EugeneSungkyunKimMDFACS, FAAP(He/Him)

Pediatric (General) Surgery • Los Angeles, CA

Director, Division of Pediatric Surgery Vice Chair, Department of Surgery Professor of Surgery and Pediatrics, Cedars-Sinai Medical Center

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Office
4650 W Sunset Blvd
Los Angeles, CA 90027
Phone+1 323-361-2322

Fax+1 323-361-4775

Summary

Trained in all aspects of pediatric surgery, my research and clinical practice has largely focused on pediatric oncology. My basic science research lab is looking at novel therapies for the aggressive children's cancer neuroblastoma. In addition to surgical oncology, I have a strong interest and practice in congenital anomalies, chest wall defects and in ECMO for infants and children with respiratory failure.

Education & Training

Cincinnati Children's Hospital Medical CenterFellowship, Pediatric Surgery, 2003 - 2005
New York Presbyterian Hospital (Columbia Campus)Residency, Surgery, 1996 - 2003
New York Presbyterian Hospital (Columbia and Cornell Campus)Fellowship, Research, 1999 - 2001
Columbia University Vagelos College of Physicians and SurgeonsClass of 1996
Harvard UniversityAB, Biochemical Sciences, Cum laude, 1989 - 1992

Certifications & Licensure

CA State Medical License 2014 - 2025
TX State Medical License 2005 - 2019
OH State Medical License 2003 - 2012
American Board of Surgery Surgery
American Board of Surgery Pediatric Surgery

Awards, Honors, & Recognition

Fellow American Surgical Association, 2020
Top Doctors Castle Connolly, 2012-2020
Member Society of University Surgeons, 2014
Fulbright and Jaworski, LLP Teaching Award Baylor College of Medicine, 2012
Fulbright & Jaworski LLP Faculty Excellence Award Baylor College of Medicine, 2012-2013
Top Doctor US News and World Report, 2011
Best Doctors in America 2011
Blakemore Prize for best body of surgical research Columbia University, Department Of Surgery, 2003
Blakemore Prize Columbia University, 2003
1st Place Resident Award AMERICAN ACADEMY OF PEDIATRICS, 2001
2nd Place, Resident Research Competition Columbia University, 2001
Resident Research Startup Grant, The Role of Neurotrophin Receptors in Neuroblastoma Development Columbia University, Department Of Surgery, 2000-2001, 2001
2nd Place, Cooption of Existing Vessels in Experimental Neuroblastoma Columbia University, Department Of Surgery, 2001
Resident Research Startup Grant, Inhibition of Growth and Metastasis of Neuroblastoma Tumor by Monoclonal Antibody to Vascular Endothelial Growth Factor and Chemotherapy Columbia University, Department Of Surgery, 1999-2000, 2000
Resident Research Startup Grant Columbia University, 1999-2000
Recipient of J.T. Tai Foundation Scholarship Columbia University College Of Physicians And Surgeons, 1993-1996, 1996
NIH-Summer Dean’s Research Fellowship Columbia University College Of Physicians And Surgeons, 1993
NIH-Summer Dean’s Research Fellowship Columbia University, 1993
J.T. Tai Foundation Scholarship Columbia University, 1993
Dean’s List all semesters Harvard University, 1989-1992, 1992
Harvard College Scholarship Harvard University, 1989-1992, 1992
Richard Perkins Parker Scholarship Harvard University, 1989-1992, 1992
Dean’s List Tufts University, 1988-1989, 1989
Dean's List Tufts University, 1988
Fellow (FACS) American College of Surgeons
Fellow (FAAP) American Academy of Pediatrics
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Publications & Presentations

PubMed

525 citations
Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T-lymphocytes
Ignazio Caruana, Barbara Savoldo, Valentina Hoyos, Gerrit Weber, Hao Liu
Nature Medicine. 2015-05-01
2 citations
Incidence and management of pleural effusions in patients with Wilms tumor: A Pediatric Surgical Oncology Research Collaborative study.
Ameer Al-Hadidi, Hannah N Rinehardt, Pattamon Sutthatarn, Lindsay J Talbot, Andrew J Murphy
International Journal of Cancer. 2022-11-15
10 citations
Initiation of immunotherapy with activated natural killer cells and anti-GD2 antibody dinutuximab prior to resection of primary neuroblastoma prolongs survival in mice.
Michael J. Zobel, Abigail K. Zamora, Hong-Wei Wu, Jianping Sun, Danny Lascano
Journal for Immunotherapy of Cancer. 2020-12-01

