HerbertLyerlyMDFACS

PubMed

• 794 citations
  A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer
  Michael A. Morse, Jennifer Garst, Takuya Osada, Shubi Khan, Amy Hobeika
  Journal of Translational Medicine. 2005-02-21
• 79 citations
  CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis
  Li-Chung Tsao, Erika J. Crosby, Timothy N. Trotter, Pankaj K. Agarwal, Bin-Jin Hwang
  JCI Insight. 2019-12-19
• 92 citations
  White paper on microbial anti-cancer therapy and prevention.
  Neil S. Forbes, Robert Coffin, Liang Deng, Laura Evgin, Steve Fiering
  Journal for Immunotherapy of Cancer. 2018-08-06

Journal Articles

• Improved Tumor Targeting of Anti-HER2 Nanobody Through N-Succinimidyl 4-Guanidinomethyl-3-Iodobenzoate Radiolabeling  
  Pruszynski M, Koumarianou E, Vaidyanathan G, Revets H, Devoogdt N, Lahoutte T, Lyerly HK, Zalutsky MR, J Nucl Med, 4/1/2014
• Modulation of Immune System Inhibitory Checkpoints in Colorectal Cancer  
  Sandip P. Patel, Takuya Osada, Koya Osada, Herbert Hurwitz, H. Kim Lyerly & Michael A. Morse, Curr Colorectal Cancer Rep, 8/13/2013
• A Randomized Phase II Study of Immunization With Dendritic Cells Modified With Poxvectors Encoding CEA and MUC1 Compared With the Same Poxvectors Plus GM-CSF for Resec...  
  Morse MA, Niedzwiecki D, Marshall JL, Garrett C, Chang DZ, Aklilu M, Crocenzi TS, Cole DJ, Dessureault S, Hobeika AC, Osada T, Onaitis M, Clary BM, Hsu D, Devi GR, Bul..., Ann Surg, 5/1/2013
• Elevated level of peripheral CD8+CD28 - T lymphocytes are an independent predictor of progression-free survival in patients with metastatic breast cancer during the co...  
  Song G, Wang X, Jia J, Yuan Y, Wan F, Zhou X, Yang H, Ren J, Gu J, Lyerly HK, Cancer Immunol Immunother, 4/21/2013
• Constitutive Internalization of the Leucine-rich G protein-coupled Receptor-5 (LGR5) to the trans-Golgi Network  
  Snyder JC, Rochelle LK, Lyerly HK, Caron MG, Barak LS, J Biol Chem, 4/1/2013
• Specific Genetic polymorphisms of IL10-592 AA and IL10-819 TT genotype lead key role for inducing docetaxel-induced liver injury in breast cancer patients  
  Cao B, Jia J, Ma L, Di L, Song G, Yuan Y, Ma B, Zhu Y, Yu J, Wang X, Zhou X, Lyerly HK, Ren J, Clin Transl Oncol, 11/1/2012
• Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling  
  Wang J, Mook RA Jr, Lu J, Gooden DM, Ribeiro A, Guo A, Barak LS, Lyerly HK, Chen W, Bioorg Med Chem, 11/1/2012
• Recombinant human endostatin could eliminate the pro-angiogenesis priority of SP cells sorted from non-small cell lung cancer cells  
  Cao B, Jia J, Ma L, Di L, Song G, Yuan Y, Ma B, Zhu Y, Yu J, Wang X, Zhou X, Lyerly HK, Ren J, Clin Transl Oncol, 8/1/2012
• Novel recombinant alphaviral and adenoviral vectors for cancer immunotherapy  
  Osada T, Morse MA, Hobeika A, Lyerly HK, Semin Oncol, 6/1/2012
• Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer  
  Cheng Q, Chang JT, Geradts J, Neckers LM, Haystead T, Spector N, Lyerly HK, Breast Cancer Res, 4/1/2012
• Phase I clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibtion  
  Hamilton E, Blackwell K, Hobeika AC, Clay TM, Broadwater G, Ren XR, Chen W, Castro H, Lehmann F, Spector N, Wei J, Osada T, Lyerly HK, Morse MA, J Transl Med, 2/1/2012
• MHC class I-presented lung cancer-associated tumor antigens identified by immunoproteomics analysis are targets for cancer-specific T cell response  
