Israel Zighelboim MD FACOG, FACS

PubMed

• 4 citations
  Role of sentinel lymph node evaluation during hysterectomy for preoperative pathology diagnosis of endometrial intraepithelial neoplasia in a community hospital setting.
  Samantha Leite, Yiting Stefanie Chen, Allison Walker, Kelly Riccio, Nicholas Taylor
  Gynecologic Oncology. 2024-05-01
• 2 citations
  Implementation of an enhanced recovery after surgery (ERAS) protocol for total abdominal hysterectomies in the division of gynecologic oncology: a network-wide quality...
  Kathleen E Ackert, Wayne Bauerle, Anna Ng Pellegrino, Jill Stoltzfus, Shaun Pateman
  Journal of Osteopathic Medicine. 2023-09-01
• Common obstetrics and gynecologic topics in critical care: A narrative review.
  Julia Ritchie, Meredith L Birsner, Israel Zighelboim, Nicholas P Taylor
  International Journal of Critical Illness and Injury Science. 2023-03-24

Journal Articles

• Assessing the prognostic role of ATR mutation in endometrioid endometrial cancer: An NRG Oncology/Gynecologic Oncology Group study  
  Zighelboim I, Ali S, Lankes HA, Backes F, Moore K, Mutch D, Robison K, Behbakht K, Waggoner S, Ghebre RG, Pearl M, Ramirez NC, Goodfellow P, Gynecol Oncol, 1/1/2015
• Awareness of the association between obesity and peri-operative risk among newly diagnosed patients with complex atypical hyperplasia and endometrial cancer  
  Kuroki LM, Benn TE, Dukes JL, Hagemann AR, Thaker PH, Powell MA, Mutch DG, Massad LS, Zighelboim I, Gynecol Oncol Case Rep, 1/1/2015
• A phase II trial of a surgical protocol to decrease the incidence of wound complications in obese gynecologic oncology patients  
  Novetsky AP, Zighelboim I, Guntupalli SR, Ioffe YJ, Kizer NT, Hagemann AR, Powell MA, Thaker PH, Mutch DG, Massad LS, Gynecol Oncol, 1/1/2014
• The prognostic significance of lymphovascular space invasion in laparoscopic versus abdominal hysterectomies for endometrioid endometrial cancer  
  Dewdney SB, Jiao Z, Roma AA, Gao F, Rimel BJ, Thaker PH, Powell MA, Zighelboim I, Eur J Gynaecol Oncol, 1/1/2014
• High frequency strand slippage mutations in CTCF in MSI-positive endometrial cancers  
  Zighelboim I, Mutch DG, Knapp A, Ding L, Xie M, Cohn DE, Goodfellow PJ, Human Mutation, 1/1/2014
• Phase II study of bevacizumab and pemetrexed for recurrent or persistent epithelial ovarian, fallopian tube or primary peritoneal cancer  
  Hagemann AR, Novetsky AP, Zighelboim I, Gao F, Massad LS, Thaker PH, Powell MA, Mutch DG, Wright JD, Obstet Gynecol, 1/1/2013
• Disclosing diagnosis of cancer: Considerations specific to gynecologic oncology patients  
  Kuroki LM, Zhao K, Jeffe DB, Powell MA, Hagemann AR, Thaker PH, Massad LS, Mutch DG, Zighelboim I, Obstet Gynecol, 1/1/2013
• Timing of genetic counseling in patients with ovarian, fallopian tube or primary peritoneal carcinoma  
  Novetsky A, Smith K, Babb S, Jeffe D, Hagemann A, Thaker P, Powell M, Mutch D, Massad L, Zighelboim I, Int J Gynecol Cancer, 1/1/2013
• Multicenter phase II trial of topotecan, cisplatin and bevacizumab for recurrent or persistent cervical cancer  
  Zighelboim I, Wright JD, Gao F, Case AS, Massad LS, Mutch DG, Powell MA, Thaker PH, Eisenhauer EL, Cohn DE, Valea FA, Secord AA, Lippman LT, Dehdashti F, Rader JS, Gynecol Oncol, 1/1/2013
