J MichaelMichaelMcintoshMD

PubMed

• Design, Synthesis, and Structure-Activity Relationships of Novel Peptide Derivatives of the Severe Acute Respiratory Syndrome-Coronavirus-2 Spike-Protein that Potently...
  Arik J Hone, Ulises Santiago, Peta J Harvey, Bassel Tekarli, Joanna Gajewiak
  Journal of Medicinal Chemistry. 2024-06-13
• Aspartic acid mutagenesis of αO-Conotoxin GeXIVA isomers reveals arginine residues crucial for inhibition of the α9α10 nicotinic acetylcholine receptor.
  An Luo, Jie He, Jinpeng Yu, Yong Wu, Peta J Harvey
  International Journal of Biological Macromolecules. 2024-06-01
• 1 citations
  Catharanthine Modulates Mesolimbic Dopamine Transmission and Nicotine Psychomotor Effects via Inhibition of α6-Nicotinic Receptors and Dopamine Transporters.
  Benjamin M Williams, Nathan D Steed, Joel T Woolley, Aubrey A Moedl, Christina A Nelson
  ACS Chemical Neuroscience. 2024-05-01

Journal Articles

• Differential roles of alpha6beta2* and alpha4beta2* neuronal nicotinic receptors in nicotine- and cocaine-conditioned reward in mice  
  Sanjakdar SS, Maldoon PP, Marks MJ, Brunzell DH, Maskos U, McIntosh JM, Bowers MS, Damaj MI, Neuropsychopharmacology, 1/1/2015
• The alpha7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions  
  Bordia T, McGregor M, Papke RL, Decker MW, McIntosh JM, Quik M, Exp Neurol, 1/1/2015
• Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents  
  Kewin K, Jordan Cameron P, Klapczynski M, McIntosh JM, Crooks PA, Dwoskin LP, Lysakowski, J Neurosci, 1/1/2015
• Nicotine and ethanol cooperate to enhance ventral tegmental area AMPA receptor function via alpha6-containing nicotinic receptors  
  Engle SE, McIntosh JM, Drenan RM, Neuropharmacology, 1/1/2015
• Key residues in the nicotinic acetylcholine receptor beta2 subunit contribute to alpha-conotoxin LvIA binding  
  Zhangsun D, Zhu X, Wu Y, Hu Y, Kaas Q, Craik DJ, McIntosh JM, Luo S, J Biol Chem, 1/1/2015
• Molecular interaction of alphaconotoxin RgIA with the rat alpha9alpha10 nicotinic acetylcholine recepto  
  Azam L, Papakyriakou A, Zouridakis M, Giastas P, Tzartos SJ, McIntosh JM, Mol Pharmacol, 1/1/2015
• Evidence for a role for alpha6( *) nAChRs in ldopa- induced dyskinesias using Parkinsonian alpha6( *) nAChR gain-of-function mice  
  Bordia T, McGregor M, McIntosh JM, Drenan RM, Quik M, Neuroscience, 1/1/2015
• Cloning, synthesis, and characterization of alphaO-conotoxin GeXIVA, a potent alpha9alpha10 nicotinic acetylcholine receptor antagonist  
  Luo S, Zhangsun D, Harvey PJ, Kaas Q, Wu Y, Zhu X, Hu Y, Li X, Tsetlin VI, Christensen S, Romero HK, McIntyre M, Dowell C, Baxter JC, Elmslie KS, Craik DJ, McIntosh JM, Proc Natl Acad Sci U S A, 1/1/2015
• alphaS-conotoxin GVIIIB potently and selectively blocks alpha9alpha10 nicotinic acetylcholine receptors  
  Christensen SB, Bandyopadhyay PK, Olivera BM, McIntosh JM, Biochem Pharmacol, 1/1/2015
• alpha6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity  
  Berry JN, Engle SE, McIntosh JM, Drenan RM, Neuroscience, 1/1/2015
• r-bPiDI, an alpha6beta2* Nicotinic Receptor Antagonist, Decreases Nicotine- Evoked Dopamine Release and Nicotine Reinforcement  
  Beckmann JS, Meyer AC, Pivavarchyk M, Horton DB, Zheng G, Smith AM, Wooters TE, McIntosh JM, Crooks PA, Bardo MT, Dwoskin LP, Neurochem Res, 1/1/2015
