GabrielCLegerMDFRCPC

PubMed

• 4 citations
  Multisite ALLFTD study modeling progressive empathy loss from the earliest stages of behavioral variant frontotemporal dementia.
  Gianina Toller, Yann Cobigo, Patrick Callahan, Brian S Appleby, Danielle Brushaber
  Alzheimer's & Dementia. 2023-07-01
• 31 citations
  Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders.
  Tania F Gendron, Michael G Heckman, Launia J White, Austin M Veire, Otto Pedraza
  Cell Reports. Medicine. 2022-04-19
• 8 citations
  Amygdala sign, a FDG-PET signature of dementia with Lewy Bodies.
  Jagan A. Pillai, Guiyun Wu, Babak Tousi, Mykol Larvie, Gabriel C. Léger
  Parkinsonism & Related Disorders. 2019-07-01

Journal Articles

• Structural and Functional MRI Differences in Master Sommeliers: A Pilot Study on Expertise in the Brain  
  Banks SJ, Sreenivasan KR, Weintraub DM, Baldock D, Noback M, Pierce ME, Frasnelli J, James J, Beall E, Zhuang X, Cordes D, Leger GC, Frontiers in Human Neuroscience, 1/1/2016
• Memory Test Performance on Analogous Verbal and Nonverbal Memory Tests in Patients with Frontotemporal Dementia and Alzheimer's Disease  
  Baldock D, Miller JB, Leger GC, Banks SJ, Dement Geriatr Cogn Disord Extra, 1/1/2016
• Relationship between the Activities of Daily Living Questionnaire and the Montreal Cognitive Assessment  
  Durant J, Leger GC, Banks SJ, Miller JB, Alzheimers Dement, 1/1/2016
• Randomized controlled trials in frontotemporal dementia: cognitive and behavioral outcomes  
  Miller, J.B., Banks, S.J., Leger, GC, and Cummings, J.L., Translational Neurodegeneration, 1/1/2014
• Pharmacological Treatment of Alzheimer’s Disease  
  Massoud, F and Leger, GC, Can J Psychiatry, 1/1/2011
• Helping the FTD patient-care giver dyad  
  Leger, GC and Massoud, F, Can J Neurol Sci, 1/1/2011
• Troubles cognitifs et pathologies psychiatriques: s’y retrouver malgre l’enchevêtrement  
  Michaud I, Shamlian N, & Leger GC, Le Medecin du Quebec, 1/1/2010
• Evolution of the Diagnostic Criteria for Tauopathies  
  Thibodeau M-P, Chertkow H, & Leger GC, Can Rev Alz Dis Other Dement, 1/1/2009
• Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia  
  Mesulam M, Wicklund A, Johnson N, Rogalski E, Leger GC, Rademaker A, Weintraub S, Bigio EH, Ann Neurol, 1/1/2008
• Toward a revision of criteria for the dementias  
  Rockwood K, Bouchard RW, Camicioli R, Leger GC, Alzheimer's Dement, 1/1/2007
• Dementia-like presentation of striatal hypermetabolic state with antistriatal antibodies responsive to steroids.  
  Léger GC, Johnson N, Horowitz SW, Dale RC, Church AJ, Mesulam M-M., Arch Neurol, 5/2004
• Dementia-like presentation of striatal hypermetabolic state with striatal antibodies responsive to steroids  
  Leger GC, Johnson N, Horowitz S, Dale R, Church A, Mesulam MM, Arch Neurol, 1/1/2004
• Effect of catechol-Omethyltransferase inhibition on brain uptake of [18F]fluorodopa: implications for compartmental modelling and clinical usefulness  
  Leger GC, Gjedde A, Kuwabara H, Guttman M, Cumming P, Synapse, 1/1/1998
• Regional striatal DOPA transport and decarboxylase activity in Parkinson’s disease  
  Kuwabara H, Cumming P, Yasuhara Y, Leger GC, Guttman M, Diksic M, Evans AC, Gjedde A, J Nucl Med, 1/1/1995
• Striatal Ldopa decarboxylase activity in Parkinson’s disease in vivo: implications for the regulation of dopamine synthesis  
  Gjedde A, Leger GC, Cumming P, Yasuhara Y, Evans AC, Guttman M, Kuwabara H, J Neurochem, 1/1/1993
• Pharmacokinetics of plasma 6-[18F] fluoro-L-3, 4dihydroxyphenylalanine ([18F]Fdopa) in humans  
  Cumming P, Leger GC, Kuwabara H, Gjedde A, J Cereb Blood Flow Metab, 1/1/1993
• Human striatal Ldopa decarboxylase activity estimated in vivo using 6-[18F]fluoro-dopa and positron emission tomography: error analysis and application to normal subjects  
  Kuwabara H, Cumming P, Reith J, Leger GC, Diksic M, Evans AC, Gjedde A, J Cereb Blood Flow Metab, 1/1/1993
• Reduction of circulating 3-O-methyldopa by inhibition of catechol-O-methyltransferase with OR-611 and OR-462 in cynomolgus monkeys: implications for the treatment of P...  
  Cedarbaum JM, Leger GC, Guttman M, Clin Neuropharmacol, 1/1/1991
• Synthesis and Biomethylation of two Homoallylically Fluorinated Oleic Acids  
  Buist PH, Findlay JM, Leger GC, Pon, RA, Tetrahedron Letters, 1/1/1987
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Books/Book Chapters

