HorngHChenMD

Cardiology • Rochester, MN

Echocardiography, Heart Failure & Transplantation

Professor, Internal Medicine, Mayo Medical School

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Office
200 1st St Sw
Rochester, MN 55905
Phone+1 507-284-2511

Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Cardiovascular Disease, 1997 - 2000
Mayo Clinic College of Medicine and Science (Rochester)Residency, Internal Medicine, 1994 - 1997
Royal College of Surgeons IrelandClass of 1993

Certifications & Licensure

IA State Medical License 2014 - 2026
MN State Medical License 1996 - 2025
WI State Medical License 2014 - 2025
American Board of Internal Medicine Advanced Heart Failure and Transplant Cardiology
American Board of Internal Medicine Cardiovascular Disease
National Board of EchocardiographyComprehensive TTE and TEE echocardiography

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 2012
Fellow (FACC) American College of Cardiology

Clinical Trials

Cardiac Hormone Replacement With Brain Natriuretic Peptide (BNP) in Heart Failure Start of enrollment: 2000 Jan 01
Completed
Phase 1, Phase 2
BNP (Nesiritide) vs. Placebo to Protect Kidney Function in Patients Undergoing Heart Bypass Surgery. Start of enrollment: 2003 Mar 01
Completed
Phase 1, Phase 2
BELIEVE Study: Nesiritide and Post Myocardial Infarction Left Ventricular Modeling Start of enrollment: 2002 Aug 01
Terminated
Phase 1
Use of Nesiritide (BNP) in Kidney Function in Patients With Congestive Heart Failure (CHF) and Kidney Failure Start of enrollment: 2005 Dec 01
Terminated
Phase 1, Phase 2
Natriuretic Peptide System as Therapy in Human Preclinical Left Ventricle Dysfunction Start of enrollment: 2006 Feb 01
Completed
Phase 1, Phase 2
Human Brain Natriuretic Peptide (BNP) (or Nesiritide) to Help Heart, Kidney and Humoral Function. Start of enrollment: 2008 Mar 01
Completed
Phase 1, Phase 2
Human B-type Natriuretic Peptide (BNP) (Nesiritide) to Help Heart, Kidney, and Hormonal Functions in Persons With Lower Heart Pumping Function Start of enrollment: 2006 Jun 01
Completed
Phase 1, Phase 2
Nesiritide Therapy to Preserve Function of the Left Ventricle After Myocardial Infarction Start of enrollment: 2006 Sep 01
Completed
Phase 2
Study of Low Dose Nesiritide With or Without Sildenafil in Congestive Heart Failure Patients With Renal Dysfunction Start of enrollment: 2009 Feb 01
Terminated
Phase 1
The Effects of Decreasing the Lasix Dose on the Cardiorenal System Start of enrollment: 2009 Jul 01
Completed
Phase 1, Phase 2
Tadalafil and Nesiritide as Therapy in Pre-clinical Heart Failure Start of enrollment: 2012 Feb 01
Completed
Phase 1, Phase 2
CR Aim #2 - AT1 Receptor Blockade & ACE Inhibition Effect on Humoral Function Start of enrollment: 2012 Feb 01
Completed
Phase 1, Phase 2
Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Systolic Cardiomyopathy (Aim2) Start of enrollment: 2014 Jan 09
Completed
Phase 1, Phase 2
Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Diastolic Cardiomyopathy (Aim3) Start of enrollment: 2014 Mar 01
Completed
Phase 1, Phase 2
PDD in Type 2 Diabetes W/wo Diastolic Dysfunction Start of enrollment: 2018 May 01
COMPLETED
PHASE2
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Publications & Presentations

PubMed

Baseline NT-proBNP nonresponse score and health status measures in assessing treatment responses in heart failure with reduced ejection fraction.
Thanat Chaikijurajai, Horng H Chen, W H Wilson Tang
American Heart Journal. 2025-05-01
1 citations
Natriuretic peptide levels and predicting risk of developing new diabetes mellitus and metabolic syndrome.
Jasraj Singh, Fadi W Adel, Christopher G Scott, Horng H Chen
Diabetes, Obesity & Metabolism. 2025-02-01
Association of Impaired Relaxation Mitral Inflow Pattern (Grade 1 Diastolic Function) With Long-Term Noncardiovascular and Cardiovascular Mortality.
Kathleen A Young, Richard J Rodeheffer, Jared G Bird, William R Miranda, Horng H Chen
Journal of the American Society of Echocardiography. 2025-01-15

Journal Articles

Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients with Heart Failure with Preserved Ejection Fraction
Gregory D Lewis, David J Whellan, Martin M LeWinter, Margaret M Redfield, Andrew L Smith, Eugene Braunwald, Michael M Givertz, Adrian F Hernandez, Sanjiv J Shah, Horng..., JAMA

Other

Natriuretic peptide measurement in heart failure
Chen HH, Colucci WS
http://www.uptodate.com/contents/natriuretic-peptide-measurement-in-heart-failure
UpToDate, Wolters Kluwer Health - 2012-04-20
Natriuretic peptide measurement in non-heart failure settings
Chen HH, Colucci WS
http://www.uptodate.com/contents/natriuretic-peptide-measurement-in-non-heart-failure-settings
UpToDate, Wolters Kluwer Health - 2013-01-28

Press Mentions

Diabetes an Independent Risk Factor for Heart FailureJanuary 3rd, 2020
Diabetes Is an Independent Risk Factor for Development of Heart Failure, Study ShowsJanuary 2nd, 2020
Diabetes Is an Independent Predictor for Heart Failure - Docwire NewsJanuary 2nd, 2020
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Grant Support

Human Cardiorenal SyndromeMAYO CLINIC ROCHESTER2009–2027
Cardiovascular Peptides And Myocardial InfarctionNational Heart, Lung, And Blood Institute2012
Protein Therapeutics To Prevent Heart Failure Post Myocardial InfarctionNational Heart, Lung, And Blood Institute2010–2011
Natriuretic Peptide System As Therapy In Human Preclinical LV DysfunctionNational Heart, Lung, And Blood Institute2007–2009
ANP As Therapy In Human Preclinical LV DysfunctionNational Heart, Lung, And Blood Institute2005–2006
Cardiac Hormone Replacement With SQ BNP: A Novel Therapeutic StrategyNational Center For Research Resources2005
Cardiac Hormone Replacement--Bnp, Novel Therapy For CHFNational Center For Research Resources2004
Angiotensin II Regulation Of Renal Function In Patients W/ Mild CHF On DiureticsNational Center For Research Resources1999