Journal Articles

Identifying and reducing early complications of surgical central lines in infants and toddlers
Fallon SC, Kim ME, Fernandes CJ, Vasudevan SA, Nuchtern JG, Kim ES, J Surg Res, 1/1/2014
A small molecule inhibitor of UBE2N induces neuroblastoma cell-death via activation of p53 and JNK pathways
Cheng J, Fan YH, Xu X, Zhang H, Dou J, Tang Y, Zhong X, Rojas Y, Yu Y, Zhao Y, Vasudevan SA, Zhang H, Nuchtern JG, Kim ES, Chen X, Lu F, Yang J, Cell Death Dis, 1/1/2014
The use of mitomycin C for refractory esophageal stricture following tracheoesophageal fistula repair
Lakoma A, Fallon SC, Mathur S, Kim ES, Eu J Ped Surg Reports, 5/9/2013
Current Readings: Surgical repair experience of congenital chest wall deformities
Lakoma A, Kim ES, Semin Thoracic Surg, 1/1/2013
Giant invasive spinal schwannoma in children: case report and review of the literature
Vadivelu S, Prasad P, Adesina AM, Kim E, Luerssen TG, Jea A, J Med Case Rep, 1/1/2013
Targeting vascular endothelial growth factor in neuroblastoma
Hsu DM, Shohet JM, Kim ES, Current Angiogenesis, 1/1/2013
Needle-core versus open biopsy for diagnosis of intermediate and high-risk neuroblastoma in children Reply to correspondence
Kim ES, Louis CU, Nuchtern JG, J Ped Surg, 1/1/2012
Retroperitoneal lipoblastoma: a discussion of current management
Burchhardt D, Fallon SC, Lopez ME, Kim ES, Hicks MJ, Brandt ML, J Ped Surg, 1/1/2012
Endoscopic specimen pouch technique for removal of giant fibroadenomas of the breast
Cheng PJ, Vu L, Cass DL, Hicks MJ, Brandt ML, Kim ES, J Ped Surg, 1/1/2012
Gastric duplication cysts of the pancreas: clinical presentation and surgical management
Lee TC, Kim ES, Ferrell LB, Brandt ML, Minifee PK, Midgen C, Domingo RP, Kearney DL, Eur J Ped Surg, 1/1/2011
Thorascopic sympathectomy for treatment of refractory long QT syndrome in children: a case report and review of the literature
Hwang S, Thomas J, Whitehead W, Curry D, Dauser R, Kim E, Luerssen T, Jea A, J Neurosurg: Pediatr, 1/1/2011
Pre-clinical models of pediatric solid tumors (neuroblastoma) and their use in drug discovery
Patterson DM, Shohet JM, Kim ES, Curr. Protoc. Pharmacol, 1/1/2011
Low-grade myofibroblastic sarcoma of the sacrum: case report and literature review
Humphries WE, Satyan KB, Relyea K, Kim ES, Adesina AM, Chintagumpala M, Jea A, J Neurosurg Pediatr, 1/1/2010
Targeted Molecular Therapy for Neuroblastoma: The Arf/MDM2/p53 Axis Editorial
Kim ES, Shohet JM, J Nat Cancer Inst, 1/1/2009
A 360 degree evaluation of a night-float system for general surgery: a response to mandated work-hours reduction
Goldstein MJ, Kim E, Widmann WD, Hardy MA, Current Surgery, 1/1/2004
Blockade of her2/neu decreases VEGF expression but does not alter HIF-1 distribution in experimental Wilms tumor
Yokoi A, McCrudden KW, Huang J, Kim ES, Soffer SZ, Frischer JS, Serur A, New T, Yuan J, Mansukhani M, O’Toole K, Yamashiro DJ, Kandel JJ, Oncol Rep, 1/1/2003
Novel use of an established agent: topotecan is anti-angiogenic in experimental Wilms tumor
Soffer S, Kim E, Moore J, Huang J, Manley C, O'Toole K, Stolar C, Yamashiro D, Kandel J, J Pediatr Surg, 1/1/2001
Effective therapy of a vascular tumor of infancy with vincristine
Moore J, Lee M, Garzon M, Soffer S, Kim E, Saouaf R, del Toro G, Yamashiro D, Kandel J, J Pediatr Surg, 1/1/2001
ECMO in the Newborn
Kim ES, Stolar CJ, Am J Perinatol, 1/1/2000
Cardiac Assistance and Replacement Therapy
Edwards N, Kim ES, Cardiovascular Reviews & Reports, 1/1/1999
In vitro evaluation of neonatal human immunity against the pig
Xu H, Oluwole SF, Edwards NM, Chen JM, Naka Y, Kim E, Michler RE, J Thorac Cardiovasc Surg, 1/1/1996
Microsurgery in a rat lung transplant model: analysis of benefit
Yano OJ, Baradarian R, Kim ES, Smith TJ, Smith ML, Smith CR, Chiu DT, Microsurgery, 1/1/1996
Blockade of her2/neu decreases VEGF expression but does not alter HIF-1 distribution in experimental Wilms tumor.
Yokoi A, McCrudden KW, Huang J, Kim ES, Soffer SZ, Frischer JS, Serur A, New T, Yuan J, Mansukhani M, O’Toole K, Yamashiro DJ, Kandel JJ, Oncol Rep; 10(5) 1271-4
Successful treatment of anastomotic leak after tracheoesophageal fistula repair with glycopyrrolate (Robinul). Reply to correspondence.
Kim ES, J Ped Surg
Tumor-associated macrophages suffocate NKT cells: an immune escape mechanism and a target for therapy.
Liu D, Song L, Wei J, Courtney AN, Gao X, Marinova E, Guo L, Heczey A, Asgharzadeh S, Kim E, Dotti G, Metelitsa LS, J Clin Invest; 122(6) 2221-33
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Books/Book Chapters

