IsaacGeorgeMDFACC, FACS

PubMed

• 47 citations
  Increased de novo ceramide synthesis and accumulation in failing myocardium.
  Ruiping Ji, Hirokazu Akashi, Konstantinos Drosatos, Xianghai Liao, Hongfeng Jiang
  JCI Insight. 2017-05-04
• 20 citations
  Polymeric prosthetic heart valves: A review of current technologies and future directions.
  Sameer K Singh, Mateusz Kachel, Estibaliz Castillero, Yingfei Xue, David Kalfa
  Frontiers in Cardiovascular Medicine. 2023-01-01
• 53 citations
  Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients: 5-Year Outcomes of the SURTAVI Randomized Clinical Trial.
  Nicolas M Van Mieghem, G Michael Deeb, Lars Søndergaard, Eberhard Grube, Stephan Windecker
  JAMA Cardiology. 2022-10-01

Journal Articles

• Focus on Tricuspid, Mitral, and Aortic Valve Interventions Effect of SAPIEN 3 Transcatheter Valve Implantation on Health Status in Patients with Severe Aortic Stenosis...  
  Susheel Kodali, Craig R Smith, Suzanne J Baron, Augusto D Pichard, Elizabeth A Magnuson, Howard C Herrmann, Vinod H Thourani, Vasilis Babaliaros, Kevin Greason, David ..., ScienceDirect
• Is Isolated Aortic Valve Replacement Sufficient to Treat Concomitant Moderate Functional Mitral Regurgitation? A Propensity-Matched Analysis  
  Craig R Smith, Michael Argenziano, Isaac George, Michael A Borger, BioMed Central
• Attenuation of the Unfolded Protein Response and Endoplasmic Reticulum Stress after Mechanical Unloading in Dilated Cardiomyopathy  
  Castillero E, Akashi H, Pendrak K, Yerebakan H, Najjar M, Wang C, Naka Y, Mancini D, Sweeney HL, D'Armiento JM, Ali Z, Schulze PC, George I, AJP Heart, Circ Phys, 1/1/2015
• Improving the Accuracy of Effective Orifice Area Assessment After Transcatheter Aortic Valve Replacement: Validation of Left Ventricular Outflow Tract Diameter and Pul...  
  Khalique O, Hamid NB, Kodali SK, Nazif T, Marcoff L, Paradis JM, Williams MR, Vahl TP, George I, Leon MB, Hahn RT, Am Soc Echocardiography, 1/1/2015
• Feasibility and Safety of Single-Stage Hybrid Coronary Intervention and Valvular Cardiac Surgery  
  George I, Nazif T, Kalesan B, Kriegel J, Yerebakan H, Kirtane A, Kodali S, Williams M, Ann Thorac Surg, 1/1/2015
• Loss of SFRP-1 Leads to Deterioriation of Cardiac Function in Mice and Plays a Role in Human Cardiomyopathy  
  Sklepkiewicz P, Takayuki S, Rajbr K, Jie S, Kwon S, Mercer B, Bodine P, Schermuly RT, George I, Schulze PC, D'Armiento JM, Circ Heart Fail, 1/1/2015
• Reversibility of Chronic Kidney Disease and Outcomes Following Aortic Valve Replacement  
  Najjar M, Yerebakan H, Sorabella R, Guglielmetti L, Vandenberge J, Kurlansky P, Williams MR, Argenziano M, Smith CR, George I, Interact Cardiovasc Thorac Surg, 1/1/2015
• Cardiac Myostatin Upregulation Occurs Immediately After Myocardial Ischemia and is Involved in Skeletal Muscle Activation of Atrophy  
  Castillero E, Akashi H, Najjar M, Kennel P, Wang C, Sweeney HL, Schulze PC, George I, Biochem Biophys Res Comm, 1/1/2015
• Transcatheter Valve Implantation in Failed Surgically Inserted Bioprosthesis  
  Hamid N, Khalique O, Kodali SK, Monaghan MJ, Dvir D, Bapat V, Nazif T, Vahl T, George I, Leon MB, Hahn RT, JACC Cardiovasc Imag, 1/1/2015
• Age Alone Should Not Preclude Surgery: Contemporary Outcomes after Aortic Valve Replacement in Nonagenarians  
  George I, Yerebakan H, Kalesan B, Nazif T, Kodali S, Smith CR, Williams MR, J Thorac Cardiovasc Surg, 1/1/2014
