IgnatiaBVan Den VeyverMD

Obstetrics & Gynecology • Houston, TX

Maternal & Fetal Medicine/High Risk, Reproductive Genetics/Prenatal Genetics

Professor, Obstetrics & Gynecology, and Molecular & Human Genetics, Baylor College of Medicine

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Office
1504 Taub Loop
Houston, TX 77030
Phone+1 713-526-4243

Fax+1 713-798-2701

Summary

I am a physician scientist with appointments in the Department of Obstetrics and Gynecology and the Department of Molecular and Human Genetics at Baylor College of Medicine (BCM) and have directed projects focused on developmental and reproductive epigenetics and the characterization of human genetic disorders for over 15 years, including the generation and analysis of mouse models, mutation identification for human genetic disorders, high-throughput array approaches and functional assays for characterization of human disease genes. my laboratory discovered that PORCN is the gene for Goltz syndrome. I am also pursuing active research on the clinical characterization and search for the genetic defect that causes a rare, but devastating neurodevelopmental disorder, Aicardi syndrome. I am regularly involved with the characterization of unknown prenatal phenotypes or the characterization of new prenatal manifestations of known genetic disorders.

Education & Training

Baylor College of MedicineFellowship, Medical Genetics and Genomics/Maternal-Fetal Medicine, 1993 - 1996
Baylor College of MedicineResidency, Obstetrics and Gynecology, 1991 - 1996
Baylor College of MedicineFellowship, Maternal-Fetal Medicine, 1991 - 1993
University of Antwerp Faculty of MedicineClass of 1986
State Universitary Center of AntwerpB.S., With honors, 1979 - 1982

Certifications & Licensure

TX State Medical License 1994 - 2025
American Board of Medical Genetics and Genomics Clinical Genetics and Genomics

Awards, Honors, & Recognition

President Elect International Society of Prenatal Diagnosis, 2014-2016
Research Mentor Award for the year Department of Obstetrics and Gynecology, BCM, 2013
Certificate of Appreciation in Resident Education Department of Obstetrics and Gynecology, BCM, 2004
Mentored clinical scientist career development award (K08) 1997
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Clinical Trials

Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles Start of enrollment: 2000 Nov 07
Active, not recruiting
Roles: Contact, Principal Investigator
Study of Selected X-Linked Disorders: Aicardi Syndrome Start of enrollment: 2002 Oct 01
Recruiting
Roles: Principal Investigator, Contact

Publications & Presentations

PubMed

3513 citations
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.
Ruthie E. Amir, Ignatia B. Van den Veyver, Mimi Wan, Charles Q. Tran, Uta Francke
Nature Genetics. 1999-10-01
151 citations
GENETIC EFFECTS OF METHYLATION DIETS
Ignatia B. Van den Veyver
Annual Review of Nutrition. 2002-01-01
53 citations
Detection of Intrauterine Viral Infection Using the Polymerase Chain Reaction
Ignatia B. Van den Veyver, Jiyuan Ni, Neil E. Bowles, Robert J. Carpenter, Carl P. Weiner
Molecular Genetics and Metabolism. 1998-02-01

