H.ScottBaldwinMD

PubMed

• 26 citations
  Tie1 is required for lymphatic valve and collecting vessel development.
  Xianghu Qu, Bin Zhou, H. Scott Baldwin
  Developmental Biology. 2015-03-01
• 112 citations
  The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells.
  Soniya Savant, Silvia La Porta, Annika Budnik, Katrin Busch, Junhao Hu
  Cell Reports. 2015-09-22
• 58 citations
  Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress–specific manner
  Kel Vin Woo, Xianghu Qu, Vladimir R. Babaev, MacRae F. Linton, Raul J. Guzman
  The Journal of Clinical Investigation. 2011-04-01

Journal Articles

• Notch1 mutation leads to valvular calcification through enhanced myofibroblast mechanotransduction  
  Chen J, Ryzhova L, Sewell-Loftin MK, Brown C, Huppert S, Baldwin HS, and Merryman, WD, Arterioscler Thromb Vasc Biol, 1/1/2015
• Tie1 is required for lymphatic valve and collecting vessel development  
  Qu X, Zhou B, and Baldwin HS, Dev Biol, 1/1/2015
• Cranial neural crest deletion of VEGFa causes cleft palate with aberrant vascular and bone development  
  Hill C, Jacobs B, Kennedy L, Rohde S, Zhou B, Baldwin HS, Goudy S, Cell Tissue Res, 1/1/2015
• Nfatc1 directs the endocardial progenitor cells to make heart valve primordium  
  Wu B, Baldwin HS, Zhou B, Trends Cardiovasc Med, 1/10/2013
• Cdc42 promotes host defenses against fatal infection  
  Lee K, Boyd KL, Parekh DV, Kehl-Fie TE, Baldwin HS, Brakebusch C, Skaar EP, Boothby M, Zent R, Infect Immun, 1/1/2013
• Spatial transcriptional profile of the chick and mouse endocardial cushions identify novel regulators of endocardial EMT in vitro  
  Delaughter DM, Christodoulou DC, Robinson JY, Seidman CE, Baldwin HS, Seidman JG, Barnett JV, J Mol Cell Cardiol, 1/1/2013
• Cimetidine-associated patent ductus arteriosus is mediated via a cytochrome P450 mechanism independent of H2 receptor antagonism  
  Cotton RB, Shah LP, Poole SD, Ehinger NJ, Brown N, Shelton EL, Slaughter JC, Baldwin HS, Paria BC, Reese J, J Mol Cell Cardiol, 1/1/2013
• Enhanced Sensitivity for High Spatial Resolution Lipid Analysis by Negative Ion Mode Matrix Assisted Laser Desorption Ionization Imaging Mass Spectrometry  
  Angel PM, Spraggins JM, Baldwin HS, Caprioli R, Anal. Chem., 1/25/2012
• "Nfatc1-positive endocardial progenitors generate coronary vascular endothelial lineages via Vegf-a/Vegfr-2 signaling"  
  Wu B, Zhang Z, Chen X, Sousa V, Miyoshi G, Fishell G, Rossant J, Baldwin HS, Chang CP, Zhou B, Cell, 1/21/2012
• Cranial Neural Crest Ablation of Jagged1 Recapitulates The Craniofacial Phenotype of Alagille Syndrome Patients  
  Humphreys,,R, Zheng, W, Prince, LS, Qu,X, Brown,C, Loome, K.,Huppert, S, Baldwin, HS and Goudy, S, Human Mol. Gen, 1/15/2012
• Endothelial Differentiation by Multipotent Fetal Mouse Lung Mesenchymal Cells  
  Yamamoto Y, Baldwin HS, Prince LS, Stem Cells Dev, 1/10/2012
• Pediatric cardiology: moving into a new era of diagnosis and therapeutic intervention  
  Baldwin HS, Curr. Opin. Pediatr., 1/1/2012
• "A Novel technique for quantifying mouse heart valve leaflet stiffness with atomic force microscopy"  
  Sewell-Loftin MK, Brown CB, Baldwin HS, Merryman WD, Journal of Heart Valve Disease, 1/1/2012
• "Pediatric cardiology: moving into a new era of diagnosis and therapeutic intervention"  
  Baldwin HS, Curr Opin Pediatr, 1/1/2012
• Erg functions as a critical regulator of EMT during cardiac valve morphogenesis  
  Vijayaraj P, Le Bras A, Mitchell N, Kondo M, Juliao S, Wasserman M, Beeler D, Spokes K, Aird WC, Baldwin HS, and Oettgen P, Development, 1/1/2012
• Nfatc1 Coordinates Valve Endocardial Cell Lineage Development Required for Heart Valve Formation  
  Wu B, Wang Y, Lui W, Langworthy M, Tompkins KL, Hatzopoulos AK, Baldwin HS, Zhou B, Circ Res, 1/8/2011
• Networked-based Characterization of Extracellular Matrix Proteins from Adult Mouse Pulmonary and Aortic Valves  
  Peggi M. Angel, David Nusinow, Chris B. Brown, Kate Violette, Joey V. Barnett, Bing Zhang, H. Scott Baldwin, and Richard M. Caprioli, J Proteom Res, 1/4/2011
• Role of Tie1 in shear stress and atherosclerosis  
  Woo KV, Baldwin HS, Trends Cardiovasc Med, 1/1/2011
• Tie1 Attenuation Reduces Atherosclerosis in a Dose Dependent and Shear Stress Specific Manner  
  Woo KV, Qu X, Babaev VR, Linton MF, Guzman RJ, Fazio S, Baldwin HS, JCI, 1/1/2011
• The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications  
  Melotte V, Qu X, Ongenaert M, van Criekinge W, de Bruïne AP, Baldwin HS, van Engeland M, FASEB J, 1/1/2010
• Abnormal embryonic lymphatic vessel development in Tie1 hypomorphic mice  
  Xianghu Qu, Kevin Tompkins, Lorene Batts, Mira Puri, H. Scott Baldwin, Development, 1/1/2010
• Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate  
  Williams C, Kim SH, Ni TT, Mitchell L, Ro HJ, Penn J, Baldwin HS, Solnica-Krezel L, ZhongTao P, Developmental Biology, 1/1/2010
• Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10  
  Menheniott TR, Woodfine K, Schulz R, Wood AJ, Monk D, Giraud AS, Baldwin HS, Moore GE, Oakey RJ, Mol Cell Biol, 1/1/2008
• DSCR1 is a transcriptional target of NFATc1 within the endocardium during heart development  
  Wu H, Kao SC, Barriantos T, Baldwin S, Olson E, Crabtree GR, Zhou, B, Chang CP, J Biol Chem, 1/19/2007
• Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts  
  Song L, Fassler R, Mishina Y, Jiao K, Baldwin HS, Dev Biol, 1/1/2007
• Join now to see all

