Irene Litvan MD

Movement Disorder, Neurodegenerative, Dementia & Geriatrics

Professor, Neurosciences, University of California San Diego School of Medicine, Director, UCSD Parkinson Foundation Center of Excellence, Research Center of Excellence in Lewy Body Dementia and Cure PSP Center of Care

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4550 Executive Dr325La Jolla, CA 92037

Summary

Dr. Irene Litvan is a neurologist in San Diego, CA and is affiliated with multiple hospitals in the area, including UC San Diego Medical Center – Hillcrest and VA San Diego Healthcare System. She received her medical degree from Universidad de la República - Facultad de Medicina and has been in practice 38 years. She also speaks multiple languages, including Spanish. She specializes in movement disorder, neurodegenerative, and dementia & geriatrics and is experienced in general neurology, multiple system atrophy, movement disorders, and dementia. She has more than 400 publications and over 60,000 citings.

Education & Training

MedStar Health Georgetown UniversityResidency, Neurology, 1989 - 1992
Saint Elizabeths Hospital-DC Department of Behavioral HealthInternship, Transitional Year, 1988 - 1989
Universidad de la República - Facultad de MedicinaClass of 1979

Certifications & Licensure

CA State Medical License 2011 - 2025
MD State Medical License 1990 - 2018
KY State Medical License 2003 - 2014
IN State Medical License 2005 - 2005
DC State Medical License 1993 - 2002
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

Top 1% of most cited scientific studies worldwide Web of Science, 2018-2022
Foreign Member of the National Academy of Medicine National Academy of Medicine of Uruguay, 2019
Movement Disorder Research Award American Academy of Neurology, 2018
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
Recognition Women4Women, 2008
Mosaic Award 2008
Innovative Doctor Louisville Magazine, 2008
Business First, most influential health care business leaders in Greater Louisville Partners in Health Care, 2008-2009
“Time and Motion Award” Parkinson Support Center of Kentuckiana, 2007
Recognition Award Society for Progressive Supranuclear Palsy, 2000
Fellow American Academy of Neurology, 1999
Investigator & Troxel Fellowship Award Society for Progressive Supranuclear Palsy, 1998
Merit Award National Institutes of Health, 1996
Elected Member American Neurological Association, 1995
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Clinical Trials

Risk Factors for Progressive Supranuclear Palsy (PSP) Start of enrollment: 2006 Aug 01
Completed
A Pilot Clinical Trial of Pyruvate, Creatine, and Niacinamide in Progressive Supranuclear Palsy. Start of enrollment: 2004 Apr 01
Completed
Not Applicable
Study to Identify Clinical, Imaging and Biologic Markers of Parkinson Disease Progression Start of enrollment: 2010 Jun 01
Completed
Phase 2
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) Start of enrollment: 2014 Sep 01
Completed
A 6 Month, Open-Label, Pilot Futility Clinical Trial of Oral Salsalate for Progressive Supranuclear Palsy Start of enrollment: 2015 Apr 01
Completed
Phase 1
Multiple Ascending Dose Study of Intravenously Administered BMS-986168 (BIIB092) in Patients With Progressive Supranuclear Palsy Start of enrollment: 2015 Oct 02
Completed
Phase 1
Safety, Tolerability, and Pharmacokinetics of C2N-8E12 in Subjects With Progressive Supranuclear Palsy Start of enrollment: 2015 Jul 01
Completed
Phase 1
4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2 Start of enrollment: 2016 Jan 01
Active, not recruiting
Flortaucipir PET Imaging in Subjects With FTD Start of enrollment: 2017 Apr 11
Completed
Phase 1
Rostock International Parkinson's Disease Study (ROPAD) Start of enrollment: 2019 May 30
ACTIVE_NOT_RECRUITING
Study of BHV-3241 in Participants With Multiple System Atrophy Start of enrollment: 2019 Jul 29
Completed
Phase 3
PDGeneration: Mapping the Future of Parkinson's Disease Start of enrollment: 2019 Aug 15
Active, not recruiting
Not Applicable
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) Start of enrollment: 2020 Mar 01
RECRUITING
Real-Time Levodopa Level Monitoring in Parkinson Disease Start of enrollment: 2021 Dec 07
RECRUITING
NA
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Publications & Presentations

PubMed

Hyperorality in Frontotemporal Dementia: How Psychiatric and Neural Correlates Change During the Disease Course.
Christopher B Morrow, Chiadi Onyike, Alexander Pantelyat, Gwenn S Smith, Jeannie Leoutsakos
The Journal of Neuropsychiatry and Clinical Neurosciences. 2025-03-26
Automated Imaging Differentiation for Parkinsonism.
David E Vaillancourt, Angelos Barmpoutis, Samuel S Wu, Jesse C DeSimone, Marissa Schauder
JAMA Neurology. 2025-03-17
Neuropsychiatric symptoms cluster and fluctuate over time in behavioral variant frontotemporal dementia.
Christopher B Morrow, Vidyulata Kamath, Bradford C Dickerson, Mark Eldaief, Neguine Rezaii
Psychiatry and Clinical Neurosciences. 2025-03-13

