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Office
10 Center Dr
Bldg 10 RM 53750 Msc1456 Nih
Bethesda, MD 20892Phone+1 301-480-6916Fax+1 301-402-0789
Education & Training
- University of Pennsylvania Health SystemResidency, Internal Medicine, 1972 - 1974
- Yale School of MedicineClass of 1972
Certifications & Licensure
- MD State Medical License 1986 - 2025
- PA State Medical License 1973 - 1976
- American Board of Internal Medicine Internal Medicine
Awards, Honors, & Recognition
- Elected Member The American Society for Clinical Investigation, 1988
Clinical Trials
- Recruitment and Apheresis Collection of Peripheral Blood Hematopoietic Stem Cells, Mononuclear Cells and Granulocytes Start of enrollment: 1994 Feb 27
- Evaluation of Patients With Immune Function Abnormalities Start of enrollment: 2005 Sep 19
- Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995 Start of enrollment: 2014 Jun 01
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Publications & Presentations
PubMed
- 641 citationsGenetic, biochemical, and clinical features of chronic granulomatous diseaseBrahm H. Segal, Thomas L. Leto, John I. Gallin, Harry L. Malech, Steven M. Holland
Medicine. 2000-05-01 - 33 citationsMutational analysis of patients with p47-phox–deficient chronic granulomatous disease: The significance of recombination events between the p47-phox gene (NCF1) and it...Nancy Vázquez, Thomas Lehrnbecher, Renee Chen, Barbara L. Christensen, John I. Gallin
Experimental Hematology. 2001-02-01 - 44 citationsEnhanced homology-directed repair for highly efficient gene editing in hematopoietic stem/progenitor cells.Suk See De Ravin, Julie Brault, Ronald J. Meis, Siyuan Liu, Linhong Li
Blood. 2021-05-13
Journal Articles
- A Novel Method for Screening Adenosine Receptor Specific Agonists for Use in Adenosine Drug DevelopmentHarry Malech, MD, Nature
Abstracts/Posters
- Preclinical Evaluation for Engraftment of Gene-Edited CD34+ Cells with a Sickle Cell Disease Mutation in a Rhesus Transplantation ModelHarry L. Malech, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
- Lentiviral Gene Therapy with Low Dose Busulfan for Infants with X-SCID Results in the Development of a Functional Normal Immune System: Interim Results of an Ongoing P...Harry L. Malech, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
- Enhanced Transduction Lentivector Gene Therapy for Treatment of Older Patients with X-Linked Severe Combined ImmunodeficiencyHarry L. Malech, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
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Press Mentions
- Waning Treatment for Immune Deficiency Is a Warning for All ‘One-and-Done’ TherapiesDecember 19th, 2019
- SIRION Biotech Licenses Technology to National Institute of Allergy and Infectious Diseases to Boost Clinical Efficacy of Lentivector Gene Therapy for X-linked SCIDJune 11th, 2019
- Gene Therapy Cures Babies with “Bubble Boy” DiseaseApril 19th, 2019
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Grant Support
- Gene Therapy Basic Research To Treat Inherited Primary Immune DeficienciesNational Institute Of Allergy And Infectious Diseases2009–2011
- Basic Research On Hematopoietic Human Stem CellsNational Institute Of Allergy And Infectious Diseases2009–2011
- Gene Therapy Basic Research To Treat Inherited Immune DeficienciesNational Institute Of Allergy And Infectious Diseases2007–2008
- Clinical Treatment Of Patients With Chronic Graft Versus Host DiseaseNational Institute Of Allergy And Infectious Diseases2007–2008
- Basic Research On Hematopoietic Adult Human Stem CellsNational Institute Of Allergy And Infectious Diseases2007–2008
- Gene Therapy Clinical Trials For X-Linked Severe Combined ImmunodeficiencyNational Institute Of Allergy And Infectious Diseases2007
- Clinical Diagnostic Studies And Treatment Of Patients With Immune DeficienciesNational Institute Of Allergy And Infectious Diseases2007
- Gene Therapy And Allogeneic Transplantation For Immune DNational Institute Of Allergy And Infectious Diseases2006
- Biology Of Peripheral Blood Progenitors--A Target For GENational Institute Of Allergy And Infectious Diseases2002–2006
- Biology Of Peripheral Blood ProgenitorsNational Institute Of Allergy And Infectious Diseases2005
- Gene Therapy For Immune DeficienciesNational Institute Of Allergy And Infectious Diseases1992–2005
- Peripheral Blood Progenitors--Target For Gene TransferNational Institute Of Allergy And Infectious Diseases2004
- Biology Of Peripheral Blood Progenitors In Gene TransferNational Institute Of Allergy And Infectious Diseases2003
- Peripheral Blood Progenitors--A Target For Gene TransferNational Institute Of Allergy And Infectious Diseases2001
- Biology Of Peripheral Blood Progenitors--A Target For Gene TransferNational Institute Of Allergy And Infectious Diseases1992–2000
- Peripheral Blood Progenitors-Target For Gene TransferNational Institute Of Allergy And Infectious Diseases1998
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