Journal Articles

A genome-wide screen for copy number alterations in an adolescent pilot cohort with mullerian anomalies
70. Murry JB, Santos XM, Wang X, Wan YW, Van den Veyver IB, Dietrich JE, Fertility and sterility, 2/2/2015
Counseling challenges with variants of uncertain significance and incidental findings in prenatal genetic screening and diagnosis
Westerfield L, Darilek S, Van den Veyver IB, J. Clin. Med, 1/1/2014
Non-random X chromosome inactivation in Aicardi syndrome
Eble TN, Sutton VR, Sangi-Haghpeykar H, Wang X, Jin W, Lewis RA, Fang P, Van den Veyver IB, Human genetics, 1/1/2009
Mutations in exon 1 of MECP2are a rare cause of Rett Syndrome
Amir RE, Fang P, Yu Z, Glaze D, Percy A, Zoghbi H, Roa B, Van den Veyver IB, J Med Genet, 1/1/2005
A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by Notch in Xenopus embryos
Stancheva I, Collins AL, Van den Veyver IB, Zoghbi H, Meehan RR, Molec Cell, 1/1/2003
Cerebrovascular vasospasm in eclampsia: Transcranial Doppler ultrasound findings
Van den Veyver I, Belfort M, Rowe T, Moise K, J Mat Fetal Med, 1/1/1994
Ultrasound guided blood sampling of the rabbit fetus
Moise K, Hesketh D, Belfort M, Saade G, Van den Veyver I, Hudson K, Rodkey S, Laboratory Animal Science, 1/1/1992
Clinical aspects in the surgical treatment of varicocele in subfertile men II The role of the epididymal factor
Gerris J, Van Neuten J, Van Camp C, Gentens P, Van de Vijver I, Van Camp K., The role of the epididymal factor, Eur J ObstetGynecol Reprod Biol, 1/1/1988
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Books/Book Chapters

Obstetric Imaging (A Volume in the Expert Radiology Series)
Chapter: Deletion (DiGeorge, Shprintzen, Velocardiofacial) Syndrome
Page 693 - 697Zacharias NM and Van den Veyver IBEditors: Joshua Copel, MD.2012
Obstetric Imaging (A Volume in the Expert Radiology Series)
Chapter: 4p- Deletion Syndrome (Wolf-Hirschhorn Syndrome)
Page 698 - 701Zacharias NM and Van den Veyver IBEditors: Joshua Copel, MD.2012
Obstetric Imaging (A Volume in the Expert Radiology Series)
Chapter: 5p- Syndrome (Cri du Chat)
Page 702 - 706Zacharias NM and Van den Veyver IBEditors: Joshua Copel, MD.2012
Annual Reviews of Genomics and Human Genetics
Chapter: Noninvasive prenatal screening by next generation sequencing
Page 327 - 347Gregg AR, Van den Veyver IB, Gross SJ, Mandankumar R, Rink BD, Norton MEEditors: Aravinda Chakravarti and Eric Green.Annual Reviews Publishing, Palo Alto, CA2012
Textbook of Pediatric Dermatology
Chapter: Focal Dermal Hypoplasia
Sanchez-Valle A, Sutton VR and Van den Veyver IBBlackwell Publishing, Oxford, UK2011
The Placenta: from Development to Disease
Chapter: Imprinting in the Human Placenta
Page 87 - 95Wen S, Van den Veyver IBEditors: Helen Kay, D. Michael Nelson, Yuping Wang.Blackwell Publishing, Oxford, UK2011
The NORD Guide to Rare Disorders
Chapter: Rett syndrome
Van den Veyver IB, Glaze DGLippincott, Williams & Wilkins, Philadelphia, PA2003
Former Sciara JJ, Gynecology and Obstetrics. Vol. 5: Reproductive Endocrinology, Infertility, and Genetics. Section: Principles of Human Genetics
Chapter: Mendelian inheritance and its exceptions
Van den Veyver I, Peng HGlob. libr. women's med2001
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Abstracts/Posters

