IsaacJPowellMD

PubMed

• 1407 citations
  REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants
  Nilah M. Ioannidis, Joseph H. Rothstein, Vikas Pejaver, Sumit Middha, Shannon K. McDonnell
  American Journal of Human Genetics. 2016-10-06
• 40 citations
  Deconstructing, Addressing, and Eliminating Racial and Ethnic Inequities in Prostate Cancer Care.
  Yaw A Nyame, Matthew R Cooperberg, Marcus G Cumberbatch, Scott E Eggener, Ruth Etzioni
  European Urology. 2022-10-01
• 3 citations
  Post hoc Analysis for Detecting Individual Rare Variant Risk Associations Using Probit Regression Bayesian Variable Selection Methods in Case-Control Sequencing Studies.
  Nicholas B. Larson, Shannon K. McDonnell, Lisa A. Cannon Albright, Craig C. Teerlink, Janet L. Stanford
  Genetic Epidemiology. 2016-09-01

Journal Articles

• Neoadjuvant therapy prior to radical Prostatectomy for clinical T3/T4 carcinoma of the prostate (5-year follow-up, Phase II SWOG Study 9109).  
  Powell IJ, Tangen M, Miller G, Lowe B, Haas G, Carroll PR, J Urol
• Improved overall survival trends of men with newly diagnosed M1 prostate cancer: a SWOG phase III trial experience (S8494, S8894 and S9346).  
  Tangen CM, Hussain MH, Higano CS, Eisenberger MA, Small EJ, Wilding G, Donnelly BJ, Schelhammer PF, Crawford ED, Vogelzang NJ, Powell IJ, Thompson IM Jr, J Urol
• Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment.  
  Kong D, Heath E, Chen W, Cher M, Powell I, Heilbrun L,Sarkar F, et al, Am J Transl Res
• A health services research agenda on cellular molecular and genomic technologies in cancer care.  
  Wideroff L, Philips K, Randhawa G, Ambs A, Armstrong K, Bennett CL, Brown ML, Donaldson MS, Follen M, Goldie SJ, Hiatt RA, Khoury MJ, Graham L, McLeod H, Piper M, Powe..., J Natl Cancer Inst, Public Health Genomics
• Long-term follow-up of neoadjuvant therapy prior to radical prostatectomy for clinical T3/T4 prostate cancer.  
  Thompson I, Tangen C, Powell IJ, Bruce L, Hass G, Carroll PR, Canby-Hagino E, deVere White R, Crawford DE, J Urol
• A randomized trial comparing web-based decision aids on prostate cancer knowledge for African American men.  
  Ellison G, Weinrich S, Lou M, Xu H, Powell IJ, Baquet CR, J Natl Med Assoc 100
• A decision aid for teaching limitations of prostate cancer screening.  
  Weinrich SP, Seger RE, Rao GS, Chan EC, Hamm RM, Godley PA, Moul JW, Powell I, Chodak GW, Taylor KL, Weinrich MC, J Natl Black Nurses Assoc
• Epidemiology and pathophysiology of prostate cancer in African American Men.  
  Powell IJ, J Urol
• Validation of a food frequency questionnaire measurement of selected nutrients using biological markers in African-American men.  
  Holmes MD, Powell IJ, Campos J, Stampfer MJ, Giovannucci EL, Willett WC, Euro J Clin Nutri
• African-American race is a predictor of prostate cancer detection: Incorporation into a pre-biopsy nomogram.  
  Yanke BV, Carver BS, Bianco FJ Jr, Simoneaux WJ, Venable DD, Powell IJ, Eastham JA, Brit J Intl
• A common nonsense mutation in ephb2 is associated with prostate cancer risk in African American men with a positive family history.  
  Kittles RA, Baffoe-Bonnie AB, Collins FS, Dunston G, Powell IJ, Carpten JD, J Med Gen
• The effect of race/ethnicity on prostate cancer treatment outcome is conditional: A review of Wayne State University data.  
  Powell IJ, Banerjee M, Bianco FJ, Wood DP Jr., Dey J, Lai Z, Heath M, Pontes EJ, J Urol
• CYP3A4 genetic variant and disease free survival among Caucasian and African American men after radical prostatectomy.  
  Powell IJ, Zhou JY, Sun Y, Sakr WA, Patel NP, Heilbrun LK, Everson RB, J Urol
• Radical Prostatectomy Nomograms in Black American Men: Accuracy and applicability.  