  Shetty V, Sinnathamby G, Nickens Z, Shah P, Hafner J, Mariello L, Kamal S, Vlahovic' G, Lyerly HK, Morse MA, Philip R, J Proteomics, 5/1/2011
• HER2 overexpression elicits a pro-inflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis  
  Zachary C. Hartman, Xiao-Yi Yang, Oliver Glass, Gangjun Lei, Takuya Osada, Sandeep Dave, Michael Morse, Timothy M. Clay, H. Kim Lyerly, Cancer Res, 4/25/2011
• Polyclonal immune responses to antigens associated with cancer signaling pathways and new strategies to enhance cancer vaccines  
  Clay TM, Osada T, Hartman ZC, Hobeika A, Devi G, Morse MA, Kim Lyerly H, Immunol Res, 4/1/2011
• CSPG4 as a new target for antibody – based immunotherapy of triple negative breast cancer  
  Wang X, Osada T, Wang Y, Yu L, Sakakura K, Katayama A, McCarthy JB, Brufsky A, Chivukula M, Khoury T, Hsu DS, Barry WT, Lyerly HK, Clay TM, Ferrone S, J Natl Cancer Inst, 10/1/2010
• Immune signatures predict prognosis in localized cancer  
  Hsu DS, Kim MK, Balakumaran BS, Acharya CR, Anders CK, Clay T, Lyerly HK, Drake CG, Morse MA, Febbo PG, Cancer Invest, 8/1/2010
• Identification of select glucocorticoids as Smoothened agonists: Potential utility for regenerative medicine  
  Wang J, Lu J, Bond MC, Chen M, Ren XR, Lyerly HK, Barak LS, Chen W, Proc Natl Acad Sci U S A, 5/3/2010
• Anti-tumor immunotherapy despite immunity to adenovirus using a novel adenoviral vector Ad5 [E1-, E2b-]-CEA  
  Gabitzsch ES, Xu Y, Balint JP Jr, Hartman ZC, Lyerly HK, Jones FR, Cancer Immunol Immunother, 4/2/2010
• An adenoviral vaccine encoding full-length inactivated human HER2 exhibits potent immunogenicity and enhanced therapeutic efficacy without oncogenicity  
  Hartman Z, Osada T, Hobeika AC, Morse MA, Amalfitano A, Lyerly HK, Clay TM, Clin Cancer Res, 3/1/2010
• The Anti-Helminthic Niclosamide Inhibits Wnt/Frizzled1 Signaling  
  Chen M, Wang J, Lu J, Bond MC, Ren XR, Lyerly HK, Barak LS, Chen W, Biochemistry, 9/22/2009
• Use of tablet personal computers for sensitive patient-reported information  
  Dupont A, Wheeler J, Herndon JE 2nd, Coan A, Zafar SY, Hood L, Patwardhan M, Shaw HS, Lyerly HK, Abernethy AP, J Support Oncol, 5/1/2009
• Induction of Wilms' tumor protein (WT1)-specific antitumor immunity using a truncated WT1-expressing adenovirus vaccine  
  Osada T, Woo CY, McKinney M, Yang XY, Lei G, Labreche HG, Hartman ZC, Niedzwiecki D, Chao N, Amalfitano A, Morse MA, Lyerly HK, Clay TM, Clin Cancer Res, 4/1/2009
• The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients  
  Osada T, Chong G, Tansik R, Hong T, Spector N, Kumar R, Hurwitz HI, Dev I, Nixon AB, Lyerly HK, Clay T, Morse MA, Cancer Immunol Immunother, 8/1/2008
• Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines  
  Morse MA, Hobeika AC, Osada T, Serra D, Niedzwiecki D, Lyerly HK, Clay TM, Blood, 8/1/2008
• Current immunotherapeutic strategies in colon cancer  
  Morse M, Langer L, Starodub A, Hobeika A, Clay T, Lyerly HK, Surg Oncol Clin N Am, 10/1/2007
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Books/Book Chapters

• Cancer Vaccines 
  Lyerly HKEditors: Morse MM, Lyerly HK, Clay TA.Human Press2004
• Primary and Secondary Liver Tumors: Current and Emerging Therapies 
  Lyerly HKEditors: Clavien PA, Fong Y, Lyerly HK, Morse MM, Venook A, Crawford J.Blackwell Science, Inc., Malden, MAEdition 2nd,2004
• Pocket Surgery 
  Lyerly HKEditors: Mosca PJ, Clark LA, Pappas TN, Lyerly HK.Wilkins Publishers2002
