FrankGonzalezMD

PubMed

• 286 citations
  Inflammation in Polycystic Ovary Syndrome: Underpinning of insulin resistance and ovarian dysfunction
  Frank González
  Steroids. 2012-03-10
• 83 citations
  Effects of Exercise and Caloric Restriction on Insulin Resistance and Cardiometabolic Risk Factors in Older Obese Adults—A Randomized Clinical Trial
  Hussein N. Yassine, Christine M. Marchetti, Raj K. Krishnan, Thomas R. Vrobel, Frank González
  The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2009-01-01
• 298 citations
  Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome.
  Frank González, Neal S. Rote, Judi Minium, John P. Kirwan
  The Journal of Clinical Endocrinology and Metabolism. 2006-01-01

Journal Articles

• Adrenal involvement in polycystic ovary syndrome.  
  González F, Sem Reprod Endocrinol 1997, 15:137-157.
• Adrenal morphologic considerations in polycystic ovary syndrome.  
  González F, Speroff L, Obstet Gynecol Survey 1990, 45:491-508
• Adrenal and ovarian steroid hormone responses to gonadotropin releasing hormone agonist treatment in women with polycystic ovary syndrome.  
  González F, Hatala DA, Speroff L, Am J Obstet Gynecol 1991, 195:535-545
• Nutrient-induced inflammation in polycystic ovary syndrome: role in the development of metabolic aberration and ovarian dysfunction.  
  González F, Sem Reprod Med 2015, 33(4):276-286.
• Oxidative stress in response to saturated fat ingestion is linked to insulin resistance and hyperandrogenism in polycystic ovary syndrome.  
  González F, Considine RV, Abdelhadi OA, Acton AJ, J Clin Endocrinol Metab 2019, July 12, [Epub ahead of print].
• Saturated fat ingestion promotes lipopolysaccharide-mediated inflammation and insulin resistance in polycystic ovary syndrome.  
  González F, Considine RV, Abdelhadi OA, Acton AJ, J Clin Endocrinol Metab 2019, 104(3):934-946
• Pancreatic β-cell dysfunction in polycystic ovary syndrome: role of hyperglycemia-induced nuclear factor κB activation and systemic inflammation.  
  Malin SK, Kirwan JP, Sia CL, González F, Am J Physiol Endocrinol Metab 2015, 308(9):E770–E777
• The altered mononuclear cell-derived cytokine response to glucose ingestion is not regulated by excess adiposity in polycystic ovary syndrome.  
  González F, Sia CL, Shepard MK, Rote NS, Minium J, J Clin Endocrinol Metab 2014, 99(11):E2244-E2251.
• Evidence of mononuclear cell preactivation in the fasting state in polycystic ovary syndrome.  
  González F, Kirwan JP, Rote NS, Minium J, Am J Obstet Gynecol 2014, 211(6):635.e1-635.e7.
• Hyperandrogenism induces a proinflammatory TNF-alpha response to glucose ingestion in a receptor-dependent fashion.  
  González F, Sia CL, Bearson DM, Blair HE, J Clin Endocrinol Metab 2014, 99(5):E848-E854.
• Glucose-induced oxidative stress is inversely related to pancreatic β-cell function in polycystic ovary syndrome.  
  Malin SK, Kirwan JP, Sia CL, González F, J Clin Endocrinol Metab 2014, 99(1):322-329.
• Induction of hyperandrogenism stimulates proatherogenic inflammation in lean reproductive-age women.  
  González F, Nair KS, Basal E, Bearson DM, Schimke JM, Blair HE, Horm Metab Res 2015, 47(6):439-444.
• Glucose and lipoplysaccharide regulate proatherogenic cytokine release from mononuclear cells in women with polycystic ovary syndrome.  
  González F, Kirwan JP, Rote NS, Minium J, J Reprod Immunol 2014, 103:38-44.
• Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and meta-analysis.  
  Escobar-Morreale HF, Luque-Ramírez M, González F, Fertil Steril 2011, 95:1048-1058
• Hyperglycemia alters tumor necrosis factor-alpha release from mononuclear cells of women with polycystic ovary syndrome.  