  Bianco FJ, Kattan MW, Scardino PT, Powell IJ, J. Edson Pontes, David P. Wood, Jr, J Urol
• Prostate cancer stage shift has eliminated the gap in disease-free survival in black and white American men after radical prostatectomy.  
  Bianco FJ, Wood DP Jr, Grignon DJ, Sakr WA, Pontes JE, Powell IJ, J Urol
• Stability of self-reported family history of prostate cancer among African American Men.  
  Weinrich SP, Faison-Smith L, Hudson-Priest J, Royal C, Powell, I, J Nursing
• Aarons GH: Familial occurrence of the kartagener triad in Jamaica.  
  Powell IJ, Postgrad Med J
• Prostatectomy between African Americans and Caucasian men.  
  Powell IJ, J Urol
• African American hereditary prostate cancer study: a model for genetic research.  
  Powell IJ, Carpten J, Dunston G, Kittles R, Bennett J, Hoke G, Pettaway C, Weinrich S, Vijayakumar S, Ahaghotu CA, Boykin W, Mason T, Royal C, Baffoe-Bonnie A, Bailey-..., J Natl Med Soc
• Biochemical recurrence in African American and Caucasian men with a positive and negative family history of prostate cancer following radical prostatectomy.  
  Narain V, Tiguert R, Banerjee J, Sakr W, Grignon D, Wood DP, Pontes JE, Powell IJ, J Urol
• Should the age specific PSA cut-point for prostate biopsy be higher among African American vs. Caucasian men above 50 years.  
  Powell IJ, Banerjee M, Novallo M, Sakr W, Grignon D, Wood DP, Pontes JE, J Urol
• Diferencas no comportamento epidemiologico do cancer de prostata em negros e brancos Americanos.  
  Barroso U, Oliveira J, Barroso V, Pontes J, Powell I, Journal Brasileiro de Urologia
• Results of a clinical care pathway for radical prostatectomy Patients in an open hospital-multi physician system.  
  Gheiler EL, Lovisolo JA, Tiguert R, Tefilli MV, Grayson T, Oldford G, Powell IJ, Famiglietti G, Banerjee M, Pontes EJ, Wood DP, Eur
• Prostate cancer among African American men- from the bench to the community.  
  Powell IJ, J Natl Med Assoc
• Outcome of African American Men screened for prostate cancer the DEED (Detroit Education and Early Detection) Study.  
  Powell IJ, Heilbrun L, Littrup P, et al, J Urol 158
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Books/Book Chapters

• Advanced Therapy of Prostate Disease. 
  Chapter: Epidemiology in African Americans 
  Page 6 - 13Powell IJBC Decker Inc, Hamilton, London
• Prostate Cancer: Principles and Practice. 
  Chapter: Race and Risk 
  Page 162 - 174Powell IJLippincott, Williams & Wilkens, Philadelphia PA
• Prostate Cancer, Science and Clinical Practice. 
  Chapter: Prostate Cancer Treatment Outcome between African Americans and Caucasians 
  Page 137 - 144Powell IJAcademic Press Ltd, San Diego, CA
• Management of Prostate Cancer. 
  Chapter: The Special Problems of Prostate Cancer Among African Americans: Clinical and Molecular Factors 
  Page 107 - 119Powell IJHumana Press Incorporated, Totowa, New Jersey
• Epidemiology, Pathophysiology and Genetics of Prostate Cancer in AAM Men Affiliation. 
  Powell IJSpringer-Verlag
• Epidemiology, Pathophysiology And Genetics Of Prostate Cancer Among African Americans Compared To Other Ethnicities. 
  Powell IJHumana Press Incorporated, Totowa, New Jersey
• African American Populations: Inherited Susceptibility For Prostate Cancer. 
  Powell IJSpringer Science and Business Media
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Abstracts/Posters

• Prostate cancer stage shift has eliminated the gap in survival between African American and Caucasian men after radical prostatectomy.
  Bianco FJ, Wood DP, Pontes JE, Sakr W, Grignon DJ, Powell IJ, Detroit, MI, J Urol
• Racial variations in the utilization of pelvic lymph node dissection in men receiving a radical prostatectomy for localized/ regional prostate cancer.