• Surgical Research 
  Lyerly HKEditors: Souba WW and Willmore DW.Academic Press, San Diego2001
• Surgical Oncology: Contemporary Principles and Practice 
  Chapter: Overview of Clinical Oncology, Gene Therapy of Cancer 
  Morse MM, Clary BM, Lyerly HKEditors: Bland KI, Daly JM, and Karakousis CP.McGraw-Hill, New York2001
• Primary and Secondary Liver Tumors: Current and Emerging Therapies 
  Lyerly HKEditors: Clavien PA, Fong Y, Lyerly HK, Morse MM, Venook A, Crawford J.Blackwell Science, Inc., Malden, MA1999
• Primary and Secondary Liver Tumors: Current and Emerging Therapies 
  Chapter: Prodrug Converting Enzyme Therapy For Hepatic Tumors 
  Clary BM, Lyerly HKEditors: Clavien PA, Fong Y, Lyerly HK, Morse MM, Venook A, Crawford J.Blackwell Science, Inc., Malden, MA1999
• Primary and Secondary Liver Tumors: Current and Emerging Therapies 
  Chapter: Overview: Molecular, Genetic, Immunology and Neovascularization of Liver Tumors 
  Morse MM, Lyerly HKEditors: Clavien PA, Fong Y, Lyerly HK, Morse MM, Venook A, Crawford J.Blackwell Science, Inc., Malden, MA1999
• Textbook of Surgery Pocket Companion 
  Chapter: The Thyroid Gland: Thyroiditis 
  Lyerly HKEditors: Sabiston DC Jr and Lyerly HK.W.B. Saunders Co, Philadelphia1997
• Textbook of Surgery: The Biological Basis of Modern Surgical Practice 
  Chapter: Molecular Biology in Surgery 
  Lyerly, HK, Sullenger BAEditors: Sabiston DC Jr.W.B. Saunders Co, PhiladelphiaEdition 15th,1997
• Textbook of Surgery: The Biological Basis of Modern Surgical Practice 
  Chapter: Immunology and Immunotherapy of Neoplastic Disease 
  Lyerly HK, Gelber CEditors: Sabiston DC Jr.W.B. Saunders Co, PhiladelphiaEdition 15th,1997
• Textbook of Surgery: The Biological Basis of Modern Surgical Practice 
  Chapter: Meckel's Diverticulum 
  Clary BM, Lyerly HKEditors: Sabiston DC Jr.W.B. Saunders Co, PhiladelphiaEdition 15th,1997
• Textbook of Surgery: The Biological Basis of Modern Surgical Practice 
  Chapter: Carcinoma of the Colon and Rectum 
  Lyerly HKEditors: Sabiston DC Jr.W.B. Saunders Co, PhiladelphiaEdition 15th,1997
• Textbook of Surgery Pocket Companion 
  Chapter: Molecular Biology in Surgery 
  Lyerly, HK, Sullenger BAEditors: Sabiston DC Jr and Lyerly HK.W.B. Saunders Co, Philadelphia1997
• Textbook of Surgery Pocket Companion 
  Chapter: Immunology and Immunotherapy of Neoplastic Disease 
  Lyerly HK, Gelber CEditors: Sabiston DC Jr and Lyerly HK.W.B. Saunders Co, Philadelphia1997
• Textbook of Surgery Pocket Companion 
  Chapter: Meckel's Diverticulum 
  Clary BM, Lyerly HKEditors: Sabiston DC Jr and Lyerly HK.W.B. Saunders Co, Philadelphia1997
• Textbook of Surgery Pocket Companion 
  Chapter: Carcinoma of the Colon and Rectum 
  Lyerly HKEditors: Sabiston DC Jr and Lyerly HK.W.B. Saunders Co, Philadelphia1997
• Textbook of Surgery Pocket Companion 
  Lyerly HKEditors: Sabiston DC Jr and Lyerly HK.W.B. Saunders Co, Philadelphia1997
• Current Practice of Surgery 
  Chapter: Oncogenes in the Clinical Practice of Surgery 
  Clary BM, Winer E, Lyerly HKEditors: Warshaw A.Churchill Livingstone1995
• Essentials of Surgery 
  Chapter: Surgical Aspects of the Acquired Immunodeficiency Syndrome 
  DiMaio JM, Lyerly HKEditors: Sabiston DC Jr and Lyerly HK.W.B. Saunders Co, PhiladelphiaEdition 2nd,1994
• Oxford Textbook of Surgery 
  Chapter: Deep Vein Thrombosis and Pulmonary Embolism 