• In Vitro Chemoresponse to Cisplatin and Outcomes in Cervical Cancer  
  Grigsby PW, Zighelboim I, Powell MA, Mutch DG, Schwarz JK, Gynecol Oncol, 1/1/2013
• Novel MicroRNAs Regulating Proliferation and Apoptosis in Uterine Papillary Serous Carcinomas  
  Mach C, Kim J, Soibam B, Creighton CJ, Hawkins SM, Zighelboim I, Goodfellow P, Gunaratne PH, Odunsi K, Salem PA, Anderson ML, Cancer Lett, 1/1/2013
• Frequent mutations in the RPL22 gene and its clinical and functional implications  
  Novetsky AP, Zighelboim I, Thompson DM Jr, Powell MA, Mutch DG, Goodfellow PJ, Gynecol Oncol, 1/1/2013
• Lithium Chloride and Inhibition of Glycogen Synthase Kinase 3Beta as a Potential Therapy for Serous Ovarian Cancer  
  Novetsky AP, Thompson DM, Zighelboim I, Thaker PH, Powell MA, Mutch DG, Goodfellow PJ, Int J Gynecol Cancer, 1/1/2013
• Occult transitional cell carcinoma and Lynch syndrome incidentally revealed after laparoscopic hysterectomy and cystoscopy during staging for endometrial cancer  
  Verma V, Patel K, Peregrin I, Brandes S, Zighelboim I, Gynecologic Oncology Case Reports, 1/1/2013
• Prognostic Utility of Squamous Cell Carcinoma Antigen in Carcinoma of the Cervix: Association with Pre-and Posttreatment FDG-PET  
  Olsen JR, Dehdashti F, Siegel BA, Zighelboim I, Grigsby PW, Schwarz JK, Int J Radiat Oncol Biol Phys, 1/1/2011
• Inferior vena cava filter placement in the gynecologic oncology patient: a fifteen-year institutional experience  
  Dewdney S, Benn T, Rimel BJ, Gao F, Saad N, Vedantham S, Mutch DG, Zighelboim I, Gynecol Oncol, 1/1/2011
• Adjuvant treatment for early stage endometrial cancer  
  Zighelboim I, Powell MA, Clin Obstet Gynecol, 1/1/2011
• Perioperative maternal morbidity model for vaginal hysterectomy: Heisler et al  
  Zighelboim I, Zhang C, Kuroki L, Anand M, Dewdney S, Am J Obstet Gynecol, 1/1/2010
• The Role of PET/CT in the Management of Cervical Cancer Patients: Practice Patterns of Members of the Society of Gynecologic Oncologists  
  Kizer NT, Zighelboim I, Case AS, Dewdney SB, Thaker PH, Massad LS, Gynecol Oncol, 1/1/2009
• Cardiac Arrest during Argon Beam Coagulation of Metastatic Ovarian Cancer  
  Kizer N, Zighelboim I, Rader J, Int J Gynecol Cancer, 1/1/2009
• Response to Buda et al (Letter)  
  Zighelboim I, Goodfellow PJ, Gynecol Oncol, 1/1/2008
• Acute colonic pseudoobstruction complicating twin pregnancy  
  Tung CS, Zighelboim I, Gardner MO, J Reprod Med, 1/1/2008
• RE: Spurdle and Webb (Letter)  
  Zighelboim I, Goodfellow PJ, Gynecol Oncol, 1/1/2008
• Clustering of Lynch syndrome malignancies with no evidence of a role of DNA mismatch repair  
  Case AS, Zighelboim I, Mutch DG, Bab SA, Schmidt AP, Whelan AJ, Thibodeau SN, Goodfellow PJ, Gynecol Oncol, 1/1/2008
• The impact of microsatellite instability and epigenetic inactivation of MLH1 on the outcome of patients with endometrial carcinomas of the endometrioid type  
  Zighelboim I, Goodfellow PJ, Gao F, Gibb RK, Powell MA, Rader JS, Mutch DG, J Clin Oncol, 1/1/2007
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Books/Book Chapters

• Hematology and Oncology Subspecialty Consult 
  Chapter: Gynecologic Oncology. 
