IrwinKleinMD

PubMed

• 38 citations
  Cardiac atrophy in the heterotopically transplanted rat heart: in vitro protein synthesis.
  Irwin Klein, Chull Hong, Sydney S. Schreiber
  Journal of Molecular and Cellular Cardiology. 1990-04-01
• 104 citations
  Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly ...
  Kelly Martha, Sherrie Lynn Pietranico-Cole, J Douglas Larigan, Nancy-Ellen Haynes, Charles H. Reynolds
  Journal of Medicinal Chemistry. 2014-04-08
• 1281 citations
  Thyroid hormone and the cardiovascular system.
  Irwin Klein, Kaie Ojamaa
  The New England Journal of Medicine. 2001-02-15

Journal Articles

• Thyroid Hormones and Cardiovascular Disease  
  Salman Razvi, Avais Jabbar, Alessandro Pingitore, Sara Danzi, Bernadette Biondi, Irwin Klein, Robin Peeters, Azfar Zaman2, Giorgio Iervasi, J Am College of Cardiology, 1/1/2018
• Thyroid�Disease and the Heart  
  Klein I, Danzi S, Curr Probl Cardiol, 1/1/2016
• Position Statement of the Thyroid Dysfunction writing Group of the American Association of Clinical Endocrinologists  
  Hennessey JV, Klein I ,Woeber K Cobin R, Garber JG, Endocr Prac, 1/1/2016
• American Association of Clinical Endocrinologists and American College of Endocrinology Position Statement on Thyroid Dysfunction Case Finding  
  Hennessey JV, Garber JR, Woeber KA, Cobin R, Klein I, Written on behalf of the AACE Thyroid Scientific Committee, Endocr Prac, 1/1/2016
• Amiodarone Induced Thyroid Dysfunction  
  Danzi S, Klein I, Journal of Intensive Care Medicine, 1/1/2015
• Reductions in serum levels of LDL cholesterol, apolipoprotein B, triglycerides and lipoprotein(a) in hypercholesterolaemic patients treated with the liver selective th...  
  Angelin B, Kristensen JD, Eriksson M, Carlsson B, Klein I, Olsson AG, Ridgway EC, Ladenson PW, J Intern Med, 1/1/2015
• Aggressive Case finding: A Clinical Strategy for the Documentation of Thyroid Dysfunction  
  Hennessey JV, Klein I , Woeber K Cobin R, Garber JG, Annals of Internal Medicine, 1/1/2015
• Preoperative hypothyroidism is a risk factor for postoperative atrial fibrillation in cardiac surgical patients  
  Worku B, Tortelani A, Isom OW, Klein I, J Cardiac Surg, 1/1/2015
• Thyroid Disease and the Cardiovascular System  
  Danzi S, Klein I, Endocrine Clinics of North America, 1/1/2014
• Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydro-pyridazin-3-yloxy)-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carbonitrile (MGL-3196), a High...  
  Kelly M, Pietranico-Cole S, Larigan J, Haynes N, Reynolds C, Scott N, Vermeulen J, Dvorozniak M, Conde-Knape K, Huang K-S, So S, Thakkar K, Qian Y, Banner B, Mennona F..., Journal of Medicinal Chemistry, 1/1/2014
• Subclinical hypothyroidism�Just a high serum thyrotropin (TSH) concentration or something else?  
  Klein I, J Clin Endo Metab, 1/1/2013
• American�Thyroid�Association Taskforce on Hypothyroidism in Adults  
  Garber JR, Cobin RH, Gharib H, Hennessey JV,�Klein I, Mechanick JI, Pessah-Pollack R, Singer PA, Woeber KA, American Association of Clinical Endocrinologists, Endocr Prac, 1/1/2013
• Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association  
  Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, Pessah-Pollack, Singer PA, Woeber KA, Endocr Prac, 1/1/2012
• Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association  
  Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, Pessah-Pollack, Singer PA, Woeber KA, Thyroid, 1/1/2012
• Association of Serum Triiodothyronine with B-type Natriuretic Peptide and Severe Left Ventricular Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction  
  Selvaraj S, Klein I, Danzi S, Akhter N, Bonow R, Shah SJ, Am J Cardiol, 1/1/2012
• Thyroid Hormone and the Cardiovascular System  
  Danzi S, Klein I, Medical Clinics of North America, 1/1/2012
• Tiratricol-Induced Periodic Paralysis: A Review of Thyroid Based Nutraceuticals  
  Cohen-Lehman J, Charitou M, Klein I, Endocrine Practice, 1/1/2011
• Hyperthyroidism: Management Guidelines of The American Thyroid Association and American Association of Clinical Endocrinologists  
  Bahn RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, Laurberg P, McDougall IR, Montori VM, Rivkees SA, Ross D, Sosa JA, Stan MN, Thyroid, 1/1/2011
• Hyperthyroidism: Management Guidelines of The American Thyroid Association and American Association of Clinical Endocrinologists  
  Bahn RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, Laurberg P, McDougall IR, Montori VM, Rivkees SA, Ross D, Sosa JA, Stan MN, Endocr Prac, 1/1/2011
• Cardiac specific effects of thyroid hormone analogs  
  Danzi S, Klein I, Horm Metab Res, 1/1/2011
• Long-term effects of intensive glucose lowering on cardiovascular outcomes  
  ACCORD�Study Group, Gerstein HC, Miller ME, Genuth S, et al, New Engl J Med, 1/1/2011
• Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia  
  Ladenson PW, Kristensen JD, Ridgway EC, Olsson AG, Carlsson B, Klein I, Baxter JD and Angelin B, New Engl J Med, 1/1/2010
• Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the�ACCORD�randomised trial  
  Ismail-Beigi F, Craven T, Banerji MA, et al, Lancet, 1/1/2010
• Effects of amiodarone on thyroid function  
  Cohen-Lehman J, Dahl P, Danzi S, Klein I, Nature: Endocrinology, 1/1/2010
• Physiological Replacement of T3 Improves Left Ventricular Function in an Animal Model of Myocardial Infarction-Induced Congestive Heart Failure  
  Henderson K, Danzi S, Paul JT, Leya G, Klein I, Samarel A, Circulation: Heart Failure, 1/1/2009
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Books/Book Chapters

