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Office
1500 E Medical Center Dr
1ST floor Taubman CTR Recp B
Ann Arbor, MI 48109Phone+1 734-936-4054
Summary
- I am a physician-scientist-educator in the Department of Dermatology at the University of Michigan. I have a joint appointment at the Ann Arbor VA Hospital. My clinical practice mainly involves medical Dermatology, with a focus on psoriasis and psoriatic arthritis. My research laboratory uses genetics, immunology, and cell biology to learn more about the pathogenesis of psoriasis and psoriatic arthritis. I’m particularly interested in the nature of innate and acquired immune responses in psoriasis, and how the immune system activates the epidermal hyperproliferative response in psoriasis. I also have a long-standing in keratinocyte biology, particularly regarding autocrine signaling through the EGF receptor. Currently, these interests extend to the role of EGF receptor ligands in carcinomas of epithelial origin, including keratinocyte carcinomas, breast cancer, and head and neck squamous cell carcinoma.
Education & Training
- University of MichiganResidency, Dermatology, 1986 - 1988
- University of WashingtonResidency, Dermatology, 1983 - 1986
- University of WashingtonInternship, Internal Medicine, 1982 - 1983
- The Graduate School of Yale UniversityPh.D., Molecular Biophysics and Biochemistry, 1974 - 1982
- Yale School of MedicineClass of 1981
- Northwestern UniversityB.S., Biomedical Engineering, with Highest Distinction, 1970 - 1974
Certifications & Licensure
- MI State Medical License 1987 - 2025
- American Board of Dermatology Dermatology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
- League of Research Excellence University of Michigan, 2011
- Fine Lecturer in Dermatology Emory University, Atlanta, GA, 2010
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Publications & Presentations
PubMed
- 689 citationsIdentification of 15 new psoriasis susceptibility loci highlights the role of innate immunityLam C. Tsoi, Sarah L. Spain, Jo Knight, Eva Ellinghaus, Philip E. Stuart
Nature Genetics. 2012-12-01 - 407 citationsPervasive sharing of genetic effects in autoimmune disease.Chris Cotsapas, Benjamin F. Voight, Elizabeth J. Rossin, Kasper Lage, Benjamin M. Neale
Plos Genetics. 2011-08-10 - 223 citationsLarge scale meta-analysis characterizes genetic architecture for common psoriasis associated variantsLam C. Tsoi, Philip E. Stuart, Chao Tian, Johann E. Gudjonsson, Sayantan Das
Nature Communications. 2017-05-24
Journal Articles
- Erlotinib-induced skin inflammation is IL-1 mediated in KC-Tie2 mice and human skin organ cultureWard NL, Bhagathavula N, Johnston A, Dawes SM, Fu W, Lambert S, Gudjonsson JE, Varani J, Elder JT, Journal of Investigative Dermatology, 10/1/2014
- Comparison of molecular signatures from multiple skin diseases identifies mechanisms of immunopathogenesisInkeles MS, Scumpia PO, Swindell WR, Lopez D, Teles RMB, Graeber TG, Elder JT, Modlin RL, Pellegrini M, Journal of Investigative Dermatology, 9/18/2014
- Fine mapping of eight psoriasis susceptibility lociDas S, Stuart PE, Ding J, Tejasvi T, Li Y, Tsoi LC, Chandran V, Fischer J, Helms C, Callis Duffin K, Voorhees JJ, Bowcock, AM, Krueger GG, Lathrop GM, Nair RP, Rahman ..., European Journal of Human Genetics, 9/3/2014
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Books/Book Chapters
Abstracts/Posters
- Genome-wide serum miRNA expression profiles identify serum miRNAs as potential biomarkers for human psoriatic arthritis.Han L, Weiland M, Yin C, Lu C, Nair RP, Zhou L, Lim HW, Elder JT, Mi Q, J Invest Dermatol, 1/1/2014
- Genome wide association study of psoriasis in India.Nair, RP, Tsoi LC, Ghosh M, Kabra M, Tejasvi T, Stuart PE, Zawistowski MS, Voorhees JJ, Abecasis GR, Sharma VK, Elder JT, J Invest Dermatol, 1/1/2014
- Microanatomy of psoriasis: Sebaceous gland atrophy contributes to downregulation of lipid metabolism genes.Rittie L, Tejasvi T, Tsoi LC, Swindell WR, Nair RP, Elder JT, J Invest Dermatol, 1/1/2014
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Lectures
- Genetics of Psoriasis and Psoriatic Arthritis: What's at the End of the Rainbow?Detroit, MI - 10/2/2014
- Genetics of Skin Disease: From EGF Receptors to Psoriasis and BackValdecilla Hospital, Santander, Spain - 9/23/2014
- Omics: From Genomics to SkinomicsParis, France - 9/20/2014
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Press Mentions
- Refinement of Genetic Signals for Psoriasis by Combining European-Origin and South Asian PopulationsDecember 1st, 2021
- Research Techniques Made Simple: Itch Measurement in Clinical TrialsJuly 19th, 2018
- What Causes Psoriasis (And How to Stop It Naturally)June 7th, 2017
Grant Support
- Identification Of Psoriatic Arthritis GenesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2009–2011
- Combined Analysis Of Gene Expression And DNA Variation In PsoriasisNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2007–2011
- Training Grant In Cell And Molecular DermatologyNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2002–2011
- Linkage Analysis Of Familial PsoriasisNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1994–2011
- Design Approaches For Sequencing Disease-Associated Regions In PsoriasisNational Human Genome Research Institute2010
- Genotyping The NPF Biobank For Psoriasis Susceptibility GenesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2009–2010
- Amphiregulin In Psoriatic Epidermal HyperplasiaNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2006–2010
- Identification Of Psoriatic Arthritis Genes In Major Histocompatibility ComplexNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2007–2008
- Genetic Analysis Of Psoriasis And Psoriatic ArthritisNational Center For Research Resources2006–2007
- Identification Of Psoriatic Arthritis Genes In The MHCNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2004–2006
- Organ Culture Of Basal Cell CarcinomaNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2001–2002
- Linkage Analysis Of Familial Psoriasis(Supplement)National Institute Of Arthritis And Musculoskeletal And Skin Diseases2001
- Linkage Analysis Of Familial PsoriasisNational Center For Research Resources1996–2000
- Positional Cloning Of Epidermal Differentiation GenesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1993–1996
- Tgf-Alpha And Tyrosine Kinase Activation In PsoriasisNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1989–1993
Professional Memberships
- Fellow
- Society for Investigative Dermatology (SID)Member
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