Frank A Anania MD FACP, AGAF

PubMed

• 14 citations
  Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement.
  Brian P Lee, Katie Witkiewitz, Jessica Mellinger, Frank A Anania, Ramon Bataller
  Nature Reviews. Gastroenterology & Hepatology. 2024-09-01
• 30 citations
  Nonalcoholic Steatohepatitis: Current Thinking From the Division of Hepatology and Nutrition at the Food and Drug Administration.
  Frank A. Anania, Lara Dimick-Santos, Ruby Mehta, Joseph G. Toerner, Julie Beitz
  Hepatology. 2021-05-01
• 49 citations
  Blocking integrin α4β7-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis.
  Ravi Prakash Rai, Yunshan Liu, Smita S. Iyer, Silvia Liu, Biki Gupta
  Journal of Hepatology. 2020-11-01

Journal Articles

• Adipocytokines and Liver Fibrosis  
  Saxena NK, and Anania FA, Trends in Endocrinology and Metabolism, 1/1/2015
• Fructose induces non-alcoholic steatofibrosis and exacerbates metabolic syndrome in mice fed a western diet  
  Mells JE, Smith T, Fu P, Anania FA, J of Nutritional Biochem, 1/1/2015
• Liver fibrosis occurs through dysregulation of MyD88-dependent innate B cell activity  
  Thapa M, Chinnadurai R, Velazque V, Tedesco D, Elrod E, Han JH, Ibegbu C, Anani FA, Pulendran B, Suthar M and Grakou A, Hepatology, 1/1/2015
• Universities and sponsored research: Indirect cost recovery and the law of diminishing return  
  Anania FA, Hepatology, 1/1/2015
• Hepatitis B reactivation during successful treatment of hepatitis C with sofosbuvir and simeprevir  
  Collins JM, Raphael KL, Terry C, Cartwright EJ, Pillai A, Anania FA, Farley MM, Clin Infect Dis, 1/1/2015
• A nanoparticle with the adiponectin-agonist ADP355 reverses high grade hepatic fibrosis in CCl4-treated mice  
  Kumar P, Smith T, Anania FA, PLoS One, 1/1/2014
• Non-alcoholic steatohepatitis (NASH) guidelines for the developing world: a report to the World Gastroenterology Organization (WGO)  
  LaBrecque D, Anania FA, and others, J of Clinical Gastroenterology, 1/1/2014
• Adiponectin down regulates the focal adhesion kinase (FAK) and focal adhesion complexes by a SHP2 phosphatase-dependent mechanism  
  Kumar P, Fu PP, Anania FA, FASEB J, 1/1/2014
• Mitigation of autophagy ameliorates hepatocellular damage following ischemia reperfusion injury in murine steatotic liver  
  Gupta NA, Kolach V, Jiang R, Shenoi A, Kosters A, Anania FA, Kirk AD, Am J Physiol, 1/1/2014
• Glial Cell Line Derived Neurotrophic Factor Prevents High Fat Diet Induced Obesity  
  Srinivasan S, Mwangi SM, Marri S, Nezami BG, Fu P , Javelin CC, Shanmugham N, Sitaraman SV, Anania FA, Am J Phyisol GI and Liver, 1/1/2014
• Randomized clinical trial: Beneficial effect of VSL#3 in obese children with non-alcoholic fatty liver disease  
  Alisi A, Baviera G, Valentina G, Porro E, Paris C, Giammaria P, Reali E, Anania F, Nobili V, Alimen Pharm, and Therapeutics, 1/1/2014
• Peptide hormones and NAFLD  
  Mells JE and Anania FA, Seminars in Liver Disease, 1/1/2013
• The prevalence and clinical correlates of non-alcoholic fatty liver disease (NAFLD ) in African-Americans: The Multi Ethnic Study of Atherosclerosis (MESA)  
  Foster T, Anania, FA, Li D, Katz R, Budoff M, Dig Dis and Sci, 1/1/2013
• Connecting the dots from fatty acids to NASH – epigenetics in the spotlight  
  Selaru FM and Anania FA, Hepatology, 1/1/2013
• Update in the pathogenesis of non-alcoholic fatty liver diseases  
  Paola L and Anania FA, Hepatology Research, 1/1/2013
• A Renaissance in Medical Biochemistry-Hepatology and Endocrinology kicking it up a Notch!  
  Anania FA, J Hepatology, 1/1/2013
• Reduction of hepatic steatosis and inflammation by the long-acting glucagon-like peptide one analogue, liraglutide  
  Mells J, Fu P, Olsen D, Anania FA, Amer J Physiology, Gastrointestinal and Liver Physiol, 1/1/2012
• The Glucagon-Like Peptide-1 Receptor Agonist, Exendin 4, Has a Protective Role in Ischemic Injury of Lean and Steatotic Liver by Inhibiting Cell Death and Stimulating ...  
  Gupta NA, Kolachala VL, Jiang R, Abramowsky C, Romero R, Fifadara N, Anania FA, Knechtle S, Kirk A, Am J Pathol, 1/1/2012
• Nonalcoholic fatty liver disease and fructose: bad for us, better for mice  
  Anania FA, J Hepatol, 1/1/2011
• Adiponectin inhibits leptin signaling via multiple mechanisms to exert protective effects against hepatic fibrosis  
  Handy J, Fu P and Anania FA, Biochemical, 1/1/2011
• Adiponectin prohibits Stat3 phosphorylation by activation of AMP activated kinase (AMPK) to impede hepatic fibrosis  
  Handy J, Fu Ping, Lin S, Mells J, Gupta N, Saxena, NK and Anania FA, J Cell Biochem, 1/1/2010
• GLP-1 receptor is present in human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway  
  Gupta N, Mells J, Dunham R, Grakoui A, Handy A, Saxena NK, and Anania FA, Hepatology, 1/1/2010
• Recent changes in the relationships between medical schools and industry  
  Anania FA, Yang VW, Gastroenterology, 1/1/2010
• Subtleties in the Conflicts of Interest  
  Anania FA and Yang VW, Gastroenterology, 1/1/2010
• Model for end stage liver disease (MELD) score versus Child score in predicting the outcome of surgical procedures in patients with cirrhosis  
  Hoteit MA, Ghazale AH, Bain AJ, Rosenberg ES, Easley KA. Anania FA, and Rutherford RE, World J Gastro, 1/1/2008
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Books/Book Chapters

