Goutham Narla MD PHD

PubMed

• PP2A Attenuates Thoracic Aneurysm and Dissection in Mouse Models of Marfan Syndrome.
  Xianming Zhou, Qian Xu, Xingjian Hu, Philip A Klenotic, Alejandra Valdivia
  Hypertension. 2025-04-01
• 1 citations
  Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer.
  Terrance J Haanen 3rd, Sophie Boock, Catherine G Callahan, Irene Peris, Kaitlin P Zawacki
  Cancer Research. 2025-02-01
• Small-molecule modulators of B56-PP2A restore 4E-BP function to suppress eIF4E-dependent translation in cancer cells.
  Michelle A Lum, Kayla A Jonas, Shreya Parmar, Adrian R Black, Caitlin M O'Connor
  The Journal of Clinical Investigation. 2025-01-27

Journal Articles

• Increased alternative splicing of the KLF6 tumor suppressor gene correlates with prognosis and tumor grade in patients with pancreatic cancer.  
  Hartel M, Narla G, Wente MN, Giese NA, Martignoni ME, Martignetti JA, Friess H, Friedman SL, Eur J Cancer; 44:1895-903
• RAS/PI3-K/AKT promotes cellular growth by enhancing alternative splicing-mediated inactivation of the KLF6 tumor suppressor in human hepatocellular carcinoma.  
  Yea S, Narla G, Zhao X, Villanueva A, Martignetti JA, Llovet JM, Friedman SL, Hepatology ;46:303A-4A
• Drosophila Sin3a mediates cancer-like invasion through multiple pathways.  
  Das TK, Sangodkar J, Negre N, Narla G, and Cagan RL, Cancer Cell
• The FOXO1/KLF6 transcriptional network negatively regulates activated EGFR signaling and modulates response to anti-EGFR based therapy.  
  Sangodkar J, Dhawan N, Melville H, Singh V, Katz S, Albano T, Farrington C, Rana H, Yuan E, Arnovitz P, Galsky M, Olhmeyer M, Burstein D, Zhang D, Politi K, Difeo A, a..., JCI, Advanced Online Publication
• Carcinogen-induced hepatic tumors in KLF6 +/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation.  
  Narla G, Hepatology. 54(2):522-31
• Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone decetylase-1 selectively in premalignant and malignant prostate ...  
  Xiong SD, Yu K, Liu XH, Kirschenbaum A, Yao S, Narla G, DiFeo A, Wu JB, Yuan Y, Ho SM, Lam YW, Levine AC, Int J Cancer; 125:774-782
• Functional role of the KLF6 tumor suppressor gene in gastric cancer.  
  Sangodkar J, Shi J, DiFeo A, Schwartz R, Bromberg R, Choudhri A, McClinch K, Scheer E, Martignetti J, Hui A, Leung WK, Friedman SL, Narla G, Eur J Cancer; 45:666-76
• KLF6-SV1 is a novel anti-apoptotic protein that targets the BH3-only protein NOXA for degradation and whose inhibition extends survival in an ovarian cancer model.  
  DiFeo A, Huang F, Sangodkar J, Terzo EA, Leake D, Choudhri A, Narla G, Martignetti JA, Cancer Res; 69:4733-41
• TGF-beta regulates the expression of transcription factor KLF6 and its splice variants and promotes co-operative transactivation of common target genes through a Smad3...  
  Botella LM, Sanz-Rodriguez F, Komi Y, Fernandez LA, Varela E, Garrido-Martin EM, Narla G, Friedman SL, Kojima S, Biochem J; 419:485-95
• Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor gene in hepatocellular carcinoma.  
  Yea S, Narla G, Zhao X, Garg R, Kremer-Tal S, Hod E, Villaneuva A, Loke J, Tarocchi M, Akita K, Shirasawa S, Sasasuki T, Martignetti JA, Llovet JM, Friedman SL, Gastroenterology; 20:1521-31. PMCID: 2600656
• KLF6-SV1 is a key regulator of metastasis and survival in prostate cancer.  
  Narla G, DiFeo A, Fernandez Y, Dhanasekaran S, Huang F, Sangodkar J, Hod E, Leake D, Friedman SL, Hall S, Chinnaiyan AM, Gerald WL, Rubin MA, Martignetti JA, J Clin Invest; 118:2711-2721. PMCID: 2441856