  Underwood W III, Powell IJ, Davis DE, Gonzalez H, DeMonner S, Sanda MJ, Wei JT, J Urol
• Geographic and demographic Variations in the use of pelvic lymph node dissection in men diagnosed with clinically localized prostate cancer.
  Davis DE, Underwood W, Gonzalez H, Powell IJ, Wood DP Jr, J Urol
• Variant of CYP3A4 associated with recurrence of androgen independence in prostate cancer.
  Fisher MB, Bianco FJ, Sakr WA, Everson R, Powell IJ, J Urol
• Clinical characteristics of the African American hereditary prostate cancer study cohort.
  Ahaghotu C, Baffoe-Bonney A, Kittles R, Pettaway C, Powell I, Royal C, Vijayakumar S, Bennett J, Hoke G, Mason T, Bailey-Wilson J, Boykin W, Berg K, Carpten J, Weinric..., J Urol
• CYP3A4 genetic variant and survival analysis among a diverse population of men undergoing radical prostatectomy.
  Powell IJ, Land SJ, Dey J, Sakr WA, Hughes M, Everson R, Zhou JY, Sun Y, J Urol
• Specimen Gleason score is the only prognostic factor in pathologically organ confined prostate cancer.
  Bianco FJ, Cher MC, Powell IJ, Grignon DJ, Sakr WA, Wood DP, Pontes JE, J Urol
• Validation of Kattan preoperative and postoperative nomograms in African-American men with prostate cancer.
  Bianco FJ, Kattan M, Scardino PT, Powell, IJ, Pontes E, Wood DP, J Urol
• Race/ethnicity as an independent predictor of prostate cancer outcome is conditional.
  Powell, IJ, Bianco FJ, Dey J, Wood DP, J Urol
• Impact of the SRD5A2 A49T genetic polymorphism on progression after prostatectomy among Caucasian and African American men.
  Powell IJ, Sakr WA, Butler C, Zhou JY, Sun Y, Wang C, Patel NP, Heilbrun L, Everson R, J Urol
• Presence of extraprostatic disease after radical prostatectomy diminishes survival significantly in African American men.
  Bianco FJ, Wood DP, Grignon DJ, Sakr W, Pontes JE, Powell IJ, J Urol
• Neoadjuvant Zoladex and Flutamide in bulky and non-bulky clinical stage C carcinoma of the prostate.
  Powell IJ, Tangen CM, Haas GP, Crawford D, Miller GJ, Lowe, BA, Thompson IM, J Urol
• Modeling prostate cancer distribution for exceedingly small tumor volumes in radical prostatectomy specimens: Implications for biopsy approach.
  Andea A, Dey J, deGuia K, Grignon DJ, Pontes JE, Wood DP, Powell IJ, Sakr W, J Urol
• The Impact of Socioeconomic Factors on PCA Outcome for Whites and African Americans.
  Powell IJ, Nelson J, Severson R, J Urol
• An explanation for differences in survival between African Americans and Caucasians treated by radical prostatectomy and radiotherapy.
  Powell IJ, Forman J, Chuba P, Cher M, Wood D, Dey J, Pontes JE, J Urol
• Presence of circulating prostate cancer cells in African American males adversely affects disease free survival.
  Bianco FJ, Cher ML, Beaman A, Nemeth JA, Powell IJ, Wood DP, J Urol
• Volume of “Index” tumor, number of tumor foci and distribution of high grade pin in radical prostatectomy specimens (RPS) between 1991-1999.
  Sakr W, deGuia GK, Grignon D, Powell IJ, Wood DP. Detroit, MI, J Urol
• Predictors of biological aggressiveness of early prostate cancer.
  George V, Bianco, FJ, Domalles EJ, Cher ML, Wood DP, Sakr W, Pontes JE, Powell IJ, J Urol
• T1C disease in black men: A more aggressive disease results from the search database.
  Klink JC, Banez LL, Powell IJ, Aronson WJ, Terris MK, Kane CJ, Amling CL, Freeland SJ, J Urol
• Defined Standards of Care, Its Impact on Malpractice.
  Powell IJ, The Michigan Urological Society Meeting, Harper Hospital, Kresge Auditorium
• Urethral Diverticula of the female.
  Powell IJ and Hollowell ML, North Central Section of American Urological Association
• Earlier age for prostate cancer screening of African American men is needed to eliminate racial mortality disparity.