• Essentials of Gastroenterology 
  Chapter: Liver Embryology, Gross and Microscopic Anatomy and Cell Biology of the Liver Lobule 
  Anania FAEditors: Anania FA Associate Editor, Liver Section, et. Al. Sitaraman SV and Freidman L, Eds.Wiley, West Sussex, United Kingdom2012
• Gastroenterology 
  Chapter: Non-Alcoholic Fatty Liver Disease 
  Anania FA and Cohen DEEditors: Norton Greenberger.McGraw Hill, New York, NYEdition 1st,2009
• Comprehensive Hospital Medicine 
  Chapter: Cirrhosis 
  Bala V and Anania FAEditors: M. V. Williams.Saunders (Elsevier), Philadelphia, PA2007
• New Insights into the Biochemical, Cellular, and Molecular Mechanisms of Liver Diseases 
  Chapter: Pathobiology of Non-Alcoholic Fatty Liver Disease 
  Anania FAEditors: D. Mann, S. Friedman, and S. Ali.M/s Sc Pub; IBH Pub, Oxford, United Kingdom; India2006
• Gastroenterology Pearls of Wisdom. 
  Chapter: Liver: Alcoholic Liver Disease and Non-Alcoholic Steatohepatitis 
  Anania FAEditors: John DiBaise.Medical Publishing Company, Boston, MA2000
• Gastroenterology Pearls of Wisdom. 
  Chapter: Liver: Metabolic Disorders 
  Anania FAEditors: John DiBaise.Medical Publishing Company, Boston, MA2000
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Abstracts/Posters