• Rat Model of Veno-Arterial Extracorporeal Membrane Oxygenation  
  Ali A, Downey P, Singh G, Qi W, George I, Takayama H, Kirtane A, Krishnan P, Zalewski A, Freed D, Large SR, Ashley EA, Leon MB, Bacchetta M, Ali ZA, J Translat Med, 1/1/2014
• Deep RNA Sequencing Reveals Dynamic Regulation of Myocardial Noncoding RNA in Failing Human and Remodeling with Mechanical Circulatory Support  
  Yang KC, Yamada KA, Patel AY, Topkara V, George I, Cheema FH, Ewald GA, Mann DL, Nerbonne JM, Circulation, 1/1/2014
• Acute Kidney Injury After Aortic Valve Replacement: Incidence, risk factors, and outcomes  
  Najjar M, Salna M, George I, Expert Review of Cardiovascular Therapy, 1/1/2014
• Annular Sizing Using a Novel 3-Dimensional Echocardiography Method: Utility and Comparison to Cardiac Computer Tomography  
  Khalique O, Kodali S, Paradis JM, Nazif T, Williams MR, Einstein AJ, Pearson GD, Harjai K, Grubb K, George I, Leon MB, Hahn RT, Circulation: Cardiovasc Imag, 1/1/2014
• Transthoracic Access for Transcatheter Aortic Valve Replacement: Technique and Experience using the Edwards Sapien Retroflex Delivery System  
  Transthoracic Access for Transcatheter Aortic Valve Replacement: Technique and Experience using the Edwards Sapien Retroflex Delivery System., Annals Thorac Surg, 1/1/2014
• Quantity and Location of Aortic Valve Complex Calcification Predicts Severity and Location of Paravalvular Regurgitation and Frequency of Post-Dilatation After Balloon...  
  Khalique O, Hahn RT, Gada H, Nazif T, Vahl T, George I, Kalesan B, Williams MR, Leon MB, Kodali SK, JACC Cardiovasc Interv, 1/1/2014
• Neutrophil gelatinase-associated lipocalin and cystatin C for the prediction of clinical events in pateints with advanced heart failure, after ventricular assist devic...  
  Proschinske KB, Qiu S, Wu C, Kato TS, Khawaja T, Takayama H, Naka Y, Templeton D, George I, Farr MA, Mancini DM, Schulze PC, J Heart Lung Transplant, 1/1/2014
• Aortic stenosis and coronary artery disease: What do we know? What don't we know? A comprehensive review of the literature with proposed treatment algorithms  
  Paradis JM, Fried J, Nazif T, Kirtane A, Harjai K, Khalique O, Grubb K, George I, Hahn R, Williams M, Leon MB, Kodali S, Eur Heart J, 1/1/2014
• Myocardial Protection Using del Nido Cardioplegia Solution in Adult Reoperative Aortic Valve Surgery  
  Sorabella R, Akashi H, Yerebakan H, Najjar M, Mannan A, Williams MR, Smith CR, George I, J Cardiac Surgery, 1/1/2014
• Del Nido Cardioplegia Can be Safely Administered in High-Risk Coronary Artery Bypass Grafting Surgery After Acute Myocardial Infarction: A Propensity Matched Comparison  
  Yerebakan H, Sorabella R, Najjar M, Castillero E, Mongero L, Beck J, Hossain M, Takayama H, Williams MR, Naka Y, Argenziano M, Bacha E, Smith CR, George I, J Cardiothoracic Surg, 1/1/2014
• Impact of Major Bleeding on Long Term Mortality in Anemic versus Nonanemic Patients Undergoing Percutaneous Coronary Intervention using Bivalirudin  
  Ali ZA, Poludasu S, Qureshi YH, Krishnan P, Ali AA, Tatonetti N, Downey P, Zalewski A, Nazif T, George I, Mandava A, Baber U, Dangas G, Mehran R, Kini A, Sharma SK, Am J Cardiol, 1/1/2014
• Ventricular Assist Device Implantation Improves Skeletal Muscle Function, Oxidative Capacity and Growth Hormone/Insulin-like Growth Factor-1 Axis Signaling in Patients...  
