EzraBursteinMDPhD

Professor and Chief, Division of Digestive and Liver Diseases, Dept of Internal Medicine, University of Texas Southwestern Medical Center, Southwestern Medical School

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Office
5323 Harry Hines Boulevard
Dallas, TX 75390
Phone+1 214-645-8600

Fax+1 214-645-8601

Summary

I am a physician-scientist with clinical training in gastroenterology and research training and expertise in the area of molecular immunology. I was born and raised in Peru, where I obtained my medical degree, and immigrated to the USA to continue my training in Internal Medicine (UT Southwestern), Gastroenterology (University of Michigan) and Immunology (NIH/Vaccine Research Center).

As a clinician, I have devoted the past 15 years to the care of patients with inflammatory bowel disease. Also, given my expertise in molecular biology and genetics, I see patients with genetic syndromes involving the GI tract. As a scientist, the work in my laboratory is focused on basic mechanisms that control inflammatory responses in human disease, particularly inflammatory bowel disease (IBD). Earlier work from the lab focused on the NF-kappaB transcription factor, and in the context of those studies, I discovered the COMMD protein family and have continued to investigate the basic functions of these factors. Other work of the lab focuses on genetic determinants of Mendelian inflammatory disorders in humans.

In the course of my career, I have had the opportunity to serve as a mentor to several junior scientists and faculty members, including as program director of an T32-supported training grant. Besides my passion for education and training of the next generation of investigators, I have also been fortunate to serve in a number of organizations that have an important impact on our field, including the AGA, the NIH and the Crohn's and Colitis Foundation.

Currently, I have the privilege of serving as the Chief of the Division of Digestive and Liver Diseases at UT Southwestern. As you can read in the sites liked to this profile, this is a vibrant and robust Division that is in the process of growing.

Ezra Burstein, M.D., Ph.D. - Faculty Profile - UT Southwestern

Ezra Burstein, M.D., Ph.D.

Division of Digestive and Liver Diseases at UTSW

The Division is one of the top academic gastroenterology and hepatology units in the Country. As with other Divisions in the Department of Internal Medicine, it

Faculty - Digestive and Liver Diseases at UTSW

Christian Mayorga, M.D. Assistant ProfessorClinical Chief, Digestive & Liver Diseases Senior Medical Director, Medical Specialty Services Parkland Health & Hosp

Education & Training

University of GroningenPh. D., Medical Sciences - Molecular Genetics, 2012 - 2013
University of MichiganFellowship, Gastroenterology, 1998 - 2001
U Michigan1998 - 2001
University of Texas Southwestern Medical CenterResidency, Internal Medicine, 1995 - 1998
Cayetano Heredia UniversityClass of 1994
Cayetano Heredia UniversityBS, Science and Philosophy, 1988 - 1992

Certifications & Licensure

TX State Medical License 2008 - 2026
MI State Medical License 1999 - 2009
American Board of Internal Medicine Gastroenterology

Awards, Honors, & Recognition

Physician of the Year North Texas Chapter, Crohn's and Colitis Foundation, 2017
Elected Member The American Society for Clinical Investigation, 2012
Helmsley Scholar Crohn’s and Colitis Foundation of America, 2010
Disease Oriented Research Scholar (DOCS) Award UT Southwestern Medical Center, 2008
Research Excellence in GI and Liver (REGAL) Award University of Kansas Medical Center, 2005
AGA Research Scholar Award Foundation for Digestive Health and Nutrition, 2003
John S. Miller Award for Outstanding Performance as a House Officer UT Southwestern Medical Center, Department of Internal Medicine, 1998
Valedictorian of Medical School Class Cayetano Heredia University, 1994
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Publications & Presentations

PubMed

214 citations
Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling
Kerrie E. McNally, Rebecca A. Faulkner, Florian Steinberg, Matthew Gallon, Rajesh Ghai
Nature Cell Biology. 2017-09-11
334 citations
Precision editing of the gut microbiota ameliorates colitis
Wenhan Zhu, Maria G. Winter, Mariana X. Byndloss, Luisella Spiga, Breck A. Duerkop
Nature. 2018-01-03
81 citations
Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer.
Wenhan Zhu, Naoteru Miyata, Maria G. Winter, Alexandre Arenales, Elizabeth R. Hughes
The Journal of Experimental Medicine. 2019-10-07