Books/Book Chapters

• Avery's Diseases of the Newborn 
  Chapter: "Embryology and Physiology of the Cardiovascular System" 
  Page 699 - 713Baldwin, HS and Dees EEditors: Christine A Gleason and Sherin U. Devaskar.Elsevier, PhiladelphiaEdition 9th,2012
• Congenital Heart Defects: From Origin to Treatment 
  Chapter: "Non-Syndromic Conotruncal Anomalies" 
  Page 218 - 260Dees E, Baldwin HS, Bichell D, Doyle T, and Graham TPEditors: Diego Wyszynski, Adolfo Correa-Villasenor and Thomas P. Graham.Oxford University Press, Oxford2010
• Avery's Diseases of the Newborn 
  Chapter: "Embryology and Development of the Cardiovascular System" 
  Page 790 - 801Maschoff KL, Baldwin HSEditors: Taeusch HW, Ballard RA, and Gleason, CA.Elsevier Saunders, PhiladelphiaEdition 8th,2004
• Fetal and Neonatal Physiology 
  Chapter: "Molecular Determinants of Embryonic Vascular Development" 
  Page 621 - 634Baldwin HS, Grindley JEEditors: Polin RA, Fox WW, Abman, SH.Elsevier Saunders, PhiladelphiaEdition 3rd,2004
• Assembly of the Vasculature and its Regulation 
  Chapter: "Role of cell adhesion receptors in vascular development: An overview" 
  Page 97 - 110Robson P, Pichala S, Zhou B, Baldwin HSEditors: Tomanek RJ.SpringerVerlag, NY2002
• Moss and Adams: Heart Disease in Children, Infants and Adolescents 
  Chapter: "Molecular Determinants of Cardiovascular Development" 
  Page 3 - 23Srivastav D, Baldwin HS2001
• Etiology and Morphogenesis of Congenital Heart Disease 
  Chapter: "The Role of NFATc in Semilunar Valve Development" 
  Page 169 - 174Zhou B, Ranger A, Glimcher L, Baldwin HSEditors: Clark,EB; Nakazawa M, Takao A.Futura, Armonk, NY2000
• Methods in Molecular Biology, Vol 135: Developmental Biology Protocols, Vol 1 
  Chapter: "The Application of Adenoviral Vectors in the Study of Mammalian Cardiovascular Development" 
  Page 537 - 543Mickanin C and Baldwin HSEditors: Tuan RS and Lo CW.Humana Press, Totowa, NJ1999
• Fetal and Neonatal Physiology 
  Chapter: "Molecular determinants of vascular development" 
  Page 801 - 813Baldwin HSEditors: Polin RA and Fox WW.Sunders, PhiladelphiaEdition 2nd,1998
• "Genetic Control of Heart Development" 
  Chapter: "Role of cell adhesion receptors in early vascular ontogeny" 
  Page 131 - 140Baldwin HSEditors: EN Olson, RP Harvey, RA Schulz, JA Altman.HFSP, Strasbourg1997
• Cell Adhesion and Human Disease 
  Chapter: Creation and characterization of E-selectin and VCAM-1 deficient mice. 
  Page 17 - 34Kwee, L, Rummberger, J, Burns, DK, Rumbergert, JM, Norton, C, Wolitzky, B, Terry, R, Lombard-Gillooly, KM, Shuster, DJ, Kontgen, F, Stewart, C, McIntyre, K, Baldwin HS...Wiley, Chicester1995
• Phenotypic Mapping of Down's Syndrome and other Aneuploid Conditions 
  Chapter: Molecular and phenotypic analysis of the chromosome 22 microdeletion syndromes. 
  Page 207 - 224Emanuel, BS, Driscoll, D, Goldmuntz, E, Baldwin HS, Biegel, JL, Zackai, EH, McDonald-McGinn, D, Sellinger, B, Gorman, N, Budarf, MLEditors: Epstein, C.J..Wiley Liss, New York, NY1993
• The Merck Manual 
  Chapter: Hemorrhage shock and encephalopathy 
  Baldwin HSEditors: Berkow R.Merck, Sharp and Dohme Research Labs, Rahway, NJ1987
• Basic Mechanisms of Pediatric Respiratory Disease 
  Chapter: "Mechanism of Lung Vascular Development" 
  Page 49 - 67Schachtner SK, Taichman DB, Baldwin HSEditors: Haddad GG, Abman SH, Chernick V.B.C. Decker, Inc., Hamilton, OntarioEdition 2nd,
• Neural Crest Induction and Differentiation 
  Chapter: Neural Crest Contribution to the Cardiovascular System 
  Brown CB, Baldwin HSEditors: Jean-Pierre Sain-Jeannet.Landes Bioscience
• Join now to see all

