Howard J. Worman MD

PubMed

• Apoptosis-induced translocation of nesprin-2 from the nuclear envelope to mitochondria is associated with mitochondrial dysfunction.
  Hila Zohar, Liora Lindenboim, Oren Gozlan, Gregg G Gundersen, Howard J Worman
  Nucleus. 2024-12-01
• 5 citations
  mTOR Inhibition Prolongs Survival and Has Beneficial Effects on Heart Function After Onset of Lamin A/C Gene Mutation Cardiomyopathy in Mice.
  Wei Wu, Qi Jin, Cecilia Östlund, Kurenai Tanji, Ji-Yeon Shin
  Circulation. Heart Failure. 2024-04-01
• 3 citations
  Dynamic regulation of hepatic lipid metabolism by torsinA and its activators.
  Antonio Hernandez-Ono, Yi Peng Zhao, John W Murray, Cecilia Östlund, Michael J Lee
  JCI Insight. 2024-02-08

Journal Articles

• Cell signaling abnormalities in cardiomyopathy caused by lamin A/C gene mutations  
  Worman, H. J., Biochem. Soc. Trans., 1/1/2018
• Gunter Blobel: Pioneer of molecular cell biology (1936�2018)  
  Blobel Laboratory Trainees (authors in footnote), J. Cell Biol., 1/1/2018
• Permanently farnesylated prelamin A, progeria and atherosclerosis  
  Worman, H. J. and Michaelis, S., Circulation, 1/1/2018
• Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth  
  Shin, J. Y. Mendez-Lopez, I., Hong, M. Wang, Y. Tanji, K., Wu, W., Shugol, L, Krauss, R. S., Dauer, W. T. and Worman, H. J., Hum. Mol. Genet., 1/1/2017
• Extracellular matrix remodeling and transforming growth factor-beta signaling abnormalities induced by lamin A/C variants that cause lipodystrophy  
  Le Dour, C., Wu, W., Bereziat, V., Capeau, J., Vigouroux, C. and Worman, H. J., J. Lipid Res., 1/1/2017
• Decreased WNT/beta-catenin signaling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin A/C gene  
  Le Dour, C., Macquart, C., Sera, F., Homma, S., Bonne, G., Morrow, J. P., Worman, H. J. and Muchir, A., Hum. Mol. Genet., 1/1/2017
• Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation  
  Wu, W., Chordia, M. D., Hart, B. P., Kumarasinghe, E. S., Ji, M. K., Bhargava, A., Lawlor, M. W., Shin, J. Y., Sera, F., Homma, S., Muchir, A., Khire, U. R. and Worman..., Bioorg. Med. Chem., 1/1/2017
• TorsinA controls TAN line assembly and the retrograde flow of dorsal perinuclear actin cables during rearward nuclear movement  
  Saunders, C. A., Harris, N. J., Willey, P. W., Woolums, B. M., Wang, Y., McQuown, A. J., Schoenhofen, A., Worman, H. J., Dauer, W. T., Gundersen, G. G. and Luxton, G. ..., J. Cell Biol., 1/1/2017
• ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene  
  Chatzifrangkeskou, M., Le Dour, C., Wu, W., Morrow, J. P., Joseph, L. C., Beuvin, M., Sera, F., Homma, S., Vignier, N., Mougenot, N., Bonne, G., Lipson, K. E., Worman,..., Hum. Mol. Genet., 1/1/2016
• A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder  
  Wang, Y., Lichter-Konecki, U., Anyane-Yeboa, K., Shaw, J. E., Lu, J. T., Ostlund, C., Shin, J. Y., Clark, L. N., Gundersen, G. G., Nagy, P. L. and Worman, H. J., J. Cell Sci., 1/1/2016
• Targeting mitogen-activated protein kinase signaling in mouse models of cardiomyopathy caused by lamin A/C gene mutations  