• alpha-Conotoxins Identify the alpha3beta4* Subtype as the Predominant Nicotinic Acetylcholine Receptor Expressed in Human Adrenal Chromaffin Cells  
  Hone AJ, McIntosh JM, Azam L, Lindstrom J, Lucero L, Whiteaker P, Passas J, Blazquez J, Albillos A, Mol Pharmacol, 1/1/2015
• Nicotine Dependence Reveals Distinct Responses from Neurons and Their Resident Nicotinic Receptors in Medial Habenula  
  Shih PY, McIntosh JM, Drenan RM, Mol Pharmacol, 1/1/2015
• Chronic Nicotine Exposure Attenuates Methamphetamine-Induced Dopaminergic Deficits  
  Vieira-Brock PL, McFadden LM, Nielsen SM, Ellis JD, Walters ET, Stout KA, McIntosh JM, Wilkins DG, Hanson GR, Fleckenstein AE, J Pharmacol Exp Ther, 1/1/2015
• Limited efficacy of alpha-conopeptides  
  Wright AB, Norimatsu Y, McIntosh JM, Elmslie KS, eNeuro, 1/1/2015
• The influence of nondisclosure on the mental health of urban African- American adolescents exposed to community violence  
  Dinizulu SM, Grant KE, McIntosh JM, J Prev Interv Community, 1/1/2014
• Monkey Adrenal Chromaffin Cells Express alpha6beta4* Nicotinic Acetylcholine Receptors  
  Hernandez-Vivanco A, Hone AJ, Scadden ML, Carmona-Hidalgo B, McIntosh JM, Albillos A, PLoS ONE, 1/1/2014
• Enhanced synthesis and release of dopamine in transgenic mice with gain-of-function alpha6* nAChRs  
  Wang Y, Lee JW, Oh G, Grady SR, McIntosh JM, Brunzell DH, Cannon JR, Drenan RM, J Neurochem, 1/1/2014
• ABT-089 and ABT-894 reduce levodopa-induced dyskinesias in a monkey model of Parkinson's disease  
  Zhang D, Bordia T, McGregor M, McIntosh JM, Decker MW, Quik M, Mov Disord, 1/1/2014
• A novel alpha4/7-conotoxin LvIA from Conus lividus that selectively blocks alpha3beta2 vs alpha6/alpha3beta2beta3 nicotinic acetylcholine receptors  
  Luo S, Zhangsun D, Schroeder CI, Zhu X, Hu Y, Wu Y, Weltzin MM, Eberhard S, Kaas Q, Craik DJ, McIntosh JM, Whiteaker P, FASEB J, 1/1/2014
• Discovery of a potent and selective alpha3beta4 nicotinic acetylcholine receptor antagonist from an alpha-conotoxin synthetic combinatorial library  
  Chang YP, Banerjee J, Dowell C, Wu J, Gyanda R, Houghten RA, Toll L, McIntosh JM, Armishaw CJ, J Med Chem, 1/1/2014
• Presence of multiple binding sites on alpha9alpha10 nAChR receptors alludes to stoichiometric-dependent action of the alphaconotoxin, Vc11  
  Indurthi DC, Pera E, Kim HL, Chu C, McLeod MD, McIntosh JM, Absalom NL, Chebib M, Biochem Pharmacol, 1/1/2014
• Acute Ethanol Inhibits Dopamine Release in the Nucleus Accumbens via alpha6 Nicotinic Acetylcholine Receptors  
  Schilaty ND, Hedges DM, Jang EY, Folsom RJ, Yorgason JT, McIntosh JM, Steffensen SC, J Pharmacol Exp Ther, 1/1/2014
• alpha6beta2*- subtype nicotinic acetylcholine receptors are more sensitive than alpha4beta2*-subtype receptors to regulation by chronic nicotine administration  
  Marks MJ, Grady SR, Salminen O, Paley MA, Wageman CR, McIntosh JM, Whiteaker P, J Neurochem, 1/1/2014
• The alpha3beta4* nicotinic Ach receptor subtype mediates physical dependence to morphine: mouse and human studies  
  Muldoon PP, Jackson KJ, Perez E, Harenza JL, Molas S, Rais B, Anwar H, Zaveri NT, Maldonado R, Maskos U, McIntosh JM, Dierssen M, Miles MF, Chen X, De Biasi M, Damaj MI, Br J Pharmacol, 1/1/2014
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Books/Book Chapters