Abstracts/Posters

• Tie 1 is Required for Semilunar Valve Form and Function.
  Brown CB, Qu X, Violettte K, Sewell MK, Merryman WD, Zhou B, and Baldwin HS, Weinstein Conference, Chicago, IL, 1/4/2012
• Glycerophospholipids and sphingolipids are modulated within the aortic valve substructure and are differentially regulated during normal transitional circulation.
  Angel PM, Bayoumi A, Mettler B, Bichell D, Mayer JE, Baldwin HS, Caprioli RM, Weinstein Cardiovascular Development Conference, 1/1/2012
• "Endocardium: The Ignored Cardiovascular Progenitor."
  Brown CB, Baldwin HS, PCBC, Boston, MA, 1/16/2011
• Modeling Spatial Localization of Novel Molecular Expression in the Juvenile Valve by MALDI Imaging Mass Spectrometry.
  Angel PM, Gottlieb D, Bayoumi, Bern M, Mayer JE, Mettler B, Bichell D, Baldwin HS, Caprioli RM, Weinstein Cardiovascular Development Conference, 1/1/2011
• Immortalized Epicardial Cells lacking Tgfbr3 have Dysregulated Expression of Genes associated with Apoptosis and Proliferation in vitro.
  DeLaughter DL, Angel PM, Hill C, Baldwin HS, Siedman JG, Barnett JV, Weinstein Cardiovascular Development Conference, 1/1/2011
• Glycerophosphocholines and Sphingolipids are Compartmentalized within Ovine and Human Aortic Valve Substructures and are Differentially Regulated during Ovine Transiti...
  Angel PM, Bayoumi A, Bern M, Mayer JE, Mettler B, Bichell D, Baldwin HS, Caprioli RM, outheastern Regional Lipid Conference, 1/1/2011
• Attenuation of endothelial Tie1 reduced shear stress-induced NF-kB signaling.
  Woo KV, Qu X, Babaev V, Linton,MF, Guzman RJ, Fazio S, Baldwin HS, American Physician Scientists Association Southeast Meeting, Atlanta, GA, 1/1/2011
• Integrated Analysis of Semilunar Heart Valve Mechanisms.
  Angel PM, Gottlieb D, Bayoumi A, Bern M, Mayer JE, Rose KL, Baldwin HS, Caprioli RM, Systems-based Consortium for Organ Design and Engineering, 1/1/2011
• Functional Organization of Valvular Subanatomy by Proteomics and MALDI Imaging Mass Spectrometry.
  Angel PM, Nusinow D, Brown C, Violette K, Woo K, DeLaughter D, Tompkins,K, Baldwin, HS, Barnett JV, Caprioli R, 4th Biennial Heart Valve Biology & Tissue Engineering Meeting, Hilton Head, SC, 1/1/2010
• Tie1 attenuation results in a location-specific and shear stress-defined reduction in atherosclerosis.
  Woo KV, Qu X, Babaev V, Linton MF, Guzman RJ, Fazio S, Baldwin HS, American Society of Clinical Investigators / American Physician Scientists Association Combined Conference, Chicago, IL, 1/1/2010
• Tie1 attenuation results in a location-specific and shear stress-defined reduction in atherosclerosis.
  Woo KV, Qu X, Babaev V, Linton MF, Guzman RJ, Fazio S, Baldwin HS, American Federation for Medical Research / Central Society for Clinical Research Combined Conference, Chicago, IL, 1/1/2010
• Tie1attenuation results in a location-specific and shear stress-defined reduction in atherosclerosis.
  Woo KV, Qu X, Babaev V, Linton MF, Guzman RJ, Fazio S, Baldwin HS, 78th European Arteriosclerosis Society Congress, Hamburg, Germany, 1/1/2010
• A Novel Role for Tie1 in Late Gestational Semilunar Valve Remodeling