• Braunwald�s Heart Disease 
  Chapter: Endocrine disorders and cardiovascular disease 
  Page 2051 - 2065Klein IEdition 11th,2018
• Thyroid and Heart Failure, From Pathophysiology to Clinics 
  Chapter: Changes in thyroid hormone metabolism and gene expression in the failing heart: therapeutic implications 
  Page 97 - 107Danzi S, Klein IEditors: G. Iervasi, A. Pingitore.Springer-Verlag, Italy2009
• Advanced Therapy in hypertension and Vascular Disease 
  Chapter: Treatment of Hypertension and Thyroid Disease 
  Page 354 - 360Danzi S, Klein IEditors: Mohler ER, Townsend RR.BC Decker, Inc., Ontario, Canada2006
• T3 and T4: Are We Missing Half the Picture? 
  Chapter: T3 and T4: Are We Missing Half the Picture? 
  Page 5 - 8Klein IClinical Cornerstone2005
• Treatment Options for Human Thyroid Disease 
  Chapter: Low T3 Syndrome in a Patient with Acute Myocarditis 
  Page 28 - 29Brokhin M, Klein IClinical Cornerstone2005
• Treatment Options for Human Thyroid Disease 
  Chapter: Potential Uses of T3 in the Treatment of Human Disease 
  Page 9 - 15Danzi S, Klein IClinical Cornerstone2005
• Werner & Ingbar’s The Thyroid: A Fundamental and Clinical Text 
  Chapter: The cardiovascular system in hypothyroidism 
  Page 777 - 782Klein I and Ojamaa KEditors: L. Braverman and R. Utiger.Lippincott Williams & Wilkins, Philadelphia, PAEdition 8th,2000
• Werner & Ingbar’s The Thyroid: A Fundamental and Clinical Text 
  Chapter: The cardiovascular system in thyrotoxicosis 
  Page 596 - 604Klein I and Levey GSEditors: L. Braverman and R. Utiger.Lippincott Williams & Wilkins, Philadelphia, PAEdition 8th,2000
• Werner and Ingbar�s The Thyroid 
  Chapter: The cardiovascular system in hypothyroidism 
  Page 799 - 804Klein I and Ojamaa KEditors: L Braverman and R Utiger.Lippincott-Raven PublishersEdition 7th,1996
• Werner and Ingbar�s The Thyroid 
  Chapter: The cardiovascular system in thyrotoxicosis 
  Page 607 - 615Klein I and Levey GEditors: L Braverman and R Utiger.Lippincott-Raven PublishersEdition 7th,1996
• Cardiovascular Drug Therapy 
  Chapter: Thyroid hormone (T4 and T3) 
  Klemperer J, Ojamaa K and Klein IEditors: Miserli.1996
• Hypertension: Pathophysiology, Diagnosis and Management 
  Chapter: Thyroid hormone and blood pressure regulation 
  Page 2247 - 2262Klein I and Ojamaa KEditors: JH Laragh and BM Brenner.Raven Press, Ltd., New York, NYEdition 2nd,1995
• Stein�s Textbook of Medicine 
  Chapter: Disorders of the thyroid 
  Levey GS and Klein ILittle Brown & Co., Boston, MAEdition 2nd,1994
• Hypertension Primer 
  Chapter: Treatment of hypertensive patients with thyroid disease 
  Page 369 - 371Klein I and Ojamaa KEditors: Izzo and Black.1993
• Hypertension Primer 