• Neuronal Nicotinic Receptors 
  Chapter: Toxin antagonists of the neuronal nicotinic acetylcholine receptor 
  Page 455 - 476McIntosh JMEditors: Clementi F, Fornasari D, Gotti C.Springer-Verlag, Berlin, Germany2000
• Animal Toxins - Facts and Protocols 
  Chapter: Conus peptides and their iodinated derivatives as probes for ion channels and receptors 
  Page 74 - 89Cruz LJ, McIntosh JM, Imperial JS, Gray WREditors: Rochat H, Martin-Eauclaire MF.Birkhauser Verlag, Basel, Switzerland1999
• Aspects in Marine Pharmacology 
  Chapter: alpha-Conotoxins and nicotinic acetylcholine receptors 
  Page 28 - 33McIntosh JMEditors: Lazarovici P, Spira M, Zlotkin E.Alaken Inc., Fort Collins, CO1996
• Technologies in Protein Chemistry VI 
  Chapter: MS based scanning methodologies applied to Conus venom 
  Page 31 - 38Craig AG, Fischer WH, Rivier JE, McIntosh JM, Gray WREditors: Crabb JW.Academic Press, San Diego, CA1995
• Gene-Brain-Behaviour, Proceedings of the 21st Gottingen Neurobiology Conference 
  Chapter: Conus peptides as tools for the neuroscientist 
  Page 159 - 169Olivera BM, McIntosh JM, Cruz LJEditors: Elsner N, Heisenberg M.Georg Thieme Verlag, Stuttgart, Germany; New York, NY1993
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Abstracts/Posters

• alpha-Conotoxin ImI, a selective ligand for neuronal nAChRs
  McIntosh JM, Johnson DS, Yoshikami D, Mahe E, Nielsen DB, Rivier JE, Gray WR, Olivera BM, International Symposium on Nicotine: The Effects of Nicotine on Biological Systems, Basel, Switzerland, 1/1/1994

Lectures

• Nicotinic Acetylcholine Receptors as Therapeutic Targets 
  1/1/2010
• Natrual Peptides to Drugs 
  Zurmatt, Switzerland - 1/1/2008
• Nicotinic Acetylcholine Receptors 
  Cambridge UK - 1/1/2008
• Similar expression pattern of alpha-conotoxin MII sites and the dopamine transporter in control and MPTP lesioned monkey basal ganglia 
  1/1/2001
• Effects of the nicotinic acetylcholine receptor b4 subunit null mutation on synaptosomal neurotransmitter release 
  Paris, France - 1/1/2001
• Nicotinic receptors on noradrenergic neurons in rat and human cortex 
  Lyon, France - 1/1/2001
• Most mousebrain [125I]alpha-conotoxin MII-binding sites are unaffected by alpha3 nicotinic subunit-null mutation 
  Paris, France - 1/1/2001
• alpha-Conotoxin MII differentially inhibits nicotine-induced Ca2+ changes in rat striatal synaptosomes 
  1/1/2000
• New conotoxins which affect neuronal sodium channels in mammals 
  Germany - 1/1/1996
• alpha-Conotoxin MII blocks nicotine-stimulated dopamine release 
  1/1/1996
• The use of conotoxins for the study of sodium channels in Aplysia 
  1/1/1995
• Isolation and characterization of an alpha-conotoxin from Conus ermineus 
  1/1/1994
• The pharmacology of Conus peptides 
  1/1/1994
• Ontogenetic changes in N-type calcium channels of the human cerebellum, hippocampus and frontal cortex 
  1/1/1994
• Conotoxins targeted to voltage-sensitive sodium channels 
  1/1/1994
• Purification and characterization of a novel phospholipase A2 from the venom of Conus magus 
  Bath, England - 1/1/1993
• Postnatal ontogeny of N-type calcium channels in rat brain: caudo-rostral evolution and transient expression 
  1/1/1993
• Identification of a novel calcium channel antagonist from the venom of Conus magus 
  1/1/1992
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