JaeKeithJoungMDPhD

PubMed

• 48 citations
  Engineered CRISPR prime editors with compact, untethered reverse transcriptases.
  Julian Grünewald, Bret R Miller, Regan N Szalay, Peter K Cabeceiras, Christopher J Woodilla
  Nature Biotechnology. 2023-03-01
• 57 citations
  Multidimensional control of therapeutic human cell function with synthetic gene circuits.
  Hui-Shan Li, Divya V Israni, Keith A Gagnon, Kok Ann Gan, Michael H Raymond
  Science. 2022-12-16
• Author Correction: Augmenting and directing long-range CRISPR-mediated activation in human cells.
  Y Esther Tak, Joy E Horng, Nicholas T Perry, Hayley T Schultz, Sowmya Iyer
  Nature Methods. 2022-07-01

Journal Articles

• Defining CRISPR–Cas9 Genome-Wide Nuclease Activities with CIRCLE-Seq  
  Jae Joung, MD, Nature
• Discovery of Widespread Type I and Type V CRISPR-Cas Inhibitors  
  J Keith Joung, Jenny Y Zhang, Science Magazine
• Efficient CRISPR/Cas9-mediated Editing of Trinucleotide Repeat Expansion in Myotonic Dystrophy Patient-Derived iPS and Myogenic Cells  
  J Keith Joung, J Keith Joung, Nucleic Acids Research
• Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo  
  Zuris JA, Thompson DB, Shu Y, Guilinger JP, Bessen JL, Hu JH, Maeder ML, Joung JK, Chen ZY, Liu DR, Nat Biotechnol., 10/30/2014
• Towards a functional understanding of variants for molecular diagnostics using genome editing  
  Tsai SQ, Iafrate AJ, Joung JK, Nat Med., 10/8/2014
• Systematic screening reveals a role for BRCA1 in the response to transcription associated DNA damage  
  Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, ..., Genes Dev, 9/1/2014
• IkB kinaseB (IKBKB) Mutations in Lymphomas that constitutively activate canonical nuclear factor kB (NFkB) signaling  
  Kai X, Chellappa V, Donado C, Reyon D, Sekigami Y, Ataca D, Louissaint A, Mattoo H, Joung JK, Pillai S, J Biol Chem., 8/8/2014
• Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function  
  Liu Y, Kretz CA, Maeder ML, Richter CE, Tsao P, Vo AH, Huarng MC, Rode T, Hu Z, Mehra R, Olson ST, Joung JK, Shavit JA, Blood, 7/3/2014
• Dimeric CRISPR RNA-guided FokI nucleases for high specific genome editing  
  Tsai SQ, Wyvekens N, Khayter C, Foden JA, Thapar V, Reyon D, Goodwin MJ, Aryee MJ, Joung JK, Nat Biotechnol., 6/1/2014
• An improved predictive recognition model for Cys2-His2 zinc finger proteins  
  Gupta A, Christensen RG, Bell HA, Goodwin M, Patel RY, Pandey M, Enuameh MS, Rayla AL, Zhu C, Thibodeau-Beganny S, Brodsky MH, Joung JK, Wolfe SA, Stormo GD, Nucleic Acids Res., 4/1/2014
• Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity  
  Guilinger JP, Pattanayak V, Reyon D, Tsai SQ, Sander JD, Joung JK, Liu DR, Nat Methods, 4/1/2014
• Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1  
  Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley..., Cell Stem Cell, 4/1/2014
