FredrickJohnSeilMD

Neurology • Berkeley, CA

Neuroimmunology/Multiple Sclerosis, Neurophysiology

Professor Emeritus of Neurology, Oregon Health & Science University

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Office
1 Twain Avenue
Berkeley, CA 94708
Phone+1 510-841-2398

Summary

Dr. Fredrick Seil is a retired neurologist in Berkeley, CA. He received his medical degree from Stanford University School of Medicine in 1960. His areas of research interest include neuroimmunology and neural development and plasticity. He is a Professor Emeritus of Neurology at the Oregon Health & Science University in Portland, where he has been a faculty member since 1976. During his tenure as Director of the US Department of Veterans Affairs Office of Regeneration Research Programs he founded and co-founded two ongoing international symposia on neural regeneration.

ResearchGate

https://www.researchgate.net/profile/Fredrick_Seil/publications

Education & Training

Mt. Sinai HospitalFellowship, NINDB, 1965 - 1966
Montefiore Medical Center/Albert Einstein College of MedicineFellowship, NINDB, 1966
Columbia University1966
Stanford Health Care-Sponsored Stanford UniversityFellowship, Neuropathology, 1964 - 1965
Stanford Health Care-Sponsored Stanford UniversityResidency, Neurology, 1961 - 1964
Stanford Health Care-Sponsored Stanford UniversityChief Residency, Neurology, 1962 - 1963
Kaiser Foundation Hospital1960 - 1961
Stanford University School of MedicineClass of 1960, MD
Stanford Health Care-Sponsored Stanford UniversityFellowship, Clinical Neurophysiology, 1959
Oberlin CollegeAB, 1952 - 1956
Phillips AcademyHS, 1947 - 1952

Certifications & Licensure

OR State Medical License 1976 - 2018
CA State Medical License 1960 - 1978

Awards, Honors, & Recognition

V.A. Recognition Award Dept. of Veterans Affairs, 2001
V.A. Statement of Recognition and Thanks Dept. of Veterans Affairs, 1999
V.A. Certificate of Appreciation Dept. of Veterans Affairs, 1995
V.A. Clinical Investigatorship 1976-1979, 1979
V.A. Merit Promotion 1971, 1973, 1975
U.S.P.H.S. Summer Fellowship in Psychiatry 1959
Society of Sigma Xi 1956
American Men and Women of Science, 15th ed
Who’s Who in the West, 14th ed
Who’s Who in Frontiers of Science and Technology, 2nd ed
Who’s Who in Science and Engineering
Who’s Who in America, 46th ed
Who’s Who in Medicine, 2nd ed
Who’s Who in Medicine and Healthcare
Who’s Who in the World, 22nd ed
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Publications & Presentations

PubMed

89 citations
Astrocytes play a role in regulation of synaptic density.
Charles K. Meshul, Fredrick J. Seil, Robert M. Herndon
Brain Research. 1987-01-27
17 citations
NEURAL PLASTICITY IN CEREBELLAR CULTURES
Fredrick J. Seil
Progress in Neurobiology. 1996-12-01
35 citations
Induction of dendritic spine proliferation by an astrocyte secreted factor.
Fredrick J. Seil, Felix P. Eckenstein, Paul J. Reier
Experimental Neurology. 1992-07-01