  Muchir, A. and Worman, H. J., Methods Enzymol., 1/1/2016
• Purification and structural analysis of LEM-domain proteins  
  Herrada, I., Bourgeois, B., Samson, C., Buendia, B., Worman, H. J. and Zinn-Justin S., Methods Enzymol., 1/1/2016
• Neurofilament light polypeptide gene N98S mutation in mice leads to neurofilament network abnormalities and a Charcot-Marie-Tooth type 2E phenotype  
  Adebola, A. A., Di Castri, T., He, C. Z., Salvatierra, L. A., Zhao, J., Brown, K., Lin, C. S., Worman, H. J. and Liem R. K. H., Hum. Mol. Genet., 1/1/2015
• Muscular dystrophy mutations impair the nuclear envelope emerin self-assembly properties  
  Herrada, I., Samson, C., Velours, C., Renault, L., Ostlund, C., Chervy, P., Puchkov, D., Worman, H. J., Buendia, B. and Zinn-Justin, S., ACS Chem. Biol., 1/1/2015
• Acute liver injury associated with a newer formulation of the herbal weight loss supplement Hydroxycut  
  Araujo, J. L. and Worman, H. J., BMJ Case Rep., 1/1/2015
• Nuclear membrane diversity: underlying tissue-specific pathologies in disease?  
  Worman, H. J. and Schirmer, E. C., Curr. Opin. Cell Biol., 1/1/2015
• Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activa...  
  Wu, W., Iwata, S., Homma, S., Worman, H. J. and Muchir, A., Hum. Mol. Genet., 1/1/2014
• Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization  
  Meinke, P., Mattioli, E., Haque, F., Antoku, S., Columbaro, M., Straatman, K. R., Worman, H. J, Gundersen, G. G., Lattanzi, G., Wehnert, M. and Shackleton, S., PLoS Genet., 1/1/2014
• Emery-Dreifuss muscular dystrophy  
  Worman, H. J., MedLink Neurology, 1/1/2014
• Lamin A/C depletion enhances DNA damage induced stalled replication fork arrest  
  Singh, M., Hunt, C. R., Pandita, R. K., Kumar, R., Yang, C. R., Horikoshi, N., Bachoo, R., Sarag, S., Story, M. D., Shay, J. W., Powell, S. N., Gupta, A., Jeffery, J.,..., Mol. Cell. Biol., 1/1/2013
• Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy cause...  
  Muchir, A., Kim, Y. J., Reilly, S. A., Wu, W. Choi, J. C. and Worman, H. J., Skelet. Muscle, 1/1/2013
• Inhibition of TGF-beta signaling at the nuclear envelope: characterization of interactions between MAN1, Smad2 and 3, and PPM1A  
  Bourgeois, B., Gilquin, B., Tellier-Lebegue, C., Ostlund, C., Wu, W., Perez, J., El Hage, P., Lallemand, F., Worman, H. J. and Zinn-Justin, S., Sci. Signal., 1/1/2013
• Perturbation of nuclear lamin A causes cell death in chondrocytes  
  Attur, M., Dave, M., Ben-Artzi, A., Yang, Q., Al-Mussawir, H. E., Worman, H. J., Palmer, G. and Abramson, S. B., Arthritis Rheum., 1/1/2012
• Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene  
  Muchir, A., Reilly, S. A.,Wu, W., Iwata, S., Homma, S., Bonne, G. and Worman, H. J., Cardiovasc. Res., 1/1/2012
• Epitope-specific antinuclear antibodies are expressed in a mouse model of primary biliary cirrhosis and are cytokine-dependent  
  Yang, C. Y., Leung, P. S.C., Yang, G. X., Kenny, T. P., Zhang, W., Coppel, R., Norman, G. L., Ansari, A. A., Mackay, I. R., Worman, H. J. and Gershwin, M. E., Clin. Exp. Immunol., 1/1/2012
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Books/Book Chapters

