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Office
Rm 507, Science Building, 435. 30th St
Department of Medicine, NYU SOM
New York, NY 10016Phone+1 212-263-9440
Summary
- Dr. Silverman is Professor of Medicine and Pathology, Associate Director of the Division of Rheumatology, and the Director of the Laboratory of B-cell Immunobiology at the NYU School of Medicine. He is an elected member of AOA, ASCI and the Henry Kunkel Society. After training in Internal Medicine at UCSD, he was a fellow at The Scripps Research Institute in rheumatology and clinical immunology, with a focus on molecular immunology and the structural basis of immune recognition. He has authored over 160 publications and he is on the editorial board of several prestigious journals. Work in his lab is highly translational, with a special interest in B cells and the properties of autoantibodies. and more recently he is studying the contributions of the gut microbiome to autoimmune disease.
Education & Training
- Scripps Clinic/Scripps Green HospitalFellowship, Rheumatology, 1984 - 1987
- University of California (San Diego) Medical CenterResidency, Internal Medicine, 1981 - 1984
- Rutgers Robert Wood Johnson Medical SchoolClass of 1981
- Brandeis UniversityB.A., Biochemistry, Cum laude, 1977
Certifications & Licensure
- CA State Medical License 1983 - Present
- NY State Medical License 2011 - 2026
- American Board of Internal Medicine Internal Medicine
- American Board of Internal Medicine Rheumatology
Awards, Honors, & Recognition
- Henry Kunkel Society
- Clifford M. Clarke Science Award, commendation for scientific accomplishment by a Senior Investigator Arthritis Foundation, 2008
- “50th Anniversary Postdoctoral Fellowship Program Research Hero” – of 1000 recipients of fellowships over 50 years, 50 recipients nationwide were honored for their scientific contributions National Arthritis Foundation, 2001
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Publications & Presentations
PubMed
- 142 citationsAlternative and Classical NF-κB Signaling Retain Autoreactive B Cells in the Splenic Marginal Zone and Result in Lupus-like DiseaseThomas Enzler, Giuseppina Bonizzi, Gregg J. Silverman, Dennis C. Otero, George F. Widhopf
Immunity. 2006-09-01 - 126 citationsConfounding B-cell defences: lessons from a staphylococcal superantigenGregg J. Silverman, Carl S. Goodyear
Nature Reviews. Immunology. 2006-06-01 - 150 citationsDeath by a B Cell Superantigen In Vivo VH-targeted Apoptotic Supraclonal B Cell Deletion by a Staphylococcal ToxinCarl S. Goodyear, Gregg J. Silverman
The Journal of Experimental Medicine. 2003-05-05
Journal Articles
- Review Targeting the Programmed Cell Death-1 Pathway in Rheumatoid ArthritisAdam Mor, Greg J. Silverman, Sabina Sandigursky, ScienceDirect
- Rethinking the red wolf disease: Does Protein S suppress SLE clinical activity?Silverman GJ, Arthritis Res Therapy, 1/1/2010
- Nucleic acid TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupusKono DH, Haraldsson KM, Lawson BR, Pollard KM, Koh Y, Du X, Arnold CN, Baccala R, Silverman GJ, Beutler B, and Theofilopoulos AN, Proc Natl Acad Sci USA, 1/1/2009
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Authored Content
- ACR: The Meeting That Almost Wasn'tNovember 2020
Press Mentions
- FDA Approves Saphnelo, First New Lupus Treatment Since 2011August 2nd, 2021
- Highlights, Pearls & News from ACR Convergence 2020March 15th, 2021
- Five Researchers Combine Expertise to Pursue New Insights in Lupus Risk Factors & FlaresAugust 8th, 2018
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Grant Support
- Lupus And The Inhibitory Dual Receptor HypothesisNational Institute Of Allergy And Infectious Diseases2010–2011
- Lupus And The Inhibitory Dual Receptor HypothesisNational Institute Of Allergy And Infectious Diseases2010
- Cell Death And Antibody-Mediated Protection From AutoimmunityNational Institute Of Allergy And Infectious Diseases2010
- Cell Death And Antibody-Mediated Protection From AutoimmunityNational Institute Of Allergy And Infectious Diseases2006–2010
- Alpha4beta1 Intergrin Signaling In Immunity And ArthritisNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2009
- B Cell Superantigens And Immune RegulationNational Institute Of Allergy And Infectious Diseases1998–2008
- Arthritis Research Conference 2007National Institute Of Arthritis And Musculoskeletal And Skin Diseases2007
- Rheumatic Diseases Core CenterNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2001–2006
- Arthritis Research Conference 2005National Institute Of Arthritis And Musculoskeletal And Skin Diseases2005
- BCR Mediated Apoptotic Death Of Leukemia B CellsNational Cancer Institute2005
- Mechanisms To Induce Protective Natural AutoimmunityNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2003–2004
- Core--Molecular BiologyNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2001–2002
- Engineered B-Cell Superantigens And Immune ToleranceNational Institute Of Allergy And Infectious Diseases2000–2001
- Optimization Of DNA Hardware For Allergen Gene VaccinationNational Institute Of Allergy And Infectious Diseases1997–2001
- Core--Molecular Biology And Protein Purification FacilityNational Institute Of Allergy And Infectious Diseases1997–2001
- Core--Molecular BiologyNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1998–2000
- Engineered B Cell Superantigens And Immune ToleranceNational Institute Of Allergy And Infectious Diseases1999
- Bacterial B-Cell SuperantigensNational Institute Of Allergy And Infectious Diseases1996–1997
- B Cell Superantigens And Human Immune RegulationNational Institute Of Allergy And Infectious Diseases1993–1997
- Variable Region Gene Expression In Human AutoantibodiesNational Institute Of Allergy And Infectious Diseases1990–1992
- Variable Region Gene Expression In Human AutoantibodiesNational Institute Of Allergy And Infectious Diseases1988–1990
Research History
- Associate Director of Basic Sciences, Division of Rheumatology2011 - 2029
Professional Memberships
- Member
- Fellow
- American Society for Clinical InvestigationMember
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