  Page 287 - 298Hagemann AR, Zighelboim IEditors: Cashen AF, Wildes TM.Wolters Kluwer/ Lippincott Williams & Wilkins, PhiladelphiaEdition 2nd,2008
• Gynecologic Oncology 
  Chapter: Uterine Corpus Cancer. 
  Zighelboim I, Powell MAEditors: Gehrig P and Alvarez Secord A.Landes Bioscience, USA2006

Abstracts/Posters

• Patient awareness of the association between obesity and perioperative risk among newly diagnosed endometrial cancer patients.
  Kuroki L, Benn T, Dukes J, Thaker PH, Hagemann AR, Powell M, Mutch D, Massad LS, Zighelboim I, 2015 Annual Meeting on Women's Cancer, Chicago, IL, 1/28/2015
• The effect of using a delayed-absorbable subdermal skin closure on postoperative wound complications undergoing abdominal gynecologic surgery.
  Gonzalez Rios AR, Tha T, Taylor N, Zighelboim I, Anasti JN, Obstet Gynecol, ACOG Annual Clinical and Scientific Meeting. The American College of Obstetricians and Gynecologists, San Francisco, CA, 1/2/2015
• Prospective protocol to decrease the incidence of wound complications in obese gynecologic patients.
  Novetsky AP, Zighelboim I, Guntupalli SR, Ioffe YJM, Kizer NT, Hagemann AR, Powell MA, Thaker PH, Mutch DG, Massad LS, 45th Annual Meeting on Women's Cancer, Tampa, FL, 1/22/2014
• Timing of Genetic Counseling in Patients with Ovarian, Fallopian Tube or Primary Peritoneal Carcinoma.
  Novetsky A, Smith K, Babb S, Jeffe D, Hagemann A, Thaker P, Powell M, Mutch D, Massad L, Zighelboim I, 44th Annual Meeting on Women's Cancer, Los Angeles, CA, 1/9/2013
• Post-radiation Damage to the Pelvic Girdle in Cervical Cancer Patients: Is Intensity Modulated Radiation Therapy Safer Than Conventional Radiation?
  Ioffe YJ, Hillen T, Zhou G, Schwarz J, Mutch D, Powell M, Rader J, Zighelboim I, Hagemann A, Thaker PH, Annual Meeting of the Western Association of Gynecologic Oncologists (WAGO), Huntington Beach, CA, 1/27/2012
• Improved surgical outcomes after neoadjuvant chemotherapy among women with advanced stage ovarian, fallopian tube, or primary peritoneal cancer with disease involving ...
  Benn T, Kizer N, Gao F, Zighelboim I, Thaker P, Powell M, Mutch D, 43rd Annual Meeting of the Society of Gynecologic Oncology, Austin, TX, 1/24/2012
• In Vitro chemoresponse analysis and clinical outcomes in cervical cancer.
  Grigsby P, Gan CM, Zighelboim I, Powell MA, Mutch DG, Schwarz JK, 14th Biennial Meeting of the International Gynecologic Cancer Society (IGCS), Vancouver, BC, Canada, 1/13/2012
• Phase II trial of bevacizumab and pemetrexed for recurrent or persistent epithelial ovarian, fallopian tube, or primary peritoneal cancer.
  Hagemann AR, Zighelboim I, Novetsky AP, Gao F, Massad LS, Thaker PH, Powell MA, Mutch DG, Wright JD, American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, IL, 1/1/2012
• Phase II trial of topotecan, cisplatin, and bevacizumab for recurrent or persistent cervical cancer.
  Zighelboim I, Wright JD, Gao F, Case AS, Massad LS, Mutch DG, Powell MA, Thaker PH, Eisenhauer EL, Cohn DE, Valea FA, Secord AA, Lippmann LT, Rader JS, American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, IL, 1/1/2012
• Enhanced Imaging of Endometrial Carcinoma Using Conditionally Replicative Adenoviruses.
  Zighelboim I, Dmitriev IP, Piwnica-Worms D, Curiel DT, NCI Translational Science Meeting, Washington, DC, 1/28/2011
• The Prognostic Significance of Lymphovascular Space Invasion in Laparoscopic Versus Abdominal Hysterectomies for Endometrioid Endometrial Cancer.
