GrantMatthewFischerMD

Anatomic Pathology, Clinical Pathology

Pathology Resident

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I am a physician-scientist currently training in the pathology residency program at Brigham and Women's Hospital. My doctoral research focused on improving our understanding of the features, drivers, and heterogeneity of melanoma brain metastases to improve our ability to treat this deadly disease complication.

Please visit my LinkedIn or ORCID (https://orcid.org/0000-0003-3730-9004) accounts for a full listing of my publications, presentations, experience, and activities.

Brigham and Women's HospitalResidency, Pathology-Anatomic and Clinical, 2020 - 2023
McGovern Medical School at UTHealthClass of 2020, MD, Alpha Omega Alpha (AOA) Honor Medical Society Member
University of Texas MD Anderson Cancer Center / UTHealth Graduate School of Biomedical Sciences (UT-MDACC/UTHealth GSBS)PhD - Michael Davies Lab, Cancer Biology, 2015 - 2019

Alpha Omega Alpha (AOA) Honor Medical Society Member, McGovern Medical School at UTHealth (August 2019)
Presidents’ Research Scholarship ($5,000), UT-MDACC/UTHealth GSBS (August 2019)
Medical Student Travel Award Recipient ($1,200), College of American Pathologists (CAP) (April 2019)
Scholar-In-Training Award Recipient ($500), American Association for Cancer Research (AACR) (December 2018)
Travel Award Recipient ($500), UT-MDACC/UTHealth GSBS (October 2018)
Schissler Foundation Fellowship Recipient, UT-MDACC/UTHealth GSBS (July 2018)
Poster Competition Award Recipient, M.D. Anderson Cancer Center Translational Molecular Pathology Department Retreat (June 2018)
Center for Clinical & Translational Sciences (CCTS) TL1 Program Trainee, UTHealth (December 2016 – June 2018)
Caroline Ross Endowed Fellowship Recipient ($500), M.D. Anderson Cancer Center Brain Tumor Center Research Program (January 2018)
Poster Competition Award Recipient, M.D. Anderson Cancer Center Cancer Biology Program Retreat (October 2017)
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PubMed

Pembrolizumab-induced Stevens-Johnson syndrome-like reaction: An atypical clinical presentation.
Arjun Mahajan, Ryan Chen, Grant M Fischer, Yuqing Xiong, Sepideh Ashrafzadeh
JAAD Case Reports. 2024-12-01
A Comparative Genomic Study of Conventional and Undifferentiated Melanoma.
Grant M Fischer, Navin R Mahadevan, Jason L Hornick, Christopher D M Fletcher, Eleanor Russell-Goldman
Modern Pathology. 2024-12-01
PRAME expression in melanoma is negatively regulated by TET2-mediated DNA hydroxymethylation.
Rui Fang, Tuulia Vallius, Arianna Zhang, Devon Van Cura, Francisco Alicandri
Biorxiv. 2024-07-26

Journal Articles

Molecular and immunological associations of elevated serum lactate dehydrogenase in metastatic melanoma patients: A fresh look at an old biomarker
Fischer GM, Carapeto FCL, Joon AY, Haydu L, Chen H, Wang F, Van Arnam JS, McQuade JL, Wani K, Kirkwood JM, Thompson JF, Tetzlaff MT, Lazar AJ, Tawbi HA, Gershenwald JE..., Cancer Med (Accepted for publication), 2020
Sample matrix interference phenomenon in the headspace-gas chromatography of aldehydes
Fischer GM, Power MD, J Und Chem Res, 2011

Books/Book Chapters

Melanoma
Chapter: Melanoma brain metastasis: insights, progress, challenges, and opportunities
Fischer GM, Davies MAEditors: Fisher DE, Bastian BC.2019

Abstracts/Posters

Preclinical modeling of leptomeningeal disease (LMD) from melanoma to facilitate therapeutic development
Fischer GM, Carapeto FCL, Tetzlaff MT, Hudgens CW, Huse JT, Davies MA, Ferguson SD, 16th International Congress of the Society for Melanoma Research (SMR 2019), Salt Lake City, UT, 11/22/2019
Oxidative phosphorylation (OXPHOS) correlates with clinically significant molecular and immune features in melanoma brain metastases (MBMs)
Fischer GM, Kotrotsou A, Ahmed S, O’Neal P, Sahnoune I, Vashisht Gopal YN, Hudgens CW, Colen R, Tetzlaff MT, Davies MA, 2019 College of American Pathologists Annual Meeting (CAP 2019), Orlando, FL, 9/23/2019
Comprehensive molecular profiling of melanoma brain metastases (MBMs) and patient-matched extracranial metastases (ECMs)
Fischer GM, Jalali A, Joon A, Tetzlaff MT, Lazar AJ, Carapeto F, Petaccia de Macedo M, Hudgens C, McQuade JL, Wani K, Conner B, Singh B, Davies MA, 2018 American Association for Cancer Research Annual Meeting (AACR 2018), Chicago, IL, 4/17/2018
Oxidative phosphorylation: a targetable metabolic strategy utilized by a subset of melanoma brain metastases
Fischer GM, Yennu-Nanda VG, Tetzlaff MT, Hudgens C, Knighton B, Deng W, Davies MA, Translational Science 2017, Washington DC, 4/19/2017
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Lectures

Oxidative phosphorylation (OXPHOS): a feature, driver, and therapeutic target in melanoma brain metastases (MBMs)
15th International Congress of the Society for Melanoma Research (SMR 2018); Manchester, UK - 10/26/2018
Comprehensive molecular profiling of melanoma brain metastases (MBMs) and patient-matched extracranial metastases (ECMs)
2018 Massachusetts General Hospital Brain Metastasis Symposium - 6/29/2018