Journal Articles

Myelin antigens and antimyelin antibodies
Fredrick J. Seil, Antibodies 7, 2, 2018, 1/2/2018
Activity-dependent inhibitory synaptogenesis in cerebellar cultures
Seil, Fredrick J., Brain Plasticity 1:207-214, 1/1/2016
Signaling for activity-dependent inhibitory synaptogenesis via the TrkB receptor.
Seil, F.J, Exp. Neurol., 171:422-424
Differential effects of granule cell transplantation on two sprouted axonal systems in granuloprival coeruleocerebellar cultures.
Seil, F.J. and Woodward, W.R, Develop. Brain Res. 43:153-157
TrkB receptor ligands promote activity-dependent inhibitory synaptogenesis.
Seil, F.J. and Drake-Baumann, R, J. Neurosci. 20:5367-5373
Effects of exposure to low-dose pyridostigmine on neuromuscular junctions in vitro.
Drake-Baumann, R. and Seil, F.J, Muscle Nerve 22:696-703
BDNF and NT-4, but not NT-3, promote development of inhibitory synapses in the absence of neuronal activity.
Seil, F.J, Brain Res. 818:561-564
Influence of functional glia on the electrophysiology of Purkinje cells in organotypic cerebellar cultures.
Drake-Baumann, R. and Seil, F.J, Neuroscience 88:507-519
The extracellular matrix molecule, laminin, induces Purkinje cell dendritic spine proliferation in granule cell depleted cerebellar cultures.
Seil, F.J, Brain Res. 795:112-120
Serial changes in granuloprival cerebellar cultures after transplantation with granule cells and glia: A timed ultrastructural study.
Seil, F.J, Neuroscience 77:695-711
Activity-dependent changes in "transplanted" cerebellar cultures.
Seil, F.J. and Drake-Baumann, R, Exp. Neurol. 138:327-337
Circuit reorganization in Ara C treated cerebellar cultures chronically exposed to picrotoxin.
Seil, F.J. and Drake-Baumann, R, Int. J. Dev. Neurosci. 14:45-54
Electrophysiological differences between Purkinje cells in organotypic and granuloprival cerebellar cultures.
Drake-Baumann, R. and Seil, F.J, Neuroscience 69:467-476
Circuit reorganization in granuloprival cerebellar cultures in the absence of neuronal activity.
Seil, F.J. and Drake-Baumann, R, J. Comp. Neurol. 356:552-562
Persistence of heterotypical synapses in transplanted cerebellar cultures in the absence of functional glia.
Seil, F.J, Int. J. Dev. Neurosci. 12:411-421
Reduced cortical inhibitory synaptogenesis in organotypic cerebellar cultures developing in the absence of neuronal activity.
Seil, F.J. and Drake-Baumann, R, J. Comp. Neurol. 342:366-377
Dystrophic dendrites induced in cultured Purkinje cells by exposure to vinblastine.
Seil, F.J., Drake-Baumann, R. and Johnson, M.L, Brain Res. 636:87-97
Morphological correlates of altered neuronal activity in organotypic cerebellar cultures chronically exposed to anti-GABA agents.
Seil, F.J., Drake-Baumann, R., Leiman, A.L., Herndon, R.M. and Tiekotter, K.L, Develop. Brain Res. 77:123-132
Cytosine arabinoside effects in mouse cerebellar cultures in the presence of astrocytes.
Seil, F.J., Drake-Baumann, R., Herndon, R.M. and Leiman, A.L, Neuroscience 51:149-158
Induction of dendritic spine proliferation by an astrocyte secreted factor.
Seil, F.J., Eckenstein, F.P. and Reier, P.J, Exp. Neurol. 117:85-89
Tyrosine hydroxylase expression in noncatecholaminergic cells in cerebellar cultures.
Seil, F.J., Johnson, M.L., Nishi, R. and Nilaver, G, Brain Res. 569:164-168
Myelination of axons within Ara C treated mouse cerebellar explants by cultured rat oligodendrocytes.
Seil, F.J., Johnson, M.L., Saneto, R.P., Herndon, R.M. and Mass, M.K, Brain Res. 503:111-117
Antisera to the ganglioside GM1 do not have anti-myelin or anti-axon activities in vitro.
Bourdette, D.N., Zalc, B., Baumann, N. and Seil, F.J, Brain Res. 478:175-180
Serum anti-myelin antibodies in chronic relapsing experimental allergic encephalomyelitis.
Whitham, R.H., Nilaver, G., Bourdette, D.N. and Seil, F.J, J. Neuroimmunol. 18:155-170
Review of book “Cell and Tissue Regeneration: A Biochemical Approach,” by M.G. Ord and L. A. Stocken.
Seil, F.J, American Scientist 73:585
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Books/Book Chapters

