishing Fruitful Collaborations Between Clinical and Academic Researchers 
  Phoenix, AZ - 5/5/2011
• Join now to see all