• The Kruppel-like factor 6 (KLF6) genotype is associated with fibrosis in non-alcoholic fatty liver disease (NAFLD).  
  Miele S, Beale G, Patman G, Nobili V, Leathart J, Greco A, Abate M, Friedman SL, Narla G, Bugianesi E, Day CP, Reeves HL, Gastroenterology; 134:1521-31
• The apolipoprotein(a) gene is regulated by sex hormones and acute phase inducers in YAC transgenic mice.  
  Frazer KA, Narla G, Zhang JL, Rubin EM, Nat Genet ;9:424-31
• Insulin-like growth factor-1 regulates KLF6 gene expression in a p53-dependent manner.  
  Bentov I, Narla G, Schayek H, Akita K, Plymate SR, LeRoith D, Friedman SL, Werner H, Endrocrinology; 149:1890-7
• In vivo Regulation of p21 by the KLF6 Tumor Suppressor Gene in Mouse Liver and Human Hepatocellular Carcinoma.  
  Narla G, Kremer-Tal S, Matsumoto N, Zhao X, Yao S, Kelley K, Tarocchi M, Friedman SL, Oncogene; 26:4428-34
• Role of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination.  
  DiFeo A, Narla G, Hirschfeld J, Camacho-Vanegas O, Yao S, Rose S, Kalir T, Friedman SL, Buller RE, Martignetti JA, Clin Cancer Res; 12:3730-9
• Targeted inhibition of the KLF6 splice variant KLF6SV1 suppresses prostate cancer growth and spread.  
  Narla G, DiFeo A, Yao S, Banno A, Hod E, Reeves H, Qiao RF, Camacho-Vanegas O, Levine A, Kirschenbaum A, Chan AM, Friedman SL, Martignetti JA, Cancer Res; 65:5761-8
• Regulation of KLF6 tumor suppressor activity by acetylation.  
  Li D, Yea S, Dolios G, Martignetti JA, Narla G, Wang R, Walsh MJ, Friedman SL, Cancer Res; 65:9216-25
• KLF6 promotes preadipocyte differentiation through histone deacetylase 3 (HDAC3)-dependent repression of Dlk1.  
  Li D, Yea S, Cooreman MP, Li S, Narla G, Laborda J, Banck MS, Friedman SL, Walsh MJ, J Biol Chem; 280:26941-52
• Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor (KLF6) tumor suppressor protein: potential interactions between...  
  Rubinstein M, Idelman G, Plymate SR, Narla G, Friedman SL, Werner H, Endocrinology; 145:3769-77
• Kruppel-like factor 6 (KLF6) is a tumor suppressor gene frequently inactivated in colorectal cancer.  
  Reeves HL, Narla G, Ogunbiyi O, Haq AI, Katz A, Benzeno S, Hod E, Harpaz N, Goldberg S, Kremer-Tal S, Eng FJ, Arthur MJ, Martignetti JA, Friedman SL, Gastroenterology; 126:1090-103
• Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile fibromatosis and infantile systemic hyalinosis.  
  Dowling O, DiFeo A, Ramirez MC, Tukel T, Narla G, Bonafe L, Kayserili H, Yuksel-Apak M, Paller AS, Norton K, Teebi AS, Grum-Tokars V, Martin GS, Davis GE, Glucksman MJ..., Am J Human Genet; 73:957-66. PMCID: 1180616
• KLF6, a candidate tumor suppressor gene in prostate cancer.  
  Narla G, Heath KE, Reeves HL, Li D, Giono LE, Kimmelman AC, Glucksman MJ, Narla J, Eng FJ, Chan AM, Ferrari AC, Martignetti JA, Friedman SL, Science; 21:2563-6
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Books/Book Chapters

• Alternative Splicing in Cancer. 
  Chapter: Alternative splicing of KLF6 and KLF6-SV1 in human cancer. Beyond guilt by association. 
  Page 1 - 20Narla G, DiFeo A, Martignetti JAEditors: JP Venables.ransworld Research Network, Trivandrum, India
• The Biology of Kruppel-like Factors. 
  Chapter: Kruppel-like factors and the liver. 
  Page 141 - 150Narla G, Friedman SLEditors: R Nagai, SL Friedman, M Kasuga.Springer, New York, NY
• The Biology of Kruppel-like Factors. 
  Chapter: Diagnostic and Therapeutic applications of Kruppel-like Factors. 
  Page 223 - 244DiFeo A, Narla G, Martignetti JAEditors: R Nagai, SL Friedman, M Kasuga.Springer, New York, NY