• Improving CRISPR-Cas nuclease specificity using truncated guide RNAs (*Selected by Faculty of 1000 as a Recommended Article: Faculty of 1000 Prime: 2014)  
  Fu Y, Sander JD, Reyon D, Cascio V, Joung JK, Nat Biotechnol., 3/1/2014
• Toddler: An Embryonic Signal That Promotes Cell Movement via Apelin Receptors  
  Pauli A, Norris ML, Valen E, Chew GL, Gagnon JA, Zimmerman S, Mitchell A, Ma J, Dubrulle J, Reyon D, Tsai SQ, Joung JK, Saghatelian A, Schier AF, Science, 2/14/2014
• Correction of Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair  
  Low BE, Krebs MP, Joung JK, Tsai SQ, Nishina PM, Wiles MV, Invest Ophthalmol Vis Sci., 1/20/2014
• Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation  
  Kieffer-Kwon KR, Tang Z, Mathe E, Qian J, Sung MH, Li G, Resch W, Baek S, Pruett N, Grøntved L, Vian L, Nelson S, Zare H, Hakim O, Reyon D, Yamane A, Nakahashi H, Kov..., Cell, 12/1/2013
• Targeted DNA Demethylation and Endogenous Gene Activation Using Programmable TALE-TET1 Fusions (*Selected by Faculty of 1000 as a Recommended Article: Faculty of 100...  
  Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson MF, Joung JK, Nat Biotechnol., 12/1/2013
• Locus- specific editing of histone modifications at endogenous enhances  
  Mendenhall EM, Williamson KE, Reyon D, Zou JY, Ram O, Joung JK, Bernstein BE, Nat Biotechnol., 12/1/2013
• Targeted Deletion and Inversion of Tandemly Arrayed Genes in Arabidopsis thaliana Using Zinc Finger Nucleases  
  Qi Y, Li X, Zhang Y, Starker CG, Baltes NJ, Zhang F, Sander JD, Reyon D, Joung JK, Voytas DF, G3 (Bethesda), 10/1/2013
• In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites  
  Sander JD, Ramirez CL, Linder SJ, Pattanayak V, Shoresh N, Ku M, Foden JA, Reyon D, Bernstein BE, Liu DR, Joung JK, Nucleic Acid Res., 10/1/2013
• CRISPR RNA-guided activation of endogenous human genes  
  Maeder ML, Linder SJ, Cascio VM, Fu Y, Ho QH, Joung JK, Nat Methods, 10/1/2013
• High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells  
  Fu Y, Foden JA, Khayter C, Maeder ML, Reyon D, Joung JK*, Sander JD* (*Co-corresponding authors), Nat Biotechnol., 9/1/2013
• Engineering Customized TALE Nucleases (TALENs) and TALE Transcription Factors by Fast Ligation-Based Automatable Solid-Phase High-Throughput (FLASH) Assembly  
  Reyon D, Maeder ML, Khayter C, Tsai SQ, Foley JE, Sander JD, Joung JK, Curr Protoc Mol Biol., 7/1/2013
• piggyBac transposase tools for genome engineering  
  Li X, Burnight ER, Cooney AL, Malani N, Brady T, Sander JD, Staber J, Wheelan SJ, Joung JK, McCray PB Jr, Bushman FD, Sinn PL, Craig NL, Proc Natl Acad Sci U S A, 6/18/2013
• TALEN-based Gene Correction for Epidermolysis Bullosa  
  Osborn MJ, Starker CG, McElroy AN, Webber BR, Riddle MJ, Xia L, Defeo AP, Gabriel R, Schmidt M, Von Kalle C, Carlson DF, Maeder ML, Joung JK, Wagner JE, Voytas DF, Bla..., Mol Ther., 6/1/2013
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Books/Book Chapters