  Powell IJ, Vigneau FD, Ruterbusch J, Heilbrun LK, Bock C, J Urol
• Is There a different gene expression profile for African American men versus European American men?
  Powell IJ, Schwartz A, Land S, Bock C, Ruterbusch J, Beebe-dimmer J, Lenk S, Everson R, Giroux C, J Urol
• CYP3A gene cluster, population stratification, and prostate cancer risk.
  Bonilla C, Bock C, Ahaghotu C, Ruterbusch J, Kittles R, Powell IJ, J Urol
• Evidence in support of earlier PSA testing in African American men age 35.
  Powell IJ, Ruterbusch J, Schwartz A, Bock C, J Urol
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Lectures

• Advanced stage prostate cancer 2, Primary therapeutic protocols. 
  Prostate Cancer Symposium, New York, 1
• Lecture Molecular and Clinical Epidemiology of Prostate Cancer. 
  American Cancer Society Health Disparity Conference
• Eliminating Cancer Disparities among African American. 
  Black Health Care Coalition, Inc
• Ethnic Differences in The Biology of Prostate Cancer. 
  Michigan State Legislators
• Prostate Cancer among African American and European Americans. 
  Karmanos Cancer Institute, Detroit, MI
• African American Heredity Prostate Cancer, Disparities and Similarities. 
  American Urological Association, Annual Meeting
• What Do You Know About Prostate Cancer. 
  American Urological Association Foundation, Prostate Cancer DV
• Clinical evidence supports a faster growth rate for prostate cancer among African Americans compared to European American men. 
  American Urologic Association annual meeting
• Evidence in support of earlier PSA testing in African American men age 35. 
  American Urologic Association annual meeting
• State of prostate health in America. 
  Morehouse Prostate Cancer Conference
• Prostate cancer metabolic syndrome and the African American male. 
  National Medical Association. Las Vegas
• The Role of Genetics in Prostate Cancer Ethnic Disparity2. 
  National Medical Association Annual Meeting
• Screening/early detection of prostate cancer. 
  First National Conference on Cancer Control, Kuwait
• Treatment of locally advanced prostate cancer. 
  First National Conference on Cancer Control, Kuwait
• Prostate cancer prevention trial (PCPT). 
  First National Conference on Cancer Control, Kuwait
• Is there a different gene expression profile for African American men versus European American men? 
  American Urologic Association annual meeting, San Francisco, Calif
• Genetic causation for prostate cancer mortality disparity among young African American men. 
  Congressional Prostate Cancer Awareness Symposium, Wash. DC
• Prostate cancer growth kinetics in African American men. 
  International Consortium Prostate Cancer Genetics presentation, Paris France
• Prostate cancer outcomes. 
  The Science of Global Prostate Cancer Disparities in Black Men, Jacksonville, Fla
• Geographical and Outcome Variation: Racial differences in prostate cancer outcomes. 
  The Science of Global Prostate Cancer Disparities in Black Men, Jacksonville, Fla
• Clinical and genetic evidence support a faster growth rate for prostate cancer among African American compared to European American men. 
  Department of Defense ImPact meeting. Orlando Fla
• PAUSA society presentation, Washington DC Metabolic syndrome and prostate cancer. 
  American Urologic Association annual meeting
• Clinical and Molecular Epidemiology Prostate Cancer. 
  University of Michigan G.U. Oncology Conference
• International Conference on Prostate Cancer Early Detection and Control. 
  Atlanta
• An Overview of Prostate Cancer in African Americans. 
  Seminar on Biological/Translational Research in Prostate Cancer among African American Men
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Other

• Fibrosarcoma of kidney. 
  Kansara V, Powell IJ
• Villous adenoma and villous adenocarcinoma of the female urethra. 
  Powell IJ, Cartwright H, Jano F
• Importance of marker chromosomes in superficial transitional cell carcinoma of bladder: 50 patients followed up to 17 years, by W.H. Falor and R.M. Ward Skinner. 
  Kleer E, Powell IJ, Tyrkus M
• Apparent correlation of sex chromosome loss and disease course in urothelial cancer. 
  Powell IJ, Tyrkus M Kleer E
• Cytogenetics of primary prostatic adenocarcinoma - clonality and chromosome instability. 
  Micale MA, Mohammed A. Sakr W, Powell IJ, and Wolman SR
• Defining the extent and nature of cytogenetic events in prostatic adenocarcinoma: Paraffin FISH vs. metaphase analysis. 
