Giselle Lopez MD

PubMed

• 24 citations
  Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1.
  Patrick J Cimino, Courtney Ketchum, Rust Turakulov, Omkar Singh, Zied Abdullaev
  Acta Neuropathologica. 2023-01-01
• 1 citations
  Papillary Glioneuronal Tumor With a Novel GPR37L1-PRKCA Fusion.
  Janice S Ahn, John F. Ervin, Thomas J. Cummings, Giselle Y. Lopez, Shih-Hsiu Wang
  Journal of Neuropathology and Experimental Neurology. 2021-10-26
• Eosinophilic globules in a classic ependymoma: evidence of a possible secretory role.
  Janice S Ahn, Maureen Petersen, Allan H. Friedman, Edward M López, Thomas J. Cummings
  Ultrastructural Pathology. 2020-11-05

Journal Articles

• The genetic landscape of gliomas arising after therapeutic radiation  
  Lopez GY, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Clarke J, Oberheim Bush NA, Taylor J, Chang S, Butowski N, Banerjee A, Mueller S, Kline C, Torkildson..., Acta Neuropathol, 1/8/2018
• Perilesional edema associated with an intracranial calcifying pseudoneoplasm of the neuraxis in a child: case report and review of imaging features  
  Safaee MM, Jonzzon S, Lopez GY, Asaikar S, Tihan T, Glenn OA, Gupta N, J Neurosurg Pediatr, 1/1/2018
• Autoimmune pancerebellitis associated with pembrolizumab therapy  
  Vitt JR, Kreple C, Mahmood N, Dickerson E, Lopez GY, Richie MB, Neurology, 1/1/2018
• CDKN2A/B Loss is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma  
  Lopez GY, Perry A, Harding B, Li M, Santi M, Neuropathol Appl Neurobiol, 1/1/2018
• Metastatic cervical paravertebral solitary fibrous tumor detected by fluorodeoxyglucose positron emission tomography-computed tomography  
  Cheung H, Lawhn-Heath C, Lopez G, Vella M, Aparici CM, Radiol Case Rep, 1/1/2018
• Occipital headache in chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)  
  Cordano C, Lopez GY, Bollen AW, Nourbakhsh B, Headache, 1/1/2018
• Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H33 K27M mutant protein expression  
  Lopez GY, Oberheim Bush NA, Phillips JJ, Bouffard JP, Moshel YA, Jaeckle K, Kleinschmidt-DeMasters BK, Rosenblum MK, Perry A, Solomon DA, Acta Neuropathol, 1/1/2017
• Diffuse non-midline gliomas with H3F3A K27M mutation: a prognostic and treatment dilemma  
  Lopez G, Oberheim Bush NA, Berger MS, Perry A, Solomon DA, Acta Neuropathol Commun, 1/1/2017
• Supratentorial tanycytic ependymoma in an adult male: case report and review of the literature  
  Lopez G, McLendon RE, Peters KB, Case Rep Oncol, 1/1/2015
• Clinic-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations  
  Lopez GY, Grant GA, Fuchs HE, Liethe LG, Gururangan S, Bigner DD, Yan H, McLendon RE, He Y, Neuropathol Appl Neurobiol, 1/1/2014
• EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis  
  Feng H, Lopez GY, Kim CK, Alvarez A, Duncan CG, Nishikawa R, Nagane M, Su AJ, Auron PE, Hedberg ML, Wang L, Raizer JJ, Kessler JA, Parsa AT, Gao WQ, Kim SH, Minata M, ..., J Clin Invest, 1/1/2014
• Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas  
  Jin, G, Reitman ZJ, Duncan CG, Spasojevic I Gooden DM, Rasheed BA, Yang R, Lopez GY, He Y, McLendon RE, Bigner DD, Yan H, Cancer Res, 1/1/2013
• Mutant IDH1 is required for IDH1 mutated tumor cell growth  
  Jin G, Pirozzi CJ, Chen LH, Lopez GY, Duncan CG, Feng J, Spasojevic I, Bigner DD, He Y, Yan H, Oncotarget, 1/1/2012
• Frequent ATRX, CIC, and FUBP1 mutations refine the classification of malignant gliomas  
  Jiao Y, Killela PJ, Reitman ZJ, Rasheed AB, Heaphy CM, de Wilde RF, Rodriguez FJ, Rosemberg S, Oba-Shinjo SM, Marie SK, Bettegowda C, Agrawal N, Lipp E, Pirozzi C, Lop..., Oncotarget, 1/1/2012
• Transcriptional regulation of N-acetylglutamate synthase  
  Heibel SK, Lopez GY, Panglao M, Sodha S, Marino-Ram�rez L, Tuchman M, Caldovic L, PLoS One, 1/1/2012
• Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation  
  Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, Losman JA, Joensuu P, Bergmann U, Gross S, Travins J, Weiss S, Looper R, Ligon KL, Verhaak RGW, Yan H, Kaeli..., Nature, 1/1/2012
• Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers, and therapeutic target  
  Guo C, Pirozzi CJ, Lopez GY, Yan H, Curr Opin Neurol, 1/1/2011
• IDH1 mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain  
  Lopez GY, Reitman ZJ, Solomon D, Waldman T, Bigner DD, McLendon R, Rosenberg SA, Samuels Y, Yan H, Biochem Biophys Res Commun, 1/1/2010
• Gastrin-releasing peptide, immune responses, and lung disease  
  Degan S, Lopez GY, Kevill K, Sunday ME, Ann NY Acad Sci, 1/1/2008
• Biochemical properties of recombinant human and mouse N-acetylglutamate synthase  
  Caldovic L, Lopez GY, Haskins N, Panglao M, Shi D, Morizono H, Tuchman M, Mol Genet Metab, 1/1/2006
• Late onset N-acetylglutamate synthase deficiency caused by hypomorphic alleles  
  Caldovic L, Morizono H, Panglao MG, Lopez GY, Shi D, Summar ML, Tuchman M, Hum Mutat, 1/1/2005
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Books/Book Chapters

