FredricAustinGorinMDPhD

Neurology • Sacramento, CA

Professor and Chairperson Neurology, UC, Davis School of Medicine

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Office
4860 Y St Ste 3700
Dept of Neurology UC Davis Medical Center
Sacramento, CA 95817
Phone+1 916-734-3588

Summary

PROFESSIONAL SUMMARY :
•    First correctly predictive pharmacophore for opioid peptides binding to the mu opioid receptor.
•    First human muscle disorder cloned and chromosomally mapped (glycogen phosphorylase, McArdles Disease).
•    Demonstration of an acquired metabolic myopathy of glycogenolysis of fast twitch skeletal muscle following nerve regeneration. Metabolic myopathy explains clinically observed rhabdomyolysis in high intensity muscular activity.
•    Identified that neural activity in fast-twitch skeletal muscle alters metabolic gene expression by regulating their transcript stability via calcium flux of the sarcoplasmic reticulum
•    Designed, co-developed, and implemented a JAVA software tool that generates neuroanatomical metadata indexing and reconciling the names of thalamic structures from different mammalian species. A novel, concept-based vector space model (VSM) employed automated relevance feedback adapted from genomic sequence alignment algorithms. The categorized metadata was applied to archive and retrieve semi-structured graphical neuroscientific information as part of the NIH-funded Human Brain Project.
•    Identified a new class of anti-cancer small molecules that cause a previously unreported form of programmed necrosis in proliferating and non-proliferating, hypoxically transformed cancer initiator cells (CICs). Patented by University of California, these small molecules kill independently of cell cycle by initiating selective endosomal mis-trafficking.
* New class of small molecules that inhibit nitric oxide release from macrophages and microglia
•    As Chairperson, implemented first Telestroke and TeleNeurology programs in the UC Davis Health System. TeleNeurology outreach includes public health initiatives with Central Valley hospital facilities.

Education & Training

University of California (San Francisco)Residency, Neurology, 1980 - 1983
Washington University/B-JH/SLCH ConsortiumInternship, Internal Medicine, 1979 - 1980
Washington U. Med. SchoolPhD, Physiology and Biophysics, 1973 - 1979
Washington University in St. Louis School of MedicineClass of 1979
University of California, DavisBS, Biochemistry, 1969 - 1973

Certifications & Licensure

CA State Medical License 1981 - 2025
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

member Phi Kappa Phi, 1972
Phi Beta Kappa 1972
UC Davis Graduation with Highest Honors 1973
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2012
US Patent # 7,863,415 (January 4, 2011) International Patent Application (WHO 2005/073247) “Amino acid and peptide conjugates of amiloride and methods of use thereof” International Patent Application (WHO 2005/073247), 2005
Inhibitors of intracellular urokinase plasminogen activator and methods of use thereof US 20120108494 A1 USPO, 2012
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Publications & Presentations

PubMed

50 citations
Dynamics of tyrosine hydroxylase mediated regulation of dopamine synthesis
Poorvi Kaushik, Fredric A Gorin, Shireen Vali
Journal of Computational Neuroscience. 2007-04-01
6 citations
A Novel Carboline Derivative Inhibits Nitric Oxide Formation in Macrophages Independent of Effects on Tumor Necrosis Factor α and Interleukin-1β Expression
Ana Cristina Grodzki, Bhaskar Poola, Nagarekha Pasupuleti, Michael H. Nantz, Pamela J. Lein
The Journal of Pharmacology and Experimental Therapeutics. 2015-03-01
16 citations
Stiff-man syndrome: a GABAergic autoimmune disorder with autoantigenic heterogeneity.
Fredric A Gorin, B. Baldwin, Robert C. Tait, R. Pathak, Masud Seyal
Annals of Neurology. 1990-11-01

