FranklinCharlesWefaldMDFACC

Adult Congenital Heart Disease, Echocardiography, Nuclear Cardiology, Cardiac Critical Care

Millennia Cardiovascular, President

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Office
101 E Market St
Suite 1-H
Smithfield, NC 27577
Phone+1 919-209-9856

Fax+1 919-209-9859

Dr. Franklin Wefald is a cardiologist in Smithfield, NC and is affiliated with WakeMed Raleigh Campus. He received his medical degree from Johns Hopkins University School of Medicine and has been in practice 32 years. He specializes in adult congenital heart disease, echocardiography, nuclear cardiology, and cardiac critical care and is experienced in echocardiography, nuclear cardiology, critical care medicine, and clinical research.

Listed as one of the top cardiologists in North Carolina "Best Doctors in America, Inc.", 1999
Teacher of the Year American Academy of Family Physicians, 1994
Fellow American College of Cardiology, 1992
American Academy of Family Physicians Award St. Joseph's Medical Center and Memorial Hospital, 1992
Merck Fellowship American College of Cardiology, 1988
E.R. Squibb and Sons Senior Thesis Prize Department of Biochemical Sciences, Princeton University, 1981
Phi Beta Kappa 1981
Sigma Xi 1981
Medical Scientist Training Program Johns Hopkins University School of Medicine, 1981
Fellow (FACC) American College of Cardiology
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Journal Articles

Functional heterogeneity of mammalian TATA box sequences as revealed by interaction with a muscle-specific enhancer
Wefald FC, Devlin BH, Williams RS, Nature, 1/1/1990
Nuclear proteins from skeletal myotubes and cardiomyocytes bind to a muscle specific enhancer of the human myoglobin gene
Kraus WE, Wefald FC, William RS, J Biol Chem, 1/1/1990
The myoglobin muscle-specific enhancer contains positive and negative cis-acting elements and binds muscle-specific nuclear factors distinct from MyoD1
Wefald FC, Krause WE, Bernard TS, Williams RS, J Biol Chem, 1/1/1990
Negative transcriptional regulation of the human myoglobin gene
Krause WE, Wefald FC, Bernard TS, Devlin BH, Williams RS, J Biol Chem, 1/1/1990
Identification of a muscle-specific enhancer within the 5' flanking region of the human myoglobin gene
Devlin BH, Wefald FC, Krause WE, Bernard TS, William RS, J Biol Chem, 1/1/1989
Structure of two human alpha-tubulin genes
Wilde CD, Chow LT, Wefald FC, Cowan NJ, Proceedings of the National Academy of Sciences, 1/1/1982
Structural variation among human beta-tubulin genes
Cowan NJ, Wilde CD, Chow LT, Wefald FC, Proceedings of the National Academy of Sciences, 1/1/1981
Metabolism of benzo a pyrene by cultured tracheobronchial tissues from mice, rats, hamsters, bovines, and humans
Autrup H. Wefald, FC, et al, Int. J. Cancer, 1/1/1980
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Abstracts/Posters

Regulation of myoglobin gene expression.
Devin BH, Bolster MB, Krause WE, Wefald FC, Williams RS, J. Cellular Biochem, 1/1/1998
Is 3-Dimensional intracoronary ultrasound a gimmick or a useful clinical tool? Experience in coronary atherectomy.
Smucker ML, Kil D, Sarnat WS, Wefald FC, Howard PF, Journal of the American College of Cardiology, 1/1/1992
Trans-inactivation of the myoglobin muscle-specific enhancer by the transcriptional repressor GCF.
Wefald FC, Kraus WE, Bernard TS, Devlin BH, Williams RS, Circulation, 1/1/1990
A 100 kD nuclear protein from C2 myotubes binds specifically to a muscle-specific enhancer-like element to the human myoglobin gene.
Wefald FC, Kraus WE, Williams RS, J. Cell Biochem, 1/1/1989
Evidence for two functional sites within the myoglobin muscle-specific enhancer-like element to the human myoglobin gene.
Kraus WE, Wefald FC, Williams RS, Clin Res, 1/1/1989
Evidence for two functional sites within the myoglobin muscle-specific enhancer.
Wefald FC, Bernard TS, Williams RS, Circulation, 1/1/1989
Specific TATA sequences are required for activity of the myoglobin muscle-specific enhancer.
Wefald FC, Benjamin LJ, Williams RS, Circulation, 1/1/1989
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Lectures

"Code STEMI: A Community Hospital Approach" (Co-Course Director)
Raleigh, NC - 11/10/2007
"Intravascular Ultrasonography" (Co-Course Director)
Raleigh, NC - 11/1/2006
"Vioxx and Cardiovascular Disease" (Co-Course Director)
Raleigh, NC - 11/1/2005
"The Use of Angiotensin Receptor Inhibitors In The Management Of Cardiomyopathy"
Indianapolis, IN - 4/1/1999
"Evidence Based Management of Hyperlipidemia"
Baldwin, MI - 10/1/1998
"Regression Of Coronary Artery Disease Utilizing Reductase Inhibitors"
South Bend Country Club, South Bend, IN - 9/1/1996
"Update In Cardiology"
The South Bend Marriott And Blackthorn Golf Course, June 1995 - 6/1/1996
"Results Of The West of Scotland Study"
St. Joseph's Hospital Of Marshall County, Plymouth, IN - 6/1/1996
"Cardiovascular Update" Invited Keynote Speaker
5/1/1996
"Treatment Of Hypercholesterolemia"
Elkhart General Hospital, Elkhart, IN - 4/1/1996
"Controversies in Cardiology" (Invited Speaker)
Snowmass Resort, Aspen, CO, February 1995, January 1994 - 2/1/1996
"Door to Drug" (Featured Speaker)
Chesterton, IN - 5/1/1995
"Treatment Of Acute Myocardial Infarction" (Featured Speaker)
Chesterton, IN - 5/1/1995
"Hibernating And Stunned Myocardium" (Featured Speaker)
1/1/1993
"Therapeutic Considerations Of The treatment Of Heart Failure"
St. Joseph's Medical Center, South Bend, IN - 10/1/1992
"Results Of The Gusto Trial"
St. Joseph's Medical Center, South Bend, IN - 1/1/1992
"Regulation Of The Human Myoglobin Gene"
Anaheim, CA - 11/1/1990
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