FrederickSouthwickMDFACP CPPS

PubMed

• 1612 citations
  Multifactorial Index of Cardiac Risk in Noncardiac Surgical Procedures
  Lee Goldman, Debra L. Caldera, Samuel R. Nussbaum, Frederick S. Southwick, Donald J. Krogstad
  The New England Journal of Medicine. 1977-10-20
• 238 citations
  Listeria monocytogenes moves rapidly through the host-cell cytoplasm by inducing directional actin assembly.
  Guissou A. Dabiri, Jean M. Sanger, Daniel A. Portnoy, Frederick S. Southwick
  Proceedings of the National Academy of Sciences of the United States of America. 1990-08-01
• 43 citations
  Arrest of Listeria movement in host cells by a bacterial ActA analogue: implications for actin-based motility.
  Frederick S. Southwick, Daniel L. Purich
  Proceedings of the National Academy of Sciences of the United States of America. 1994-05-24

Journal Articles

• Applying Athletic Principles to Medical Rounds to Improve Teaching and Patient Care  
  Southwick, F, Lewis, M, Treloar, D, Cherabuddi, K, Radhakrishnan, N, Leverence,, R, Han, X. and Cottler, L, Acad. Med, 1/1/2014
• Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread  
  Bishai, EA, Sidhu, GS, Li, W, Dhillon, J, Bohil, AB, Cheney, RE, Hartwig, JH and Southwick, FS, Cellular Micro, 1/1/2013
• A Business School Perspective on Medical Interprofessional Rounds: Transforming Rounding Groups into Rounding Teams  
  Bharwani, AM., Harris, GC, and Southwick, FS, Acad Med, 1/1/2012
• Bacillus anthracis Lethal Toxin Induces Broad Transcriptional Responses in Human Peripheral Monocytes  
  Chauncey, KM, MC.Lopez, G Sidhu1, S E Szarowicz, HV Baker,, C Quinn and FS Southwick, BMC Immunology, 1/1/2012
• IDSA Guidelines for Improving the Teaching of Preclinical Medical Microbiology and Infectious Diseases  
  Southwick, F., Katona, P., Kauffman, C. Monroe, S, Pirofski, L-A, Del Rio, C., Gallis, H. and Dismukes, Acad Med, 1/1/2010
• Who was caring for Mary Revisited: A call for all academic physicians caring for patients to focus on systems and quality improvement  
  Southwick, F. and Spear S, Acad Med, 1/1/2009
• Methicillin-resistant Staphylococcus aureus Infection in a College Football Team: Risk Factors Outside the Locker Room and Playing Field  
  Archibald, L.K., Shapiro, J., Pass, A. , Rand, K., and Southwick, F.S, Infect. Control and Hosp. Epidemiol, 1/1/2008
• Spare me the PowerPoint, bring back the medical textbook  
  Southwick, F.S, Transactions of the American Clinical and Climatological Association, 1/1/2007
• Phosphoinositide-3-kinase is required for intracellular Listeria monocytogenes actin-based motility and filopod formation  
  Sidhu, G.S., W. Li, N. Laryngakis, E. Bishai, T. Balla, and F.S. Southwick, J Biol Chem, 1/1/2005
• Actin based endosome and phagosome rocketing in macrophages: Activation by the secretagogue antagonist lanthanum and zinc  
  Southwick, F.S. , Li, W., Zhang, F., Zeile, W.L. and Purich, D.L, Cell Motility and Cytoskeleton, 1/1/2003
• The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins  
  Tchernev, V.T., Mansfield, T.A., Giot, L., Kumar, A.M. Nandabalan, K., Li, Y., Mishra, V.S., Detter, J.C., Rothberg, J.M., Wallace, M.R., Southwick, F.S., Kingsmore, S.F, Molecular Medicine, 1/1/2002
• Gelsolin and ADF/cofilin enhance the actin dynamics of motile cells Commentary  
  Southwick, F.S, Proc. Natl. Acad. Sci, 1/1/2000
• Gelsolin, a barbed-end actin capping and filament severing protein, enhances Listeria actin-based motility in host cells  
  Laine, R.O., Phaneuf, K.L, Kwiatkowski, D.A., Azuma, T. and Southwick, F.S, Infection and Immunity, 1/1/1998
• Mechanisms of Disease: Intracellular pathogenesis of Listeriosis  
  Southwick, F.S. and Purich, D.L, N. Engl. J. Med, 1/1/1996
• Inhibition of Listeria Locomotion by Mosquito Oostatic Factor, a Natural Oligoproline Peptide Uncoupler of Profilin Action  
  Southwick, F.S. and Purich, D.L, Southwick, F.S. and Purich, D.L, 1/1/1995
• Who was caring for Mary?  
  Southwick, F.S, Ann. Intern. Med, 1/1/1993
• Host cell actin assembly is necessary and likely to provide the propulsive force for the intracellular movement of Listeria monocytogenes  
  Sanger, J.M., Sanger, J.W., and Southwick, F.S, Infect. and Immun, 1/1/1992
• Stimulation of human polymorphonuclear leukocyte phosphatidylinositol-4-phosphate kinase by Con A and FMLP is calcium independent: correlation with maintenance of acti...  
  Pike, M.C., Costello, K. and Southwick, F.S, J. Immunol, 1/1/1991
• Listeria monocytogenes moves rapidly through the host cell cytoplasm by inducing directional actin assembly  
  Dabiri, G.A., Sanger, J.M., Portnoy, D.A., Southwick, F.S, Proc. Natl. Acad. Sci. USA, 1/1/1990
• Polymorphonuclear leukocyte adherence induces actin polymerization by a transduction pathway which differs from chemotactic agents  
  Southwick, F.S., Dabiri, G.A., Paschetto, M., and Zigmond, S.H, J. Cell Biol, 1/1/1989
• Contractile Proteins in Leukocytes  
  DiNubile, M.J., Southwick, F.S, Methods of Enzymology, 1/1/1988
• Septic thrombosis of the dural venous sinuses  
  Southwick, F.S., Richardson, E.P. Jr., Swartz, M.N, Medicine, 1/1/1986
• Effects of macrophage profilin on actin in the presence and absence of acumentin and gelsolin, proteins which block the opposite ends of actin filaments  
  DiNubile, M.J., Southwick, F.S, J. Biol. Chem, 1/1/1985
• The Motor of Leukocytes  
  Stossel, T.P., Hartwig, J.H., Yin, H.L., Southwick, F.S., Zaner, K.S, Fed. Proc, 1/1/1984
• Sphenoid Sinusitis: A Review of 30 Cases  
  Lew, P.D., Southwick, F.S., Montgomery, W.W., Weber, A.L., Baker, A.S, N. Engl. J. Med, 1/1/1983
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Books/Book Chapters