• Glial cell lin-derived neurotorphic factor (GDNF) induces liver defatting: a novel strategy to enable transplantation of steatotic liver.
  Sahar V, Kailar R, Rahman K, Mwangi SM. Anania FA, Srinivasan S, Gastroenterology; DDW, 1/1/2015
• Intestinal epithelial barrier integrity regulates non-alcoholic fatty liver disease (NAFLD) progression.
  Rahman K, Thorn NE, Iyer SS, Kumar P, Smith T, Nusrat A, Parkos CA, Anania FA, Keystone Symposium, British Columbia, Canada, 1/1/2015
• Compromised intestinal epithelial barrier function is a major contributor in the progression of diet-induced non-alcoholic fatty liver disease (NAFLD) to steatohepatit...
  Rahman K, Thorn N, Kumar P, Nusrat A, Parkos CA, Anania FA, AASLD Meeting, Boston, MA, 1/1/2014
• CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) deficient mice protect against apoptotic hepatocyte cell death and permits ER-stress related adaptatio...
  Kumar P, Khalidur R, Anania FA, Hepatology; AASLD, 1/1/2013
• Exercise increases GDNF and protects against diabetic-associated enteric neuron degeneration.
  Mawngi S, Mallappa A, Anania FA, and Srinivasan S, Gastroenterology; DDW, Orlando, FL, 1/1/2013
• Adiponectin and a SHP-2 dependent mechanism disrupt focal adhesion kinase-mediated anti-fibrogenic effects.
  Kumar P, Fu PP, Mells JE, and Anania FA, Gastroenterology; DDW, Orlando, FL, 1/1/2013
• Compromised intestinal epithelial barrier integrity in Junctional Adhesion Molecule (JAM-A) global knockout mice regulates the severity of diet-induced non-alcoholic s...
  Khalidur R, Kumar P, Nusrat A, Parkos P, and Anania FA, Hepatology; AASLD, Washington, DC, 1/1/2013
• GLP-1 modulates cardiac function through a Ang II receptor mediated response.
  Anania FA and Sorescu D, American Heart Association, 1/1/2012
• GDNF protects against diet-induced fatty liver Disease.
  Mwangi S, Nezami B, Mallappa A, Fu PP, Anania FA and Srinivasan S, Hepatology; Hepatology Late Breaking Abstract; AASLD Annual Meeting, Boston, MA, 1/1/2012
• The prevalence of non-alcoholic fatty liver disease in African-Americans: beyond the MESA cohort.
  Foster TY and Anania FA, Hepatology; AASLD Annual Meeting, Boston, MA, 1/1/2012
• Outcomes of the MESA cohort: true prevalence of non-alcoholic steatohepatitis in African-Americans.
  Foster, TY and Anania FA, Emory Department of Medicine Research Day, 1/9/2011
• Adiponectin acts to disrupt focal adhesions in activated hepatic stellate cells by prohibiting activation of focal adhesion kinase (FAK).
  Kumar P, Fu PP, Mells JE, and Anania FA, Emory Department of Medicine Research Day, 1/9/2011
• GDNF is protective against weight gain and metabolic syndrome in high-fat fed mice.
  Mangwi S, Sitaraman SV, Anania FA, Srinivasan, Gastroenterology; DDW, Chicago, IL, 1/1/2011
• GLP-1 analogue ameliorates hepatic steatosis and cardiac hypertrophy in mice fed trans fat and high fructose corn syrup diet.
  Mells JE, Sharma S, Fu PP, Handy JA, Saxena NK, Anania FA, Experimental Biology Meeting, Washington, DC, 1/1/2011
• Western diet-induced insulin resistance leads to cardiac hypertrophy and dysfunction via activation of FoxO3A in murine heart.
  Lihong Cheng, Jamie E. Mells, Atsuko Tanaka, Torahiro Matsuda, Zhe Jiao, Qianhong Qin, Alexandru Barbulescu, Frank A. Anania and Dan Sorescu, American Heart Association, 1/1/2011
• The adiponectin receptor R1 and not and not adenosine monophosphate kinase (AMPK) up regulates protein tyrosine phosphatase 1B (PTP1B)-a mechanism to prevent fibrosis.
  Kumar P, Handy JA, Fu PP, Mells JE, Anania FA, Hepatology; AASLD Annual Meeting, San Francisco, CA, 1/1/2011
• Adiponectin disrupts focal adhesion in activated rat hepatic stellate cells in vitro and in vivo, and activates matrix metalloproteinase I: implications for matrix rem...
  Kumar P, Fu PP, Mells JE, Anania FA, Hepatology; AASLD Annual Meeting, San Francisco, CA, 1/1/2011
• Adiponectin a guardian angel hormone against the malignant enhancing effect of leptin in hepatocarcinogenesis.
  Nagalingam A, Fu P, Mells J, Sharma S, Handy J, Wang J, Cohen C, Sharma D, Anania FA, Saxena NK, Hepatology; American Association for the Study of Liver Disease, Boston, MA, 1/1/2010
• Daily Administration of Liraglutide Ameliorates the Deleterious Effects of high-fructose corn syrup and trans-fat feeding in C57BL6 mice: Implications for NAFLD.
  Mells JE, Fu PP, Sharma S, Handy JA, Saxena NK, Anania FA, Hepatology; American Association for the Study of Liver Disease, Boston, MA, 1/1/2010
• Adiponectin enhances SOCS-3/OB-R association and PTP-1B expression to suppress leptin signaling: implications for hepatic fibrosis.
  Handy A, Fu PP, Mells JE, Sharma S, Saxena NK, Anania FA, Hepatology; American Association for the Study of Liver Disease, Boston, MA, 1/1/2010
• The glucagon-like peptide-1 (GLP-1) analogue Exendin-4 eliminates hepatic steatosis by reducing endoplasmic reticular (ER) stress-related CHOP expression and promotes ...
  Sharma S, Mells JE, Fu PP, Handy JA, Saxena NK, Anania FA, Hepatology; American Association for the Study of Liver Disease, Boston, MA, 1/1/2010
• Role of GLP-1R agonists in decreasing hepatic steatosis and apoptosis in ob/ob mice undergoing ischemia reperfusion injury.
  Gupta NA, Kwun J, Kirk AD, Anania FA, Romero RR, Knechtle SJ, Hepatology; American Association for the Study of Liver Disease, Boston, MA, 1/1/2010
• Adiponectin negatively modulates the pro-cancerous effects of leptin on HepG2 and Huh7 cells and xenograft-tumor growth in nude mice.
  Sharma D, Fu P, Anania FA, and Saxena NK, Gastroenterology; DDW, New Orleans, LA, 1/1/2010
• Glucagon-like peptide-1 receptor (GLP-1R) is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the ...
  Mells JE, Gupta NA, Dunham R, Grakoui A, Handy JA, Saxena NK, and Anania FA, Fourth Annual Frontiers of Clinical Investigation-Bench to Bedside: Metabolism Symposium, sponsored by Nature Medicine, Torrey Pines, CA, 1/1/2009
• Long acting glucagon-like peptide 1 proteins (Exenatide) have insulin sensitizing properties in human hepatocytes: efficacy in non-alcoholic fatty liver disease (NAFLD).
  Anania FA, Saxena NK, Fu P, Mells J, Gupta N, J Hepatol; European Association for the Study of the Liver, Bologna, Italy, 1/1/2009
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Lectures