  Lyerly, HK, Sabiston, DCEditors: Morris PJ and Malt RA.Oxford University Press, New YorkEdition 1st,1994
• Biologic Therapy of Cancer Updates 
  Chapter: Specific Active Immunotherapy With Cytokine Gene Modified Tumor 
  Gilboa, E, Lyerly, HKJ.B. Lippincott Company, Philadelphia1994
• Essentials of Surgery 
  Chapter: The Colon and Rectum 
  Lyerly HK, Clary BMEditors: Sabiston DC Jr and Lyerly HK.W.B. Saunders Co, PhiladelphiaEdition 2nd,1994
• Essentials of Surgery 
  Chapter: The Breast 
  Lyerly HKEditors: Sabiston DC Jr and Lyerly HK.W.B. Saunders Co, PhiladelphiaEdition 2nd,1994
• Essentials of Surgery 
  Chapter: Tumor Markers 
  Lyerly HKEditors: Sabiston DC Jr and Lyerly HK.W.B. Saunders Co, PhiladelphiaEdition 2nd,1994
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Abstracts/Posters

• Increased disease-free survival following adoptive transfer of tumor-specific T lymphocytes to mice with breast cancer
  Coveney E, Clary BM, Philip R, Lyerly HK, 82nd Clinical Congress of the American College of Surgeons, 10/1/1996
• Active immunotherapy of pancreatic cancer with IFN and IL2 secreting tumor cell vaccinations
  Clary BM, Coveney EC, Blazer DG III, Philip R, Gilboa E, Lyerly HK, The North Carolina Chapter of the American College of Surgeons, Resident’s Forum, 7/1/1996
• Generation of IL-2 gene transduced breast cancer cells for use in active specific immunotherapy
  Clary BM, Philip R, Coveney EC, Philip M, Gilboa E, and Lyerly HK, 18th Annual Breast Cancer Symposium, 12/1/1995
• Interleukin-7 enhances the generation of human cytotoxic T lymphocytes against Epstein-Barr Virus Transformed Cell Lines; Implications for Adoptive Immunotherapy
  Coveney E, Clary B, Iacobucci M, Philip R, Gilboa E., Lyerly HK, 81st Clinical Congress of the American College of Surgeons, 10/25/1995
• Gene Modification of Primary Tumor Cells for Active Immunotherapy of Human Breast and Ovarian Cancer
  Philip R, Clary B, Brunette E, Kilinski L, Murugesh D, Sorich M, Lebkowski J, Lyerly HK, Philip M, Biological Therapy of Cancer, 4/1/1995
• High level cytokine expression in irradiated primary human melanoma tumor cells following adeno-associated virus plasmid: cationic liposome-mediated gene transfer
  Clary BM, Coveney EC, Philip R, Blazer DG III, Seigler H, Gilboa E, Lyerly HK, The Society of University Surgeons, 37th Annual Surgical Residents’ Conference, 2/1/1995
• CD83 is a marker for mature dendritic cells (DC) generated from peripheral blood mononuclear cells (PBMC)
  Morse, MA, LJ Zhou, TF Tedder, HK Lyerly, and C Smith, Blood, 1/1/1995
• Inhibition of established pancreatic cancers following vaccination with interleukin-2 gene transduced tumor cells
  Clary BM, Coveney EC, Philip R, Blazer DG III, Morse M, Gilboa E, Lyerly HK, Association for Academic Surgery Annual Meeting, 1/1/1995
• Anti-Melanoma Cytotoxic T Lymphocytes Maintain Their Function and Phenotype Following Transformation With Herpesvirus Saimiri
  DiMaio JM, Clary BM, Coveney EC, Darrow T, Seigler H, Lyerly HK, Association for Academic Surgery, 11/1/1994
• Inhibition of Breast Cancer Metastasis by Cytokine Gene-Modified Tumor Vaccination in Tumor-Bearing Mice
  Coveney EC, Clary BM, DiMaio JM, Vieweg J, Gilboa E, Lyerly HK, American College of Surgeons 80th Annual Clinical Congress, 10/1/1994
• Gene Modification of Primary Tumor and Effector T Cells Using Adeno-Associated Viral Plasmid DNA: Liposome Complexes for Human Cancer Gene Therapy