• Case Studies in Dementia 
  Chapter: Atypical presenile progressive aphasia – A case of Alzheimer’s disease with severe cerebral amyloid angyopathy. 
  Leger GCCambridge University Press2011
• Case Studies in Dementia 
  Chapter: Presenting with both cognitive impairment and stroke 
  Deschaintre Y, Massoud F, Leger GCCambridge University Press2011
• Neuropsychologie clinique et neurologie du comportement 
  Chapter: Le Lobe Parietal 
  Leger GCEditors: T. Botez-Marquard and F. Boller.Les Presses de l'Universite de Montreal & Masson, Montreal, Quebec, Canada2005
• Proceedings of Brain PET '93 AKITA: Quantification of Brain Function, Akita, Japan, 29-31 May, 1993. 
  Chapter: Cerrection for partial volume effects in PET using MRI-based 3D simulations of individual human brain metabolism, in: Quantification of Brain Function: tracer kinetics and image analysis in brain PET. 
  Page 113 - 123Rousset OG, Ma Y, Leger GC, Gjedde AH, Evens ACEditors: K Uemura, NA Lassen, T Jones, and I Kanno.Experpta Medica, Amsterdam, The Netherlands1993
• Proceedings of Brain PET '93 AKITA: Quantification of Brain Function, Akita, Japan, 29-31 May, 1993. 
  Chapter: Parametric dopa decarboxylase imaging in vivo: method and error analysis, in: Quantification of Brain Function: tracer kinetics and image analysis in brain PET. 
  Page 269 - 280Leger GC, Kuwabara H, Gjedde AHEditors: K Uemura, NA Lassen, T Jones, and I Kanno.Experpta Medica, Amsterdam, The Netherlands1993
• Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT. 
  Chapter: PET Scans in Movement Disorders 
  Page 409 - 426Guttman M, Leger GCEditors: M Diksic and R Reba.CRC Press, Cleveland, OH1990
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Abstracts/Posters