  Khawaja T, Chokshi A, Ji R, Kato T, Xu K, Zizola C, Wu C, Forman DE, Ota T, Takayama H, Naka Y, George I, Mancini D, Schulze PC, Cachexia, Sarcopenia, and Muscle, 1/1/2014
• Aggressive Infective Endocarditis and the Importance of Early Repeat Echocardiography Imaging  
  Eudailey K, Lewey J, Hahn RT, George I, J Thorac Cardiovasc Surg, 1/1/2014
• Management of Significant Left Main Coronary Obstruction Before and After Trans-Apical Transcatheter Aortic Valve Replacement in a Patient with Complex Arterial Disease  
  Paradis JM, George I, Deneault B, Nazif T, Leon MB, Moses JW, Kodali S, Williams M, Catheter Cardiovasc Interv, 1/1/2013
• Management of Significant Left Main Coronary Obstruction Before and After Trans-Apical Transcatheter Aortic Valve Replacement in a Patient with Complex Arterial Disease  
  Paradis JM, George I, Deneault B, Nazif T, Leon MB, Moses JW, Kodali S, Williams M, Catheter Cardiovasc Interv, 1/1/2013
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Books/Book Chapters

• Heart Disease 
  Chapter: The Future of TAVR. 
  George I, Smith CREditors: Saunders, Elsevier Science.Edition 9th,2013
• Cardiac Surgical Techniques 
  Chapter: Transcatheter Valve-in-Valve Replacement as a Treatment for Failed Bioprosthetic Valves. 
  Grubbs, K, George I, Williams MREditors: Franco K, Roselli E, Slaughter M, Thourani V.Edition 1st,2013
• Mastery of Cardiothoracic Surgery 
  Chapter: George I, Reiss GR, Williams MR 
  George I, Reiss GR, Williams MREditors: Kaiser L, Kron I, Spray T.Wolters Kluwer Health IncEdition 3rd,2013
• Cardiac Surgery in the Adult 
  Chapter: Myocardial Revascularization after Acute Myocardial Infarction. 
  George I, Williams MREditors: Cohn LH, Edmunds LH Jr.The McGraw-Hill Companies, Inc.Edition 4th,2011
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Abstracts/Posters

• Transcatheter Versus Surgical Aortic Valve Replacement in Underweight Patients.
  Sorabella R, Kimchy A, Nazif T, Gomez A, Vahl TV, Hamid N, Khalique O, Argenziano M, Borger M, Hahn RT, Leon MB, Smith CR, Kodali SK, George I, Society of Thoracic Surgeons, Annual Meeting, 1/1/2015
• miR-195 Regulates Myocardial SIRT3 Expression and Mitochondrial Enyzme Acetylation.
  Zhang X, Ji R, Liao X, Brunjes D, Castillero E, Kennel P, George I, Hirano M, Schulze PC, Scientific Sessions of the American Heart Association, Annual Meeting, 1/1/2015
• Impaired SRT3-dependent Deacetylation of the Mitochondrial Proteome Induces Mitochondrial Metabolic Dysfunction in the Failing Myocardium.
  Zhang X, Ji R, Liao X, Brunjes D, Castillero E, Kennel P, George I, Hirano M, Schulze PC, Scientific Sessions of the American Heart Association, Annual Meeting, 1/1/2015
• Screening for tranthyretin cardiac amyloidosis using Tc-pyrophosphate scintigraphy in patients undergoing trancatheter aortic valve replacement.
  Narotsky D, Kodali SK, Maurer MS, Bokhari S, Hamid N, Pozniakoff T, Weinberg R, Nazif T, George I, Hahn RT, Castano A, Scientific Sessions of the American Heart Association, Annual Meeting, 1/1/2015
• Dysregulation of the neutral amino acid carrier SLCA5 decreases glutamine levels in the failing myocardium.
  Kennel PJ, Liao X, Ji R, Zhang X, Castillero E, Brunjes D, Takayama H, Naka Y, George I, Mancini D, Schulze PC, Scientific Sessions of the American Heart Association, Annual Meeting, 1/1/2015
• Myocardial Amino Acid Profiling in Patients with Advanced Heart Failure Before and After Mechanical Unloading Through Ventricular Assist Device Implantation.
  Kennel PJ, Liao X, Ji R, Zhang X, Castillero E, Brunjes D, Takayama H, Naka Y, George I, Mancini D, Thomas T, Lynch CC, Jain MK, Schulze PC, Scientific Sessions of the American Heart Association, Annual Meeting, 1/1/2015
• Flow Characteristics of CoreValve Transcatheter Aortic Valve: Implications for Calculation of Stroke Volume and Effective Orifice Area.
  Hamid N, Khalique OK, Williams M, George I, Nazif T, Vahl T, White J, Parikh P, Kodali SK, Leon MB, Hahn RT, Transcatheter Cardiovascular Therapeutics Annual Meeting, 1/1/2015
• Prosthesis-Patient Mismatch after Aortic Valve-in-Valve Implantation: Insights from the Valve-in-Valve International Data (VIVID) Registry).
