HowardJ.WormanMD

Hepatology & Liver Transplantation

Professor of Medicine and Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University

Overview of Dr. Worman

Dr. Howard Worman is a physician-scientist in New York, NY. He is Professor of Medicine and Pathology and Cell Biology at Columbia University and an Attending Physician at NewYork-Presbyterian Hospital/Columbia University Irving Medical Center. He received his BA from Cornell University and MD from University of Chicago Division of the Biological Sciences The Pritzker School of Medicine. Dr. Worman is an internist who specializes in hepatology. His research is focused on genetic disorders caused by mutations in genes encoding nuclear envelope proteins and liver diseases including nonalcoholic steatohepatitis and primary biliary cirrhosis.

Office
161 Fort Washington Avenue
New York, NY 10032
Book by Phone+1(929) 325-2625

Education & Training

Icahn School of Medicine at Mount SinaiPost-Doctoral Fellowship, Transplant Hepatology, 1990 - 1991
The Rockeller UniversityPost-Doctoral Fellowship, 1987 - 1990
New York Presbyterian Hospital (Cornell Campus)Residency, Internal Medicine, 1985 - 1987
University of Chicago Division of the Biological Sciences The Pritzker School of MedicineClass of 1985
Cornell UniversityBA, Chemistry and Biology, Cum Laude, 1977 - 1981

Certifications & Licensure

NY State Medical License 1986 - 2025
IL State Medical License 2003 - 2005
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

Elected Member Association of American Physicians, 2010
Elected Member The American Society for Clinical Investigation, 1998
Silberberg Award Columbia University College of Physicians and Surgeons, 1995
Trainee Award in Clinical Research American Federation for Clinical Research, 1989
Franklin McLean Award for meritorious medical student research University of Chicago, 1985
Calvin Fentress Research Fellowship Award University of Chicago, 1984
Phi Beta Kappa Cornell University, 1980
Marquis Who�s Who in America
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Publications & Presentations

PubMed

76 citations
LMNA cardiomyopathy: cell biology and genetics meet clinical medicine.
Jonathan T. Lu, Antoine Muchir, Peter L. Nagy, Howard J. Worman
Disease Models & Mechanisms. 2011-09-01
100 citations
Structural organization of the human gene (LMNB1) encoding nuclear lamin B1.
Feng Lin, Howard J. Worman
Genomics. 1995-05-20
152 citations
Intracellular trafficking of emerin, the Emery-Dreifuss muscular dystrophy protein
Cecilia Östlund, Jan Ellenberg, Einar Hallberg, J. Lippincott-Schwartz, Howard J. Worman
Journal of Cell Science. 1999-06-01