In obstetrics, is surprise ever a good thing?
Salmanian B, Antony K, Fox K, Ballas J, Hosseinzadeh P, Wagner R, Moaddab A, Van den Veyver IB, Dildy G, Lee W, Aagaard K, Ramin S, Belfort M, Shamshirsaz A, SMFM: The Pregnancy Meeting, San Diego, CA, 1/2/2015
Nervous System: The role of prenatal exposures in modulation of neurodevelopment using the SHANK3e4-9/+ mutant mouse model
Bravo J, Fang H, Engler D, Balasa A, Van den Veyver IB, Environmental Stressors in disease and implications for human health by the Endocrine Society, Boston, MA, 1/26/2014
Positive NIPT resulting from structurally abnormal chromosomes highlights importance of invasive confirmatory testing
Smith JL, Cvjetkovic N, Fosler L, Van den Veyver IB, Peacock S, Breman A, Patel A, ACMG Annual Clinical Genetics Meeting, Nashville, TN, 1/25/2014
Not a simple false positive: genetic counseling challenges in cases of discrepant NIPT and invasive testing results
Coles K, Cvjetkovic N, Lemoine J, Van den Veyver IB, ACMG Annual Clinical Genetics Meeting, Nashville, TN, 1/25/2014
CLOVES Syndrome: The First Prenatal Molecular Diagnosis
Murphy L, Emrick L, Shamshirsaz A, Ruano R, Cassady C, Liu L, Chang , Sutton RV, Li, Van den Veyver IB, ACMG Annual Clinical Genetics Meeting, Nashville, TN, 1/25/2014
Role of NLRP7 in imprinting and anomalous reproductive outcomes
Mahadevan S, Wan Y-W, Liu Z, Van den Veyver IB, Mammalian Reproduction, Gordon Research Conference, New London, NH, 1/10/2014
HIV and pregnancy, a review
Van den Veyver I, Lindeque G, Ob Gyn Forum, South Africa, 1/1/2014
Exploring the role of NLRP7 in reprogramming of CpG methylation in the oocyte and early embryo
Mahadevan S, Van den Veyver IB, American Society of Human Genetics Annual Meeting, Epigenetics, Boston, MA, 1/22/2013
Comparison of three single-cell whole genome amplification (WGA) methods for detection of genomic aberrations by array CGH: A step towards noninvasive prenatal diagnos...
Breman A, Bi W, Shaw CA, Van den Veyver I, Shaw CJ, Stubbs A, Withers M, Fruhman G, Patel A, Lupski J.R, Beaudet A, American Society of Human Genetics Annual Meeting, Prenatal and Reproductive Genetics, Boston, MA, 1/22/2013
Chronic maternal protein deprivation affects body composition and energy expenditure of adult male offspring
Balasa A, Fiorotto M, Van den Veyver IB, SGI 60th Annual Scientific Meeting “Plasticity: Molecules to Motherhood and Beyond”, Orlando, FL, 1/20/2013
Transcriptome analysis of the hypothalamus of 21-day and 1-year old male mice exposed to chronic maternal protein deprivation during early development
Balasa A, Dove C, Anders A, Allen G, Van den Veyver IB, SGI 60th Annual Scientific Meeting “Plasticity: Molecules to Motherhood and Beyond”, Orlando, FL, 1/20/2013
Chronic maternal protein deprivation causes anxiety-like traits in adult male offspring mice
Balasa A, Van den Veyver IB, SGI 60th Annual Scientific Meeting “Plasticity: Molecules to Motherhood and Beyond”, Orlando, FL, 1/20/2013
Exposure to chronic unpredictable mild stress (CUMS) during early development causes autistic like traits in genetically predisposed Shank3 mutant male mice
Balasa A, Stinnett G, Bravo J, Mahadevan S, Pautler R, Van den Veyver IB, SGI 60th Annual Scientific Meeting “Plasticity: Molecules to Motherhood and Beyond”, Orlando, FL, 1/20/2013
Prenatal Presentations of 4q Interstitial Deletions
Murphy L, Breman A, Brown C, Cheung S, Maliszewski K, Stankiewicz P, Tam Tam K, Van den Veyver IB, ACMG Annual Clinical Genetics Meeting, Phoenix, AZ, 1/19/2013
The PDPK1 gene variants do not seem to be associated with Premature Ovarian Failure
Liu Q, Van den Veyver I, Gibbons WE, and Kovanci E., Conjoint Meeting of the International Federation of Fertility Societies and the American Society for Reproductive Medicine, Boston, MA, 1/12/2013
Transcriptome analysis of the hypothalamus of 1-year-old male mice exposed during early development to chronic maternal protein deprivation
Balasa A, Dove CL, Van den Veyver IB, 59th Annual Society for Gynecologic Investigation, San Diego, CA, 1/21/2012
Evaluating NLRP7 mutations in hydatidiform moles
Mahadevan S, Wen S, Balasa A, Van den Veyver IB, 59th Annual Society for Gynecologic Investigation, San Diego, CA, 1/21/2012
Sequencing analysis of NLRP7 and NLRP2: Can their mutations cause infertility or are they specific only for gestational trophoblastic disease?
Aghajanova L, Mahadevan S, Altmae S, Stavreus-Evers A, Van den Veyver I, 59th Annual Society for Gynecologic Investigation, San Diego, CA, 1/21/2012
Rapid Prenatal Diagnosis of Cytogenic Abnormalities by Array CGH Analysis
Cheung SW, Shaw CA, Kang S-HL, Simovich MJ, Pursley AN, Darilek S, Ward PA, Chinault AC, Patel A, Lupski JR, Beaudet AL, Eng CM, Van den Veyver IB, Society for Maternal-Fetal Medicine 28st Annual meeting – The Pregnancy Meeting, Am J Ob Gyn, Dallas, TX, 1/7/2012
Metagenomic-based approach to a comprehensive characterization of the vaginal microbiome signature in pregnancy
Aagaard K, Versalovic J, Petrosino J, Mistretta T, Riehle K, Coarfa C, Raza S, Dowlin D, Rosenbaum S, Van den Veyver I, Milosavljevic A, Society for Maternal-Fetal Medicine 31st Annual meeting – The Pregnancy Meeting, Am J Obstet Gynecol, San Francisco, CA, 1/7/2012
Evaluation of fetal demise by array comparative genomic hybridization of formalin-fixed paraffin-embedded tissue: a pilot study
Evaluation of fetal demise by array comparative genomic hybridization of formalin-fixed paraffin-embedded tissue: a pilot study, Society for Maternal-Fetal Medicine 31st Annual meeting – The Pregnancy Meeting, San Francisco, CA, 1/7/2012
Prenatal array comparative genomic hybridization: When it is indicated and what sample is best? Our experiences in over 1000 Prenatal Cases
Cheung SW, Breman A, Pursley A, Hixson P, Bi W, Ward P, Shaw C, Lupski J, Van den Veyver I, Beaudet A, Patel A, Society for Maternal-Fetal Medicine 32nd Annual meeting – The Pregnancy Meeting, Am J Obstet Gynecol, Dallas, TX, 1/6/2012
Genome-wide profiling of human uniparental tissues to search for novel imprinted genes
Wen S, Wan W, Balasa A, Mahadevan S, Liu Z, Van den Veyver IB, American Society of Human Genetics Annual Meeting, San Francisco, CA, 1/6/2012
Analysis of Aicardi syndrome genome using array CGH and EXOME sequencing
Liu W, Bainbridge M, Balasa A, Wang X, Murdock D, Gibbs R, Van den Veyver IB, American Society of Human Genetics Annual Meeting, San Francisco, CA, 1/6/2012
Counseling for variants of uncertain clinical significance (VOUS) in prenatal chromosomal microarray analysis (pCMA)
Breman A. Pursley A, Ward P, Patel A, Bi W, Lupski J, Van den Veyver IB, Beaudet A, 16th International conference for prenatal diagnosis, Miami, FL, 1/3/2012
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Lectures