  Dewdney SB, Jiao Z, Roma A, Gao F, Rimel BJ, Thaker PH, Powell MA, Massad LS, Mutch DG, Zighelboim I, 42nd Annual Meeting of the Society of Gynecologic Oncologists, Orlando, FL, 1/6/2011
• Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: A conserved regulatory mechanism important in tumorigenesis?
  Ioffe Y, Chiappinelli K, Pollock P, Powell M, Zighelboim I, Thaker P, Mutch D, Goodfellow P, 42nd Annual Meeting of the Society of Gynecologic Oncologists, Orlando, FL, 1/6/2011
• Trends in pelvic exenteration in gynecologic oncology.
  Brooks R, Benn T, Zighelboim I, Dewdney S, Rimel B, Thaker P, Zhang J, Powell M, Massad L, Mutch D, 41st Annual Meeting of the Society of Gynecologic Oncologists, San Francisco, CA, 1/10/2010
• Clinical correlates of death from ovarian cancer. An analysis at 100 days.
  Rimel B, Dewdney S, Ramsey A, Zhang J, Zighelboim I, Brooks R, Thaker P, Mutch D, Massad L, 41st Annual Meeting of the Society of Gynecologic Oncologists, San Francisco, CA, 1/10/2010
• Utility of peritoneal biopsies in upstaging early ovarian cancer.
  Shroff R, Brooks R, Zighelboim I, Powell M, Thaker P, Mutch D, Massad L, 41st Annual Meeting of the Society of Gynecologic Oncologists, San Francisco, CA, 1/10/2010
• Lower uterine segment involvement in surgically staged early stage endometrial cancer: Does it matter?
  Kizer N, Gao F, Guntupalli S, Thaker P, Powell M, Goodfellow P, Mutch D, Zighelboim I, 41st Annual Meeting of the Society of Gynecologic Oncologists, San Francisco, CA, 1/10/2010
• Comorbid conditions are associated with worse outcomes in patients with endometrial cancer.
  Brooks R, Mutch D, Piccirillo J, Peipert J, Zhang J, Kallogjeri D, Thaker P, Zighelboim I, Powell M, Massad L, 41st Annual Meeting of the Society of Gynecologic Oncologists, San Francisco, CA, 1/10/2010
• Lymphvascular space invasion and uterine high-intermediate-risk criteria are associated with increased risk for lymph node metastases in patients with endometrioid end...
  Guntupalli S, Zighelboim I, Kizer N, Powell M, Thaker P, Goodfellow P, Mutch D, 41st Annual Meeting of the Society of Gynecologic Oncologists, San Francisco, CA, 1/10/2010
• The role of neoadjuvant chemotherapy in stage IIIC/IV ovarian, fallopian tube and primary peritoneal carcinoma: Patterns of care among members of the Society of Gyneco...
  Dewdney S, Rimel B, Kizer N, Brooks R, Massad L, Thaker P, Powell M, Mutch D, Zighelboim I, 41st Annual Meeting of the Society of Gynecologic Oncologists, San Francisco, CA, 1/10/2010
• The effects of body mass index on curative radiation therapy in cervical carcinoma: An analysis of complications and survival.
  Kizer N, Thaker P, Gao F, Massad L, Zighelboim I, Powell M, Rader J, Mutch D, Grigsby P, 41st Annual Meeting of the Society of Gynecologic Oncologists, San Francisco, CA, 1/10/2010
• Phase II trial of topotecan, cisplatin, and bevacizumab for recurrent or persistent cervical cancer-Trials in Progress Session.
  Zighelboim I, Wright JD, Powell MA, Case AS, Eisenhauer EL, Cohn DE, Valea FA, Secord AA, Lippmann LT, Rader JS, American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, IL, 1/4/2010
• Chemoradiation in locally advanced cervical carcinoma: An analysis of cisplatin administration and other clinical prognostic factors.
  Nugent E, Case AS, Zighelboim I, DeWitt L, Thaker PH, Massad LS, Powell MA, Mutch DG, Trinkhaus K, Rader JS, 45th ASCO Annual Meeting, Orlando, FL, 1/29/2009
• The effects of body mass index on curative radiation therapy in cervical carcinoma: An analysis of complications and survival.
