Hadine Joffe MD MSc

Sleep Medicine, Women Focused

Executive Director, Mary Horrigan Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital; Paula A. Johnson Professor of Psychiatry in the field of Women's Health, Harvard Medical School

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55 Fruit StCPZN 185 2296 Massachusetts General HospitalBoston, MA 02114
Phone+1 617-724-5600
Fax+1 617-643-3080

Education & Training

Mass General Brigham/Massachusetts General Hospital/McLean HospitalResidency, Psychiatry, 1994 - 1998
Weill Cornell MedicineClass of 1994

Certifications & Licensure

MA State Medical License 1996 - 2027
American Board of Psychiatry and Neurology Psychiatry

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2014-2018
Thomas B. ClarksonOutstanding Clinical & Basic Science Research Award North American Menopause Society, 2014

Clinical Trials

Venlafaxine With or Without Zolpidem in Treating Hot Flashes and Associated Sleep Disorders in Women With Breast Cancer OR at High Risk for Developing Breast Cancer Start of enrollment: 2004 May 01
Completed
Not Applicable
Estrogen for Treating Depression in Menopausal Women With Hot Flashes and Insomnia Start of enrollment: 2003 Aug 01
Completed
Phase 4
Understanding Experimentally Induced Hot Flushes Start of enrollment: 2005 Nov 28
Completed
Phase 4
Impact of Hot Flashes on Sleep and Mood Disturbance Start of enrollment: 2009 Nov 03
Completed
Phase 4
MsFLASH-03: Comparative Efficacy of Low-Dose Estradiol and Venlafaxine XR for Treatment of Menopausal Symptoms Start of enrollment: 2011 Nov 01
Completed
Not Applicable
Effect of Nuvigil on Fatigue Start of enrollment: 2011 Oct 01
Completed
Phase 4
Gabapentin for Insomnia Symptoms and Nighttime Vasomotor Symptoms (VMS) in Peri- and Postmenopausal Women Start of enrollment: 2014 Jan 01
Completed
Not Applicable
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Publications & Presentations

PubMed

Barriers and solutions in women's health research and clinical care: a call to action.
Judith G Regensteiner, Melissa McNeil, Stephanie S Faubion, C Noel Bairey-Merz, Martha Gulati
Lancet Regional Health. Americas. 2025-04-01
The Relation between Systemic Inflammation and the Menopause Transition: The Study of Women's Health Across the Nation.
Samar R El Khoudary, Xirun Chen, Meiyuzhen Qi, Karen A Matthews, Arun Karlamangla
The Journal of Clinical Endocrinology and Metabolism. 2025-03-24
Sleep Timing, Sleep Timing Regularity, and Cognitive Performance in Women Entering Late Adulthood: The Study of Women's Health Across the Nation (SWAN).
Leslie M Swanson, Michelle M Hood, Rebecca C Thurston, Meryl A Butters, Christopher E Kline
Sleep. 2025-02-16

Press Mentions

Women Are Still Under-Represented in Medical Research. Here’s Where the Gender Gap Is Most PronouncedNovember 1st, 2024
Why Hormone Therapy Is a Lifeline for Some Women During MenopauseSeptember 23rd, 2024
Women Have Been Misled About MenopauseFebruary 1st, 2023
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Grant Support

Using allopregnanolone to probe behavioral and neurobiological mechanisms that underlie depression in women across perimenopausal stageBRIGHAM AND WOMEN'S HOSPITAL2022–2027
Using allopregnanolone to probe behavioral and neurobiological mechanisms that underlie depression in women across perimenopausal stageBRIGHAM AND WOMEN'S HOSPITAL2022–2027
Center for Stress and Neural Regulation of Reproductive Aging Health OutcomesBRIGHAM AND WOMEN'S HOSPITAL2020–2025
Center for Stress and Neural Regulation of Reproductive Aging Health OutcomesBRIGHAM AND WOMEN'S HOSPITAL2020–2025
Center for Stress and Neural Regulation of Reproductive Aging Health OutcomesBRIGHAM AND WOMEN'S HOSPITAL2020–2025
Center for Stress and Neural Regulation of Reproductive Aging Health OutcomesBRIGHAM AND WOMEN'S HOSPITAL2020–2025