Neural Regeneration and Transplantation, Frontiers of Clinical Neuroscience, Vol. 6.
Chapter: Axonal sprouting in response to injury
Page 123 - 135Seil, F.JEditors: F.J. Seil.Alan R. Liss, New York
Discussion in Cell, Tissue and Organ Cultures in Neurobiology.
Page 673 - 674Seil, F.JEditors: S. Fedoroff and L. Hertz.Academic Press, New York
Encyclopedia of Neuroscience
Chapter: Demyelination and Demyelinating Antibodies
Seil, F.JElsevier, AmsterdamEdition 3,
Encyclopedia of Neuroscience, Vol. 3.
Chapter: Demyelination and Demyelinating Antibodies
Page 423 - 425Seil, F.JAcademic Press, Oxford
Multiple Sclerosis and the Demyelinating Diseases: The Basic Sciences.
Chapter: Tissue culture studies of demyelination and remyelination
Page 105 - 112Seil, F.JEditors: R.M. Herndon.Demos, New York
Encyclopedia of Life Sciences.
Chapter: Nerve regeneration: mammalian
Seil, F.JNature Publishing Group, Macmillan, London
Neural Plasticity and Regeneration, Progress in Brain Research, Vol. 128.
Chapter: Neurotrophins and activity-dependent inhibitory synaptogenesis
Page 219 - 229Seil, F.J. And Drake-Baumann, REditors: F.J. Seil.Elsevier, Amsterdam
Encyclopedia of Neuroscience.
Chapter: Demyelination, demyelinating antibodies
Page 536 - 537Seil, F.JEditors: G. Adelman and B.H. Smith.Elsevier, AmsterdamEdition 2,
Cerebral Ischemia and Basic Mechanisms.
Chapter: Models of neural circuit reorganization after injury
Page 312 - 324Seil, F.JEditors: A. Hartmann, F. Yatsu and W. Kuschinsky.Springer-Verlag, Berlin
Multiple Sclerosis: Current Status of Research and Treatment.
Chapter: Effects of humoral factors on myelin in organotypic cultures
Page 33 - 50Seil, F.JEditors: R.M. Herndon and F.J. Seil.Demos, New York
In Vitro Biological Systems: Preparation and Maintenance (Methods in Toxicology, Vol. 1).
Chapter: Organotypic neural cultures
Page 7 - 26Seil, F.JEditors: C.A. Tyson and J.M. Frazier.Academic Press, Orlando
Encyclopedia of Human Biology, Vol. 6.
Chapter: Plasticity, nervous system
Page 37 - 41Seil, F.JEditors: R. Dulbecco.Academic Press, OrlandoEdition 2,
A Dissection and Tissue Culture Manual of the Nervous System.
Chapter: Thionin stain for nerve tissue cultures
Page 277 - 279Seil, F.JEditors: A. Shahar, J. de Vellis, A. Vernadakis and B. Haber.Alan R. Liss, New York
A Dissection and Tissue Culture Manual of the Nervous System.
Chapter: Cerebellar explants without granule cells or myelin
Page 80 - 82Seil, F.JEditors: A. Shahar, J. de Vellis, A. Vernadakis and B. Haber.Alan R. Liss, New York