  Kate Violette, Xianghu Qu, Stan Hoffman, Peggi Angel, Hyunsoo Kim, Bin Zhou, Daniel O'Connell, Richard Maas, and Chris Brown, H. Scott Baldwin, 4th Biennial Heart Valve Biology & Tissue Engineering Meeting, Hilton Head, SC, 1/1/2010
• High Spatial Resolution Definition of Lipids in the Healthy Semilunar Valve Substructure by MALDI Imaging Mass Spectrometry: Implications for Aortic Valve Stenosis.
  Angel, PM, Bayoumi A, Violette K, Tompkins K, Mayer JE, Baldwin HS, Caprioli RM, National Institute of Biomedical Imaging and Bioengineering Training Grantees Meeting, 1/1/2010
• All Gunked Up and No Where to Flow: Profiles of Murine Atherosclerotic Plaques by High Spatial Resolution MALDI Imaging Mass Spectrometry.
  Angel PM, Spraggins J, Woo K, Tompkins K, Baldwin HS, Caprioli R, The 58th Annual Conference of the American Society for Mass Spectrometry on Mass Spectrometry and Allied Topics, 1/1/2010
• Abnormal embryonic lymphatic vessel development in Tie1 mutant mice.
  Qu X, Tompkins K, Batts L, Baldwin, HS, Weinstein Cardiovascular Development Conference, San Francisco, CA, 1/7/2009
• "A role for Tie1 in late gestational semilunar valve remodeling"
  Violette K, Qu X, Zhou B, Tompkins K Baldwin, HS, Weinstein Cardiovascular Development Conference, San Francisco, CA, 1/7/2009
• Tie1 Attenuation Results in a Location-Specific and Shear Stress-Defined Reduction in Atherosclerosis.
  Woo KV, Babaev V, Zjang Y, Linton MF, Fazio S, Baldwin HS, Arteriosclerosis, Thrombosis and Vascular Biology, Washington, DC, 1/1/2009
• Tie1 attenuation results in a location-specific and shear stress-defined reduction in atherosclerosis.
  Woo, KV, Qu X, Babaev V, Linton MF, Guzman RJ, Fazio S, Baldwin HS, Arteriosclerosis, Thrombosis and Vascular Biology Conference, Washington, DC, 1/1/2009
• Attenuation Results in a Location-Specific and Shear Stress-Defined Reduction in Atherosclerosis.
  Woo KV, Babaev V, Zjang Y, Linton MF, Fazio S, Guzman RJ, Baldwin HS, Keystone Symposium, Keystone, CO, 1/1/2009
• Visualization of Mouse Cardiovascular Modeling at Embryonic Day 14 and Adult by High Spatial Resolution MALDI Imaging.
  Angel P, Chaurand P, Violette K, Baldwin HS, Barnett JV, Caprioli R, The 57th Annual Conference of the American Society for Mass Spectrometry on Mass Spectrometry and Allied Topics, 1/1/2009
• Shear Stress Regulation of endothelial Tie1 expression and activation.
  Woo KV, Guzman R, Baldwin HS, 3rd International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease, Rotterdam, The Netherlands, 1/24/2008
• Tracking endocardial differentiation in vivo and in vitro demonstrates the close developmental relationship between cardiovascular components.
  Misfeldt AM, Zhou B, Tompkins KH, Batts L, and Baldwin HS, 4th Annual Stem Cell Research & Therapeutic Conference, Boston, MA, 1/17/2008
• Ndrg4 is required for normal myocyte proliferation during early cardiac development and is downstream of tbx5 activation in zebrafish.
  Qu X, Jia H, Garrity DM, Tompkins K, Batts L, Appel B, Zhong TP, Baldwin HS, Weinstein Cardiovascular Development Conference, Houston, TX, 1/15/2008
• A Role for Tie1: A Receptor Tyrosine Kinase Involved in Cardiac Valve Ontogeny.
  Violette K, Qu X, Hoffrman S Zhou B and Baldwin HS, Weinstein Cardiovascular Development Conference, Houston, TX, 1/15/2008
• Join now to see all