  Bleiziffer S, Webb J, Kornowski R, Holzny D, Simonato M, George I, Sinning JM, Napodano M, Franco LN, Nissen H, Rudolph T, Brecker S, Horlick E, Shah A, Petrusson P, C..., Transcatheter Cardiovascular Therapeutics Annual Meeting, 1/1/2015
• Calcium Volume Score on Contrast-Enhanced Computer Tomography Prior to Transcatheter Aortic Valve Replacement: what's the most accurate threshold cutoff?
  Bettinger N, Hamid N, Pulerwitz TC, Kodali SK, Hahn RT, White J, Parikh P, Vahl TP, George I, Leon MB, Khalique OK, Transcatheter Cardiovascular Therapeutics Annual Meeting, 1/1/2015
• Anatomic and Procedural Predictors of Paravalvular Leak following Transcatheter Aortic Valve Replacement with a Self-Expanding Prothesis at a High Volume Center.
  Bettinger N, Hamid N, Hahn RT, Kodali SK, Vahl TP, White J, Nazif T, Parikh P, George I, Leon MB, Khalique OK, Transcatheter Cardiovascular Therapeutics Annual Meeting, 1/1/2015
• Transcatheter Mitral Valve-in-Valve Implant Complicated by LVOT Obstruction.
  Sorabella RA, White J, Nazif T, Khalique O, Hahn RT, Kodali SK, George I, Heart Valve Society Annual Meeting, Monaco, 1/1/2015
• Use of the Edwards Sapien 3 Valve for Surgical Mitral Valve Replacement in Infants.
  Chai P, George I, Nazif T, Kalfa D, Kodali SK, Torres A, Vincent JA, Leon MB, Bacha EB, Mitral Conclave Annual Meeting, New York, NY, 1/1/2015
• Flow Characteristics of the CoreValve Transcatheter Aortic Valve: Importance in Calculation of the Effective Orifice Area.
  Hamid N, Khalique O, Williams M, George I, Nazif T, Vahl T, White J, Parikh P, Kodali S, Leon MB, Hahn RT, American Society of Echocardiography Annual Meeting, 1/1/2015
• Use of the Edwards Sapien 3 Valve and the Medtronic Melody Valve for Surgical Mitral Valve Replacement in Infants and Children.
  Chai P, George I, Nazif T, Kalfa D, Kodali SK, Torres A, Vincent JA, Leon MB, Bacha EB, Heart Valve Society Annual Meeting, 1/1/2015
• Use of Circulatory Arrest Does Not Worsen Perioperative Survival.
  Sorabella RA, Krishnamoorthy, Najjar M, Castillero EC, Schulze PC, Mancini D, Naka Y, Takayama H, George I, International Society of Heart Lung Transplantation, 1/1/2015
• Cardiac Donor Characteristics Predictive of One Year Post-Heart Transplant Mortality: Analysis of the UNOS Transplant Database.
  Sorabella R, Najjar M, Castillero E Kantor A, Liu A, Topkara V, Colombo P, Farr MJ, Takayama H, Schultz PC, Mancini D, Naka Y, George I, International Society of Heart Lung Transplantation, 1/1/2015
• Effect of the 2006 U.S. Donor Heart Allocation Policy Change on Waitlist Complications and Mortality Among Candidates Supported with Mechanical Circulatory Support.
  Wever-Pinzon O, Naka Y, Colombo P, Farr, MJ, George I, Takayama H, Mancini D, Schulze PC, International Society of Heart Lung Transplantation, 1/1/2015
• Deep Sequencing Reveals Dynamics in Circulating miRNAs Following Heart Transplantation.
  Givens R, Akat KM, Brisco D, Brunkens DJ, Kennel PJ, Naka Y, Takayama H, George I, Mancini DM, Tuschl T, Schulze P, International Society of Heart Lung Transplantation, 1/1/2015
• Serum-derived exosomal proteome analysis of patients with Heart Failure and after Heart Transplantation.
  Kennel PJ, Givens R, Templeton D, Castillero E, Chen E, Takayama H, Naka Y, George I, Schulze PC, International Society of Heart Lung Transplantation, 1/1/2015
• Outcomes of Concomitant Transcatheter Aortic Valve Replacement and Percutaneous Coronary Intervention in High-Risk Patients with Severe Aortic Stenosis and Obstructive...
  Wilson E, Vahl T, Gada H, George I, Khalique O, Hahn R, Leon M, Williams M, Kodali S, American College of Cardiology, Annual Meeting, 1/1/2015
• The effect of oversizing on the hemodynamic performance of the Sapien 3 transcatheter heart valve.
