HsinlinTChengMDPh

PubMed

• 641 citations
  Diabetic neuropathy: clinical manifestations and current treatments
  Brian C. Callaghan, Hsinlin T. Cheng, Catherine L. Stables, Andrea L. Smith, Eva L. Feldman
  The Lancet. Neurology. 2012-06-01
• 460 citations
  Diabetic neuropathy: mechanisms to management.
  James L. Edwards, Andrea M. Vincent, Hsinlin T. Cheng, Eva L. Feldman
  Pharmacology & Therapeutics. 2008-10-01
• 79 citations
  Increased axonal regeneration and swellings in intraepidermal nerve fibers characterize painful phenotypes of diabetic neuropathy
  Hsinlin T. Cheng, Jacqueline R. Dauch, Michael T. Porzio, Brandon M. Yanik, Wilson Hsieh
  The Journal of Pain. 2013-09-01

Journal Articles

• Neurogenic factor-induced Langerhans cell activation in painful diabetic neuropathy  
  Dauch JR, Bender D, Luna-Wong LA, Hsieh W, Yanik BM, Kelly ZA, Cheng HT, Journal of Neuroinflammation, 1/1/2013
• 3-Dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies  
  Dauch JR, Lindblad CN, Hayes JM, Lentz SI, Cheng HT, The Journal of Visualized Experiments, 1/1/2013
• Diabetic neuropathy: Clinical manifestations and current treatment  
  Callanghan BC, Cheng HT, Stables CL, Smith AL, Feldman EL, Lancet Neurology, 1/1/2012
• Neuron-astrocyte signaling network in spinal cord dorsal horn mediates painful neuropathy of type 2 diabetes  
  Dauch JR, Yanik BM, Oh S, Hsieh W, Cheng HT, Glia, 1/1/2012
• Increased Peptidergic Intraepidermal Nerve Fiber Densities during Mechanical Allodynia in an Animal Model of Type 2 Diabetes  
  Cheng HT, Dauch JR, Hayes JM, Yanik BM, Feldman EL, Neurobiology of Disease, 1/1/2012
• P38 Mediates Mechanical Allodynia in a Mouse Model of Type 2 Diabetes  
  Cheng HT, Dauch JR, Oh S, Hayes JM, Hong Y, Feldman EL, Molecular Pain, 1/1/2010
• Insulin-like growth factor-I and Bcl-X(L) inhibit c-jun N-terminal kinase activation and rescue Schwann cells from apoptosis  
  Cheng HL. Steinway ML. Xin X. Feldman EL, Journal of Neurochemistry, 1/1/2001
• Feldman EL Insulin-like growth factor-I and over-expression of Bcl-xL prevent glucose-mediated apoptosis in Schwann cells  
  Delaney CL. Russell JW. Cheng HL, Journal of Neuropathology & Experimental Neurology, 1/1/2001
• GTPases and phosphatidylinositol 3-kinase are critical for insulin-like growth factor-I-mediated Schwann cell motility  
  Cheng HL. Steinway ML. Russell JW. Feldman EL, Journal of Biological Chemistry, 1/1/2000
• IGF-I promotes Schwann cell motility and survival via activation of Akt  
  Cheng HL. Steinway M. Delaney CL. Franke TF. Feldman EL, Molecular & Cellular Endocrinology, 1/1/2000
• Insulin-like growth factor-I prevents caspase mediated apoptosis in Schwann cells  
  Delaney CL, Cheng H-L, Feldman EL, Journal of Neurobiology, 1/1/1999
• IGF-I promotes peripheral nervous system myelination  
  Cheng H-L, Russell JW, Feldman EL, Annals of the New York Academy of Sciences, 1/1/1999
• Caveolin-1 expression in Schwann cells  
  Mikol DD, Hong H, Cheng H-L, Feldman EL, Glia, 1/1/1999
• Insulin receptor substrate-2 and Shc play different roles in insulin-like growth factor-I signaling  
  Kim B, Cheng H-L, Margolis B, Feldman EL, Journal of Biological Chemistry, 1/1/1998
• Bidirectional regulation of p38 kinase and c-Jun N-terminal protein kinase by insulin-like growth factor-I  
  Cheng H-L, Feldman EL, Journal of Biological Chemistry, 1/1/1998
• Insulin-like growth factor-I (IGF-I) and IGF binding protein-5 in Schwann cell differentiation  
  Cheng H-L, Feldman EL, Journal of Cellular Physiology, 1/1/1997
• Characterization of insulin-like growth factor-I (IGF-I), IGF-I receptor and binding proteins in transected nerves and cultured Schwann cells  
  Cheng H-L, Randolph A, Yee D, Delafontaine P, Tennekoon G, Feldman EL, Journal of Neurochemistry, 1/1/1996
• Immunohistochemical localization of insulin-like growth factor binding protein-5 in the developing rat nervous system  
  Cheng H-L, Sullivan KA, Feldman EL, Developmental Brain Research, 1/1/1996
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Books/Book Chapters