• Relationship Between the Activities of Daily Living Questionnaire and the Montreal Cognitive Assessment
  Durant, J, Leger, GC, Banks, SJ, and Miller, JB, Journal of the International Neuropsychological Society, 1/1/2015
• Brain Activation and Functional Connectivity: Study of olfactory perception in sommeliers.
  Sreenivasan, K., Zhuang, X., Baldock, D., Weintraub, D., Pierce, M., Frasnelli, J., Beall, E., Leger, G., Banks, S. and Cordes, D, Organization for Human Brain Mapping, Honolulu, HI, 1/1/2015
• Effective Connectivity Analysis of Olfactory Perception in Sommeliers
  Sreenivasan, K., Zhuang, X., Baldock, D., Weintraub, D., Pierce, M., Frasnelli, J., Beall, E., Leger, G., Banks, S. and Cordes, D, Organization for Human Brain Mapping, Honolulu, HI, 1/1/2015
• Functional Connectivity and Insula Partition Analysis in Sommeliers
  Zhuang, X., Sreenivasan, K., Baldock, D., Weintraub, D., Pierce, M., Frasnelli, J., Beall, E., Leger, G., Banks, S. and Cordes, D., Organization for Human Brain Mapping, Honolulu, HI, 1/1/2015
• Cognitive test scores in pathologically verified frontotemporal dementia
  Banks, S.J., Leger, G.C., 9th International Conference on Frontotemporal Dementia, Vancouver, Canada, 1/1/2014
• Difference between patients with Frontotemporal Dementia and Alzheimer’s Dementia on a Test of Practical Judgment
  Banks, S.J., Baldock, D., Leger, G.C., 9th International Conference on Frontotemporal Dementia, Vancouver, Canada, 1/1/2014
• The Confusing Case of the Stuttering
  Leger, G.C., and Banks, S.J., Sommelier National Academy of Neuropsychology Annual Conference, Puerto Rico, 1/1/2014
• Neuropsychiatric symptom profile differs based on pathology in patients with clinically diagnosed frontotemporal dementia
  Leger, GC & Banks, S, 8th International Conference on Frontotemporal Dementias, Manchester, United Kingdom, 1/1/2012
• Correlating imaging with language impairment in degenerative dementias: How well do PIB and FDG PET match behavior?
  Chertkow H, Nikelski J, Leger G, Probst S, Pilon R, Solomon S, et al, Alzheimer's and Dementia, 1/1/2011
• Convergence of findings in PiB & FDG PET with Volumetric MRI in the diagnosis of atypical dementias
  Leger, GC, Nikelski, J, Litwin L, Whitehead V, Evans AC, Chertkow H, Organization for Human Brain Mapping Annual Meeting, Barcelona, Spain, 1/1/2010
• Use of MRI cortical thickness, FDG PET, and PIB (Pittsburgh B) PET imaging to distinguish atypical Alzheimer's Disease and frontotemporal dementia cases.
  Chertkow H, Nikelski J, Leger GC, Litwin L, Whitehead V, Evans AC, Frontiers in Human Neuroscience, 1/1/2010
• When the imaging and clinical diagnosis of dementia differ, The Frontal Lobes
  Leger GC, Nikelski, J, Litwin L, Whitehead V, Evans AC, Chertkow H, 20th Annual Rotman Research Institute Conference, Toronto, Ontario, Canada, 1/1/2010
• For atypical FTD presentations, PiB-PET is no better than FDG-PET at implicating AD as disease etiology
  Leger, GC, Nikelski, J, Litwin L, Whitehead V, Evans AC, Chertkow H, 7th International Conference on Frontotemporal Dementias, Indianapolis, IN, 1/1/2010
• Dementia-like presentation of striatal hyperkinetic state with striatal antibodies responsive to steroids
  Leger GC, Johnson N, Horowitz S, Dale R, Mesulam MM, 4th International Congress on Autoimmunity; Alzheimer's Disease Day, Northwestern University, Chicago, IL, 2003; Budapest, Hungary, 2004, 1/1/2004
• Retronasal presentation of a food odor preferentially activates cortical chemosensory areas compared to orthonasal presentation of the same odor and retronasal present...
  Leger GC, Hummel T, Conley D, Mak EY, Simmons K, Small D, AChemS, Sarasota, FL, 1/1/2003
• Facial Diplegia: Another Cranial Nerve Variant of Guillain-Barre Syndrome.
  Leger GC and Chalk, CH, Neurology, Minneapolis, MN, 1/1/1998
• Parametric dopa-decarboxylase imaging in vivo: method and error analysis.
  Lger GC, Kuwabara H, and Gjedde AH, Ann Nucl Med, Los Angeles, CA, 1/1/1993
• Parametric dopa-decarboxylase imaging in vivo.
  Leger GC, Kuwabara H, and Gjedde AH, M´edical Scientist Training Program, Annual Meeting, Aspen, CO, 1/1/1993
• Parametric dopa-decarboxylase imaging in vivo.
  Leger GC, Kuwabara H, and Gjedde AH, JNM, Washington, DC, 1/1/1992
• Reduced striatal dopa-decarboxylase activity in Parkinson's disease in vivo measured with PET.
  Leger GC, Kuwabara H, M Guttmam, Cumming P, Reith J, and Gjedde AH, Proceedings of the 10th International Symposium on Parkinson's Disease, Tokyo, Japan, 1/1/1991
• PET Studies in Cynomolgus Monkeys show that OR--611 Increases Striatal Fluorodopa Uptake.
  Leger GC, Reches A, JM Cedarbaum, Kuwabara H, Gjedde AH, and Guttman M, Neurology, Boston, MA, 1/1/1991
• Simultaneous Work and 31P-NMR Metabolic Analysis in Exercising Ischemic Human Gastrocnemius Muscle In Vivo.
  Leger GC, Johnson R, and Arnold D, SMRM, Ninth Annual Meeting, New York, NY, 1/1/1990
• Inhibition of 3-OMethylfluorodopa formation with OR-462: Attempts to Simplify the Fluorodopa Model for PET Analysis.
  Leger GC, Guttman M, Leblanc C, Cedarbaum J, Gjedde A, and Reches A, Neurology, Miami, FL, 1/1/1990
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Lectures