• Protein-Protein Interactions: A Molecular Cloning Manual 
  Chapter: A bacterial two-hybrid system for studying and modifying protein-protein interactions. 
  Page 195 - 216Giesecke A, Joung JKEditors: E.A. Golemis.Cold Spring Harbor Laboratory PressEdition 2nd,2005
• Clinical Chemistry – Laboratory Management and Clinical Correlations 
  Chapter: Laboratory Safety: An Overview. 
  Page 40 - 50Joung JK, Lewandrowski KBEditors: Lewandrowski KB.Lippincott Williams & Wilkins2002
• Protein-Protein Interactions: A Molecular Cloning Manual 
  Chapter: Yeast and Bacterial Two-hybrid Selection Systems for Studying Protein- Protein Interactions. 
  Page 93 - 142Serebriiskii I, Joung JKEditors: E.A. Golemis.Cold Spring Harbor Laboratory Press2001

Abstracts/Posters

• Precise Genome Editing Directed by ssODNs and TAL Effector Nucleases (TALENs) or RNA-guided Nucleases (RGNs).
  Tsai SQ, Reyon D, Khayter C, Fu Y, Maeder ML, Hwang WY, Peterson RT, Yeh JR, Sander J, Joung JK, Keystone Conference: Precision Genome Engineering and Synthetic Biology: Designing Genomes and Pathways (Selected for Oral Presentation), Breckenridge, CO, 1/1/2013
• Precise Modification of Human Genes Directed by Single-stranded DNA Oligonucleotides and TALENs or RNA-guided Nucleases (RGNs).
  Tsai SQ, Reyon D, Khayter C, Joung JK, American Society of Gene and Cell Therapy Annual Meeting (Selected for Oral Presentation), Salt Lake City, UT, 1/1/2013
• High-throughput gene editing in human cells enabled by fast ligation-based automatable solid-phase high-throughput (FLASH) assembly of TALENs.
  Reyon D, Tsai SQ, Khayter C, Foden JA, Sander JD, Joung JK, American Society of Gene & Cell Therapy Annual Meeting (Selected for Oral presentation), Philadelphia, PA, 1/1/2012
• Zinc-Finger Nuclease-Mediated Correction of RS-SCID.
  Rahman S, Kühle J, Maeder M, Riedel H, Cantz T, Joung K, Schambach A, Cathomen T, American Society of Gene & Cell Therapy Annual Meeting (Selected for Oral presentation), Philadelphia, PA, 1/1/2012
• Upregulation of the Pluripotency-Associated miRNA 302-367 Cluster Using Engineered Transcription Activator-Like (TALE) Activators.
  Maeder ML, Angstman JF, Linder SJ, Reyon D, Joung JK, American Society of Gene TherapyAnnual Meeting, Philadelphia, PA, 1/1/2012
• Synergistic Activation of Gene Expression by FLASH-Assembled TALE Transcription Factors.
  Maeder ML, Linder SJ, Reyon D, Angstman JF, Fu Y, Sander JD, Joung JK, FASEB Science Research Conference on Genome Engineering: Research & Applications (Selected for Oral presentation), Lucca, Italy, 1/1/2012
• Oligomerized Pool Engineering (OPEN) 2.0: A Simplified Zinc Finger Nuclease Engineering Platform with Expanded Targeting Range.
  Sander JD, Dahlborg E, Regan M, Goodwin M, Maeder M, Joung JK, FASEB Science Research Conference on Genome Engineering: Research and Applications (Selected for Oral presentation), Lucca, Italy, 1/1/2012
• Targeted mutagenesis of soybean paralogous genes.
  Curtin S, Zhang F, Sander JD, Haun WJ, Starker C, Baltes NJ, Reyon D, Dahlborg EJ., Goodwin MJ, Coffman AP, Dobbs D, Joung JK, Voytas DF, Stupar RM, Annual Meeting of the American Society of Plant Biologists, Minneapolis, MN, 1/1/2011
• Further Improvements and Applications of Context-Dependent Assembly (CoDA): A Publicly Available, Selection-Free Method for Engineering Zinc Finger Nucleases.
  Sander JD, Reyon D, Kuzmickas R, Khayter C, Morgan ML, Joung JK, American Society of Gene & Cell Therapy Annual Meeting, Seattle, WA, 1/1/2011
• Further Improvements and Applications of OPEN (Oligomerized Pool ENgineering): A Rapid, Robust, and Publicly Available Method for Engineering Customized Zinc Finger Nu...
  Maeder ML, Yeh JRJ, Foley JE, Zou J, Thibodeau-Beganny S, Cheng L, Peterson RT, Joung JK, American Society of Gene Therapy Annual Meeting (Selected for Oral presentation), San Diego, CA, 1/1/2009
• Engineering Zinc Finger Nucleases by Modular Assembly - Proceed with Caution
  Joung JK, Invited Speaker (abstract), American Society of Gene Therapy Annual Meeting, Boston, MA, 1/1/2008
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Lectures