• Nutrition and Health-Fatty Liver and Obesity 
  1/1/2015
• Fatty Liver and Insulin Resistance 
  1/1/2015
• Intestinal JAMS and fatty liver disease. 
  Emory University School of Medicine - 1/1/2015
• Blue Skies, Intestinal JAMS: fatty liver lessons learned. 
  Albert Einstein College of Medicine, New York, NY - 1/1/2014
• Iron Metabolism: Beyond C282Y 
  1/1/2014
• Junctional Adhesion Molecule A and Hepatic Steatofibrosis-Circling the Wagons of Digestive Diseases 
  Vanderbilt University - 1/1/2014
• Modulation of focal adhesion Kinase Activity: Implications for reversing hepatic fibrogenesis by a synthetic adiponectin decamer. 
  University of Arkansas Medial System, Little Rock, AR - 1/1/2014
• Targets in NASH Fibrosis-hitting Two Targets. 
  Chicago, IL - 1/1/2014
• NASH and gut peptides, why bile matters. 
  Americus, GA - 1/1/2014
• Hepatocellular Carcinoma 
  Murcia, Spain - 1/1/2013
• Fibrosis and FAK Biology 
  Georgia State University - 1/1/2013
• Symposium on Liver Disease and Transplantation: A Multidisciplinary Approach 
  Emory University School of Medicine, Atlanta, Georgia - 12/1/2012
• The liver and kidney a tale of two organs. 
  Emory University - 1/1/2012
• Liver Fibrogenesis-Targets for Hepatic Fibrosis 
  San Diego, CA - 1/1/2012
• NAFLD and its impact on liver transplantation in the United States. 
  Emory University - 1/1/2012
• The Role of the Psychologist in the Evaluation of Liver Transplant Candidates 
  Atlanta VAMC, Atlanta, GA - 1/1/2012
• Leptin, Adiponectin: The Yin and Yang of Fatty Liver Diseases and Fibrosis 
  1/1/2011
• Fibrosis, Cancer and Fat. 
  Brigham and Women’s Hospital, Harvard Medical School, Boston, MA - 1/1/2010
• Liver Injury and Repair: Fat and Fibrogenesis. Visiting Professor 
  University of Maryland, Boston, MA, School of Medicine, Baltimore, MD - 1/1/2010
• Insights into molecular metabolism of adipocytokines and small GLP proteins in chronic liver disease and: implications for treatment. 
  Snowmass, CO - 1/1/2010
• Multiple Small Feedings of the Mind in Hepatology 
  Philadelphia, PA - 1/1/2009
• Non-alcoholic fatty liver disease-what every medical practitioner needs to know. 
  University of Kansas Medical Center, Kansas City, KS - 1/1/2009
• Non-alcoholic Fatty Liver Disease 
  Bologna, Italy - 1/1/2009
• Conflict of Interest 
  Emory University School of Medicine, Atlanta, GA - 1/1/2009
• Fundamentals of Hepatic Fibrosis-Past, Present, and Future 
  Mayo Clinic, Scottsdale, AZ - 1/1/2008
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Other

• The Service Portfolio-what to include when facing promotion. Teaching Aid 
  Anania FA, Department of Psychiatry, EUSOM
  1/1/2012
• 2nd Year Pathophysiology Lecture Handout 
  Anania FA
  Johns Hopkins University - 1/1/1998