• Critically Ill: A 5-Point Plan to Cure Healthcare Delivery - A toolkit for nurses and others who aspire to transform care in our hospitals and clinics 
  Southwick, F.SNo Limits Publishing Group, Carlsbad, CAEdition 2nd,2014
• Infectious Diseases: A Clinical Short Course, Lange Series 
  Southwick, F.SMcGraw-Hill, New YorkEdition 3rd,2014
• Uptodate 
  Chapter: Brain Abscess: Diagnosis and Treatment 
  Southwick, F.S2012
• Uptodate 
  Chapter: Septic Dural Sinus Thrombosis 
  Southwick, F.S2012
• Cecil Medicine 
  Chapter: Nocardiosis 
  Southwick, F.SEditors: Aussiello, D. and Goldman, L.Saunders, Elsevier2012
• Uptodate 
  Chapter: Brain Abscess: Pathogenesis and clinical manifestations 
  Southwick, F.S2006
• Phagocytosis of Bacteria and Bacterial Pathogenicity 
  Chapter: Listeria invasion and spread in nonprofessional phagocytes 
  Southwick, F.SEditors: Ernst, J.D. , and Stendahl, O.Campbridge Press2006
• ACP Medicine 
  Chapter: Gram positive rods 
  Southwick, F.SEditors: Dale, D. and Federman, D.2005
• Cellular Microbiology 
  Chapter: The Actin Cytoskeleton: Regulation of Actin Filament Assembly and Disassembly 
  Southwick, F.SEditors: Cossart, P. Boquet, P., Normark, S., and Rappuloli, R.ASM Press2005
• Infectious Disease Quick Glance 
  Southwick, F.SMcGraw-Hill, New York2004
• Infectious Diseases in 30 days 
  Southwick, F.SMcGraw-Hill, New York2003
• Cytoskeleton: signaling and cell regulation 
  Chapter: Video microscopy: protocols for examining the actin-based motility of Listeria, Shigella, Vaccinia and lanthanum-induced endosomes 
  Zeile, W.L., Purich, D.L. and Southwick, F.SEditors: Carraway, K.L. and Carraway, C.A.C.Oxford University Press2000
• Current Topics in Infectious Diseases 
  Chapter: Septic Thrombophlebitis of Major Dural Sinuses 
  Southwick, F.SEditors: Remington, J. and Swartz, M.N.1995
• Infectious Diseases 
  Chapter: Intracranial suppuration 
  Southwick, F.SEditors: P. Hoeprich, C. Jordan, A. Ronald.Edition 5th,1994
• Key References in Infectious Diseases: An Annotated Guide 
  Southwick, F.S. and Schooley, R.TChurchill Livingston, New York1982
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Abstracts/Posters