  Philip R, Philip M, Kilinski L, Brunette E, Murugesh D, Clary B, Lyerly HK, Lebkowski J, Cold Spring Harbor Laboratory Meeting on Gene Therapy, 9/21/1994
• Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo
  DiMaio JM, Via DF, Berend KR, Jordan PB, Isenberg AV, Clary BM, Lyerly HK, The Society of University Surgeons, 55th Annual Meeting, 2/1/1994
• Interleukin-6 expression is not regulated by HIV-1 protein Tat
  Chen H, Boyle TJ, Lyerly HK, Proceedings of the 8th International Conference on AIDS, 1/1/1992
• Transdominant Rev protein inhibits HIV replication without affecting T-cell function
  Malim MH, Freimuth WW, Liu J, Boyle TJ, Lyerly HK, Cullen BR, Nabel GJ, Annual Meeting of the American Federation for Clinical Research, 1/1/1992
• Biologic Containment of HIV-1: a Tat and Rev deficient virus
  Chen H, Malim MH, Boyle TJ, Berend KR, Cullen BR, Lyerly HK, Keystone Symposium: Prevention and Treatment of AIDS, 1/1/1992
• Interleukin-6 levels are elevated in SCID mice developing human B-cell lymphoma
  Boyle TJ, Coles RE, Kizilbash AM, Lyerly HK, Annual Meeting of the Society of Surgical Oncology, 1/1/1992
• Human B-cell lymphoma in SCID mice following active infection with EBV
  Boyle TJ, Tamburini M, Berend K, Kizilbash AM, Lyerly, HK, 53d Annual Meeting of the Society of University Surgeons, 1/1/1992
• ACTG augmentation of non-MHC restricted cellular cytotoxicities in patients receiving Zidovudine plus Interleukin-2
  Weinhold KJ, Tyler DS, Austin AA, Lyerly HK, Bolognesi DP, Bartlett JA, Proceedings of the 5th International Conference on AIDS, 1/1/1989
• Analysis of the immune response in a laboratory worker infected with the HTLV-IIIB strain of HIV
  Matthews TJ, Langlois AJ, Weinhold KJ, Skinner MA, Lyerly HK, Blattner WA, Bolognesi DP, Fourth International Conference on AIDS, 6/12/1988
• Ontogeny and specificity of ADCC following HIV-1 infection
  Lyerly HK, Redfield R, Arthur L, Matthews TJ, Blattner W, Tyler DS, Bolognesi DP, Weinhold KJ, Fourth International Conference on AIDS, 6/12/1988
• HIV specific killer cells armed in situ with cytophilic antibodies
  Tyler DS, Nastala CL, Lyerly HK, Stanley SD, Matthews TJ, Bolognesi DP, Weinhold KJ, Fourth International Conference on AIDS, 6/12/1988
• Non-MHC restricted cellular anti-HIV cytotoxicity: a manifestation of direct ADCC: retroviruses of human AIDS and related diseases
  Weinhold KJ, Tyler DS, Lyerly HK, Foundation Macel Merieux, 1/1/1988
• Combined Zidovudine plus Interleukin-2 therapy of asymptomatic HIV-1 seropositive patients. development of cytokines for the treatment of AIDS
  Weinhold KJ, Bartlett JA, Lyerly HK, Tyler DS, Depamphilis J, Lehrman S, Bolognesi DP, Joint Meeting of the National Institute of Allergy and Infectious Diseases, National Cancer Institute and National Institute of Environmental Health Sciences, 1/1/1988
• Cytophilic anti-HIV antibodies: The role of anti-GP120 arming antibodies in therapeutic and vaccine strategies
  Tyler DS, Nastala CL, Lyerly HK, Matthews TJ, Bolognesi DP, Weinhold KJ, Modern Approaches to New Vaccines, 1/1/1988
• Type specific binding of surface expressed GP120 by anti-GP120 serum
  Lyerly HK, Weinhold KJ, Matthews TJ, Putney S, Rusche J, Langlois AJ, Bolognesi DP, J Cellular Biochem, 1/1/1987
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