• The LINC Complex: Methods and Protocols. Methods in Molecular Biology 
  Editors: Gundersen, G. G. and Worman, H. J..Humana Press, New York2018
• The LINC Complex: Methods and Protocols 
  Chapter: Next-generation sequencing and mutational analysis: implications for genes encoding LINC complex proteins 
  Page 321.0 - 336.0Nagy, P. L and Worman, H. J.Editors: Gundersen G. G. and Worman, H. J..Humana Press, New York2018
• The Functional Nucleus 
  Chapter: Human diseases related to nuclear envelope proteins 
  Page 3.0 - 25.0Worman, H. J.Editors: Bazett-Jones, D. J. and Dellaire, G..Springer International Publishing, Cham, SwitzerlandEdition 1st,2016
• Molecular and Cellular Biology of Aging 
  Chapter: Aging of the nucleus 
  Page 498.0 - 514.0Worman, H. J. and Gundersen, G. G.Editors: Vijg, J., Campisi, J. and Lithgow, G.Gerontological Society of America, Washington, DC2015
• Brenner�s Encyclopedia of Genetics 
  Chapter: Nuclear envelope, transport 
  Page 108.0 - 111.0Worman, H. J.Editors: Maloy, S. and Hughes, K..Academic Press, OxfordEdition 2nd,2013
• Magnetic Resonance Spectroscopy 
  Chapter: NMR spectroscopy as a tool to provide mechanistic clues about protein function and disease pathogenesis 
  Page 143.0 - 166.0Bourgeois, B., Worman, H. J. and Zinn-Justin, S.Editors: Kim, D. H..In Tech, Rijeka2012
• New Opathies: An Emerging Molecular Reclassification of Human Disease 
  Chapter: Laminopathies 
  Page 1.0 - 22.0Dauer, W. T. and Worman, H. J.Editors: Friedberg, E. C., Castrillon, D. H., Galindo, R. L. and Wharton, K..World Scientific Publishing Company, Singapore2012
• Business Briefings: US Gastroenterology Review 2006 
  Chapter: Primary biliary cirrhosis � etiology, diagnosis, natural history and treatment 
  Worman, H. J.Touch Group, PLC, London2006
• The Liver Disorders and Hepatitis Sourcebook 
  Worman, H. J.McGraw-Hill, New YorkEdition 2nd,2006
• Business Briefing: Global Healthcare 
  Chapter: Chronic hepatitis B � the problem, prevention, treatment and politics 
  Worman, H. J.World Markets Research Centre, Ltd., London2003
• Dynamics of Nuclear Envelope Assembly in Embryos and Somatic Cells 
  Chapter: Targeting and retention of proteins in the inner and pore membranes of the nuclear envelope 
  Page 29.0 - 41.0Ostlund, C., Wu, W. and Worman, H. J.Editors: Collas, P..Landes Bioscience, Georgetown, TX2002
• The Hepatitis C Sourcebook 
  Worman, H. J.McGraw Hill-Contemporary Books, New York2002
• Gastroenterology and Hepatology Pearls of Wisdom 
  Chapter: Autoimmune and overlap conditions 
  Page 210.0 - 214.0Worman, H. J.Editors: DiBaise, J. K..Boston Medical Publishing Corp., Boston2000
• Proceedings of Falk Symposium 114, Immunology and the Liver 
  Chapter: ANCA in liver diseases 
  Page 137.0 - 151.0Terjung, B. and Worman, H. J.Editors: Manns, M. P., Paumgartner, G. and Leuschner, U..Kluwer Academic Publishers, Dordrecht2000
• Proceedings of Falk Symposium 114, Immunology and the Liver 
  Chapter: Nuclear protein antigens in primary biliary cirrhosis 
  Page 257.0 - 267.0Worman, H. J., Terjung, B. and Courvalin, J.-C.Editors: Manns, M. P., Paumgartner, G. and Leuschner, U..Kluwer Academic Publishers, Dordrecht2000
• The Liver Disorders Sourcebook 
  Worman, H. J.Lowell House, Los Angeles1999
• Autoimmune Liver Diseases 
  Chapter: Antineutrophil cytoplasmic and other autoantibodies in primary sclerosing cholangitis 
  Page 305.0 - 320.0Semrad, C. E., Terjung, B. and Worman, H. J.Editors: Krawitt, E. L., Wiesner, R. H. and Nisioka, M..Elsevier Science Publisher B. V., AmsterdamEdition 2nd,1998
• Subecellular Biochemistry, Volume 31: Intermediate Filaments 
  Chapter: Nuclear lamin binding proteins 
  Page 587.0 - 610.0Ye, Q., Barton, R. and Worman, H. J.Editors: Herrmann, H. and Harris, J. R..Plenum Press, London1998
• Hepatic Transport and Bile Secretion: Physiology and Pathophysiology 
  Chapter: Hepatocyte differentiation: cellular and molecular biology 
  Page 117.0 - 134.0Worman, H. J.Editors: Tavoloni, N. and Berk, P. D..Raven Press, Ltd., New York1993
• Membrane Biophysics II: Physical Methods in the Study of Epithelia 
  Chapter: ATP-driven electrogenic proton translocation in plasma membrane vesicles from turtle bladder cells 
  Page 159.0 - 171.0Youmans, S. J., Worman, H. J. and Brodsky, W. A.Editors: Dinno, M. A., Callahan, A. B. and Rozzell, T. C..Alan R. Liss, Inc., New York1983
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Lectures