Journal Articles

Size-stable solid lipid nanoparticles loaded with Gd-DOTA for magnetic resonance imaging
Andreozzi E, Wang P, Valenzuela A, Tu C, Gorin F, Dhenain M, Louie A, Bioconjug Chem, 9/1/2013
5’-Benzylglycinyl-Amiloride Kills Proliferating and Nonproliferating Malignant Glioma Cells through Caspase-Independent Necroptosis Mediated by Apoptosis-Inducing Factor
Pasupuleti N, Leon L, Carraway KL 3rd, Gorin F, J Pharmacol Exp Ther, 3/1/2013
2-Amidino Analogs of Glycine-Amiloride Conjugates: Inhibitors of Urokinase-type Plasminogen Activator
Massey, AP, Harley, WR, NagaRekha Pasupuleti, Gorin, FA, Nantz MH, Bioorg Med Chem Lett, 4/1/2012
Dynamics of Tyrosine Hydroxlase mediated regulation of dopamine synthesis
Kaushik, P., Gorin, F., Vali, S, J Comput Neurosci, 4/1/2007
Amiloride peptide conjugates: prodrugs for sodium-proton exchange inhibition
Palandoken, H, By,K., Hegde, M. Harley,W. Gorin,F.A. and Nantz, MH, J. Pharmacol. Exp. Therap, 1/1/2005
Glycogen synthesis correlates with androgen-dependent growth arrest in prostate cancer
Schnier JB, Nishi K, Gumerlock PH, Gorin FA, Bradbury EM, BMC Urology, 1/1/2005
Sarcoplasmic Calcium Mediates Activity-dependent Regulation of Glycogen Phosphorylase Gene Expression in Contractile Skeletal Muscle Cells
Vali, S., Pessah, I., Carlsen, R.C., and Gorin, F, J. Cell. Physiol, 1/1/2000
Role of E and CArG Boxes in Developmental Regulation of Muscle Glycogen Phosphorylase Promoter during Myogenesis
Froman, B. and Gorin, F.A, DNA and Cell Biol, 1/1/1998
Botulinum-induced muscle paralysis alters metabolic gene expression and fatigue recovery
Gorin F.A., Herrick, K, Froman, B., Palmer W. Tait, R., Carlsen, R, Am. J. Physiol, 1/1/1996
A Subgroup of Human VH3 Genes that encode a High-Avidity Synovial Rheumatoid Factor
Wong, B.S. Tait, R.C., Kenny T, Gorin F. , Robbins, D, Autoimmunity, 1/1/1995
Coordinated Expression of Phosphorylase Kinase Subunits in Regenerating Skeletal Muscle
Cawley, K.C., Akita, C.G., Wineinger, M.A., Carlsen,R.C., Gorin, F.A., Walsh, D.A, J. Biol Chem, 1/1/1992
Reduced Glycolytic Metabolism in Regenerated Skeletal Muscle
Wineinger, M., Gorin, F., Tait, R., Froman, B., Carlsen, R, Am. J. Physiol., 1/1/1991
Brain Isozyme of Glycogen Phosphorylase: Immunohistochemical Localization within the Central Nervous System
Ignacio, P., Baldwin, B., Vijayan, V., Tait, R., and GORIN, F, Brain Res, 1/1/1990
Novel Analogues of Enkephalin: Identification of Functional Groups Required for Biological Activity
Gorin, F.A., Balasubramanian, T.M., Cicero, T.J., Schweitzer, J. and Marshall, G.R, J. Medicinal Chem, 1/1/1979
Elucidation of the Receptor-Bound Conformation of the Enkephalins
Gorin, F.A., Balasubramanian, T.M., Barry, C.D. and Marshall, G.R, J. Supramolec. Structure, 1/1/1978
Proposal for the Biologically Active Conformations of Opiates and Enkephalin
Gorin, F.A. and Marshall, G.R, Proc. Natl. Acad. Sci. USA, 1/1/1977
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Grant Support

Novel Glioma Upa Inhibitor Design Guided By Intracellular Signaling PathwaysNational Institute Of Neurological Disorders And Stroke2009–2010
Novel Amiloride Conjugates Selectively Kill GliomasNational Institute Of Neurological Disorders And Stroke2005–2007
Inhibition Of NA-H Exchanger Selectively Kills GliomasNational Institute Of Neurological Disorders And Stroke2001–2003
Brain Glycogen Phosphorylase In Hypoxic-Ischemic EventsNational Institute Of Neurological Disorders And Stroke1985–1986

Professional Memberships

American Neurological Association
Fellow
Society for Neuro-Oncology
Member
American Chemical Society
Member
American Society for Pharmacology and Experimental Therapeutics
Member