• Imaging in Dementia 
  Las Vegas, NV - 1/1/2016
• Trouble finding words? 
  Las Vegas, NV - 1/1/2016
• Frontotemporal Dementias 
  Cleveland, OH - 1/1/2016
• Clinical PET imaging in dementia 
  Las Vegas, NV - 1/1/2016
• Frontotemporal Dementias in Older Adults 
  Washington, DC - 1/1/2015
• Frontotemporal disorders: an overview 
  Las Vegas, NV - 1/1/2014
• Machaskee lecture: Dementia – Does the differential matter? 
  Green Valley Ranch, Henderson, NV - 1/1/2014
• Behavioral changes in dementia 
  Las Vegas, NV - 1/1/2014
• Behavior & dementia 
  Las Vegas, NV - 1/1/2014
• Young-Onset Dementias 
  Las Vegas, NV - 1/1/2013
• The neurological exam 
  1/1/2011
• Frontotemporal dementias: Diagnosis and Differentiation from Alzheimer’s disease 
  Institut Universitaire de Geriatrie de l’Universite de Sherbrooke - 1/1/2011
• The cognitive and behavioral exam at the bedside 
  1/1/2011
• What’s new in the frontotemporal dementias? 
  Quebec, Canada - 1/1/2010
• Imaging technologies and the dementias 
  Cite de la Sante, Laval, Quebec, Canada - 1/1/2010
• La demence frontotemporal et ses aphasies progressives 
  Le Saguenay, Quebec, Canada - 1/1/2010
• The frontotemporal dementias 
  Douglas Hospital - 1/1/2009
• The 3rd Canadian consensus guidelines for the treatment of Alzheimer’s disease. 
  Montreal, Quebec, Canada - 1/1/2008
• L'examen comportemental et cognitif au chevet (The bedside cognitive and behavioral exam) 
  CHUM, Montreal, Quebec, Canada - 1/1/2007
• Update on dementia treatment 
  McGill University, Montreal, Quebec, Canada - 1/1/2006
• Of clocks and dementia 
  Hopital Jean-Talon, Montreal, Quebec, Canada - 1/1/2006
• Les demences frontotemporales 
  Montreal, Quebec, Canada - 1/1/2005
• Le large spectre des demences 
  Montreal, Quebec, Canada - 1/1/2005
• Striatal autoimmunity causes a reversible frontal demantia 
  Western University, London, Ontario, Canada - 1/1/2005
• Le diagnostic et le traitement de la maladie d’Alzheimer 
  1/1/2004
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