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10 Center DrBldg 10 RM 53750 Msc1456 NihBethesda, MD 20892
Phone+1 301-480-6916
Fax+1 301-402-0789
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Education & Training
University of Pennsylvania Health SystemResidency, Internal Medicine, 1972 - 1974
Yale School of MedicineClass of 1972
Certifications & Licensure
MD State Medical License 1986 - 2025
PA State Medical License 1973 - 1976
American Board of Internal Medicine Internal Medicine
Awards, Honors, & Recognition
- Elected Member The American Society for Clinical Investigation, 1988
Clinical Trials
- Recruitment and Apheresis Collection of Peripheral Blood Hematopoietic Stem Cells, Mononuclear Cells and Granulocytes Start of enrollment: 1994 Feb 27
- Evaluation of Patients With Immune Function Abnormalities Start of enrollment: 2005 Sep 19
- Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995 Start of enrollment: 2014 Jun 01
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Publications & Presentations
PubMed
- 1 citationsOutcomes in hematopoetic cell transplantation in the setting of mold infections in patients with chronic granulomatous disease.Ahnika Kline, Mark Parta, Jennifer Cuellar-Rodriguez, Juan Gea-Banacloche, Corin Kelly
Bone Marrow Transplantation. 2025-02-01 - High symptom burden in female X-linked chronic granulomatous disease carriers.Mary Ann Miranda, Athanasios Tsalatsanis, Jessica R Trotter, Danielle E Arnold, Jacqueline D Squire
Clinical Immunology. 2024-11-01 - High-fidelity PAMless base editing of hematopoietic stem cells to treat chronic granulomatous disease.Vera Bzhilyanskaya, Linyuan Ma, Siyuan Liu, Lauren R Fox, Madelynn N Whittaker
Science Translational Medicine. 2024-10-16
Journal Articles
- A Novel Method for Screening Adenosine Receptor Specific Agonists for Use in Adenosine Drug DevelopmentHarry Malech, MD, Nature
Abstracts/Posters
- Preclinical Evaluation for Engraftment of Gene-Edited CD34+ Cells with a Sickle Cell Disease Mutation in a Rhesus Transplantation ModelHarry L. Malech, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
- Lentiviral Gene Therapy with Low Dose Busulfan for Infants with X-SCID Results in the Development of a Functional Normal Immune System: Interim Results of an Ongoing P...Harry L. Malech, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
- Enhanced Transduction Lentivector Gene Therapy for Treatment of Older Patients with X-Linked Severe Combined ImmunodeficiencyHarry L. Malech, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
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Press Mentions
Waning Treatment for Immune Deficiency Is a Warning for All ‘One-and-Done’ TherapiesDecember 19th, 2019
SIRION Biotech Licenses Technology to National Institute of Allergy and Infectious Diseases to Boost Clinical Efficacy of Lentivector Gene Therapy for X-linked SCIDJune 11th, 2019
Gene Therapy Cures Babies with “Bubble Boy” DiseaseApril 19th, 2019- Join now to see all
Grant Support
- Basic Research On Hematopoietic Human Stem CellsNational Institute Of Allergy And Infectious Diseases2009–2011
- Gene Therapy Basic Research To Treat Inherited Immune DeficienciesNational Institute Of Allergy And Infectious Diseases2007–2008
- Clinical Treatment Of Patients With Chronic Graft Versus Host DiseaseNational Institute Of Allergy And Infectious Diseases2007–2008
- Basic Research On Hematopoietic Adult Human Stem CellsNational Institute Of Allergy And Infectious Diseases2007–2008
- Gene Therapy Clinical Trials For X-Linked Severe Combined ImmunodeficiencyNational Institute Of Allergy And Infectious Diseases2007
- Clinical Diagnostic Studies And Treatment Of Patients With Immune DeficienciesNational Institute Of Allergy And Infectious Diseases2007
- Gene Therapy And Allogeneic Transplantation For Immune DNational Institute Of Allergy And Infectious Diseases2006
- Biology Of Peripheral Blood Progenitors--A Target For GENational Institute Of Allergy And Infectious Diseases2002–2006
- Biology Of Peripheral Blood ProgenitorsNational Institute Of Allergy And Infectious Diseases2005
- Gene Therapy For Immune DeficienciesNational Institute Of Allergy And Infectious Diseases1992–2005
- Peripheral Blood Progenitors--Target For Gene TransferNational Institute Of Allergy And Infectious Diseases2004
- Biology Of Peripheral Blood Progenitors In Gene TransferNational Institute Of Allergy And Infectious Diseases2003
- Peripheral Blood Progenitors--A Target For Gene TransferNational Institute Of Allergy And Infectious Diseases2001
- Biology Of Peripheral Blood Progenitors--A Target For Gene TransferNational Institute Of Allergy And Infectious Diseases1992–2000
- Peripheral Blood Progenitors-Target For Gene TransferNational Institute Of Allergy And Infectious Diseases1998
- Zotatifin treatment of adults with mild to moderate COVID-19NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESPresent
- Gene Therapy and Hematopoietic Stem Cell Research to Treat Inherited Primary Immune DeficienciesNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESPresent
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