  González F, Rote NS, Minium J, Kirwan JP, J Clin Endocrinol Metab 2005, 90:5336-5342.
• Inflammation in polycystic ovary syndrome: underpinning of insulin resistance and ovarian dysfunction.  
  González F, Steroids 2012, 77:300-305
• Adrenal dysfunction in PCOS – has it been lost to follow-up?  
  González F, Fertil Steril 2013, 99:352-353.
• Reassessment of adrenal androgen secretion in women with polycystic ovary syndrome.  
  Carmina E, González F, Chang L, Lobo RA, Obstet Gynecol 1995, 85:971-976
• Evidence for heterogeneous etiologies of adrenal dysfunction in polycystic ovary syndrome.  
  González F, Chang L, Horab T, Lobo RA, Fertil Steril 1996, 66:354-361
• The contributions of estrogen and growth factors to increased adrenal androgen secretion in polycystic ovary syndrome.  
  Carmina E, González F, Vidali A, Stanczyk FZ, Ferin M, Lobo RA, Hum Reprod 1999, 14:307-311
• Adrenal dynamic response to physiologic and pharmacologic ACTH stimulation before and after ovarian steroid modulation in polycystic ovary syndrome.  
  González F, Chang L, Horab T, Stanczyk FZ, Crickard K, Lobo RA, Fertil Steril 1999, 71:439-444
• Elevated serum levels of tumor necrosis factor alpha in normal weight women with polycystic ovary syndrome.  
  González F, Thusu K, Abdel-Rahman E, Prahbala A, Tomani M, Dandona P, Metabolism 1999, 48:437-441
• Evidence that insulin and androgens participate in the regulation of serum leptin in women.  
  Carmina E, Ferin M, González F, Lobo RA, Fertil Steril 1999, 72:926-931
• Normal ovulatory women with polycystic ovaries have hyperandrogenic pituitary-ovarian responses to gonadotropin releasing hormone-agonist testing.  
  Chang PL, Lindheim SR, Lowre C, Ferin M, González F, Bergland L, Carmina E, Sauer MV, Lobo RA, J Clin Endocrinol Metab 2000, 85:995-1000
• Glucose ingestion stimulates atherothrombotic inflammation in polycystic ovary syndrome.  
  González F, Kirwan JP, Rote NS, Minium J, Am J Physiol Endocrinol Metab 2013, 304:E375-E383.
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Books/Book Chapters

• Polycystic Ovary Syndrome: Current and Emerging Concepts. 
  Chapter: Obesity, Dysmetabolic and Proinflammatory Milieus of Polycystic Ovary Syndrome 
  Page 155 - 190Morong JJ, González FEditors: Pal L and Seifer DB.Springer, Inc, New YorkEdition 2nd,2022
• Polycystic Ovary Syndrome: Current and Emerging Concepts. 
  Chapter: Obesity, Metabolic Dysfunction and Inflammation in Polycystic Ovary Syndrome. 
  Page 117 - 144Aubuchon M, Bickhaus JA, González FEditors: Pal L.Springer, Inc, New YorkEdition 1st,2014
• Encyclopedia of Reproduction. 
  Chapter: Adrenarche. 
  Page 51 - 61González FEditors: Knobil E and Neill J.Academic Press, San Diego1999

Abstracts/Posters

• Androgen administration induces the expression of NFkB, TNFalpha and IL-1beta in mononuclear cells of normal reproductive-age women.
  González F, Daniels JK, Schimke JM, Nair KS, 8th meeting of the Androgen Excess and Polycystic Ovary Syndrome Society, Program pg 31, Munich, Germany
• Insulin sensitivity and hyperandrogenism in polycystic ovary syndrome are related to activated nuclear factor KB from mononuclear cells in the fasting state
  González F, Rote NS, Minium J, Kirwan JP, 89th meeting of the Endocrine Society, Program pg 142, Toronto, Ontario, Canada
• HDL cholesterol is a strong predictor of insulin resistance in older Caucasian adults.