Journal Articles

Cell signaling abnormalities in cardiomyopathy caused by lamin A/C gene mutations
Worman, H. J., Biochem. Soc. Trans., 1/1/2018
Gunter Blobel: Pioneer of molecular cell biology (1936�2018)
Blobel Laboratory Trainees (authors in footnote), J. Cell Biol., 1/1/2018
Permanently farnesylated prelamin A, progeria and atherosclerosis
Worman, H. J. and Michaelis, S., Circulation, 1/1/2018
Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth
Shin, J. Y. Mendez-Lopez, I., Hong, M. Wang, Y. Tanji, K., Wu, W., Shugol, L, Krauss, R. S., Dauer, W. T. and Worman, H. J., Hum. Mol. Genet., 1/1/2017
Extracellular matrix remodeling and transforming growth factor-beta signaling abnormalities induced by lamin A/C variants that cause lipodystrophy
Le Dour, C., Wu, W., Bereziat, V., Capeau, J., Vigouroux, C. and Worman, H. J., J. Lipid Res., 1/1/2017
Decreased WNT/beta-catenin signaling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin A/C gene
Le Dour, C., Macquart, C., Sera, F., Homma, S., Bonne, G., Morrow, J. P., Worman, H. J. and Muchir, A., Hum. Mol. Genet., 1/1/2017
Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation
Wu, W., Chordia, M. D., Hart, B. P., Kumarasinghe, E. S., Ji, M. K., Bhargava, A., Lawlor, M. W., Shin, J. Y., Sera, F., Homma, S., Muchir, A., Khire, U. R. and Worman..., Bioorg. Med. Chem., 1/1/2017
TorsinA controls TAN line assembly and the retrograde flow of dorsal perinuclear actin cables during rearward nuclear movement
Saunders, C. A., Harris, N. J., Willey, P. W., Woolums, B. M., Wang, Y., McQuown, A. J., Schoenhofen, A., Worman, H. J., Dauer, W. T., Gundersen, G. G. and Luxton, G. ..., J. Cell Biol., 1/1/2017
ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene
Chatzifrangkeskou, M., Le Dour, C., Wu, W., Morrow, J. P., Joseph, L. C., Beuvin, M., Sera, F., Homma, S., Vignier, N., Mougenot, N., Bonne, G., Lipson, K. E., Worman,..., Hum. Mol. Genet., 1/1/2016
A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder
Wang, Y., Lichter-Konecki, U., Anyane-Yeboa, K., Shaw, J. E., Lu, J. T., Ostlund, C., Shin, J. Y., Clark, L. N., Gundersen, G. G., Nagy, P. L. and Worman, H. J., J. Cell Sci., 1/1/2016
Targeting mitogen-activated protein kinase signaling in mouse models of cardiomyopathy caused by lamin A/C gene mutations
Muchir, A. and Worman, H. J., Methods Enzymol., 1/1/2016
Purification and structural analysis of LEM-domain proteins
Herrada, I., Bourgeois, B., Samson, C., Buendia, B., Worman, H. J. and Zinn-Justin S., Methods Enzymol., 1/1/2016
Neurofilament light polypeptide gene N98S mutation in mice leads to neurofilament network abnormalities and a Charcot-Marie-Tooth type 2E phenotype
Adebola, A. A., Di Castri, T., He, C. Z., Salvatierra, L. A., Zhao, J., Brown, K., Lin, C. S., Worman, H. J. and Liem R. K. H., Hum. Mol. Genet., 1/1/2015
Muscular dystrophy mutations impair the nuclear envelope emerin self-assembly properties
Herrada, I., Samson, C., Velours, C., Renault, L., Ostlund, C., Chervy, P., Puchkov, D., Worman, H. J., Buendia, B. and Zinn-Justin, S., ACS Chem. Biol., 1/1/2015
Acute liver injury associated with a newer formulation of the herbal weight loss supplement Hydroxycut
Araujo, J. L. and Worman, H. J., BMJ Case Rep., 1/1/2015
Nuclear membrane diversity: underlying tissue-specific pathologies in disease?
Worman, H. J. and Schirmer, E. C., Curr. Opin. Cell Biol., 1/1/2015
Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activa...
Wu, W., Iwata, S., Homma, S., Worman, H. J. and Muchir, A., Hum. Mol. Genet., 1/1/2014
Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization
Meinke, P., Mattioli, E., Haque, F., Antoku, S., Columbaro, M., Straatman, K. R., Worman, H. J, Gundersen, G. G., Lattanzi, G., Wehnert, M. and Shackleton, S., PLoS Genet., 1/1/2014
Emery-Dreifuss muscular dystrophy
Worman, H. J., MedLink Neurology, 1/1/2014
Lamin A/C depletion enhances DNA damage induced stalled replication fork arrest
Singh, M., Hunt, C. R., Pandita, R. K., Kumar, R., Yang, C. R., Horikoshi, N., Bachoo, R., Sarag, S., Story, M. D., Shay, J. W., Powell, S. N., Gupta, A., Jeffery, J.,..., Mol. Cell. Biol., 1/1/2013
Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy cause...
Muchir, A., Kim, Y. J., Reilly, S. A., Wu, W. Choi, J. C. and Worman, H. J., Skelet. Muscle, 1/1/2013
Inhibition of TGF-beta signaling at the nuclear envelope: characterization of interactions between MAN1, Smad2 and 3, and PPM1A
Bourgeois, B., Gilquin, B., Tellier-Lebegue, C., Ostlund, C., Wu, W., Perez, J., El Hage, P., Lallemand, F., Worman, H. J. and Zinn-Justin, S., Sci. Signal., 1/1/2013
Perturbation of nuclear lamin A causes cell death in chondrocytes
Attur, M., Dave, M., Ben-Artzi, A., Yang, Q., Al-Mussawir, H. E., Worman, H. J., Palmer, G. and Abramson, S. B., Arthritis Rheum., 1/1/2012
Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene
Muchir, A., Reilly, S. A.,Wu, W., Iwata, S., Homma, S., Bonne, G. and Worman, H. J., Cardiovasc. Res., 1/1/2012
Epitope-specific antinuclear antibodies are expressed in a mouse model of primary biliary cirrhosis and are cytokine-dependent
Yang, C. Y., Leung, P. S.C., Yang, G. X., Kenny, T. P., Zhang, W., Coppel, R., Norman, G. L., Ansari, A. A., Mackay, I. R., Worman, H. J. and Gershwin, M. E., Clin. Exp. Immunol., 1/1/2012
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Books/Book Chapters