• Entertaining Science: From Nuclear Membranes to Aging�What a Long, Strange Trip It�s Been 
  The Cornelia Street Cafe, New York, NY - 1/1/2018
• Biomedical Research in the Next Decade 
  New York, NY - 1/1/2018
• A Precision Medicine Approach to the Laminopathies 
  Multiple locations, 2016, 2017 - 1/1/2017
• Nuclear Envelope in Tissue Maintenance and Disease 
  Rutgers New Jersey Medical School, Newark, NJ - 1/1/2017
• Personalized Medicine and Rare Diseases: The Laminopathies 
  Christiana Care Health System, Newark, DE - 1/1/2016
• Laminopathies and the Long Strange Trip from Cell Biology to Therapy 
  Multiple locations, 2009, 2011, 2013, 2015 - 1/1/2015
• Nuclear Laminopathies and the Long Strange Trip from Cell Biology to Therapy 
  Nassau University Medical Center, East Meadow, NY - 1/1/2015
• Introduction to the Liver 
  The School at Columbia University, New York, NY - 1/1/2015
• Nuclear Envelope: An Intriguing Focal Point in Inherited Diseases 
  University of Michigan, Ann Arbor, MI - 1/1/2015
• The Nuclear Envelope and Muscular Dystrophy 
  The Research Institute at Nationwide Children�s Hospital, Columbus, OH - 1/1/2015
• Novel LMNA Mutation Causing a Mandibuloacral Dysplasia-like Phenotype 
  Columbia University, New York, NY - 1/1/2015
• Intermediate Filaments 
  Tilton, NH, 2010; West Dover, VT, 2014 - 1/1/2014
• Nuclear Lamina/Nuclear Matrix 
  Nice, France - 1/1/2014
• The Nuclear Envelope as a Signaling Node in Development and Disease 
  Cincinnati Children�s Hospital Medical Center, Cincinnati, OH - 1/1/2014
• Panel Discussion on Progeria 
  Harvard College, Cambridge, MA - 1/1/2013
• Primary Biliary Cirrhosis: Clinical Features, Autoantibodies, and Speculations About Pathogenesis 
  Columbia University Medical Center, New York, NY - 1/1/2012
• LMNA Cardiomyopathy and p38alpha Signaling 
  Boulder, CO - 1/1/2012
• The Nuclear Envelope: a Signaling Node in Human Disease 
  North Brunswick, NJ, 2010; University of Alberta, Edmonton, Alberta, Canada, 2011 - 1/1/2011
• LMNA Cardiomyopathy 
  Strasburg, PA - 1/1/2011
• The Nuclear Envelope: a Signaling Node in Development and Disease 
  University of Rochester, Rochester, NY - 1/1/2010
• Pathogenesis and Treatment of Cardiomyopathy Caused by Lamin A/C Gene Mutation 
  University of Wisconsin School of Medicine and Public Health, Madison, WI - 1/1/2010
• Laminopathies: A Long Strange Trip from Basic Cell Biology to Therapy 
  Durham, UK - 1/1/2009
• Nuclear Envelopathies: Rare Disease Models of Common Human Conditions 
  Columbia University College of Physicians and Surgeons, New York, NY, 2008; Metropolitan Hospital Ce - 1/1/2009
• Pathogenesis and Treatment of Cardiomyopathy Caused by Lamin A/C Gene Mutations 
  Columbia University Medical Center, New York, NY - 1/1/2009
• Organization of the Nuclear Lamina in Development and Disease 
  San Francisco, CA - 1/1/2008
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Other

• Computers and technology: creating a website 
  Worman, H. J., AGA News
  1/1/1997
• Electronic prescription services offer potential savings and improvements in efficiencies 
  Weinstein, D. R. and Worman, H. J., AGA News
  1/1/1997
• Military AIDS tests can't be conclusive (letter) 
  Worman, H. J., The New York Times
  1/28/1985
• Cardiac stress test is far from routine (letter) 
  Worman, H. J., The New York Times
  1/30/1988
• When life is toxic (letter) 
  Worman, H. J., The New York Times Magazine
  1/14/1990
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