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Harold Brem, MD, General Surgery, Newark, NJ

HaroldBremMD

General Surgery • Newark, NJ

Professor of Surgery Rutgers New Jersey Medical School Chief, Division of Wound Healing and Regenerative Medicine Department of Surgery

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  • Office

    201 Lyons Ave
    Newark, NJ 07112
    Phone+1 973-854-4335

Summary

  • Dr. Harold Brem is a board-certified general surgeon with over 27 years of experience specializing in wound healing and regenerative medicine. He currently serves as Professor of Surgery at Rutgers New Jersey Medical School and Chief, Division of Wound Healing & Regenerative Medicine Department of Surgery at Newark Beth Israel Medical Center. Dr. Brem pioneered the field of academic wound healing and clinical research and continues to apply this to his daily practice. Dr. Brem's dedication to treating complex wounds is evident in his comprehensive, patient-centered approach, which combines clinical expertise with ongoing research to improve patient outcomes particularly related to hidradenitis suppurativa, diabetic foot ulcers, vasculitis, osteomyelitis related to wounds, venous ulcers, limb salvage, pressure treatment, and acute care surgery.

    Throughout his career, Dr. Brem has made significant contributions to the field of wound healing including:
    •    Developing the first evidence-based clinical protocols for diabetic foot ulcers, which have been adopted globally.
    •    Identifying genes that impair wound healing, enhancing the understanding of wound pathology.
    •    Pioneering the use of regenerative medicine, such as human fibroblast keratinocytes and stem cells, to treat chronic wounds.
    •    Establishing innovative surgical debridement techniques guided by molecular markers to optimize healing.

Education & Training

  • Ohio State University Hospital
    Ohio State University HospitalResidency, Surgery, 1987 - 1995
  • Harvard Medical School
    Harvard Medical SchoolResearch Fellow in Surgery, Wound Healing Research, 1989 - 1992
  • McGill University Faculty of Medicine
    McGill University Faculty of MedicineClass of 1987

Certifications & Licensure

  • NJ State Medical License
    NJ State Medical License 2017 - 2025
  • NY State Medical License
    NY State Medical License 1995 - 2025
  • American Board of Surgery Surgery

Clinical Trials

Publications & Presentations

PubMed

Grant Support

  • Developing Strategies for Effective Debridement in Patients for Venous Leg UlcersNational Institute of Arthritis and Musculoskeletal and Skin Diseases2019–2023
  • Cellular Mechanism of Healing of Chronic WoundsGemstone Biotherapeutics Inc.2016–2017
  • A Prospective clinical outcome study of the Use of Type 1 Purified Collagen Matrix (Puraply) in the Treatment of Chronic WoundsOrganogenesis2016–2017
  • Clinical Research Center to Decrease Limb Amputation Rate in People with DiabetesNIH, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)2011–2017
  • A randomized, double-blind, multicenter, superiority, placebo-controlled phase 3 study of pexiganan acetate cream 0.8% applied twice daily for 14 days in the treatment of adults with mild infections oDipexium Pharmaceuticals DPX 3062015
  • Evaluate the safety, tolerability and efficacy of cureXcell as an adjunct to good wound care measures in treating lower extremity chronic ulcers in adults w/diabetesMacro Cure/ MC- 102 Core, follow up and open label2013
  • Wound EMR to Decrease Limb Amputations in Persons with DiabetesDepartment of Health and Human Services Agency for Healthcare Research and Quality2010–2013
  • Emotional Stress and Wound Healing in Diabetes (clinical trial)NIH, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)2011–2012
  • Development of the Cellular Biomarker for Diabetic Foot UlcersNIH, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)2009–2012
  • Wound EMR to Decrease Limb Amputations in Persons with DiabetesAHRQ, Agency for Healthcare Research and Quality2010–2011
  • Diabetic Foot and Pressure Ulcer Databank- Admin SupplementNIH, National Library of Medicine (NLM)2009–2010
  • Experimental Model for Pressure Ulcers in Human Skin: The Role of the Extracellular Matrix and AgingNIH, National Institute of Aging (NIA)2008–2010
  • Establishment of a clinical research & translational wound centerHelen and Martin Kimmel Foundation2008–2010
  • Randomized, Double-Blind, Placebo-Controlled, Single- and Double-Dose Comparator Arm (Standard Care), Multi-center Phase 2b Study of Typical GAM501 (Ad5PDGF-B/bovine type I collagen gel) in the TreatmTissue Repair Company2007–2008
  • Epidermal Genes and Their Regulators in Wound HealingNational Institute of Nursing Research (NINR)2003–2008
  • Wounds, Local Angiogenic Therapy for Diabetic UlcersNIH, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)2002–2006
  • Local Sustained Release with the Angiogenic Molecule VEGF to Treat Experimental Diabetic WoundsAmerican Diabetes Association2002–2005
  • Local Angiogenic Gene Therapy with VEGF to Treat Diabetic UlcersNIH, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)2002–2004
  • Pathophysiology and Treatments for Pressure UlcersUnited Spinal Association1998–2004
  • An Open Prospective Clinical Outcome to Measure the Effect of an Alternating Pressure Air Mattress Upon the Closure Rates of Sub-Dermal Pressure UlcersPegasus/ Edgerton Ltd.2000–2002
  • A double-blind, placebo-controlled, parallel group, randomized study evaluating the effect of Regranex (becaplermin) gel versus placebo gel in the treatment of full-thickness pressure ulcersJohnson and Johnson1998–2001
  • A prospective, multicenter, randomized, single-masked, controlled, clinical investigation of Dermagraft in patients with plantar diabetic foot ulcersAdvanced Tissue Sciences1999–2000

Dr. Harold Brem, Dr. Harold Brem, MD, Dr. H Brem