Angiogenesis: Insights from a Systematic Review.
Chapter: Targeting VEGF-mediated tumor angiogenesis in neuroblastoma
Hsu DM, Kim ESEditors: Santulli G.
Atlas of Pediatric Surgical Techniques.
Chapter: Inguinal hernias and hydroceles
Page 303 - 310Kawaguchi AL, Kim ESEditors: Chung D and Chen M.
Up To Date.
Chapter: Spontaneous Intestinal Perforation of the Newborn
Kim ES, Brandt MLEditors: Rose BD.Waltham, MA
Newborn Surgery.
Chapter: Extracorporeal membrane oxygenation for neonatal respiratory failure
Page 317 - 327Kim ES, Stolar CJHEditors: Puri P.Edition 2nd,
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Abstracts/Posters

Assessing Tumor Angiogenesis with Computed Tomography and a Novel Nanoparticle Contrast Agent in an In Vivo Model of Neuroblastoma
Lakoma A, Ghaghada KB, Adhikari C, Kaffes CC, Rojas Y, Shohet JM, Annapragada A, Kim ES, 9th Annual Academic Surgical Congress and J Surg Res, 1/1/2014
Optimizing chemotherapy prior to surgery in high-risk neuroblastoma
Rojas Y, Louis CU, Nuchtern JG, Kim ES, American Academy of Pediatrics, National Conference and Exhibition, Section on Surgery, 1/1/2014
The epigenetic modifier CHAF1A opposes neuroblastoma differentiation via metabolic reprogramming
Barbieri E, Chen Z, Lakoma A, Kim ES, Shohet JM, Advances in Neuroblastoma Research Conference, 1/1/2014
The novel MDM2 inhibitor RG7388 is highly effective against neuroblastoma in vitro and in vivo
Lakoma A, Barbieri E, McVay M, Chen Z, Adhihari C, Shohet JM, Kim ES, AACR Pediatric Cancer at the Crossroads: Translating Discovery into Improved Outcomes Conference and Cancer Res, 1/1/2013
Radiation Therapy to the Primary and Postinduction Chemotherapy MIBG-Avid Sites in High-Risk Neuroblastoma
Mazloom A, Louis C, Nuchtern J, Kim E, Russell H, Allen-Rhoades W, Krance R, Paulino A, Int J Rad Onc Bio Phys, 1/1/2013
The novel MDM2 inhibitor RG7388 is highly effective against neuroblastoma in vitro and in vivo
Lakoma A, Barbieri E, McVay M, Chen Z, Adhihari C, Shohet JM, Kim ES, American Association of Cancer Research Pediatric Cancer at the Crossroads: Translating Discovery into Improved Outcomes Conference, 1/1/2013
The epigenetic modifier CHAF1A opposes neuroblastoma differentiation via metabolic reprogramming
Barbieri E, Chen Z, Lakoma A, Kim, E, Shohet J, American Association of Cancer Research Pediatric Cancer at the Crossroads: Translating Discovery into Improved Outcomes Conference, 1/1/2013
Targeting STAT3 Pathway by Stattic Inihibits the Neuroblastoma Cancer Stem Cell-like Cells
Agarwal S, Hsu DM, Chen Z, Kim ES, Shohet JM, Cancer Prevention & Research Institute of Texas: Innovations in Cancer Prevention and Research Conference, 1/1/2012
Epigenetic regulation of differentially expressed microRNAs in neuroblastoma cancer stem cell-like population
Agarwal S, Patterson DM, Chen Z, Barbieri E, Coarfa C, Kim E, Gunaratne P, Shohet JM, 2012 Advances in Neuroblastoma Research Conference, Toronto, 1/1/2012
Primary Malignant Pancreatic Neoplasms in Children and Adolescents – a 20 Year Experience
Rojas Y, Werneke CL, Dhamne CA, Tsao K, Nuchtern JG, Lally KP, Vasudevan SA, Hayes-Jordan A, Cass DL, Herzog CE, Hicks MJ, Austin MT, Kim ES, 3rd Annual Texas Children’s Hospital Department of Surgery Research Day, 1/1/2012
Isolation and Characterization of Highly Tumorigenic Neuroblastoma Cancer Stem Cells
Patterson D, Sikorski N, Barbieri E, Gao D, Chen Z, Shohet J, Kim E, 2nd Annual Texas Children’s Hospital Department of Surgery Research Day, 1/1/2011