  Yassine H, Marchetti CM, Brooks LM, Krishnan RK, González F, Kirwan JP, 67th Scientific Sessions of the American Diabetes Association, Diabetes 56 (2 Suppl):A626, Chicago, IL
• Effects of an acute lipid challenge on hepatic glucose output before and after exercise/diet intervention programs in older obese adults with impaired glucose tolerance.
  Kirwan JP, Marchetti CM, Krishnan RK, Edmison J, González F, 67th Scientific Sessions of the American Diabetes Association, Diabetes 56 (2 Suppl):A39, Chicago, IL
• Insulin sensitivity, abdominal adiposity and hyperandrogenism in polycystic ovary syndrome are related to oxidative stress in the fasting state.
  González F, Rote NS, Minium J, Kirwan JP, 63th meeting of the American Society Reproductive for Medicine, Fertil Steril 88 (2 Suppl):S76-S77, Washington D.C
• Hudson SB, Coddington CC. Impact of sperm morphology as assessed by strict or World Health Organization (WHO) version 3 criteria on outcome of intrauterine insemination.
  Hughes PM, Morbeck DE, Wilstrom R, González F, 63th meeting of the American Society for Reproductive Medicine, Fertil Steril 87 (2 Suppl):S370, Washington D.C
• Effects of age on fat oxidation in obese humans.
  Solomon PJ, Marchetti CM, Krishnan RK, González F, Kirwan JP, 26th meeting of the North American Organization for the Study of Obesity, Obesity 15 (9 Suppl):A64-A, New Orleans, LA
• Nampt/PBEF/Visfatin is related to the insulin response to oral glucose following exercise training in obese elderly individuals.
  Haus JM, Marchetti CM, Brooks LM, O’Leary VB, González F, Kirwan JP, 68th Scientific Sessions of the American Diabetes Association, Diabetes 57 (1 Suppl):A304, San Francisco, CA
• Elevated macrophage migration inhibitory factor levels in polycystic ovary syndrome – relationship with abdominal adiposity, C-reactive protein and hyperandrogenism.
  González F, Rote NS, Minium J, Kirwan JP, 90th meeting of the Endocrine Society, Program pg 746, San Francisco, CA
• Elevated circulating tissue factor levels in polycystic ovary syndrome – relationship with insulin sensitivity, abdominal adiposity and hyperandrogenism.
  González F, Rote NS, Minium J, Kirwan JP, 64th meeting of the American Society for Reproductive Medicine, Fertil Steril 90 (2 Suppl):S15, San Francisco, CA
• Insulin sensitivity and hyperandrogenism in polycystic ovary syndrome are related to proatherogenic inflammation in the fasting state.
  González F, Rote NS, Minium J, Kirwan JP, 56th meeting of the Society for Gynecologic Investigation, Reprod Sci 16 (2 Suppl):82A, Glasgow, Scotland
• Insulin sensitivity and hyperandrogenism in polycystic ovary syndrome are related to increased lipopolysaccharide-stimulated TNF release from mononuclear cells.
  González F, Rote NS, Minium J, Kirwan JP, 7th meeting of the Androgen Excess and Polycystic Ovary Syndrome Society, Program pg 26, Washington, D.C
• Hyperandrogenism is related to the circulating matrix metallopreinase-9 response to hyperglycemia in women with polycystic ovary syndrome.
  González F, Rote NS, Minium J, Kirwan JP, 65th meeting of the American Society for Reproductive Medicine, Fertil Steril 92 (2 Suppl):S38, Atlanta, GA
• Anti-inflammatory effect of hyperandrogenism in polycystic ovary syndrome.
  González F, Nair KS, Coddington CC, Blair HE, 57th meeting of the Society for Gynecologic Investigation, Reprod Sci 17 (3 Suppl):249A-250A, Orlando, FL
• Androgen administration stimulates reactive oxygen species generation from leukocytes of normal reproductive-age women.
  González F, Daniels JK, Blair HE, Nair KS, 57th meeting of the Society for Gynecologic Investigation, Reprod Sci 17 (3 Suppl):265A-266A, Orlando, FL
• The effects of 7-day exercise training and a low versus high glycemic diet on insulin resistance in older obese adults.