The LINC Complex: Methods and Protocols. Methods in Molecular Biology
Editors: Gundersen, G. G. and Worman, H. J..Humana Press, New York2018
The LINC Complex: Methods and Protocols
Chapter: Next-generation sequencing and mutational analysis: implications for genes encoding LINC complex proteins
Page 321.0 - 336.0Nagy, P. L and Worman, H. J.Editors: Gundersen G. G. and Worman, H. J..Humana Press, New York2018
The Functional Nucleus
Chapter: Human diseases related to nuclear envelope proteins
Page 3.0 - 25.0Worman, H. J.Editors: Bazett-Jones, D. J. and Dellaire, G..Springer International Publishing, Cham, SwitzerlandEdition 1st,2016
Molecular and Cellular Biology of Aging
Chapter: Aging of the nucleus
Page 498.0 - 514.0Worman, H. J. and Gundersen, G. G.Editors: Vijg, J., Campisi, J. and Lithgow, G.Gerontological Society of America, Washington, DC2015
Brenner�s Encyclopedia of Genetics
Chapter: Nuclear envelope, transport
Page 108.0 - 111.0Worman, H. J.Editors: Maloy, S. and Hughes, K..Academic Press, OxfordEdition 2nd,2013
Magnetic Resonance Spectroscopy
Chapter: NMR spectroscopy as a tool to provide mechanistic clues about protein function and disease pathogenesis
Page 143.0 - 166.0Bourgeois, B., Worman, H. J. and Zinn-Justin, S.Editors: Kim, D. H..In Tech, Rijeka2012
New Opathies: An Emerging Molecular Reclassification of Human Disease
Chapter: Laminopathies
Page 1.0 - 22.0Dauer, W. T. and Worman, H. J.Editors: Friedberg, E. C., Castrillon, D. H., Galindo, R. L. and Wharton, K..World Scientific Publishing Company, Singapore2012
Business Briefings: US Gastroenterology Review 2006
Chapter: Primary biliary cirrhosis � etiology, diagnosis, natural history and treatment
Worman, H. J.Touch Group, PLC, London2006
The Liver Disorders and Hepatitis Sourcebook
Worman, H. J.McGraw-Hill, New YorkEdition 2nd,2006
Business Briefing: Global Healthcare
Chapter: Chronic hepatitis B � the problem, prevention, treatment and politics
Worman, H. J.World Markets Research Centre, Ltd., London2003
Dynamics of Nuclear Envelope Assembly in Embryos and Somatic Cells
Chapter: Targeting and retention of proteins in the inner and pore membranes of the nuclear envelope
Page 29.0 - 41.0Ostlund, C., Wu, W. and Worman, H. J.Editors: Collas, P..Landes Bioscience, Georgetown, TX2002
The Hepatitis C Sourcebook
Worman, H. J.McGraw Hill-Contemporary Books, New York2002
Gastroenterology and Hepatology Pearls of Wisdom
Chapter: Autoimmune and overlap conditions
Page 210.0 - 214.0Worman, H. J.Editors: DiBaise, J. K..Boston Medical Publishing Corp., Boston2000
Proceedings of Falk Symposium 114, Immunology and the Liver
Chapter: ANCA in liver diseases
Page 137.0 - 151.0Terjung, B. and Worman, H. J.Editors: Manns, M. P., Paumgartner, G. and Leuschner, U..Kluwer Academic Publishers, Dordrecht2000
Proceedings of Falk Symposium 114, Immunology and the Liver
Chapter: Nuclear protein antigens in primary biliary cirrhosis
Page 257.0 - 267.0Worman, H. J., Terjung, B. and Courvalin, J.-C.Editors: Manns, M. P., Paumgartner, G. and Leuschner, U..Kluwer Academic Publishers, Dordrecht2000
The Liver Disorders Sourcebook
Worman, H. J.Lowell House, Los Angeles1999
Autoimmune Liver Diseases
Chapter: Antineutrophil cytoplasmic and other autoantibodies in primary sclerosing cholangitis
Page 305.0 - 320.0Semrad, C. E., Terjung, B. and Worman, H. J.Editors: Krawitt, E. L., Wiesner, R. H. and Nisioka, M..Elsevier Science Publisher B. V., AmsterdamEdition 2nd,1998
Subecellular Biochemistry, Volume 31: Intermediate Filaments
Chapter: Nuclear lamin binding proteins
Page 587.0 - 610.0Ye, Q., Barton, R. and Worman, H. J.Editors: Herrmann, H. and Harris, J. R..Plenum Press, London1998
Hepatic Transport and Bile Secretion: Physiology and Pathophysiology
Chapter: Hepatocyte differentiation: cellular and molecular biology
Page 117.0 - 134.0Worman, H. J.Editors: Tavoloni, N. and Berk, P. D..Raven Press, Ltd., New York1993
Membrane Biophysics II: Physical Methods in the Study of Epithelia
Chapter: ATP-driven electrogenic proton translocation in plasma membrane vesicles from turtle bladder cells
Page 159.0 - 171.0Youmans, S. J., Worman, H. J. and Brodsky, W. A.Editors: Dinno, M. A., Callahan, A. B. and Rozzell, T. C..Alan R. Liss, Inc., New York1983
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Lectures

