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Publications & Presentations
PubMed
- 178 citationsChemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.Wen Shen, Cheryl L De Hoyos, Michael T. Migawa, Timothy A. Vickers, Hong Sun
Nature Biotechnology. 2019-04-29 - 54 citationsAcute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS p...Wen Shen, Cheryl L De Hoyos, Hong Sun, Timothy A. Vickers, Xue-hai Liang
Nucleic Acids Research. 2018-03-16 - 54 citationsCellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides.Shiyu Wang, Nickolas Allen, Timothy A. Vickers, Alexey S. Revenko, Hong Sun
Nucleic Acids Research. 2018-04-20
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