• Targeted Genome Editing Using TALENs and CRISPR RNA-Guided Nuclease 
  MD Anderson, Houston, TX - 1/1/2014
• Improving and Defining the Specificity of CRISPR-Cas Nucleases 
  Waltham, MA - 1/1/2014
• Targeted Genome & Epigenome Editing Using Engineered CRISPR and TALE Technologies 
  Biogen Idec, Cambridge, MA - 1/1/2014
• Targeted Genome and Epigenome Editing to Understand Biology and Treat Disease 
  Cambridge, MA - 1/1/2014
• Editing the Genome and Epigenome to Understand and Treat Disease 
  Cambridge, MA (Nature Publishing Group, Johnson & Johnson Innovation, Janssen Labs, Merck, and Goodw - 1/1/2014
• Editing Genomes and Epigenomes Using CRISPR-Cas Technology 
  MGH/BIDMC - 1/1/2014
• Targeted Genome and Epigenome Editing Using Engineering CRISPR and TALE Technologies 
  Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA - 1/1/2014
• Targeted Genome and Epigenome Editing Using CRISPR and TALE Technologies 
  Department of Neurology, MGH - 1/1/2014
• Targeted Genome & Epigenome Editing Technologies 
  1/1/2014
• Targeted Genome and Epigenome Editing Using CRISPR-Cas and TALE Technologies 
  University of California Berkeley, CA - 1/1/2014
• Targeted Genome and Epigenome Editing Using Engineered CRISPR-Cas and TALE Technologies 
  The Korean Academy of Science and Technology, Pasadena, CA - 1/1/2014
• Engineered CRISPR-Cas Systems for Targeted Genome Editing and Gene Regulation 
  Washington, DC - 1/1/2014
• Genome and Epigenome Editing Using TALEs and CRISPR-Cas Technologies 
  University of Georgia, Athens, GA - 1/1/2014
• Targeted Genome & Epigenome Editing Using CRISPR-Cas and TALE Proteins 
  George Town, Cayman Islands - 1/1/2014
• Targeted Genome & Epigenome Editing Using Engineered CRISPR & TALE Technologies 
  Nassau, Bahamas - 1/1/2014
• Targeted Genome and Epigenome Editing Using TALEs and CRISPR-Cas Proteins 
  Ames, IA - 1/1/2013
• Genome and Epigenome Editing Using Engineered TALE and CRISPR Technologies 
  The Children’s Hospital of Pennsylvania/University of Pennsylvania, Philadelphia, PA - 1/1/2013
• Targeted Genome and Epigenome Editing Using TALE and CRISPR-Cas Proteins 
  East Carolina University, Greenville, NC - 1/1/2013
• Editing Genes to Understand and Treat Disease 
  East Carolina University, Greenville, NC - 1/1/2013
• Targeted Genome Editing Using ZFNs, TALENs and CRISPR RNA-Guided Nucleases 
  University of California Berkeley, CA - 1/1/2013
• Targeted Genome and Epigenome Editing Using TALE and CRISPR-Cas Technologies 
  Brigham & Women’s Hospital, Boston, MA - 1/1/2013
• FLASH Assembly of TALENs for Targeted Modification of Zebrafish Genes 
  Asilomar, CA - 1/1/2013
• Genome editing using ZFNs, TALENs, and CRISPR RNA-guided nucleases. 
  Janelia Farms, Howard Hughes Medical Institute, Ashburn, VA - 1/1/2013
• Engineered TALENs and CRISPR-Cas RNA-Guided Nucleases (RGNs) for Targeted Genome Editing 
  Salt Lake City, UT - 1/1/2013
• Engineered Zinc Finger and TALE Transcription Factors for Targeted Gene Regulation 
  Saxtons River, VT - 1/1/2013
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Other

• Studies of Prokaryotic Transcriptional Activator Synergy and Dimerization Specificity. (Thesis) 
  Joung JK, Harvard University
  Cambridge, MA - 1/1/1996