• Bacillus anthracis Edema Toxin Impairs Neutrophil Chemotaxis and Enhances Filopodia Formation by Phosphorylating VASP
  Szarowicz, S.E., Chauncey, K. Sidhu, G. Gibson, B., Gertler, F., and Southwick, F., American Society of Cell Biology, 1/1/2009
• Myosin-X Facilitates Shigella Filopodia Formation and Cell-to-Cell Spread
  Bishai, E.A, Sidhu, G.S., Li, W., Bohil, A.P., Cheney, R.E. and Southwick, F.S, American Society of Cell Biology, 1/1/2008
• Bacillus anthracis Edema Toxin Impairs Neutrophil Actin-based Motility
  Szarowicz, S.E., During, R.L., Li, W., Quinn, C.P., Tang, W-J., and Southwick, F.S, American Society of Cell Biology, 1/1/2008
• A CapG Gain-of-function Mutant Reveals Critical Structural and Functional Determinants for Actin Filament Severing
  Zhang, Y., Vorobiev, S.M., Gibson, B.G., Hao, B., Sidhu, G.S., Mishra, V.S., Yarmola, E.G., Bubb. M.R., Almo, S.C. and Southwick, F.S, American Society of Cell Biology, 1/1/2006
• Shigella utilizes Myosin X for intracellular movement and cell-to-cell spread
  Bishai, E., Cheney, R., Sidhu, G. and Southwick, F.S, American Society of Cell Biology, 1/1/2006
• Anthrax Toxins Paralyze Neutrophil Actin-based Motility
  During, R. L. , Li, W., Stephens, D. S, Quinn¬, C. P. and Southwick, F.S, American Society of Microbiology, 1/1/2005
• PI3 Kinase is required for Listeria Actin Based Motility
  Sidhu, G., Li, W., Laryngakas, N. , Balla, T. and Southwick, F.S, J. Infect Disease, 1/1/2004
• Calcium regulation of actin kinetics in Listeria infected cells
  Larson, L. Arnaudeau S., Krause, R., Li, W., Lew, PD, Demaurex N. and Southwick, F.S, J. Infect Dis, 1/1/2002
• Calcium regulation of actin kinetics in Listeria infected cells
  Southwick, F.S. , Arnaudeau S., Krause, R., Li, W., Zeile, W., Lew, PD, Demaurex N, Molec. Biol. Cell, 12/1/2001
• Profilin promotes barbed-end actin filament assembly without lowering the critical concentration
  Purich, D.L., Kang, F., and Southwick, F.S, Molec. Biol. Cell, 12/1/1999
• Actin-based Vaccinia Locomotion in Host Cells Involves ABM-1 and ABM-2 Sequence Recognition
  Zeile, W.L., Condit, R.C., Purich, D.L., and Southwick, F.S, Molec. Biol. Cell, 12/1/1998
• Purification of annexin VI from human leukocytes, intracellular localization in human neutrophils and monocytes, and differential expression during HL-60 differentiation
  Maun, N.A., Ernst, J., and Southwick, F.S, Blood, 1/1/1997
• Role of Vinculin in Shigella Actin-Based Motility in 5.51 and 229 Vinculin-Deficient Host Cells
  Southwick, F.S., E.D. Adamson, and D.L. Purich, Mol. Biol. Cell, 1/1/1997
• Vinculin proteolysis: A molecular switch for Actin Based Motility of Shigella
  Southwick, F.S., Laine, R.O., Zeile, W., Kang, F. and Purich, D.L, Mol. Biol. Cell, 1/1/1996
• Human macrophage CapG: Characterization of gain-of-function mutants with actin-severing activity
  Southwick, F.S. and Bubb, M.R, Cold Spring Harbor Symposium. The Cytoskeleton and Cell Function, 1/1/1995
• Identification of a clone containing the 5' upstream region of the gene encoding for the human actin-binding protein Cap G
  Mishra, V.S. and Southwick, F.S, Mole. Biol. Cell, 1/1/1994
• Intracellular motility of Shigella Flexneri in host cells is blocked by microinjection of a synthetic acta oligoproline peptide
  Zeile, W.L., Purich, D.L., and Southwick, F.S, Mole. Biol. Cell, 1/1/1994
• Human polymorphonuclear leukocyte (PMN) annexin VI is a barbed end actin filament capping protein
  Maun, N.A., Speicher, D.W., and Southwick, F.S, 33rd Annual American Society for Cell Biology meetings, 12/1/1993
• Macrophage capping protein: A unique member of the gelsolin-villin family which is upregulated in macrophages
  Dabiri, G.A., Young, C.L., Southwick, F.S, Clin Res, 1/1/1992
• Macrophage capping protein:barbed end capping and monomer binding require different Ca++concentrations
  Young, C.L. Southwick F.S, Mol Biol Cell, 1/1/1992
• Macropohage capping protein: A unique member of the gelsolin-villin family which is upregulated in macrophages
  Dabiri G.A., Young, C.L., and Southwick, F.S, Clin Res, 1/1/1992
• Supernatants from Listeria Monocytogenes increase the rate of actin polymerization in macrophage extracts
  DiNubile, M.J., Smith, E.R., Southwick, F.S, Clin Res, 1/1/1991
• Macrophage capping protein: a Ca2+-sensitive regulator of actin filament assembly in phagocytes
  Young, C.L., Dabiri, G.A., Southwick, F.S, Clin Res, 1/1/1991
• Analysis of intracellular motility and actin polymerization induced by Listeria monocytogenes in PtK2 Cells
  Sanger, J.M., Mittal,B., Southwick, F.S. and Sanger, J.W, J Cell Biol, 1/1/1990
• Chemoattractant stimulation dissociates profilin-actin complexes in human polymorphonulcear leukocytes
  Southwick, F.S. and Young, C.L, J Cell Biol, 1/1/1989
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Lectures