• Atlas of Neuromuscular Diseases 
  Chapter: Chronic Pain in Neuromuscular Disease. (Chapter 4) 
  Page 37 - 41Cheng HT, Oaklander ALEdition 2nd,2014
• Neuropathic Pain: Mechanisms, Diagnosis and Treatment 
  Chapter: Painful Diabetic Neuropathy. (Chapter 11) 
  Page 165 - 189Cheng HT, Callanghan B, Dauch JR, Feldman ELEditors: David Simpson, Justin McArthur, and David Dworkin.2012
• Encyclopedia of Pain 
  Chapter: Diabetic Neuropathy. 
  Cheng HT, Oaklander ALEdition 2nd,2012
• Cytoskeleton of the Nervous System 
  Chapter: Cytoskeleton, Axonal Transport, and the Mechanisms of Peripheral Neuropathy. (Chapter 27) 
  Page 657 - 678Cheng HT, Callanghan B, Dauch JR, Feldman ELEditors: Ralph A. Nixon and Aidong Yuan.2011
• Neural Plasticity in Chronic Pain 
  Chapter: Spinal Cord Neural Plasticity in Chronic Pain and Its Clinical Implication Pain. (Chapter 3) 
  Dauch JR, Cheng HT2011
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Abstracts/Posters

• Dysregulation of cytokines mediates painful diabetic neuropathy.
  Yanik BM, Dauch JR, Bruno E, Feldman EL, Cheng HT, American Academy of Neurology, 1/1/2015
• Analgesic effects of IL-10 in a murine model of painful diabetic neuropathy.
  Yanik BM, Dauch JR, Bruno E, Feldman EL, Cheng HT, Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes (NEURODIAB), 1/1/2014
• High fat diet induces impaired glucose tolerance and painful peripheral neuropathy.
  Dauch JR, Cheng HT, Hayes JM, Oh S, and Feldman EL, Peripheral Nerve Society, 1/1/2013
• High fat diet induces impaired glucose tolerance and painful peripheral neuropathy.
  Cheng HT, Dauch JR, Hayes J, Oh S, and Feldman EL, American Neurological Association, 1/1/2012
• Useful biomarkers for the diagnosis of painful diabetic neuropathy.
  Cheng HT, Dauch JR, Porzio M, Yanik BM, Hsieh W, Smith GA, Singleton RJ, and Feldman EL, American Academy of Neurology, 1/1/2012
• “The use of skin biopsy for the diagnosis of painful diabetic neuropathy”
  Cheng HT, Platform presentation, Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes (NEURODIAB), Porto, Portugal, 1/1/2011
• “Characterization of intraepidermal nerve fiber morphology in pain associated with diabetic neuropathy and impaired glucose tolerance”
  Cheng HT, American Neurological Association, SIG for headache and neuropathic pain, platform presentation, San Diego, CA, 1/1/2011
• Characterization of intraepidermal nerve fiber morphology in pain associated with diabetic neuropathy and impaired glucose tolerance.
  Cheng HT, Dauch JR, Smith GA, Singleton RJ, Yanik BM, and Feldman EL, American Neurological Association, 1/1/2011
• The use of skin biopsy for the diagnosis of painful diabetic neuropathy.
  Cheng HT, Dauch JR, Smith GA, Singleton RJ, Yanik BM, and Feldman EL, Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes (NEURODIAB), 1/1/2011
• Characterization of Intraepidermal Nerve Fiber Morphology in Pain Associated with Diabetic Neuropathy and Impaired Glucose Tolerance.
  Cheng HT, Dauch JR, Smith GA, Singleton RJ, Yanik BM, and Feldman EL, Peripheral Nerve Society, 1/1/2011
• Spinal Cord Neuorn-glial Interactions Mediate Pain in Type 2 Diabetes.
  Dauch JR, Yanik BM, and Cheng HT, American Society for Neurochemistry, 1/1/2011
• Increased Peptidergic Intraepidermal Nerve Fiber Densities during Mechanical Allodynia in Type 2 Diabetes.
  Cheng HT, Dauch JR, Oh S, Hong Y, and Feldman EL, Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes (NEURODIAB), 1/1/2010
• P38 Mediates Mechanical Allodynia in a Mouse Model of Type 2 Diabetes.