A Dissection and Tissue Culture Manual of the Nervous System.
Chapter: Cerebellar explants in Maximow chambers
Page 77 - 79Seil, F.JEditors: A. Shahar, J. de Vellis, A. Vernadakis and B. Haber.Alan R. Liss, New York
Neural Mechanisms of Learning and Memory.
Chapter: Neural subsystems and learning: Tissue-culture approaches
Page 390 - 398Seil, F.J. and Leiman, A.LEditors: M.R. Rosenweig and E.L. Bennett.MIT Press, Cambridge, Massachusetts
Transplantation into the Mammalian CNS, Progress in Brain Research, Vol. 78.
Chapter: Synapse regulation by transplanted astrocytes: A tissue culture study
Page 395 - 399Seil, F.J., Meshul, C.K. and Herndon, R.MEditors: D.M. Gash and J.R. Sladek, Jr.Elsevier, Amsterdam
Cellular and Molecular Aspects of Neural Development and Regeneration, NATO ASI Series, Vol. H22.
Chapter: Neuronal rescue in cerebellar cultures
Page 429 - 438Seil, F.JEditors: A. Gorio, J.R. Perez Polo, J. de Vellis and B. Haber.Springer Verlag, New York
Encyclopedia of Neuroscience, Vol. 1.
Chapter: Demyelinating antibodies
Page 312 - 314Seil, F.JEditors: G. Adelman.Birkhauser Boston, Inc., Cambridge, MA
Encyclopedia of Neuroscience, Vol. 1.
Chapter: Explant cultures of cerebellum
Page 198 - 200Seil, F.J. and Leiman, A.LEditors: G. Adelman.Birkhauser Boston, Inc., Cambridge, MA
Experimental Allergic Encephalomyelitis: A Good Model for Multiple Sclerosis.
Chapter: Serum antimyelin factors in experimental allergic encephalomyelitis and multiple sclerosis
Page 199 - 206Seil, F.J. and Agrawal, H.CEditors: .W. Kies, E.C. Alvord, Jr. and J.J. Suckling.Alan R. Liss, Inc., New York
Nerve, Organ and Tissue Regeneration: Research Perspectives.
Chapter: Circuit reorganization in granuloprival and transplanted cerebellar cultures
Page 283 - 300Seil, F.J., Blank, N.K. and Leiman, A.LEditors: F.J. Seil.Academic Press, New York
Advances in Cellular Neurobiology, Vol. 3.
Chapter: Demyelination
Page 235 - 274Seil, F.JEditors: . Fedoroff and L. Hertz.Academic Press, New York
Glutamate as a Neurotransmitter.
Chapter: Kainate effects in cerebellar cultures
Page 347 - 354Seil, F.J., Blank, N.K., Woodward, W.R. and Leiman, A.LEditors: G. DiChiara and G.L. Gessa.Raven Press, New York
Tissue Culture in Neurobiology.
Chapter: Myelin proteins dissociated from induction of antimyelin antibodies
Page 477 - 488Seil, F.J., Kies, M.W., Agrawal, H.C., Quarles, R.H. and Brady, R.OEditors: E. Giacobini, A. Vernadakis and A. Shahar.Raven Press, New York
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Abstracts/Posters

