Jack T Stapleton MD
Professor, Internal Medicine, Microbiology and Immunology, University of Iowa College of Medicine
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200 Hawkins DrIowa City, IA 52242
Phone+1 319-356-3168
Fax+1 319-356-4600
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Education & Training
University of North Carolina HospitalsFellowship, Infectious Disease, 1983 - 1986- University of North Carolina HospitalsResidency, Internal Medicine, 1980 - 1983
University of Kansas School of MedicineClass of 1980
Certifications & Licensure
IA State Medical License 1986 - 2027
NC State Medical License 1982 - 1999
American Board of Internal Medicine Internal Medicine- American Board of Internal Medicine Infectious Disease
Awards, Honors, & Recognition
- Regional Top Doctor Castle Connolly, 2022
Clinical Trials
- TIV and High Dose TIV in Subjects With Rheumatoid Arthritis Start of enrollment: 2011 Oct 01
- Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV Infection Start of enrollment: 2014 Apr 28
Publications & Presentations
PubMed
- Anti-neuraminidase and anti-hemagglutinin stalk responses to different influenza a(H7N9) vaccine regimens.Hana M El Sahly, Evan J Anderson, Lisa A Jackson, Kathleen M Neuzil, Robert L Atmar
Vaccine. 2025-02-15 - Integrated analysis of protein sequence and structure redefines viral diversity and the taxonomy of the.Peter Simmonds, Anamarija Butković, Joe Grove, Richard Mayne, Jonathon C O Mifsud
Biorxiv. 2025-01-18 - Antiretroviral Therapy Suppresses RNA-Methyladenosine Modification in Peripheral Blood Mononuclear Cells from HIV-1-Infected Individuals.Tarun Mishra, Stacia Phillips, Crystal Maldonado, Jack T Stapleton, Li Wu
AIDS Research and Human Retroviruses. 2024-09-01
Journal Articles
- Semen Exosomes Promote Transcriptional Silencing of HIV-1 by Disrupting NF-kB/Sp1/Tat CircuitryJack Stapleton, MD, mBio
Press Mentions
‘No One Believed That It Would Ever Come to This Place’: Fear and Hatred Clouded Efforts to Care for Iowa’s Early AIDS PatientsMay 16th, 2023- Modified Vaccinia Ankara Vaccine Efficacious for Smallpox Protection in Phase 3 StudyNovember 14th, 2019
Grant Support
- SARS CoV-2 Immune Evasion MechanismsIOWA CITY VA MEDICAL CENTER2009–2026
- Research Training in Infectious DiseasesUNIVERSITY OF IOWA1988–2025
- GBV-C Effects On CD4 Activation And ExpansionNational Institute Of Allergy And Infectious Diseases2009–2011
- GB Virus Type C Natural History, Epidemiology, HIV InteractionNational Institute Of Allergy And Infectious Diseases2007–2008
- Smallpox Vaccination On Endothelial Function And Human Gene ExpressionNational Center For Research Resources2005–2006
- GBV-C Natural History, Epidemiology, HIV InteractionNational Institute Of Allergy And Infectious Diseases2004–2006
- Effect Of GB Virus C Infection On HIV Infection, CD4 Cell Counts And HIV RNANational Center For Research Resources2005
- Effects Of Statins On Hepatitis C And GBV-C Viral LoadsNational Center For Research Resources2004–2005
- Smallpox Vaccination On Endothelial FunctionNational Center For Research Resources2004
- Informed Consent To Use Stored Human Biological MaterialsNational Center For Research Resources2004
- Aventis Pasteur'S Smallpox Vaccine In Vaccinia-NaiveNational Center For Research Resources2004
- ACTG A5088 Interleukin-2 And Pegylated InterferonNational Center For Research Resources2004
- Clinical Evaluation Of Echinacea And Hypericum In HIV-1 Infected SubjectsNational Institute Of Environmental Health Sciences2002
- Trial Of IV Wf10 (TCDO) In Patients With LATE Stage HIV DiseaseNational Center For Research Resources2000–2002
- Treatment Rollover For PTS Formerly On ACTG 328: IL-2National Center For Research Resources2000–2002