Implementation of Prenatal Diagnostic Exome Sequencing: Scenarios and Challenges
Salt Lake, UT - 1/24/2015
NIPT: Technology and biology
San Diego, CA - 1/23/2015
Roles of NLRP7, NLRP2 and KHDC3L in imprinting and reproductive outcome
Galveston, TX - 1/15/2015
Whole genome and whole exome sequencing
San Diego, CA - 1/3/2015
Current Advances in Prenatal Genetic Diagnosis and Counseling
The Houstonian Hotel, Houston, TX - 1/24/2014
Ethical issues in future PND fetal exome and genome sequencing
Brisbane, Australia - 1/20/2014
CNS abnormalities and genetic syndromes
Brisbane, Australia - 1/20/2014
Counseling issues in prenatal microarrays
Brisbane, Australia - 1/20/2014
Counseling challenges for prenatal chromosomal microarray analysis; what to do with CNV’s and VOUS’s
New Orleans, LA - 1/17/2014
Microarray technology: a foundation
San Francisco, CA, 2013; Phoenix, AZ, 2013 - 1/19/2013
Arrays, NIPT and Expanded Carrier Screening: Advances and Controversies in Prenatal Genetics
Phoenix, AZ - 1/19/2013
Prenatal Genetic Diagnosis – New Techniques and Who Should Be Tested?
Houston, TX - 1/18/2013
NIPT technologies
San Francisco, CA - 1/13/2013
Current State of Aicardi Syndrome Research: Challenges and Questions
Houston, TX - 1/11/2013
Use of arrays in IUFD and miscarriage
Lisbon, Portugal - 1/2/2013
From array to exome or whole genome sequencing in prenatal diagnosis?
Lisbon, Portugal - 1/2/2013
Preconception Counseling
Houston, TX - 1/28/2012
Prenatal Genetics
Houston, TX - 1/26/2012
Research on Aicardi syndrome, update
Multiple locations, 2006, 2008, 2010, 2012 - 1/20/2012
Prenatal exposures and autism risk in genetically predisposed individuals
Houston, TX - 1/13/2012
A mouse model for Goltz syndrome
Houston, TX - 1/9/2012
Update on prenatal genetic diagnostic technologies
Houston, TX - 1/5/2012
Prenatal genetic diagnosis and screening today and in the future
Houston, TX - 1/4/2012
Array in prenatal diagnosis
Miami, FL - 1/3/2012
Update on prenatal diagnostic use of microarrays
San Francisco, CA - 1/9/2011
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Other