  Riccardi ME, Barkoukis H, Marchetti CM, Brooks LM, Nardi AE, González F, Kirwan JP, 23rd Annual Symposium of the Sports, Cardiovascular and Wellness Nutrition Group of the American ..., Austin, TX
• Androgen administration induces lipopolysaccharide tolerance and increased mononuclear cell sensitivity in normal reproductive-age women.
  González F, Daniels JK, Blair HE, Nair KS, 66th meeting of the American Society for Reproductive Medicine, Fertil Steril 94 (2 Suppl):S70, Denver, CO
• In vitro testosterone exposure suppresses lipopolysaccharide-stimulated cytokine release from mononuclear cells of normal reproductive-age women – evidence of lipopoly...
  González F, Daniels JK, Blair HE, Nair KS, 66th meeting of the American Society for Reproductive Medicine, Fertil Steril 90 (2 Suppl):S194, Denver, CO
• Androgen administration activates nuclear factor kB in mononuclear cells of normal reproductive-age women
  González F, Nair KS, Basal E, Daniels JK, 58th meeting of the Society for Gynecologic Investigation, Reprod Sci 18 (3 Suppl):S292-S293, Miami Beach, FL
• Androgen administration in normal reproductive-age women is a promoter of diet-induced oxidative stress as characterized in polycystic ovary syndrome.
  González F, Nair KS, Basal E, Daniels JK, Blair HE, 93rd meeting of the Endocrine Society, Endocr Rev 32:OR21-2, Program pg 146, Boston, MA
• Diet-induced oxidative stress is independent of abdominal adiposity in normal weight women with polycystic ovary syndrome.
  González F, Shepard MK, Rote NS, Minium J, 9th meeting of the Androgen Excess and Polycystic Ovary Syndrome Society, Program pg 64, Orlando, FL
• Androgen administration in normal reproductive-age women promotes proatherogenic inflammation as characterized in polycystic ovary syndrome.
  González F, Nair KS, Basal E, Bearson DB, Schimke JM, Blair HE, 67th meeting of the American Society for Reproductive Medicine, Fertil Steril 96 (2 Suppl):S41-S42, Orlando, FL
• Induction of hyperandrogenism in lean reproductive-age women alters the mononuclear cell interleukin-1beta response to glucose ingestion in the presence and absence of...
  González F, Daniels JK, Bearson DB, Blair HE, 59th meeting of the Society for Gynecologic Investigation, Reprod Sci 19 (3 Suppl):206A, San Diego, CA
• Suppression of lipopolysaccharide-stimulated cytokine release from mononuclear cells of lean reproductive-age by in vitro androgen exposure – an LPS tolerance phenomenon.
  González F, Daniels JK, Bearson DB, Blair HE, 59th meeting of the Society for Gynecologic Investigation, Reprod Sci 19 (3 Suppl):206A, San Diego, CA
• Hyperandrogenism increases the proinflammatory TNF response to glucose ingestion in a receptor-dependent fashion – implication of androgen-induced developmental immun...
  González F, Sia CL, Daniels JK, Bearson DB, Blair HE, Origins of PCOS update meeting of the Androgen Excess and Polycystic Ovary Syndrome Society, Program, Houston, TX
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Lectures

• Surgical Management of Obesity to Ameliorate Metabolic Syndrome in Polycystic Ovary Syndrome. 
  64th Annual Meeting of the American Society for Reproductive Medicine, San Francisco, CA
• Hyperglycemia-Induced Oxidative Stress and TNF alpha Release in Polycystic Ovary Syndrome. 
  University Hospitals of Cleveland, Dept. of Ob-Gyn, Research Seminar, Cleveland, OH
• The Role of Nutrition in the Management of Polycystic Ovary Syndrome. 
  MetroHealth Medical Center, Dept. of Nutrition, Annual Nutrition Seminar for Dietitians, Cleveland
• Misconception About Conception. 
  MetroHealth Medical Center, Dept. of Ob-Gyn, Infertile Couples Seminar, Cleveland, OH
• The Inflammation Pathway: Mechanism of Insulin Resistance in Polycystic Ovary Syndrome? 