  Cheng HT, Dauch JR, Hayes J, Hong Y, and Feldman EL, American Pain Society, 1/1/2010
• Nerve Growth Factor and P38 Mediate Increased Peptidergic Intraepidermal Nerve Fibers and Mechanical Allodynia in Type 2 Diabetes.
  Cheng HT, Dauch JR, Hayes J, Hong Y, and Feldman EL, American Neurological Association, 1/1/2010
• P38 Mediates Mechanical Allodynia in a Mouse Model of Type 2 Diabetes.
  Cheng HT, Dauch JR, Oh S, Hong Y, and Feldman EL, American Neurological Association, 1/1/2010
• “Nerve growth factor and p38 mediate increased peptidergic intraepidermal nerve fibers and mechanical allodynia in type 2 diabetes”
  Cheng HT, American Neurological Association, SIG for headache and neuropathic pain, platform presentation, San Francisco, CA, 1/1/2010
• The roles of mitogen activated protein kinases in painful neuropathy of type 2 diabetes.
  Cheng HT, Hayes J, Hong Y, and Feldman EL, Society of Neuroscience, 1/1/2009
• “The essential role of nerve growth factor in painful neuropathy of type 2 diabetes”
  Cheng HT, Society for Neuroscience, platform presentation, Washington, DC, 1/1/2008
• "Upregulation of nerve growth factor signaling in painful neuropathy of type 2 diabetes”
  Cheng HT, American Pain Society, platform presentation, Tampa, FL, 1/1/2008
• The essential role of nerve growth factor in painful neuropathy of type 2 diabetes.
  Cheng HT, Hayes J, Hong Y, and Feldman EL, Society of Neuroscience, 1/1/2008
• Upregulation of nerve growth factor signaling in painful neuropathy of type 2 diabetes.
  Cheng HT, Hayes J, Hong Y, and Feldman EL, American Pain Society, 1/1/2008
• Activation of mitogen activated protein kinases in painful diabetic neuropathy.
  Cheng HT, Hayes J, Hong Y, and Feldman EL, Society of Neuroscience, 1/1/2007
• N -Methyl-D-Aspartate receptor dependent and independent signaling pathways in the spinal cord mediate inflammatory pain.
  Cheng HT, Suzuki M, Hegarty DM, Xu Q, South SM, Ohata M and Inturrisi CE, American Pain Society, 1/1/2006
• Methyl-D-Aspartate receptor dependent and independent signaling pathways in the spinal cord mediate inflammatory pain.
  Cheng HT, Suzuki M, Hegarty DM, Xu Q, South SM, Ohata M and Inturrisi CE, Society of Neuroscience, 1/1/2005
• Phosphatidylinositol-3 kinase and GTPases mediate IGF-I induced Schwann cell motility.
  Cheng H-L, Steinway M, Xin X, Feldman EL, Molecular Biology of the Cell, 1/1/1999
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Lectures

• "The use of skin biopsy for the diagnosis of painful diabetic neuropathy” 
  Department of Neurology, National Cheng Kung University Hospital, Tainan, Taiwan - 1/1/2012
• "Useful biomarkers for the diagnosis of painful diabetic neuropathy” 
  New Orleans - 1/1/2012
• “Painful diabetic neuropathy: Not just a peripheral nerve disease” 
  Department of Neurology, Cleveland Clinic, Cleveland, OH - 1/1/2011
• “Peripheral mechanisms for painful diabetic neuropathy of type 2 diabetes” 
  Department of Endocrinology, Wayne State University, Detroit, MI - 1/1/2010
• “Botulinum toxin for neuropathic pain”. 
  Department of Neurology, Memorial Sloan Kettering Cancer Center, New York - 1/1/2006
• “N -Methyl-D-Aspartate receptor dependent and independent signaling pathways in the spinal cord mediate inflammatory pain”. 
  Department of Neurology, Memorial Sloan Kettering Cancer Center, New York - 1/1/2005
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Other

• The role of the insulin-like growth factor family in the nervous system. (Thesis) 
  Cheng H-L, The University of Michigan
  Ann Arbor, MI - 1/1/1996