Journal Articles

Tauopathy-Associated PERK Alleles Are Functional Hypomorphs That Increase Neuronal Vulnerability to ER Stress
Shauna H Yuan, Karen Chiang, Irene Litvan, Human Molecular Genetics
Corticobasal Degeneration with TDP-43 Pathology Presenting with Progressive Supranuclear Palsy Syndrome: A Distinct Clinicopathologic Subtype
J Eric Ahlskog, Keith A Josephs, Ryan J Uitti, Bradley F Boeve, Irene Litvan, Dennis W Dickson, Acta Neuropathologica
Diagnostic criteria for the neuropathological assessment of Parkinson disease
Dickson DW, Braak H, Duda, MD J E Duyckaerts C, Gasser T, Halliday GM, Hardy J, Leverenz JB, Del Tredici K, Wszolek ZW, Litvan I.*, Lancet Neurology, 12/1/2009
Initial clinical manifestations of Parkinson’s disease: features and pathophysiological mechanisms
Rodriguez-Oroz MC, Jahanshahi M, Krack P, Litvan I, Macias R, Bezard E, Obeso JA, Lancet Neurology, 12/1/2009
Critical Issues on the Etiopathogenesis of Parkinson Disease and Suggestions for Future Research (Part I)
Litvan I,* Halliday G, Hallett M, Goetz CG, Rocca W, Duyckaerts C, Ben-Shlomo Y, Dickson DW, Lang AE, Chesselet MF, Langston WJ, Di Monte DA , Gasser T, Hagg T, Hardy..., Journal of Neuropathology and Experimental Neurology, 1/1/2007
Critical Issues on the Etiopathogenesis of Parkinson Disease and Suggestions for Future Research (Part II)
*Litvan I, Chesselet MF, Gasser T, Di Monte DA, Parker D Jr., Hagg T, Hardy J, Jenner P, Myers RH, Price DL, Hallett M, Langston WJ, Lang AE, Halliday G, Rocca W, Duy..., Journal of Neuropathology and Experimental Neurology, 1/1/2007
Association of an extended haplotype in the tau gene with progressive supranuclear palsy
Baker M, Litvan I, Houlden H, Adamson J, Dickson D, Hardy J, Lynch T, Bigio E, Hutton M, Human Molecular Genetics, 1/1/1999
Academy of Neurology Therapeutic and Technology Assessment Committee Evaluation of Surgery for Parkinson’s disease
Hallett M, Litvan I and the members of the Task Force on Surgery for Parkinson’s disease, Neurology, 1/1/1999
Importance of deficits in executive functions
Grafman J, Litvan I, Lancet, 1/1/1999
Atypical parkinsonism in the French West Indies
Litvan I, Lancet, 1/1/1999
Parkinsonian Features: when is it Parkinson’s disease?
Litvan I., JAMA, 1/1/1998
Clinical Research Criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): Report of the NINDS SPSP International Workshop
Litvan I.* Agid Y, Calne D, Campbell G, Dubois B, Duvoisin RC, Goetz C, Golbe LI, Grafman J, Growdon JH, Hallett M, Jankovic J, Quinn N, Tolosa E, Zee DS, Neurology, 1/1/1996
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Books/Book Chapters

Handbook of Clinical Neurology. Dementias
Editors: Duyckaerts C, Litvan I.Elsevier2008
Atypical Parkinsonian Disorders; Clinical and Research Aspects
Litvan IHumana Press2005
Corticobasal degeneration and related disorders. Adv Neurol
Editors: Litvan I, Goetz GC, Lang AE.Lippincott Williams & Wilkins2000
Progressive Supranuclear Palsy: Clinical and Research Approaches
Editors: Litvan I. & Agid Y..Oxford University Press1992
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Lectures

Shaking out the Subtleties of Parkinson’s – A Program for Primary Care Physicians, Pharmacists & Healthcare Professionals
University of California, San Diego, La Jolla, California - 1/31/2013
Key Note Speaker at the Symposium in Movement Disorders
Modena, Italy - 1/1/2010
Key Note Speaker at the 4th Symposium in Parkinson’s disease and related movement disorders
Puebla, Mexico - 1/1/2010

Authored Content

AAN 2021 Study Preview: Effective Tau TherapiesApril 2021

Press Mentions

New Hope for Progressive Supranuclear Palsy with Innovative TrialSeptember 3rd, 2024
MJFF Supporting Trial of Retinal Tracer for Parkinson’s DiagnosisOctober 31st, 2022
CurePSP's Clinical Guide to Rare Neurodegenerative Conditions Is Published by Leading Neurology JournalJuly 1st, 2021
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Grant Support

The Progressive Supranuclear Palsy Clinical Trial Platform (PTP)UNIVERSITY OF CALIFORNIA, SAN FRANCISCO2024–2029
Real-Time L-Dopa Monitoring for Improved Management of ParkinsonNational Institutes of Neurological Disorders and Stroke2020–2023