Ismene Petrakis MD

Psychiatry•West Haven, CT

Addiction

Professor, Psychiatry, Yale University School of Medicine

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950 Campbell Ave # 116aWest Haven, CT 06516
Phone+1 203-932-5711
Fax+1 203-937-4791

Education & Training

Yale-New Haven Medical CenterResidency, Psychiatry, 1988 - 1989
Norwalk Hospital/Yale UniversityInternship, Internal Medicine, 1987 - 1988
University of Pittsburgh School of MedicineClass of 1987

Certifications & Licensure

CT State Medical License 1989 - 2025
American Board of Psychiatry and Neurology Psychiatry
American Board of Psychiatry and Neurology Addiction Psychiatry

Clinical Trials

Facilitation of NMDA Receptor Function in Patients With Schizophrenia and Co-morbid Alcoholism Start of enrollment: 2003 Jun 01
Completed
Phase 2
Naltrexone & SSRI in Alcoholics With Depression/PTSD Start of enrollment: 2001 Oct 01
Completed
Phase 3
Treatment With Mecamylamine in Smoking and Non-smoking Alcohol Dependent Patients Start of enrollment: 2004 May 01
Completed
Phase 2
Treatment With Acamprosate in Patients With Schizophrenia and Comorbid Alcoholism Start of enrollment: 2006 Sep 01
Completed
Phase 3
The Use of Anticonvulsants for Treatment of Patients With Alcohol Dependence and Post Traumatic Stress Disorder Start of enrollment: 2012 Jun 01
Withdrawn
Phase 3
Ketamine/Placebo Family History Positive Study Start of enrollment: 2001 Mar 01
Completed
Not Applicable
GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence Start of enrollment: 2005 Nov 01
Completed
Not Applicable
Intravenous Alcohol Administration Using BrAc Method in Healthy Subjects With and Without a Family History of Alcoholism Start of enrollment: 2001 Mar 01
Completed
Not Applicable
Couples-based Behavioral Psychotherapy for Male Patients With Posttraumatic Stress Disorder and Alcohol Dependence Start of enrollment: 2008 Feb 01
Withdrawn
Phase 2, Phase 3
Modification of Cognitive Processing Therapy (CPT-C) for PTSD and Alcohol Dependence Start of enrollment: 2008 Mar 01
Completed
Phase 2, Phase 3
Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD). Start of enrollment: 2009 Jan 01
Completed
Phase 3
Ketamine for Depression and Alcohol Dependence Start of enrollment: 2012 Mar 01
Completed
Phase 1
Zonisamide in Addition to E-CPT-C for Veterans With PTSD and Comorbid Alcohol Dependence Start of enrollment: 2013 Jun 01
Completed
Phase 2
Minocycline's Effects on Alcohol Responses in Humans Start of enrollment: 2015 Jul 01
Completed
Phase 1
Varenicline + Prazosin for Heavy Drinking Smokers Start of enrollment: 2014 Jul 01
Completed
Early Phase 1
Fish Oil vs. Placebo on Subjective Effects of Alcohol Start of enrollment: 2017 Mar 02
Completed
Phase 1
Effect of Sublingual Formulation of Dexmedetomidine HCl (BXCL501) - Alcohol Interaction Study Start of enrollment: 2021 Nov 09
Completed
Phase 1
Effect of Allopregnanolone on Stress-induced Craving Start of enrollment: 2019 Jul 01
Completed
Phase 1
Roles: Contact
Kappa Opioid Receptor Antagonism for the Tx of AUD and Comorbid PTSD Start of enrollment: 2019 May 20
Terminated
Phase 2
Roles: Contact
Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study Start of enrollment: 2025 Mar 10
NOT_YET_RECRUITING
PHASE1
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Dexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo-controlled crossover laboratory study.
Ismene L Petrakis, Tracy Nolen, Nathan Vandergrift, Shawn Hirsch, John H Krystal
The American Journal on Addictions. 2025-01-01
Medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression.
Kelley M Swanberg, Hetty Prinsen, Christopher L Averill, Leonardo Campos, Abhinav V Kurada
NMR in Biomedicine. 2024-11-01
2 citations
The combination of donepezil and cognitive training for improving treatment outcomes for alcohol use disorder: Design of a randomized controlled trial.
Gihyun Yoon, Mehmet Sofuoglu, Ismene L Petrakis, Brian Pittman, Morris D Bell
Contemporary Clinical Trials. 2024-10-01

Journal Articles

The Hidden Epidemic of Opioid Overdoses During the Coronavirus Disease 2019 Pandemic
Thomas R Kosten, Ismene L Petrakis, JAMA Psychiatry

Press Mentions

Yale Psychiatry's Anti-Racism Task Force Seeks to Address Diversity, Equity, InclusionSeptember 9th, 2021
Saluting Excellence in Health Professions EducationJuly 27th, 2021
New VA Annex Dedicated to Treating Serious Mental Illness Opens in Orange, CTOctober 25th, 2020
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