Abstracts/Posters

• PP2A Activators Enhance Efficacy of FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells through AKT Inactivation-Dependent Pim-1 and c-Myc Proteasomal Degradation
  Goutham Narla, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Divergent roles of matrix metalloproteinase-2 in hepatic stellate cell activation and liver fibrosis.
  Radbill B, Gupta R, Alvarez C, Narla G, Martignetti J, Friedman SL, Bansal MB, Hepatology ;40:546A-A
• KLF6 Deficiency Promotes Hepatocellular Carcinoma in Mice and Humans by Increasing Mdm2 Expression and Accelerating P53 Degradation.
  21. Tarocchi M, Lee UE, Hannivoort R, Loke JC, Narla G, Villanueva A, Llovet JM, Friedman SL, Hepatology ;50:366A-7A
• Reduced KLF6 Expression Correlates with Poor Prognosis in Human Hepatocellular Carcinoma (HCC) and Enhanced Chemical Carcinogenesis in KLF6+/- Mice.
  Tarocchi M, Narla G, Villanueva A, Llovet J, Friedman SL, Hepatology ;48:386A-A
• The KLF6 tumor suppressor regulates hepatic expression of GADD45 gamma, a cell cycle regulatory protein, in vivo and in culture.
  Paris A, Kremer-Tal S, Narla G, Yea S, Lang U, Friedman SL, Hepatology ;44:598A-A
• Blockade of hedgehog pathway signaling inhibits growth of human hepatocellular carcinoma cell lines.
  Lemmer ER, Villanueva A, Yea S, Peix J, Schwartz M, Narla G, Waxman S, Friedman SL, Llovet JM, Hepatology ;44:236A-A
• Evidence of hedgehog signaling pathway activation in hepatocellular carcinoma.
  Lemmer ER, Chen Y, Yea S, Wurmbach E, Schwartz M, Villanueva A, Narla G, Mazzaferro V, Bruix J, Waxman S, Friedman SL, Llovet JM, J Hepatology. ;44:S105-S
• PTTG1, a novel repressed target of KLF6 tumor suppressor in liver - A new pathway of carcinogenesis?.
  Lang U, Kremer-Tal S, Narla G, Paris A, Yea S, Friedman SL, Hepatology ;44:525A-6A
• Absence of KLF6 gene mutation in 71 hepatocellular carcinomas - Reply.
  Kremer-Tal S, Reeves HL, Narla G, Martignetti JA, Friedman SL, Hepatology ;41:682-3
• The Kruppel-like factor 6 tumour suppressor induces apoptosis in HepG2 cells.
  King B, MacDonald P, Kremer-Tal S, Narla G, Chattopadhyay D, Banck M, Friedman SL, Reeves HL, Hepatology ;42:310A-A.
• Alternative splicing of the KLF6 tumor suppressor gene in hepatic stellate cells during acute liver injury in vivo is an activating signal - Resolution of a paradox.
  Yea S, Katz A, Narla G, Friedman SL, Hepatology ;40:216A-A
• The tumor suppressor gene KLF6 is a key molecular determinant of anti-EGFR based therapy in lung.
  Narla G, ASCI/AAP 2010 Joint Meeting, Chicago, IL
• KLF6 expression in clinically localized and metastatic prostate cancer.
  Zhu W, Kuefer R, Narla G, Mattfeldt T, Gschwend JE, Friedman SL, Martignetti JA, Chinnaiyan AM, Rubin MA, Modern Pathol ;16:178A-A
• The role of Kruppel-like factor 6 (KLF6) in colorectal neoplasia.
  Reeves H, Arthur M, Narla G, Oginbiyi O, Haque A, Katz A, Hod E, Walewski J, Friedman SL, Gastroenterology 2003;124:A13-A
• Novel growth suppressor targets of the KLF6 tumor suppressor gene identified by stringent microarray analysis.
  Reeves HL, Arthur MJP, Narla G, Katz A, Hod E, Walewski J, Goldberg S, Harpaz N, Martignetti JA, Friedman SL, Hepatology ;38:179A-A
• KLF6 polymorphism in prostate cancer reveals a novel mechanism of tumor suppressor gene inactivation.
  Hirshfeld I, Narla G, DiFeo A, Kalir T, Buller R, Friedmann S, Martignetti JA, J Invest Med ;51:336-7
• Myogenic determinants of KLF6 gene transcription in hepatic stellate cells and during myoblast differentiation.
  Liu HX, Narla G, Laub F, Engle F, Ramirez F, Friedman SL, Hepatology ;34:264A-A
• Acetylation status of KLF6 regulates its transactivation of p21 and may be a key determinant of hepatocellular growth.
  Li D, Walsh MJ, Narla G, Eng FJ, Friedman SL, Hepatology; 34:263A-A
• Functional characterization of transcriptional regulatory elements in ribosomal protein S19 (RPS19) gene, frequently mutated in Diamond-Blackfan Anemia.
  Da Costa L, Narla G, Willig TN, Peters L, Parra M, Fixler J, Tchernia G, Mohandas N, Blood ;98:218A-A
• KLF6 induces growth arrest in vivo by transcriptional upregulation of P21 independent of P53.
  Li D, Narla G, Kelley K, Ratziu V, Albrecht JK, Eng FJ, Friedman SL, Hepatology ;32:209A-A
• A 270 Kb Yeast Artificial Chromosome Containing Apolipoprotein(a) Appropriately Expresses in Transgenic Mice.
  Frazer KA, Narla G, Zhang JL, Rubin EM, Circulation ;90:624
• Restoring sensitivity to anti-EGFR based therapy in lung adenocarcinoma by downstream modulation of the FOXO1/KLF6 transcriptional network.
  Narla G, AACR Translational Cancer Medicine, San Francisco, CA
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Lectures