• Applying Athletic Principles to Multidisciplinary Rounds Improves the Efficiency and Quality of Patient Care 
  10/1/2013
• What Our Founding Father Samuel Adams can teach us about improving health care 
  3/1/2013
• Teamwork in Medicine 
  6/1/2012
• Gatorounds, Converting Medical Groups into Medical Team 
  12/1/2011
• A Harvard Business Student Perspective on Teamwork in Medicine 
  10/1/2010
• Listeria: Lessons learned from an intracellular pathogen 
  Providence, RI - 7/1/2006
• Role of phosphoinositides in Listeria intracellular Motility 
  New London, CT - 6/1/2005
• Calcium regulation of Listeria Actin-based Motility 
  University of Geneva, Geneva, Switzerland - 9/1/2004
• Intracellular pathogenesis of Listeriosis 
  Philadelphia, PA - 11/1/1999
• Listeria and Shigella intracellular pathogenesis: The Generation of Actin Based Motors for Cell-to-Cell Spread 
  Sicily, Italy - 5/1/1998
• Medical care from the patients perspective 
  Washington, DC - 5/1/1997
• The role of oligoproline sequences in the Shigella intracellular movement and cell-to-cell spread 
  Pasteur Institute, Paris, France - 3/1/1997
• Intracellular Pathogenesis of Shigella 
  Zurich, Switzerland - 3/1/1997
• Listeriosis: Intracellular Mechanisms of Disease 
  5/1/1996
• Gain of function mutations of the actin capping protein, Cap G 
  4/1/1995
• Uncoupling of Listeria-actin based motility by oligoproline peptides 
  Plymouth, NH - 7/1/1994
• Meet the Professors 
  4/1/1994
• Leukocyte Motility: The Orchestration of Multiple Actin Regulatory Proteins 
  Sydney, Australia - 12/1/1993
• Higher intracellular gelsolin content results in longer actin filament rocket tails and more rapid intracellular movement of Listeria monocytogenes in transfected 3T3 ... 
  4/1/1993
• Actin assembly is necessary and likely to provide the propulsive force for Listeria intracellular movement 
  Plymouth, NH - 8/1/1992
• How do phagocytes regulate actin filament assembly? 
  Athens, Greece - 4/1/1989
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Other

• Pathogenesis, clinical manifestations, and diagnosis of brain abscess 
  Southwick FS
  http://www.uptodate.com/contents/pathogenesis-clinical-manifestations-and-diagnosis-of-brain-abscess
  UpToDate, Wolters Kluwer Health - 2012-01-16
• Treatment and prognosis of brain abscess 
  Southwick FS
  http://www.uptodate.com/contents/treatment-and-prognosis-of-brain-abscess
  UpToDate, Wolters Kluwer Health - 2012-02-21
• Septic dural sinus thrombosis 
  Southwick FS
  http://www.uptodate.com/contents/septic-dural-sinus-thrombosis
  UpToDate, Wolters Kluwer Health - 2012-09-14