Changes induced in granuloprival cerebellar cultures by transplantation of granule cells without functional glia.
Seil, F.J, Brain Pathology 3:311
Antisera to an axolemma-enriched fraction have anti-axon and anti-myelin effects in vitro.
Bourdette, D.N., Seil, F.J., Bigbee, J.W., DeVries, G.H., Meshul, C.K. and Agrawal, H.C, J. Neuroimmunol. 16:20
Immune response to axolemma antigens in multiple sclerosis and effects of anti-axolemmal antibody on in vitro myelination.
Calabrese, V.P., Yoshino, J.E., Bigbee, J.W., Bourdette, D.N., Seil, F.J., Hintz, S. and DeVries, G.H, J. Neuroimmunol. 16:26
Differential responses of sprouted axons in coeruleocerebellar cultures to transplantation.
Seil, F.J. and Woodward, W.R, Ann. Neurol. 24:471
Tissue culture models of neuroplasticity.
Seil, F.J, J. Neurotrauma 5:255
Reorganizational changes in cerebellar cultures exposed to Ara C: A timed ultrastructural study.
Seil, F.J., Herndon, R.M., Tiekotter, K.L. and Blank, N.K, Brain Pathology 1:319
Antibodies to N-CAM do not inhibit myelination and glial ensheathment of Purkinje cells in vitro.
Seil, F.J. and Herndon, R.M, Brain Pathology 1:319-320
Tyrosine hydroxylase expression in non-cathecholaminergic neurons in vitro.
Seil, F.J., Johnson, M.L., Nishi, R. and Nilaver, G, Brain Pathology 1:322
Chronic exposure to picrotoxin increases axosomatic synapses and functional inhibition of Purkinje cells in mouse cerebellar cultures.
Drake-Baumann, R., Leiman, A.L., Herndon, R.M., Tiekotter, K.L. and Seil, F.J, Soc. Neurosci. Abstr. 18:1287
Morphological correlates of functional inhibition of organotypic cerebellar cultures by chronic exposure to picrotoxin.
Seil, F.J., Herndon, R.M., Drake-Baumann, R., Leiman, A.L. and Tiekotter, K.L, Brain Pathology 2:261
Reduced inhibitory synapses in cerebellar cultures developing in the absence of neuroelectric activity.
Seil, F.J. and Drake-Baumann, R, J. Neuropathol. Exp. Neurol. 52:285
Anti-axonal antibody induced ultrastructural changes in explant cultures of spinal cord and dorsal root ganglia.
Bigbee, J.W., Meshul, C.K., Bourdette, D.N., Seil, F.J., Garwood, M.M., Agrawal, H.C. and DeVries, G.H, Soc. Neurosci. Abstr. 12:370
Influence of neural activity on Ara C induced circuit reorganization in cerebellar cultures.
Drake-Baumann, R. and Seil, F.J, Soc. Neurosci. Abstr. 19:648
Heterotypical synapses persist in transplanted cerebellar cultures without functional glia.
Seil, F.J, Exp. Neurol. 129:11
Activity dependent development of inhibitory circuitry in cerebellar cultures.
Seil, F.J, Prog. and Abstr.: 10th Biennial Meeting of the ISDN, p.105
Molecular compartmentation expressed in cerebellar cultures in the absence of neuronal activity.
Seil, F.J., Johnson, M.L. and Hawkes, R, Brain Pathology 4:277
Intracellular recordings from Purkinje cells in organotypic cerebellar cultures exposed to Ara C.
Drake-Baumann, R. and Seil, F.J, Soc. Neurosci. Abstr. 20:1673
Synapse elimination by transplanted astrocytes in cerebellar cultures is not activity-dependent.
Seil, F.J, Exp. Neurol. 135:169
Effects of long-term anticholinesterase exposure on neuromuscular function in vitro.
Drake-Baumann, R. and Seil, F.J, Soc. Neurosci. Abstr. 22:273
Serial changes in Ara C treated cultures after “transplantation” with granule cells and glia.
Seil, F.J, Exp. Neurol. 143:334
Laminin, an astrocyte secreted factor, induces dendritic spine proliferation in cerebellar cultures.
Seil, F.J, Exp. Neurol. 153:384
Neurotrophins and activity-dependent inhibitory synaptogenesis.
Seil, F.J. and Drake-Baumann, R, Exp. Neurol. 163:286
Reorganization in granuloprival cerebellar cultures after transplantation of granule cells and glia - light microscopic studies.
Seil, F.J. and Blank, N.K, J. Neuropath. Exp. Neurol. 40:302
Myelination inhibition factor: Its absence in sera from basic protein-sensitized animals.
Seil, F.J, Mechanisms of Demyelination, 6th Annual Winter Conference on Brain Research, pp. 68-69, Vail, Colorado
Purkinje cell dendritic development in tissue culture.
Seil, F.J, Program of the 7th Annual Winter Conference on Brain Research, Steamboat Springs, Colorado
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