- ACTG 5025 Hydroxyurea And Potent Antiretroviral TherapyNational Center For Research Resources2000–2002
- ACTG 388 Trial Of Efz Or Nfv With Lamivudine/Zdv &Indinavir In HIV InfectionNational Center For Research Resources2000–2002
- Triple Combination Drug Therapy For HIV 1 SubjectsNational Center For Research Resources1999–2002
- ACTG 398 Amprenavir As PART Of Dual Protease Inhibitor Regimens In HIVNational Center For Research Resources1999–2002
- ACTG 384, Protease &Non Nucleoside Reverse Transcriptase Inhibitor For HIVNational Center For Research Resources1999–2002
- ACTG 372--Virologic Success Of Indinavir With Nucleoside Analogs In HIVNational Center For Research Resources1998–2002
- ACTG 368--159u89 With Indivavir Sulfate And Dmp266 In HIV SubjectsNational Center For Research Resources1998–2002
- ACTG 343--Three Maintenance Regimens For HIV Infected SubjectsNational Center For Research Resources1998–2002
- ACTG 328--Recombinant Human Interleukin 2 In Subjects With HIVNational Center For Research Resources1998–2002
- Evaluation Of GB Virus C Replication And HIV InhibitionNational Institute Of Allergy And Infectious Diseases2001
- Hcv-Alcohol Interactions-- Pathogenesis And EpidemiologyNational Institute On Alcohol Abuse And Alcoholism2000–2001
- Effects Of Alcohol On HIV ReplicationNational Center For Research Resources1998–2000
- Delavirdine Mesylate With Zidovudine VS ZDV Alone In HIV1 SubjectsNational Center For Research Resources1998–2000
- Nevirapine, Lamivudine And Background Nucleoside Therapy In AIDSNational Center For Research Resources1997–2000
- Hepatitis C Virus-Alcohol Interactions-- Pathogenesis AnNational Institute On Alcohol Abuse And Alcoholism1999
- Delavirdine Mesylate With Didanosine VS DDI Alone In HIV1 SubjectsNational Center For Research Resources1998–1999
- Dapsone And Atovaquone For Prophylaxis Against PCP In HIV Infected PatientsNational Center For Research Resources1998–1999
- Asymptomatic Patients On Zidovudine Monotherapy In HIV PatientsNational Center For Research Resources1998–1999
- ACTG 320--Indinavir With Zidovudine And Lamivudine In HIV InfectionNational Center For Research Resources1998–1999
- Delavirdine Mesylate Treatment In Triple Combination For HIV PatientsNational Center For Research Resources1996–1999
- Delavirdine Mesylate With Zidovudine VS ZDV Alone In HIV 1 SubjectsNational Center For Research Resources1997
- Actg--Zidovudine Monotherapy In Asymptomatic HIV Positive AdultsNational Center For Research Resources1997
- Actg--Indinavir With Zidovudine And Lamivudine In HIV InfectionNational Center For Research Resources1997
- Alcohol Effects On HIV ReplicationNational Institute On Alcohol Abuse And Alcoholism1996–1997
- Didanosine And Nevirapine In HIV Positive AdultsNational Center For Research Resources1996–1997
- Delavirdine Mesylate With Didanosine VS DDI Alone In HIV 1 SubjectsNational Center For Research Resources1996–1997
- Actg--Dapsone And Atovaquone For Prophylaxis Against PCP In HIVNational Center For Research Resources1996–1997
- Valacyclovir Hydrochloride Prophylaxis For CMV Disease In HIV InfectionNational Center For Research Resources1996
- Dilavirdine Mesylate With Zidovudine VS ZDV Alone In HIV 1 SubjectsNational Center For Research Resources1996
- Clarithromycin VS Rifabutin VS Both To Prevent Mycobacterium Avium In HIV AdultsNational Center For Research Resources1996
- Actg--Zidovudine Therapy In HIV Positive AdultsNational Center For Research Resources1996
- Nucleosides As Monotherapy VS Combination In NON Hemophiliac HIV PatientsNational Center For Research Resources1993
- Immunogenicity Of An Inactivated Hepatitis A VaccineNational Center For Research Resources1993
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