EvanDKharaschMD

Anesthesiology • Saint Louis, MO

Professor, Anesthesiology, Washington University School of Medicine

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Office
1 Barnes Jewish Hospital Plz
Saint Louis, MO 63110
Phone+1 314-362-6973

Fax+1 314-362-1185

Summary

Dr. Evan Kharasch, MD is a board certified anesthesiologist in Saint Louis, Missouri. He is currently licensed to practice medicine in Missouri, North Carolina, and Washington. He is affiliated with Barnes-Jewish Hospital and is a Professor at Washington University School of Medicine.

Education & Training

University of WashingtonResidency, Anesthesiology, 1984 - 1988
Northwestern University The Feinberg School of MedicineClass of 1984

Certifications & Licensure

MO State Medical License 2005 - 2025
NC State Medical License 2018 - 2025
WA State Medical License 1985 - 2025
American Board of Anesthesiology Anesthesiology

Clinical Trials

Perioperative Inflammation and Cyclooxygenase 2 (COX-2) Start of enrollment: 2002 Nov 01
Completed
Phase 4
Tissue Penetration of Antibiotics in Obesity Start of enrollment: 2008 Feb 01
Completed
Methadone in Pediatric and Adult Sickle Cell Patients Start of enrollment: 2008 Jan 01
Completed
Not Applicable
Methadone in Pediatric Anesthesia Start of enrollment: 2009 May 01
Completed
Phase 4
Alfentanil: Simultaneous Testing Pilot Start of enrollment: 2009 Oct 01
Completed
Not Applicable
CYP2B6 Polymorphisms in Methadone Disposition Start of enrollment: 2012 Nov 01
Completed
Not Applicable
LAAM-HAART PET Imaging Start of enrollment: 2013 Aug 01
Completed
Early Phase 1
CYP2B6 Polymorphisms in Ketamine Start of enrollment: 2013 Nov 01
Completed
Not Applicable
Clinical Study of Generic and Brand Bupropion in Depression Start of enrollment: 2014 Jun 25
Completed
Phase 4
Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement) Start of enrollment: 2018 Nov 29
Completed
Phase 4
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Publications & Presentations

PubMed

Methadone metabolism and cytochrome P450 polymorphisms: a systematic review and meta-analysis.
Seenae Eum, Nicholas P Vernacchia, Nia Doughty, Sahar Mehrzad, Andrew H Talal
Expert Opinion on Drug Metabolism & Toxicology. 2024-11-28
Morphine and hydromorphone pharmacokinetics in human volunteers: population-based modelling of interindividual and opioid-related variability.
Konrad Meissner, Erik Olofsen, Albert Dahan, Evan D Kharasch
British Journal of Anaesthesia. 2024-11-25
Epidural methadone and morphine pharmacokinetics and clinical effects in healthy volunteers: A randomized, crossover-design trial.
Alexander Hincker, Matthew Reschke, Yehuda Ginosar, Leonid Kagan, Evan D Kharasch
British Journal of Clinical Pharmacology. 2024-11-01

Authored Content

Perioperative Gabapentinoids: Deflating the BubbleJune 2020
Novel Coronavirus 2019 and AnesthesiologyJune 2020
Novel Coronavirus 2019 and AnesthesiologyJune 2020

Press Mentions

The Prescription Opioid Ecosystem: A Novel Approach to the CrisisJanuary 29th, 2022
Opioid Scripts Have Declined, but Fatal Overdoses Have Increased. Doctors Are Offering a New ApproachDecember 30th, 2021
Restricting Supply Alone Is Not the Answer to the Opioid CrisisDecember 28th, 2021
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Grant Support

Addiction Therapy: Metabolism And Transport-Mediated Drug InteractionsNational Institute On Drug Abuse2008–2011
Methadone And HIV Drug InteractionsNational Institute On Drug Abuse2005–2011
Opioids In Cancer Pain &Drug Abuse: Optimizing TherapyNational Institute On Drug Abuse2005–2010
Novel Noninvasive Assessment Of Cytochrome P450 ActivityNational Institute Of General Medical Sciences2006–2009
CYP3A Activity And Drug EffectsNational Center For Research Resources2007
CYP2B6 Activity And Drug EffectsNational Center For Research Resources2007
Methadone And HIV/AIDS Drug InteractionsNational Center For Research Resources2006–2007
CYP3A Probes And Hepatic Blood FlowNational Center For Research Resources2006–2007
Opioids In Cancer Pain &Drug Abuse: Optimizing TherapyNational Institute On Drug Abuse2005
Methadone And HIV/AIDS Drug InteractionsNational Center For Research Resources2004–2005
Pharmacodynamics Surrogates Of Alfentanil DispositionNational Center For Research Resources2004
Methadone And HIV Drug InteractionsNational Institute On Drug Abuse2001–2004
Opioids In Cancer Pain &Drug Abuse--Optimizing TherapyNational Institute On Drug Abuse1999–2003
Novel Noninvasive Assessment Of Cytochrome P450 ActivityNational Institute Of General Medical Sciences2001–2002
Anesthetic Renal Metabolism--Mechanisms And ConsequencesNational Institute Of Diabetes And Digestive And Kidney Diseases1999–2002
Disulfiram Effects On Drug MetabolismNational Center For Research Resources1998–2000
Disulfiram Effect On Coumarin MetabolismNational Center For Research Resources1997–2000
Menstrual Cycle Variability In Alfentanil PharmacokineticsNational Center For Research Resources1996–2000
Disulfiram Effect On Chlorzoxazone MetabolismNational Center For Research Resources1998–1999
Anesthetic Toxicity--Mechanisms And PreventionNational Institute Of General Medical Sciences1994–1999
Methadone PharmacokineticsNational Center For Research Resources1996
Human Anesthetic Toxicity--Mechanisms And PreventionNational Institute Of General Medical Sciences1992–1993