• Cancer Genetics: Past, Present, and Future. 
  Grand Rounds Seminar, Department of Medicine, Mount Sinai School of Medicine, New York, NY
• The Role of Alternative Splicing in the Regulation of the KLF6 Tumor Suppressor Gene. 
  Fred Hutchinson Cancer Research Center, Seattle, WA
• Personalized Medicine and Lung Cancer Treatment. 
  Charles R. Bronfman Institute for Personalized Medicine, Mount Sinai School of Medicine, New York
• Personalized-medicine-based approaches in lung cancer treatment. 
  Molecular Biology Seminar, Department of Chemistry, Pomona College, Claremont, CA
• Genetics of Lung Cancer. 
  Pulmonary and Critical Care Seminar, Department of Medicine, Mount Sinai School of Medicine, NY
• Diverse roles for the KLF6 gene family in prostate cancer. 
  Prostate Cancer Research Study Group, Department of Medicine, Mount Sinai School of Medicine, NY
• KLF6-SV1: An Oncogenic Splice Variant in Human Cancer. 
  2010 FASEB Summer Research Conferences, Steamboat Springs, CO
• The KLF6 gene family in human cancer. 
  Cancer Center Grand Rounds, University of Michigan, Ann Arbor, MI
• The KLF6 gene in human cancer: One gene, many functions. 
  Cancer Center Seminar Series, Case Comprehensive Cancer Center, Cleveland, OH
• Small-molecule-based transcriptional modulation of a key tumor suppressor gene network in lung adenocarcinoma. 
  Research Conference, Department of Medicine, Mount Sinai School of Medicine, New York, NY
• The Physician Scientist: A story of translation and compromise. 
  New York University Langone Center, New York, NY
• The story of KLF6: a tale of one gene with many functions. 
  Grand Rounds Cancer Center, University of Vermont
• Small molecule based approaches to reactive transcriptional networks in human cancer. 
  Experimental Therapeutics Institute, Mount Sinai, New York NY
• Regulation of cancer gene function by alternative splicing. 
  RNA Center Invited Seminar
• Small molecule based approaches to reactivate transcriptional networks in cancer. 
  Department of Medicine Research Day CWRU
• Targeting transcriptional networks in cancer. 
  2012 FASEB Summer Research Conferences, Steamboat Springs, CO
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