GeoffreyA.PreidisMDPhD

Pediatric Gastroenterology • Houston, TX

Associate Professor

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Office
Pediatric Gastroenterology, Hepatology & Nutrition Research Laboratory
1102 Bates Avenue, Feigin Tower 860.24
Houston, TX 77030
Phone+1 832-822-3617

Fax+1 832-825-3633

Summary

Our goal is to define mechanisms through which early life undernutrition alters metabolism and to determine how undernutrition influences intestinal and liver function. Undernutrition causes acute medical problems, but also long term health problems that may result from permanent epigenetic changes that alter transcription or via changes in the gut microbiome. Current studies focus on how malnutrition alters hepatic secretion, transcriptional programming, gastrointestinal motility, and host-microbiome interactions to impact growth. Our work is pertinent to those suffering from nutritional deficiencies caused by a wide range of medical and socioeconomic factors, including protein-energy undernutrition in the developing world and underweight newborns in the neonatal intensive care unit.

Education & Training

Baylor College of MedicinePost-Doctoral Fellowship, Pediatric Gastroenterology, 2017 - 2018
Baylor College of MedicineFellowship, Pediatric Gastroenterology, 2014 - 2017
Baylor College of Medicine (Houston)Residency, Pediatrics, 2012 - 2014
Baylor College of MedicineClass of 2012, Medical Scientist Training Program (M.D., Ph.D.)
Harvard UniversityAB, Physics, cum laude, 1999 - 2003

Certifications & Licensure

TX State Medical License 2017 - 2026
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Gastroenterology

Publications & Presentations

PubMed

Probiotics for preterms: sharing complex decision-making.
Geoffrey A Preidis, Janet E Berrington
Nature Reviews. Gastroenterology & Hepatology. 2025-01-01
1 citations
Taking Microbiome Science to the Next Level: Recommendations to Advance the Emerging Field of Microbiome-Based Therapeutics and Diagnostics.
Robert A Britton, Elena F Verdu, Sara C Di Rienzi, Alejandro Reyes Muñoz, Phillip I Tarr
Gastroenterology. 2024-11-01
Bile acids differentially regulate longitudinal smooth muscle contractility in everted mouse ileum.
Peace N Dike, Krishnakant G Soni, Diana S Chang, Geoffrey A Preidis
FASEB Bioadvances. 2024-07-01

Authored Content

What We Know about the Gut Microbiome and Human Development10/26/2017
Expert Commentary: Prebiotics in Overweight and Obese Children6/26/2017

Press Mentions

Q&A: Spreading Awareness During Gastroparesis Awareness MonthAugust 11th, 2021
Getting Your Probiotic Fix When Taking AntibioticsMarch 9th, 2021
Probiotics May Help to Manage Childhood ObesitySeptember 15th, 2020
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Grant Support

Liver-Gut-Microbiome Axis and Fatty Acid Absorption in Preterm InfantsNational Institute of Diabetes and Digestive and Kidney Diseases2023–2028
The Metabolic Basis for Impaired Bile Acid Synthesis in MalnutritionNational Institute of Diabetes and Digestive and Kidney Diseases2022–2027
Nuclear Receptor Dysfunction Reprograms Metabolism and Cellular Proliferation in Wilson's DiseaseNational Institute of Diabetes and Digestive and Kidney Diseases2022–2027
Impaired Bile Acid Synthesis Due To CYP7A1 and CYP7B1 Suppression in MalnutritionNational Institute of Diabetes and Digestive and Kidney Diseases2021–2023
Nuclear Receptor Mediated Bile Acid Alterations and Coagulopathy in Protein-Energy UndernutritionNational Institute Of Diabetes And Digestive And Kidney Diseases2017–2022
Persistent Epigenetic and Metabolic Consequences of Early-Life UndernutritionThe Texas Medical Center Digestive Diseases Center Pilot/Feasibility Award2017–2018
Bile Acid Mediated Dysmotility in Protein-Energy UndernutritionAmerican Gastroenterological Association (AGA) - Rome Foundation Functional GI and Motility Pilot Research Award2017–2018
Microbial Mechanisms of Pathogenesis Underlying non-Helicobacter GastritisThe Alkek Center for Metagenomics and Microbiome Research Functional and Mechanistic Award2017
Bile Acid Signaling and Dysmotility in Early-Life UndernutritionAmerican Neurogastroenterology and Motility Society Research Grant2017
Nuclear Receptor Mediated Bile Acid Alterations and Coagulopathy in Protein-Energy UndernutritionChao Physician-Scientist Award2017
Microbial Dysbiosis and Epigenetics Influence Steatosis and Metabolic Consequences of Early UndernutritionThe Texas Medical Center Digestive Diseases Center Pilot/Feasibility Award2016–2017
Mechanisms of Dysregulation of Bile Acid Synthesis in Protein-Energy UndernutritionNational Institute of Diabetes and Digestive and Kidney Diseases2015–2017
Glycan Metabolism Shapes the Undernourished Intestinal Microbiome and Influences Weight GainNorth American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) Foundation / Nestle Nutrition Research Young Investigator Development Award2015–2017
Elucidating the Role of the Intestinal Microbiome in Protein-Energy UndernutritionGlobal Probiotics Council, Young Investigator Grant for Probiotics Research (YIGPRO)2013–2014
The Intestinal Microbiome as a Biomarker and Therapeutic Target in Severe Acute MalnutritionThrasher Research Fund Early Career Award2013–2014
Mechanisms Of Immunomodulation By Probiotic L. Reuteri In Acute GastroenteritisNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2011

Committees

Network Member, Human Capital and Economic Opportunity (HCEO) Working Group 2017 - Present
Board Member, AGA Center for Gut Microbiome Research and Education Scientific Advisory Board 2017 - 2023