• eLS 
  Chapter: Brain Tumours 
  Lopez GY, Cummings TJ, Bigner DD, McLendon REJohn Wiley & Sons, Ltd., Chichester2016
• Systems Biology of Cancer 
  Chapter: Genetic alterations in glioblastoma multiforme. 
  Lopez GY, Samsky M, Jones R, Adamson DC, Yan HYEditors: Sam Thiagalingam.Cambridge University Press2015

Abstracts/Posters

• "Anaplastic transformation in a Pilocytic Astrocytoma."
  Lopez GY, American Association of Neuropathologists' Annual Meeting, 1/1/2017
• "SSTR2a status and response to somatostatin analogues in acromegaly."
  Lopez GY, United States and Canadian Academy of Pathology, Annual Meeting, 1/1/2016
• "The role of IDH1 and IDH2 mutations in gliomagenesis."
  Lopez GY, Duke Pathology Graduate Retreat, 1/1/2012
• "Histopathological description of medulloblastomas with MLL2/3 gene mutations."
  Lopez GY, Pediatric Neuro-oncology Basic and Translational Research Conference, New Orleans, LA, 1/1/2011
• "Metabolism and IDH1/2 mutations."
  Lopez GY, Duke Medical Scientist Training Program Annual Symposium, 1/1/2011
• "IDH mutations as potential biomarkers in gliomas."
  Lopez GY, Duke Medical Scientist Training Program Annual Symposium, 1/1/2010
• "DCBLD2 in glioblastoma multiforme."
  Lopez GY, Duke 18th Annual Biomedical Science Graduate Student Symposium, 1/1/2009
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Lectures

• "Genetic Landscape of Gliomas Arising after Therapeutic Radiation for Childhood Cancer." 
  1/1/2018
• "Multiple sclerosis." 
  1/1/2016
• "PNET classification." 
  1/1/2016
• "Connecting the dots in neurodegenerative disease." 
  1/1/2015
• "TERT and ATRX mutations in gliomas." 
  1/1/2015
• "IDH mutations in gliomas." 
  1/1/2014
• "Biochemical characterization and genetic modeling of IDH1 mutations in progressive gliomas." 
  1/1/2013
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