  Hahn R, Fox B, Khalique O, Hamid N, Williams M, George I, Nazif T, Vahl T, Gada H, White J, Parikh P, Leon M, Kodali S, American College of Cardiology, Annual Meeting, 1/1/2015
• Hemodynamic effect of under-deployment and under-sizing the SAPIEN 3 valve.
  Hahn R, Fox B, Khalique O, Hamid N, Williams M, George I, Nazif T, Vahl T, Gada H, White J, Parikh P, Leon M, Kodali S, American College of Cardiology, Annual Meeting, 1/1/2015
• Myostatin Inhibition Improves Cardiac Glucose Metabolism in a Murine Model of Heart Failure.
  Castillero E, Akashi H, Ji R, Wang C, Ali Z, Sweeney HL, Schulze PC, George I, American College of Cardiology, Annual Meeting, 1/1/2015
• Myostatin Inhibition Improves Cardiac Glucose Metabolism in a Murine Model of Obesity.
  Castillero E, Akashi H, Ji R, Wang C, Ali Z, Sweeney HL, Schulze PC, George I, American College of Cardiology, Annual Meeting, 1/1/2015
• Early Surgery for Infective Endocarditis with Cerebral Emboli is Not Associated with Worsened Post-Operative Outcomes.
  Sorabella R, Han SM, Gribc M, Yerebakan H, Vasan S, Najjar M, Castillero E, Vanderberg J, Lambert D, Kurlansky P, Williams M, Naka Y, Argenziano M, Smith CR, Takayama ..., Society of Thoracic Surgeons, Annual Meeting, 1/1/2015
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Lectures

• Bicuspid Aortic Valve: TAVR Is Not Ready for Prime Time SAVR Is Better 
  2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019
• Transcatheter Valve Repair/Replacement: Expanding Indications 
  2019 ACC Scientific Session & Expo, New Orleans - 3/16/2019
• "Updates in Cardiac Surgery-2015." 
  New York, NY - 1/20/2015
• "Transcather Aortic Valve-in-Valve: Changing Initial Aortic Valve Surgery." 
  New York, NY - 1/19/2015
• "Anatomical and Procedural Factors Associated with Aortic Root Rupture During TAVR." 
  San Francisco, CA - 1/15/2015
• "Interventional and Surgical Management of Functional MR: Case Studies in Conflict and Consensus." 
  San Francisco, CA - 1/15/2015
• "New TAVR Technology: TAVR Systems." 
  San Francisco, CA - 1/15/2015
• "New TAVR Technology: Accessory Devices." 
  San Francisco, CA - 1/15/2015
• "Plenary Session: Live Cases-Aortic Valve and Structural Heart Disease." 
  San Francisco, CA - 1/15/2015
• "DIRECT FLOW-Technical Specifications and Clinical Trial Results (DISCOVER an SALUS Clinical Studies)." 
  San Francisco, CA - 1/14/2015
• "My Road from SAVR to TAVR." 
  Irvine, CA - 1/13/2015
• "TAVR: Updates and Strategies for Patient Management." 
  Stamford, CT - 1/13/2015
• "Technology Demonstration: Direct Flow Medical Valve System." 
  San Francisco, CA - 1/13/2015
• "Transcatheter Technologies." 
  Irvine, CA - 1/13/2015
• "Optimal Surgical Revascularization: CABG, OPCAB, or Hybrid?" 
  San Diego, CA - 1/7/2015
• "Case Presentation-AS and MR." 
  Chicago, IL - 1/5/2015
• "Mitral Valve: Gaps in the Guidelines-Heart Failure and Electrical Therapies." 
  Chicago, IL - 1/5/2015
• "TMVR Challenges and Results." 
  Chicago, IL - 1/5/2015
• "Aortic Bioskills and Live Case." 
  Chicago, IL - 1/5/2015
• "Hybrid Cardiac Surgery." 
  New York, NY - 1/3/2015
• "Functional Ischemic Mitral Regurgitation." 
  Chicago, IL - 1/1/2015
• "Hybrid Approaches to Valvular Disease." 
  Elmira, NY - 1/28/2014
• "Hybrid Approach to Coronary Disease." 
  New York, NY - 1/26/2014
• "Thoracic Aortic Aneurysms: Management and Thoracic Endografting." 
  New York, NY - 1/26/2014
• "CABG: Conduit Choice, Decision Making and Surgical Techniques." 
  New York, NY - 1/24/2014
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Other

• "Discussion of Dick Cheney Heart Transplant" 
  George I
  http://abclocal.go.com/wabc/video?id=8594336
• "Acute Mesenteric Ischemia." 
  George I
  http://www.clinicaltrialresults.org
  1/1/2007