  Thaker PH, Gao F, Zighelboim I, Powell MA, Rader JS, Mutch DG, Kizer N, 45th ASCO Annual Meeting, Orlando, FL, 1/29/2009
• The role of PET/CT in the management of patients with cervical cancer: Patterns of care among members of the Society of Gynecologic Oncologists.
  Kizer N, Zighelboim I, Case AS, Dewdney S, Thaker PH, Massad L, 40th Annual Meeting of the Society of Gynecologic Oncologists, San Antonio, TX, 1/4/2009
• Treatment of high-risk endometrial carcinoma following hysterectomy using concurrent chemoradiotherapy with intensity-modulated radiotherapy delivered with helical tom...
  Powell MA, Thaker PH, Mutch DG, Rader JS, Zighelboim I, Massad LS, Grigsby PW, 40th Annual Meeting of the Society of Gynecologic Oncologists, San Antonio, TX, 1/4/2009
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Lectures

• "Jewish Guidelines to Assist Patients and Their Families in Making End-of-Life Medical Decisions" 
  Allentown, PA - 1/17/2015
• "Cirugias reductoras de riesgo en cancer ginecologico" 
  Caracas, Venezuela - 1/7/2014
• "Cirugia abierta, laparoscopica y robotica en cancer de endometrio" 
  Caracas, Venezuela - 1/7/2014
• "Estado actual de la histerectomia radical laparoscopica y robotica en el cancer de cuello uterino" 
  Caracas, Venezuela - 1/7/2014
• "Transitioning from "Academics" to "Private Practice" 
  Los Angeles, CA - 1/9/2013
• "Displasia Cervical" 
  San Jose, Costa Rica - 1/8/2013
• "Anatomia Pelvica: Enfasis Quirurgico" 
  San Jose, Costa Rica - 1/8/2013
• The When and Why of Cancer Screenings-What Every Practitioner Should Know: Gynecologic Cancer Screening. 
  ArtsQuest Center at SteelStacks, Bethlehem, PA - 1/17/2012
• "Management of the patient with an adnexal mass" 
  St. Luke's University Hospital, Bethlehem, PA - 1/17/2012
• "Sesion de video y discusion: Cirugia laparoscopica en cancer de cuello uterino y endometrio" 
  Caracas, Venezuela - 1/3/2012
• "Sesion de video y discusion: Cirugia y/o quimioterapia en cancer de ovario avanzado. Hasta donde debemos llegar?" 
  Caracas, Venezuela - 1/3/2012
• "Lo mas relevante de ASCO 2012-Ginecologia" 
  Caracas, Venezuela - 1/3/2012
• Cancer Biology and the Evolving Treatment Paradigms for Epithelial Ovarian Cancer. 
  Siteman Cancer Center/ Washington University School of Medicine, St. Louis, MO - 1/3/2012
• "Susceptibilidad genetica en cancer ginecologico" 
  Caracas, Venezuela - 1/12/2010
• "Nuevos avances y conceptos quirurgicos en carcinoma epitelial de ovario, peritoneo y trompas de falopio" 
  Caracas, Venezuela - 1/12/2010
• "Novedades y controversias en carcinoma de endometrio" 
  Caracas, Venezuela - 1/12/2010
• "Endometrial Cancer: So Little We Know" 
  St. Louis, MO - 1/8/2009
• "Endometrial Cancer: Management Dilemmas" 
  St. Louis, MO - 1/7/2008
• Evidence based approach to uncommon gynecologic tumors: A review for the general gynecologist. 
  Washington University School of Medicine, St. Louis, MO - 1/3/2008
• Secondary surgical cytoreduction in ovarian cancer. 
  Washington University School of Medicine, St. Louis, MO - 1/18/2007
• Advances in the management of endometrial cancer: Molecular Targets. 
  Washington University School of Medicine, St. Louis, MO - 1/28/2006
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Other

• "Cancer" 
  Zighelboim I, Focus (PBS39 WLVT)-2015, Season 2, Episode 20
  http://video.wlvt.org/video/2365468011/
  1/10/2016
• "Ovarian Cancer Treatment" 
  Zighelboim I, The PeakTV-2015, Season 6, Episode 5
  http://thepeaktv.com/episodes.aspx?Season=6
  1/12/2015
• "Ashkenazi Jews and cancer, not necessarily oy vei !" 