Isolation and Characterization of Highly Tumorigenic Neuroblastoma Cancer Stem Cells
Patterson D, Sikorski N, Barbieri E, Gao D, Chen Z, Shohet J, Kim E, 7th Annual Texas Children’s Cancer Center Research Symposium, 1/1/2011
Identification of a tumor initiating cell specific microRNA signature in neuroblastoma
Patterson D, Kim E, Benham A, Mestdagh P, Chen Z, Coarfa C, Gunaratne P, Shohet JM, Keystone Symposia on Molecular and Cellular Biology – MicroRNAs and Non-Coding RNAs and Cancer, 40th Meeting Season, 1/1/2011
Cooperative inhibitory effect of bevacizumab and Nutlin-3a on tumor growth, angiogenesis, and metastasis in an experimental model of neuroblastoma
Patterson DM, Gao D, Sikorski N, Ludwig A, Barbieri E, Johnson B, Chen Z, Diaz-Miron J, Vassilev L, Shohet JM, Kim ES, J Surg Res, 1/1/2011
Challenging ventilatory management in a premature newborn with a tracheoesophageal fistula at the carina
Heyden LD, Rodriguez C, Kim E, Society of Pediatric Anesthesia, 24th Annual Meeting, 1/1/2010
The MDM2 inhibitor Nutlin-3a potently suppresses both tumor angiogenesis and tumor growth in neuroblastoma
Patterson D, Gao D, Sikorski, N, Ludwig A, Barbieri E, Johnson B, Chen Z, Vassilev L, Shohet J, Kim ES, 6th Annual Texas Children’s Cancer Center Research Symposium, 1/1/2010
The MDM2 small molecule inhibitor, Nutlin-3a potently inhibits tumor angiogenesis and tumor growth in neuroblastoma
Patterson D and Kim ES, 2010 American College of Surgeons South Texas Chapter Annual Meeting, 1/1/2010
MDM2 inhibition with Nutlin-3a strongly suppresses tumor growth and tumor angiogenesis in an in vivo model of neuroblastoma
Kim ES, Gao D, Shohet JS, International MDM2 Workshop V, 1/1/2009
VEGF-Trap inhibits growth and angiogenesis in experimental rhabdoid tumor of the kidney
Soffer SZ, Huang J, Kim ES, McCrudden KW, New TN, Manley CA, Middlesworth W, Holash J, Yancopoulos G, Yamashiro DJ, Kandel JJ, American Academy of Pediatrics National Conference, Section on Surgery, 1/1/2001
Vascular cooption in neuroblastoma: a potential mechanism of resistance to anti-angiogenic therapy
Kim E, Soffer S, Huang J, Manley C, McCrudden K, Moore J, Stolar C, Holash J, Yancopoulos G, Kandel J, Yamashiro D, Surgical Forum Volume, 1/1/2001
A new in vivo metastatic model of neuroblastoma
Yamashiro DJ, Huang J, Manley CA, Kim E, Soffer S, Moore JT, Wu N, Rowe DH, Hagani AB, O'Toole KM, Stolar CJ, Kandel JJ, Med Pediatr Oncol, 1/1/2000
Anti-VEGF antibody therapy suppresses primary tumor growth in a metastatic model of neuroblastoma
Kim ES, Manley CA, Huang J, Soffer SZ, Moore JT, Casher J, Rowe DH, Wu N, O'Toole KM, Stolar CJ, Kandel JJ, Yamashiro DJ, Advances in Neuroblastoma Research Conference, 1/1/2000
A new in vivo metastatic model of neuroblastoma in the nude mouse
Yamashiro DJ, Kim ES, Huang J, Manley CA, Soffer SZ, Moore JT, Rowe DH, Hagani A, O'Toole KM, Wu E, Stolar CJ, Kandel JJ, Advances in Neuroblastoma Research Conference, 1/1/2000
Vasopressin deficiency after cardiopulmonary bypass
Argenziano M, Choudri AF, Moazami N, Gonzalez JJ, Salehizadeh BM, Kim E, Rodino MA, Rose EA, Landry DW, Oz MC, J Am Coll Cardiol, 1/1/1996
The epigenetic modifier CHAF1A regulates neuroblastoma differentiation and is a novel prognostic indicator for poor survival.
Barbieri E, DePreter K, Chen Z, Stowers P, Agarwal S, Kim, ES, Speleman F, Shohet JM, 8th Annual Texas Children’s Cancer and Hematology Centers Research Symposium, Houston, TX
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Lectures