Entertaining Science: From Nuclear Membranes to Aging�What a Long, Strange Trip It�s Been
The Cornelia Street Cafe, New York, NY - 1/1/2018
Biomedical Research in the Next Decade
New York, NY - 1/1/2018
A Precision Medicine Approach to the Laminopathies
Multiple locations, 2016, 2017 - 1/1/2017
Nuclear Envelope in Tissue Maintenance and Disease
Rutgers New Jersey Medical School, Newark, NJ - 1/1/2017
Personalized Medicine and Rare Diseases: The Laminopathies
Christiana Care Health System, Newark, DE - 1/1/2016
Laminopathies and the Long Strange Trip from Cell Biology to Therapy
Multiple locations, 2009, 2011, 2013, 2015 - 1/1/2015
Nuclear Laminopathies and the Long Strange Trip from Cell Biology to Therapy
Nassau University Medical Center, East Meadow, NY - 1/1/2015
Introduction to the Liver
The School at Columbia University, New York, NY - 1/1/2015
Nuclear Envelope: An Intriguing Focal Point in Inherited Diseases
University of Michigan, Ann Arbor, MI - 1/1/2015
The Nuclear Envelope and Muscular Dystrophy
The Research Institute at Nationwide Children�s Hospital, Columbus, OH - 1/1/2015
Novel LMNA Mutation Causing a Mandibuloacral Dysplasia-like Phenotype
Columbia University, New York, NY - 1/1/2015
Intermediate Filaments
Tilton, NH, 2010; West Dover, VT, 2014 - 1/1/2014
Nuclear Lamina/Nuclear Matrix
Nice, France - 1/1/2014
The Nuclear Envelope as a Signaling Node in Development and Disease
Cincinnati Children�s Hospital Medical Center, Cincinnati, OH - 1/1/2014
Panel Discussion on Progeria
Harvard College, Cambridge, MA - 1/1/2013
Primary Biliary Cirrhosis: Clinical Features, Autoantibodies, and Speculations About Pathogenesis
Columbia University Medical Center, New York, NY - 1/1/2012
LMNA Cardiomyopathy and p38alpha Signaling
Boulder, CO - 1/1/2012
The Nuclear Envelope: a Signaling Node in Human Disease
North Brunswick, NJ, 2010; University of Alberta, Edmonton, Alberta, Canada, 2011 - 1/1/2011
LMNA Cardiomyopathy
Strasburg, PA - 1/1/2011
The Nuclear Envelope: a Signaling Node in Development and Disease
University of Rochester, Rochester, NY - 1/1/2010
Pathogenesis and Treatment of Cardiomyopathy Caused by Lamin A/C Gene Mutation
University of Wisconsin School of Medicine and Public Health, Madison, WI - 1/1/2010
Laminopathies: A Long Strange Trip from Basic Cell Biology to Therapy
Durham, UK - 1/1/2009
Nuclear Envelopathies: Rare Disease Models of Common Human Conditions
Columbia University College of Physicians and Surgeons, New York, NY, 2008; Metropolitan Hospital Ce - 1/1/2009
Pathogenesis and Treatment of Cardiomyopathy Caused by Lamin A/C Gene Mutations
Columbia University Medical Center, New York, NY - 1/1/2009
Organization of the Nuclear Lamina in Development and Disease
San Francisco, CA - 1/1/2008
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Other