Lectures

• "Cardiac Development: A Delicate Interplay of Form and Function." 
  San Antonio, TX - 1/25/2016
• "Normal and Abnormal Development of the Heart and Great Vessels: Understanding the Problem and Intermpreting the Findings." 
  New Orleans, LA - 1/13/2016
• "Optimal Therapy for Semilunar Valve Disease in Children: Will Developmental Biology Direct Future Strategies?" 
  The Research Institute at Nationwide Children's Hospital, Columbus, OH - 1/27/2015
• "The role of Developmental Biology in the Management of Congenital Heart Disease: Irrelevant or Essential?" 
  Orlando, FL - 1/10/2015
• "Semilunar Valve Disease in Children: A look at current and future therapies." 
  University of Indiana, Indianapolis, IN - 1/2/2015
• "Congenital Semilunar Valve Disease: The evolution of optimal therapies for children." 
  1/15/2014
• "Congenital Semilunar Valve Disease: Will Developmental Biology Direct Future Therapies?" 
  The Heart Institute at Cincinnati Children's Hospital Medical Center, Cincinnati, OH - 1/18/2013
• The Role of Endocardium in Perinatal Valve Development: Lessons learned from tissue specific gene deletion of the Tie1 RTK. 
  Tokyo, Japan - 1/14/2013
• "Semilunar Valve Disease in Children: Current Practice and Hope for the Futrue" 
  Mattel Children's Hospital, UCLA, Los Angeles, CA - 1/13/2013
• "Treatment of Valve Disease: Developmental Biology to the Rescue" 
  Kansas City, MO - 1/8/2013
• "Semilunar Valves are Not Created Equal" 
  Orlando, FL - 1/22/2012
• "Role of the Endocardium in Regulating Cardiac Development" 
  Orlando, FL - 1/22/2012
• "The Role of Non-myocardial cells in Cardiac Function and Repair" 
  Orlando, FL - 1/22/2012
• "Neuregulin: New Insights into molecular mechanisms" 
  Orlando, FL - 1/22/2012
• "Tie1 Regulates Semilunar Valve Form and Function." 
  Taos, NM - 1/22/2012
• "TIE-ing Together Atherosclerosis and Valve Development: The role of the RTK Tie1  in endothelial activation. " 
  Duke University - 1/11/2012
• Integrating MALDI Imaging Mass Spectrometry and Shotgun Proteomics for a Systems Biology Understanding of Congenital Heart Valve Disease. 
  San Diego, CA - 1/1/2012
• "Blood flow, valve formation and atherosclerosis are "Tied" together: the role of endothelial RTK tie1 on development and disease" 
  1/30/2011
• "Development Informs Adult Disease: The role of the endothelial RTK, Tie1, in Valve Development and Atherosclerosis" 
  1/30/2011
• New Design Specifications for Tissue Engineered Semilunar Valves: Unexpected insights from Developmental Biology. 
  Boston, MA - 1/27/2011
• "Blood flow, valve formation and atherosclerosis are "Tied" Together: The role of the endothelial RTK Tie1 in vascular remodeling." 
  Clarksville, TN - 1/16/2011
• "The Role of the Endothelial RTK, Tie1, in Modulating Development and Disease" 
  Furham, MA - 1/15/2011
• "Congenital Heart Disease: New Therapies on the Horizon" 
  Nashville, TN - 1/3/2011
• "Endothelial Response to Flow: A common mechanism directing embryonic valve development and Atherosclerosis." 
  Nashville, TN - 1/3/2011
• "Transcriptional Profile of the Chick and Mouse Endocardial Cushion" 
  Boston, MA - 1/1/2011
• Join now to see all