  Micale MA, Sanford JS, Powell IJ, Sakr WA, Wolman SR
• Value of preoperative PSA in predicting pathological stage of patients undergoing salvage prostatectomy. 
  Younes E, Haas GP, Montie JE, Smith JB, Powell IJ, and Pontes JE
• Flow Cytometric DNA analysis of fresh prostatic resections: Correlation with conventional prognostic parameters in patients with prostate cancer. 
  Hussain MH, Powell IJ, Zaki N, Maciorowski Z, Sakr W, Kukuruga M, Visscher D, Haas GP, Pontes JE, Ensley JF
• FISH analysis of urine, bladder washings and tumors - A new approach in the diagnosis and Isaac follow-up of bladder cancer. 
  Meloni A, Peier A, Haddad F, Powell I, Block A, Huben R, Todd I, Potter W, and Sandberg A
• Early detection issues of prostate cancer in African American men. 
  Powell IJ
• Fluorescence in situ hybridization (FISH) analysis of 8p allelic loss and chromosome 8 instability in human prostate cancer. 
  Macoska JA, Trybus TM, Sakr WA, Wolf MC, Benson PD, Powell, IJ, Pontes JE
• A successful recruitment process of African American men for early detection of prostate cancer. 
  Powell IJ, Gelfand DE, Parzuchowski J, Heilbrun L, Franklin A
• Digital rectal examinations and prostate cancer screening: attitudes of African-American men. 
  Gelfand DE, Parzuchowski J, Cort M, Powell IJ
• Equity in financial access to health care: Does it impact prostate cancer stage at presentation and survival? 
  Powell IJ, Schwartz K, Hussain MH
• Elevated 12-Lipoxygenase mRNA Expression correlates with advanced stage and poor differentiation of human prostate cancer. 
  Gao X, Grignon DJ, Chbihi T, Zacharek A, Chen YQ, Sakr W, Porter AT, Crissman JD, Pontes JE, Powell IJ, Honn KV
• Localization of potential tumor suppressor loci to a < 2 Mb region on chromosome 17q in human prostate cancer. 
  Gao X, Zacharek A, Grignon DJ, Sakr W, Powell IJ, Porter AT, Honn KV
• Epidemiology of high grade prostatic intraepithelial neoplasia. 
  Sakr WA, Grignon DJ, Haas GP, Schomer KL, Heilbrun LK, Cassin BJ, Powell IJ, Montie JB, Pontes JE, Crissman JD
• Evidence of three tumor suppressor gene loci on chromosome 8p in human prostate cancer. 
  Macoska JA, Trybus TM, Benson PD, Sakr WA, Grignon DJ, Wojno KD, Pietruk T, Powell IJ
• Epidemiology of High grade prostatic intra epithelial neoplasia. 
  Sakr WA, Grignon DJ, Haas GP, Schomer KL, Heilbrun LK, Cassin BJ, Powell IJ, Montie JE, Pontes JE, Crissman JD
• Clinically localized prostatic carcinoma (PCa) in white and Afro-American (AA) males: A detailed morphologic and flow cytometric study. 
  Sakr WA, Grignon DJ, Powell IJ, Ritchie CA, Schomer KL, Ottosen SF, Heilbrun LK, Montie JE, Pontes JE and Crissman JD
• Prostate cancer old problems and new approaches. 
  Honn KV, Aref A, Chen TQ, Cher ML, Crissman JD, Forman JD, Gao X, Grignon D, Hussain M, Porter AT, Pontes JE, Powell IJ, Redman B, Sakr W, Severson R, Tang DG, Wood DP
• Earlier detection of prostate cancer in African American men treated with radiotherapy: Results of a targeted screening program. 
  Forman JD, Jonathan R, Parzuchowski J, Littrup P, Porter AT, Powell, IJ
• A comparison of the w-stapled ileal reservoir with hand-sewn reservoirs for orthotopic bladder replacement. 
  Montie JE, Pontes JE, Powell IJ
• The predictive value of race as a clinical prognostic factor among patients with clinically localized prostate cancer: A multivariate analysis of positive surgical mar... 
  Powell IJ, Heilbrun L, Sakr W, Grignon D, Montie JE, Novallo M, Smith D, Pontes JE
• Prostate Cancer and African American Men. 
  Powell IJ
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