  Zighelboim I, Hakol Lehigh Valley's
  http://jewishlehighvalley.org/hakol
  1/1/2014
• "HPV" 
  Zighelboim I, Avellini J, Talk With Your Doctor-2013 Season
  http://www.wfmz.com/news/talk-with-your-doctor-hpv/-/121458/22203406/-/hqyd3/-/index.html
  1/30/2013
• "Invasive Cervical Cancer for the Primary Care Provider" 
  Winner B, Zighelboim I, Prevention and Treatment of Gynecologic Malignancies (Editor: Einarsson JI), Department of Continued
  https://cmeonline.med.harvard.edu/course_descriptions.asp?Course_id=178&group_name=Obstetrics+and+Gynecology
  1/15/2013
• "HPV vaccines can prevent cervical cancers and save lives" 
  Zighelboim I, Town Square/ Your View of The Morning Call
  http://www.mcall.com/opinion/yourview/mc-hpv-virus-vaccine-cancer-zighelboim-yv-20130806,0,6139426.story
  1/8/2013
• "Postmenopausal bleeding" 
  Zighelboim I, Hakol Lehigh Valley's What's up doc? Paul Lemberg, Ed.)
  http://www.jewishlehighvalley.org/hakol.aspx
  1/1/2013
• "Gynecologic Oncology" 
  Taylor N, Zighelboim I, Talk With Your Doctor-2012 Season
  http://www.wfmz.com/lifestyle/twyd/Talk-With-Your-Doctor-Gynecologic-Oncology/-/133062/17094178/-/b32banz/-/index.html
  1/1/2012
• On the frontiers in the war against ovarian cancer. 
  Zighelboim I and Corrigan P, Special to the St. Louis Jewish Light
  http://www.stljewishlight.com/news/local/article_9524ca34-e476-11e0-a9d3-001cc4c03286.html
  1/21/2011
• "Ovarian Cancer" 
  Zighelboim I, Jan Paul, Sandy Zahner, St. Louis on the Air; Host: Don Marsh (KWMU-St. Louis Public Radio)
  http://www.stlpublicradio.org/programs/slota/archivedetail.php?date=%272011-08-29%27)
  1/1/2011
• Cancer ginecologico en el siglo XXI (gynecologic cancer in the 21st century) in Salud del Siglo XXI (health of the 21st century) 
  Zighelboim I, Graces P, Venezuelan TV station-TV Familia
  1/1/2010
• Ask the Expert 
  Zighelboim I, Washington University Physicians Health Column-LN Ladue News
  1/1/2010
• Gene mutation marks aggressive endometrial cancer. 
  Zighelboim I, News release (online)
  http://mednews.wustl.edu/news/page/normal/14216.html?emailID=24334
  1/1/2009
• Siteman, Barnes-Jewish Advancing Use of da Vinci Robot in Operating Room. 
  Zighelboim I, Video (online)
  http://news.barnesjewish.org/pr/bjh/electronicplay.aspx?fid=69988&id=E0C8328
  1/1/2009
• Doctors Say Genetic Evaluation Important for People with Family History of Cancer. 
  Zighelboim I, News release (online)
  http://news.barnesjewish.org/pr/bjh/genetic-evaluation-important-for-people-with-family-history-of-cancer.aspx
  1/1/2009
• Genetic Risk Factors for Ovarian and Endometrial Cancer. 
  Zighelboim I.
  http://www.siteman.wustl.edu/internal.aspx?id=1472
  1/1/2009
• Genetics and Gynecologic cancer. 
  Zighelboim I.
  http://news.barnesjewish.org/pr/bjh/podcast-post.aspx?id=1554
  1/1/2009
• La piel y sus anexos. 
  Sosa L, Negrin M, Gil C, Zighelboim R I, Department of Normal Histology and Embriology, School of Medicine Luis Razetti, Universidad Central
  Caracas, Venezuela - 1/1/1998
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