Imaging and Technical Concerns for Tumors around the Spinal Cord
1/1/2014
Imaging the Pediatric Surgical Patient: A Surgeon’s Perspective
11/18/2013
Pus and Stuff: A Surgeon’s Guide to Subcutaneous Infections
9/19/2013
Preclinical Evaluation of a Novel MDM2 Inhibitor in Neuroblastoma
1/1/2013
Spinal Cord Ischemia in the Resection of Posterior Mediastinal Tumors
1/1/2013
So You Want to be a Surgeon: An Insider’s Guide
12/21/2012
Surgical Oncology
7/1/2012
Angiogenesis and Stem Cells in Neuroblastoma
1/1/2011
Pigtail Catheter Insertion for Patients with Simple Spontaneous Pneumothorax
10/28/2010
Surgical Infections and Abscesses
8/12/2010
Pectus Excavatum
1/15/2010
Tube Thoracostomy for the Emergency Room Patient
1/1/2009
Bowel Obstruction
1/22/2008
The Surgical Abdomen and Radiology
8/22/2006
The Surgical Abdomen and Radiology.
Baylor College of Medicine Pediatric Radiology Resident/Fellow Conference
The Best Laid Plans of Mice and Men: Animal Models of Tumor Development and Angiogenesis in Neuroblastoma.
Baylor College of Medicine, Texas Children’s Cancer Center Research Seminar
Tube Thoracostomy for the Emergency Room Patient.
Baylor College of Medicine Pediatric Emergency Medicine Resident/Fellow Conference
Pectus Excavatum.
Baylor College of Medicine, Pediatric Pulmonary Medicine Conference
Surgical Management of Inflammatory Bowel Disease.
Baylor College of Medicine, Pediatric Gastroenterology Fellow Conference
Surgical Infections and Abscesses.
Baylor College of Medicine Pediatric Emergency Medicine Resident/Fellow Conference, 2007
Pigtail Catheter Insertion for Patients with Simple Spontaneous Pneumothorax.
Baylor College of Medicine Pediatric Emergency Medicine Resident/Fellow Conference
MDM2 and Angiogenesis: Creating, Developing, and Sustaining A Basic Science Research Lab.
Baylor College Of Medicine, Department Of Surgery Grand Rounds, Houston, TX
Angiogenesis and Stem Cells in Neuroblastoma.
Sorkin Research Symposium
Necrotizing Enterocolitis.
Baylor College of Medicine Pediatric Gastroenterology Fellow Conference, 2008
Novel Therapeutic Targeting in Neuroblastoma: The Development of a Basic Science Research Program.
Baylor College Of Medicine, Department Of Urology Grand Rounds, Houston, TX
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Other

Disorders of the Umbilicus.
Minkes RK, Megison SM, Chen L, Mazziotti MV, Kim ES, Bloss RS, eMedicine from WebMD
http://emedicine.medscape.com/article/935618-overview