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Office
1500 E Medical Center Dr
Rogel Cancer Center, Rm 3215
Ann Arbor, MI 48109Phone+1 734-615-2411
Summary
- I am physician scientist who specializes in the care of high risk cancer genetics patients. I run a translational cancer research laboratory focused on identifying and characterizing the genetic regulators of cancer development and progression and developing targeted molecular therapies to these alterations.
Education & Training
- Mt Sinai SOM2008 - 2012
- Mount Sinai Hospital2008 - 2011
- Icahn School of Medicine at Mount Sinai/Mount Sinai HospitalInternship, Internal Medicine, 2006 - 2008
- Mount Sinai School of MedicinePh.D, Cancer Biology/Genetics, 2001 - 2006
- Icahn School of Medicine at Mount SinaiClass of 2006, MD
- Santa Clara UniversityBS, Biology/Economics, 1993 - 1997
Certifications & Licensure
- MI State Medical License 2018 - 2025
- OH State Medical License 2012 - 2021
- NY State Medical License 2008 - 2013
Awards, Honors, & Recognition
- Harrington Scholarship 2012
- Saul Horowitz, Jr. Memorial Award 2010
- Humanism and Excellence in Teaching, Arnold P. Gold Foundation 2008
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Publications & Presentations
PubMed
- 136 citationsKrüppel-like Factor-6 Promotes Preadipocyte Differentiation through Histone Deacetylase 3-dependent Repression of DLK1Dan Li, Steven Yea, SiDe Li, Zhu Chen, Goutham Narla
The Journal of Biological Chemistry. 2005-07-22 - 86 citationsIKKα negatively regulates ASC-dependent inflammasome activationBradley N. Martin, Chenhui Wang, Jami Willette-Brown, Tomasz Herjan, Muhammet F. Gulen
Nature Communications. 2014-09-30 - 130 citationsActivation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growthJaya Sangodkar, Abbey L. Perl, Rita Tohme, Janna Kiselar, David B. Kastrinsky
The Journal of Clinical Investigation. 2017-06-01
Journal Articles
- Increased alternative splicing of the KLF6 tumor suppressor gene correlates with prognosis and tumor grade in patients with pancreatic cancer.Hartel M, Narla G, Wente MN, Giese NA, Martignoni ME, Martignetti JA, Friess H, Friedman SL, Eur J Cancer; 44:1895-903
- RAS/PI3-K/AKT promotes cellular growth by enhancing alternative splicing-mediated inactivation of the KLF6 tumor suppressor in human hepatocellular carcinoma.Yea S, Narla G, Zhao X, Villanueva A, Martignetti JA, Llovet JM, Friedman SL, Hepatology ;46:303A-4A
- Drosophila Sin3a mediates cancer-like invasion through multiple pathways.Das TK, Sangodkar J, Negre N, Narla G, and Cagan RL, Cancer Cell
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Books/Book Chapters
Abstracts/Posters
- PP2A Activators Enhance Efficacy of FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells through AKT Inactivation-Dependent Pim-1 and c-Myc Proteasomal DegradationGoutham Narla, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
- Divergent roles of matrix metalloproteinase-2 in hepatic stellate cell activation and liver fibrosis.Radbill B, Gupta R, Alvarez C, Narla G, Martignetti J, Friedman SL, Bansal MB, Hepatology ;40:546A-A
- KLF6 Deficiency Promotes Hepatocellular Carcinoma in Mice and Humans by Increasing Mdm2 Expression and Accelerating P53 Degradation.21. Tarocchi M, Lee UE, Hannivoort R, Loke JC, Narla G, Villanueva A, Llovet JM, Friedman SL, Hepatology ;50:366A-7A
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Lectures
- Cancer Genetics: Past, Present, and Future.Grand Rounds Seminar, Department of Medicine, Mount Sinai School of Medicine, New York, NY
- The Role of Alternative Splicing in the Regulation of the KLF6 Tumor Suppressor Gene.Fred Hutchinson Cancer Research Center, Seattle, WA
- Personalized Medicine and Lung Cancer Treatment.Charles R. Bronfman Institute for Personalized Medicine, Mount Sinai School of Medicine, New York
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Press Mentions
- Researchers Zero in on Therapeutic Target for Aggressive Uterine CancerDecember 17th, 2021
- Rappta Therapeutics Appoints Sunjeet Sawhney as Chief Executive OfficerSeptember 15th, 2021
- Case Western Reserve School of Medicine Awarded $1.6 Million for Undergraduate ResearchNovember 6th, 2018
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Professional Memberships
- AACRMember
Other Languages
- Spanish, French
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