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Office
The Kirklin Clinic of UAB Hospital
2000 6th Avenue South
Birmingham, AL 35233Phone+1 205-934-7170Fax+1 205-934-6507
Summary
- I am a fellowship-trained neuro-oncology surgeon, specialized in the surgical care of brain tumors. I lead the Neuro-Oncology Program in the Comprehensive Cancer Center at UAB as co-Leader. I also contribute to various clinical trials for brain tumors.
Education & Training
- Ohio State University HospitalFellowship, Neurosurgical Oncology, 2009 - 2012
- Ronald Reagan UCLA Medical CenterPost-Doctoral Fellowship, 2006 - 2009
- Faculty of Medicine Kyoto UniversityClass of 1993
Certifications & Licensure
- CA State Medical License Current
- OH State Medical License 2012 - 2026
- AL State Medical License 2015 - 2020
Awards, Honors, & Recognition
- Young Investigator Award American Association of Neurological Surgeons, 2006-2007
Clinical Trials
- AXL Inhibitor BGB324 in Treating Participants With Recurrent Glioblastoma Undergoing Surgery Start of enrollment: 2020 Jan 02
Publications & Presentations
PubMed
- 35 citationsImidazo[1,2-a]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells.Luca Quattrini, Edoardo Luigi Maria Gelardi, Vito Coviello, Stefania Sartini, Davide M. Ferraris
Journal of Medicinal Chemistry. 2020-04-20 - 600 citationsPhosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cellsEunhee Kim, Mi-Suk Kim, Dong Hun Woo, Yongjae Shin, Jihye Shin
Cancer Cell. 2013-06-10 - 386 citationsImmune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesiclesFranz Ricklefs, Quazim A. Alayo, Harald Krenzlin, Ahmad Bakur Mahmoud, Maria C. Speranza
Science Advances. 2018-03-01
Journal Articles
- Article Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma via Intercellular Transfer of Splicing FactorsAhmed Mohyeldin, Ichiro Nakano, L James Lee, ScienceDirect
- Combined c-met/Trk Inhibition Overcomes Resistance to CDK4/6 Inhibitors in GlioblastomaIchiro Nakano, Benjamin Purow, Clinical Cancer Research
Authored Content
- On-Chip Clonal Analysis of Glioma-Stem-Cell Motility and Therapy ResistanceJuly 2016
Press Mentions
- Sustained NF-κB-STAT3 Signaling Promotes Resistance to Smac Mimetics in Glioma Stem-like Cells but Creates a Vulnerability to EZH2 InhibitionMarch 4th, 2019
- Dying Cancer Cells Make Remaining Glioblastoma Cells More Aggressive and Therapy-ResistantJune 22nd, 2018
- Dying Cancer Cells Make Remaining Glioblastoma Cells More Aggressive and Therapy-ResistantJune 21st, 2018
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Grant Support
- National Institute for HealthNational Cancer InstitutePresent
Research History
- ProfessorTherapy development and clinical trials for malignant brain tumors2015 - Present
- Associate ProfessorTherapy development and clinical trials for brain tumors2009 - 2015
Professional Memberships
- Member
- Society for Neuro-oncologyMember
Other Languages
- Japanese
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