Journal Articles

Paternal age as a risk factor for Down syndrome.
De Michelena MI, Burstein E, Lama JR, Vasquez JC, American Journal of Medical Genetics
VIAF: A conserved IAP interacting factor that modulates caspase activation.
Wilkinson JC, Richter BW, Wilkinson AS, Burstein E, Rumble JM, Balliu B, Duckett CS, Journal of Biological Chemistry
COMMD Proteins: A Novel Family of Structural and Functional Homologs of MURR1.
Burstein E, Hoberg JE, Wilkinson AS, Rumble JM, Csomos RA, Komarck CM, Maine GN, Wilkinson JC, Mayo MW, Duckett CS, Journal of Biological Chemistry
XIAP is copper binding protein deregulated in Wilson’s disease and other copper toxicosis disorders. §Equal contributors.
Mufti AR§, Burstein E§, Csomos RA, Graf TCF, Wilkinson JC, Dick RD, Challa M, Son JK, Bratton SB, Su GL, Brewer GJ, Jakob U, Duckett CS, Molecular Cell
Distinct Wilson-disease mutations in ATP7B are associated with enhanced binding to COMMD1 and reduced stability of ATP7B.
de Bie P, van de Sluis B, Burstein E, van de Berghe PVE, Muller P, Berger R, Gitlin JD, Wijmenga C, Klomp L, Gastroenterology
Copper metabolism MURR1 domain containing 1 (COMMD1) regulates Cullin-RING ligases by preventing Cullin-associated NEDD8-dissociated (CAND1) binding.
Mao X, Gluck N, Chen B, Starokadomskyy P, Li H, Maine GN, Burstein E, Journal of Biological Chemistry
COMMD1 plays an anti-inflammatory role in vivo and is linked to ulcerative colitis risk.
Li H, Chan L, Bartuzi P, Melton SD, Mao X, Starokadomskyy P, Ben-Shlomo S, Sharvit E, van Sommeren S, Mokadem M, Weisberg R, Westra HJ, Esko T, Mespalu A, Yarovinsky F..., Proceedings of the National Academy of Sciences
Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profiling.
Raetz M, Kibardin AK, Sturge C, Pifer R, Li H, Burstein E, Ozatoe K, Larin S, Yarovinsky F, Journal of Immunology
Control of cell death by transcriptional regulation of the apoptotic machinery.
Burstein E and Duckett CS. Dying for NF-anpha B, Current Opinion in Cell Biology
COMMD proteins: COMMing to the scene.
Maine GN and Burstein E, Cellular and Molecular Life Science
Bimolecular affinity purification - a variation of TAP with multiple applications.
Starokadomskyy P and Burstein E, Methods in Molecular Biology
Paraneoplastic diarrhea in a patient with lung adenocarcinoma.
Nguyen AD, Valasek MA, and Burstein E, Clinical Journal of Gastroenterology
COMMD1 disrupts HIF-1 dimerization and inhibits human tumor cell invasion.
van de Sluis B, Mao X, Zhai Y, Groot AJ, Vermeulen JF, van der Wall E, van Diest PJ, Hofker MH, Wijmenga C, Klomp LW, Cho KR, Fearon ER, Vooijs M, Burstein E, Journal of Clinical Investigation
Regulation of NF-B activity by competition between RelA acetylation and ubiquitination.
Li H, Wittwer T, Weber A, Schneider H, Moreno R, Maine GN, Kracht M, Schmitz ML, Burstein E, Oncogene
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Books/Book Chapters

Textbook of Gastroenterology, Self-Assessment Review.
Burstein EEditors: Yamada T and Chey WD.Lippincott, Williams & WilkinsEdition 3rd,
Avances en Gastroenterologia y Hepatologia.
Burstein E. Enfermedad CeliacaEditors: Bussalleu A, Ramirez-Ramos A, Tagle M.Cayetano Heredia University Press, Lima, Peru
Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract: Mechanisms, Prevention and Treatment.
Chapter: Gastroenterology
Burstein E

Abstracts/Posters

Turberculous abscess of the liver: Case report and review of literature.
Bandres MP, Burstein E, Casas J, and Verona R, Revista Gastroenterologica del Peru
GCN5 is a required co-factor for a ubiquitin ligase that targets NF-B/RelA.
Mao X, Gluck N, Maine GN, Li H, Zaidi IW, Li D, Repaka A, Mayo MW, Burstein E, Genes & Development
Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 Promotes Transcription.
Colleran A, Collins P, O'Carroll C, Ahmed A, Mao X, McManus B, Kiely PA, Burstein E, Carmody RJ, Proceedings of the National Academy of Sciences U.S.A

Lectures

XIAP regulates MURR1, a factor involved in copper homeostasis.
CSHL Meeting, Cold Spring Harbor, NY
COMMD proteins: a novel family of NF-α B inhibitors.
3rd Japan GRG/AGA Symposium, Hakone - Japan
Apoptosis en el tracto intestinal: muerte celular como mecanismo homeostatico.
Cayetano Heredia University, Lima - Peru
XIAP regulates MURR1, a factor involved in copper homeostasis.
CSHL Meeting, Cold Spring Harbor, NY
COMMD proteins: a novel family of NF-B inhibitors.
3rd Japan GRG/AGA Symposium, Hakone - Japan
Apoptosis en el tracto intestinal: muerte celular como mecanismo homeostatico.
Cayetano Heredia University, Lima - Peru
COMMD Proteins Inhibit B-Mediated Transcription by Promoting the Ubiquitination of NF-B Subunits through a Cullin E3 Ligase.
Keystone Symposium, Banff - Canada
Regulation of NF-B by COMMD proteins.
University of Utrecht, Utrecht - The Netherlands
Novel architecture of Cullin-Ring ligases: lessons from studying NF-B ubiquitination.
University of Magdeburg, Magdeburg - Germany
COMMD proteins: regulators of NF-B and beyond.
University of Groningen, Groningen - The Netherlands
COMMD proteins and hypoxic stress Keystone Symposium.
Banff - Canada
Termination of NF-B responses by ubiquitin-mediated degradation - Role of novel genes in IBD pathogenesis.
GI Research Academy Meeting, Tokyo - Japan
Novel developments in IBD pathogenesis and treatment.
23rd Peruvian Congress of Digestive Diseases, Lima - Peru
Role of COMMD1 in IBD pathogenesis.
Tel Aviv Sourasky Medical Center, Tel Aviv, Israel National
MURR1: a regulator of copper metabolism and NF-B.
University of Illinois at Chicago, Chicago, IL
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Press Mentions

Research Could Lead to Treatments for Obesity, Extreme Weight LossJune 13th, 2024
160 GIs to Know in 2021December 30th, 2021
Immune Dysfunction in Mendelian Disorders of POLA1 DeficiencyJanuary 3rd, 2021
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