Focal dermal hypoplasia
Sutton VR, Van den Veyver IB, GeneReviews™ [Internet]
Seattle, WA - 1/15/2008
Aicardi Syndrome
Sutton VR, Van den Veyver IB, GeneReviews™ [Internet]
http://www.ncbi.nlm.nih.gov/books/NBK1381/
Seattle, WA - 1/30/2006

Grant Support

Training Program In Translational Biology And Molecular MedicineNational Institute Of General Medical Sciences2010–2011
The Role Of NLRP7 And Related Genes In Hydatidiform Moles And Reproductive FailurEunice Kennedy Shriver National Institute Of Child Health &Human Development2008–2009
Genetic Studies In Gestational Trophoblastic DiseaseEunice Kennedy Shriver National Institute Of Child Health &Human Development2005–2009
New Strategies To Identify The Gene Mutated In Aicardi SyndromeEunice Kennedy Shriver National Institute Of Child Health &Human Development2007–2008
DO Diet And DNA Methylation Affect Fetal Programming?National Institute Of Environmental Health Sciences2003–2005
Pathophysiology Of Rett Syndrome /Mecp2 MutationsEunice Kennedy Shriver National Institute Of Child Health &Human Development2001–2003
Molecular Pathogenesis Of Rett SyndromeEunice Kennedy Shriver National Institute Of Child Health &Human Development2001–2002
MECP2 And DNA Methylation In Gene ExpressionEunice Kennedy Shriver National Institute Of Child Health &Human Development2001–2002
Baylor Mental Retardation Research CenterEunice Kennedy Shriver National Institute Of Child Health &Human Development1999–2001
Functional Analysis Of Candidate Genes For MLS SyndromeEunice Kennedy Shriver National Institute Of Child Health &Human Development1997–2001
Molecular Genetics Of Rett SyndromeEunice Kennedy Shriver National Institute Of Child Health &Human Development1997