Computers and technology: creating a website
Worman, H. J., AGA News
1/1/1997
Electronic prescription services offer potential savings and improvements in efficiencies
Weinstein, D. R. and Worman, H. J., AGA News
1/1/1997
Military AIDS tests can't be conclusive (letter)
Worman, H. J., The New York Times
1/28/1985
Cardiac stress test is far from routine (letter)
Worman, H. J., The New York Times
1/30/1988
When life is toxic (letter)
Worman, H. J., The New York Times Magazine
1/14/1990
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Press Mentions

Kids with Rare Rapid-Aging Disease Get Hope from Study DrugApril 24th, 2018
Unorthodox Study Claims Drug Prolongs Lives of Children with Premature Aging DiseaseMay 8th, 2014
Progeria Drug Prospect FoundMay 2nd, 2014
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Grant Support

The Nucleocytoskeleton In Progeria And AgingEunice Kennedy Shriver National Institute Of Child Health &Human Development2011–2012
Nucleocytoplasmic Interactions And Dynamics In Emery-Dreifuss Muscular DystrophyNational Institute Of Neurological Disorders And Stroke2007–2011
Pathogenesis Of Emery-Dreifuss Muscular DystrophyNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2003–2011
Lamin A Mutation And Hutchinson-Gilford ProgeriaNational Institute On Aging2006–2008
Dux4 And Facioscapulohumeral Muscular DystrophyNational Institute Of Neurological Disorders And Stroke2003–2004
Lamin A In Adipocyte Differentation And SurvivalNational Institute Of Diabetes And Digestive And Kidney Diseases2003–2004
Ribavirin PLUS Interferon Alpha-2b In Treatment Of Chronic Hepatitis CNational Center For Research Resources1998–2002
Pathobiology Of The Nuclear Envelope In CancerNational Cancer Institute1996–2000
Characterization Of Nuclear Pore Complex ProteinsNational Institute Of Diabetes And Digestive And Kidney Diseases1990–1991
Characterization Of Nuclear Pore Complex ProteinsNational Institute Of Diabetes And Digestive And Kidney Diseases1987–1989

Research History

ProfessorDepartment of Medicine and Department of Pathology and Cell Biology, Columbia University, New York, NY2007 - Present
Associate Professor (Tenured 2001)Department of Medicine and Department of Anatomy and Cell Biology, Columbia University, New York, NY1998 - 2007
Assistant ProfessorDepartment of Medicine and Department of Anatomy and Cell Biology, Columbia University, New York, NY1995 - 1998
Assistant ProfessorDepartment of Medicine and Department of Molecular Biology, Mount Sinai School of Medicine, New York, NY1990 - 1994
Postdoctoral FellowLaboratory of Cell Biology (Günter Blobel, Lab Head), Rockefeller University, New York, NY1987 - 1990