  The Mayo Clinic, Dept. of Internal Medicine, Division of Endocrinology and Metabolism
• The Inflammation Pathway: Mechanism of Insulin Resistance in Polycystic Ovary Syndrome? 
  MetroHealth Medical Center, Dept. of Ob-Gyn, Grand Rounds, Cleveland, OH
• Hyperglycemia-Induced Inflammation and Risk of Atherogenesis in Polycystic Ovary Syndrome. 
  University Hospitals of Cleveland, Dept. of Ob-Gyn, Research Seminar, Cleveland, OH
• Polycystic Ovary Syndrome – An Update. 
  Mayo Clinic, Dept. of Ob-Gyn, Ob/Gyn Clinical Reviews, Rochester, MN
• Inflammation: Effects on Insulin Resistance and Atherogenesis in Polycystic Ovary Syndrome. 
  Mayo Clinic, Dept. of Medicine, Division of Medical Endocrinology and Metabolism
• Medical and Lifestyle Intervention to Ameliorate Inflammation and Insulin Resistance in Polycystic Ovary Syndrome. 
  86th Annual Meeting of the International Gynecologic Society
• The Role of Diet-Induced Inflammation in the Promotion of Insulin Resistance in Polycystic Ovary Syndrome. 
  63rd Annual Meeting of the American Society for Reproductive Medicine, Roundtable Presentation
• Diagnóstico Y Tratamiento del Síndrome del Ovario Poliquístico. 
  Segundo Curso Internacional de Endocronología, Diabetes y Metabolismo, Quito, Ecuador
• Rol de la Inflamación en la Promoción de la Resistencia a la Insulina en el Síndrome del Ovario Poliquístico. 
  Segundo Curso Internacional de Endocronología, Postgraduate Course Lecture, Quito, Ecuador
• Overview of the Metabolic Syndrome: Diagnosis and Prevalence in Polycystic Ovary Syndrome. 
  64th Annual Meeting of the American Society for Reproductive Medicine, San Francisco, CA
• Inflammation and its Relation to Insulin Resistance and Atherogenesis in Polycystic Ovary Syndrome. 
  64th Annual Meeting of the American Society for Reproductive Medicine, San Francisco, CA
• Elucidation of the Effect of Inflammation on Insulin Resistance in Polycystic Ovary Syndrome 
  State University of New York at Buffalo, Dept. of Medicine, Division of Endocrinology
• Metabolic Syndrome and Polycystic Ovary Syndrome: Understanding the Effects of Inflammation. 
  64th Annual Meeting of the American Society for Reproductive Medicine, Roundtable Presentation, CA
• Human Oocyte Cryopreservation. 
  Resolve - Midwest Region, Cutting Edge Panel Discussion, Golden Valley, MN
• A Comprehensive Overview of Polycystic Ovary Syndrome. 
  Mayo Clinic, Dept. of Obstetrics and Gynecology, Grand Rounds, Rochester, MN
• Clinical Challenges in Polycystic Ovary Syndrome. 
  65th Annual Meeting of the American Society for Reproductive Medicine, Interactive Session, Atlanta
• Polycystic Ovary Syndrome: A Comprehensive Overview. 
  Indiana University School of Medicine, Dept. of Obstetrics and Gynecology, Grand Rounds, Indianapoli
• Diet-Induced Inflammation in Polycystic Ovary Syndrome. 
  Indiana University School of Medicine, Dept. of Medicine, Research Seminar, Indianapolis, IN
• Diet-Induced Inflammation in Polycystic Ovary Syndrome. 
  Mayo Clinic Immunochemical Core Laboratory Production Meeting, Rochester, MN
• Normal Metabolism / Abnormal Metabolism in Polycystic Ovary Syndrome. 
  66th Annual Meeting of the American Society for Reproductive Medicine, Denver, CO
• Inflammation in Polycystic Ovary Syndrome: Effect on Insulin Resistance, Atherogenesis and Ovarian Dysfunction. 
  66th Annual Meeting of the American Society for Reproductive Medicine, Denver, CO
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