  Chapter: Thyroid disease and hypertension 
  Page 108 - 110Klein I and Ojamaa KEditors: Izzo and Black.1993
• The Thyroid 
  Chapter: Metabolic, physiologic and clinical indices of thyroid function 
  Page 486 - 492Klein IEditors: Braverman and Utiger.Lippincott, Philadelphia, PAEdition 6th,1991
• Hypertension 
  Chapter: Thyroid hormone and blood pressure regulation 
  Page 1661 - 1674Klein IEditors: J Laragh, B Brenner.Raven Press1990
• Endocrine Mechanisms in Hypertension 
  Chapter: Thyroid hormone and high blood pressure 
  Page 61 - 80Klein IEditors: JH Laragh, BM Brenner, NM Kaplan.Raven Press, NY1989
• Pathophysiology of Heart Disease 
  Chapter: Role of thyroid hormone in the regulation of cardiac hypertrophy 
  Page 73 - 82Klein I and Hong CEditors: N. Dhalla.Nighoff Press1987
• International Cell Biology Symposia 
  Chapter: Biochemical basis of the morphologic phenotype of transformed cells 
  Pastan I, Willingham M, Yamada K, Davies P and Klein IEditors: B.R. Brinkley and K.R. Porter.Rockefeller Press1977
• Methods in Receptor Research 
  Chapter: The cardiac glucagon receptor 
  Klein I and Levey GSEditors: GS Levey.Elsevier Press1976
• Advances in Cyclic Nucleotide Research 
  Chapter: Glucagon and adenylate cyclase: binding studies and requirements for activation 
  Levey GS, Fletcher MD and Klein IEditors: Drummond, Grengard and Robinson.Raven Press, New York, NY1975
• Paris Collogue Inserium les Surcharges Cardiques 
  Chapter: Protein degradation in acute cardiac overload measured in the absence of reutilization of amino acids for protein synthesis 
  Schreiber SS, Klein I, Evans C, Rothschild MA and Oratz MEditors: P Hatt.1972
• Myocardiology 
  Chapter: Early changes in acute cardiac overload: studies on adenyl cyclase activity, cyclic 3�5�-AMP and myosin synthesis 
  Schreiber SS, Klein I, Oratz M, Evans C, Gueyikian I and Rothschild MAEditors: Bajusc and Rona.1972
• Myocardiology 
  Chapter: Protein degradation in acute cardiac loading: The problem of reutilization of amino acids 
  Page 589 - 601Schreiber SS, Oratz M, Klein I and Rothschild MAEditors: N Dhalla.Univ Park Press, NY
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Other

• Clinical, metabolic and organ specific indices of thyroid function 
  Klein I, Endocrinology and Metabolism Clinics of North America
  1/1/2001
• Cardiovascular effects of hypothyroidism 
  Klein I
  http://www.uptodate.com/contents/cardiovascular-effects-of-hypothyroidism
  UpToDate, Wolters Kluwer Health - 2012-08-30
• Cardiovascular effects of hyperthyroidism 
  Klein I
  http://www.uptodate.com/contents/cardiovascular-effects-of-hyperthyroidism
  UpToDate, Wolters Kluwer Health - 2012-07-25