EugeneJ.BarrettMD(He/Him)

Endocrinology • Charlottesville, VA

Diabetes, Lipid Metabolism

Professor, Internal Medicine, University of Virginia School of Medicine

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Office
415 Ray C Hunt Dr
# Uva
Charlottesville, VA 22903
Phone+1 434-924-1825

Fax+1 434-924-9616

Education & Training

Yale-New Haven Medical CenterFellowship, Endocrinology, Diabetes, and Metabolism, 1977 - 1980
University of RochesterResidency, Internal Medicine, 1975 - 1977
University of Rochester School of Medicine and DentistryClass of 1975

Certifications & Licensure

VA State Medical License 1991 - 2026
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2009, 2011-2014, 2021-2022
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
Men's Health Castle Connolly, 2007
Elected Member The American Society for Clinical Investigation, 1989
Whos Who in Medicine and Healthcare Marquis Whos Who
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Clinical Trials

The Impact of Fitness on Vascular Dysfunction in Adolescents With Type 1 Diabetes Start of enrollment: 2011 Apr 01
Completed
The Effect of Type 1 Diabetes on Pan-Arterial Vascular Function and Insulin Sensitivity in Humans Start of enrollment: 2014 Dec 01
Completed
Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults Start of enrollment: 2019 Feb 04
Completed
Early Phase 1
Effects of Empagliflozin on Cardiac Microvasculature and Insulin Sensitivity in Subjects With Type 2 Diabetes Start of enrollment: 2020 Feb 01
Recruiting
Early Phase 1
Effect of Postprandial Hyperglycemia on Vasculature in Type 1 Diabetes and Healthy Adults Start of enrollment: 2021 Apr 06
Active, not recruiting
Roles: Contact
Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome Start of enrollment: 2020 Nov 01
Recruiting
Phase 4
Roles: Contact
Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes ( ZQL007) Start of enrollment: 2019 Feb 28
Recruiting
Phase 4
Roles: Contact
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Publications & Presentations

PubMed

2 citations
Empagliflozin improves vascular insulin sensitivity and muscle perfusion in persons with type 2 diabetes.
Linda A Jahn, Lee M Hartline, Thi Nguyen, Kevin Aylor, William B Horton
American Journal of Physiology. Endocrinology and Metabolism. 2024-03-01
Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress.
Abigail G Wolpe, Melissa A Luse, Christopher Baryiames, Wyatt J Schug, Jacob B Wolpe
Science Signaling. 2024-01-30
1 citations
Insulin-induced vasoconstriction is prevalent in muscle microvasculature of otherwise healthy persons with type 1 diabetes.
Linda A Jahn, Lee M Hartline, Amanda J Kleiner, William B Horton, Farhad Hasan
American Journal of Physiology. Endocrinology and Metabolism. 2023-05-01

Lectures

Diabetes and Microvascular Biology: Novel Mechanisms of Disease
ENDO 2019 - New Orleans, LA - 3/26/2019
Insulin Does Not Traverse the CSF but Traverses the Microvascular Blood Brain Barrier to Reach Brain Parenchyma
Charlottesville, VA - 6/13/2014
Liraglutide Rescues Microvascular Insulin Sensitivity and Ameliorates Metabolic Insulin Resistance in Muscle During High-Fat Diet (HFD) Feeding
Charlottesville, VA - 6/16/2014
Salicylate Ameliorates High-Fat Diet-induced Microvascular and Metabolic Insulin Resistance
Charlottesville, VA - 6/14/2014
Pulse Wave Velocity, Augmentation Index, and Flow-mediated Dilation Provide Distinct Measures of Conduit Artery Function
Charlottesville, VA - 6/16/2014
Caveolin-1 Phosphorylation Is Required for Vascular Endothelial Insulin Uptake and Impaired by Insulin Resistance
Charlottesville, VA - 6/16/2014
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Press Mentions

Adipocyte Lipolysis Drives Acute Stress-Induced Insulin ResistanceOctober 23rd, 2020
Clinical Challenges: Preventing Peripheral Vessel Disease in T2DNovember 20th, 2019
Digging for Answers: Controlling Diabetic Microvascular DiseaseMarch 1st, 2018
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Grant Support

Pan-Arterial Insulin Resistance - A Target For Clinical InterventionNational Institute Of Diabetes And Digestive And Kidney Diseases2011–2012
Effects Of Insulin On The MicrovasculatureNational Institute Of Diabetes And Digestive And Kidney Diseases2006–2012
Research Training In Diabetes And Hormone ActionNational Institute Of Diabetes And Digestive And Kidney Diseases1995–2011
Plasma FFA Elevation On Forearm Blood Flow And CAP Recruitment After InsulinNational Center For Research Resources2008–2010
Exercise Intensity And Post-Prandial Glucose Disposal In Obese AdultsNational Center For Research Resources2008–2010
Microvascular Regulation Of Insulin Delivery To Human MuscleNational Institute Of Diabetes And Digestive And Kidney Diseases2006–2010
Insulin Mediated Forearm Muscle Microvascular Recruitment And Insulin UptakeNational Center For Research Resources2006–2010
Clinical Trial: BARI 2DNational Center For Research Resources2008–2009
Pilot--Pilot/Feasibility ProgramNational Institute Of Diabetes And Digestive And Kidney Diseases2007
Islet And CellNational Institute Of Diabetes And Digestive And Kidney Diseases2007
GeneticsNational Institute Of Diabetes And Digestive And Kidney Diseases2007
BiomolecularNational Institute Of Diabetes And Digestive And Kidney Diseases2007
Animal CareNational Institute Of Diabetes And Digestive And Kidney Diseases2007
Effect Of Elevating Plasma FFA On Forearm Blood Flow And Capillary RecruitmentNational Center For Research Resources2006–2007
Administrative CoreNational Institute Of Diabetes And Digestive And Kidney Diseases2004–2007
Insulin Effects On Skeletal Muscle Blood Flow And Microvascular VolumeNational Center For Research Resources2004–2007
BARI 2DNational Center For Research Resources2004–2007
Diabetes Endocrinology Research CenterNational Institute Of Diabetes And Digestive And Kidney Diseases2003–2007
University Of Virginia CTSA Planning GrantNational Center For Research Resources2006
The Effect Of A Meal On Forearm Blood Flow In People With Insulin ResistanceNational Center For Research Resources2005–2006
Effect Of A Mixed Meal Challenge On Forearm Blood Flow And Capillary RecruitmentNational Center For Research Resources2005
The Effects Of Insulin On The MicrovasculatureNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2005
Ultrasound For Clinical Microvascular IMAGING: Diabetes,AtherosclerosisNational Center For Research Resources2004
Ultrasound For Clinical Microvascular IMAGING: Cardiovascular ResearchNational Center For Research Resources2004
Ultrasound For Clinical Microvascular ImagingNational Center For Research Resources2004
Effect Of Mixed Meal Challenge On Forearm Blood Flow AndNational Center For Research Resources2004
Regulation Of Skeletal Muscle Protein MetabolismNational Institute Of Diabetes And Digestive And Kidney Diseases1994–2004
Administrative ComponentNational Institute Of Diabetes And Digestive And Kidney Diseases2003
Molecular Dynamics TyphoonNational Center For Research Resources2002
Trial Of Cp-368,296 In Type 2 Diabetes MellitusNational Center For Research Resources2000–2002
Toleration &Bioavailability Of Inhaled Insulin In AsthmNational Center For Research Resources2000–2002
Metabolic Response To Growth Hormone In Women Versus MenNational Center For Research Resources1999–2002
Insulin As Regulator Of Skeletal Muscle Blood FlowNational Center For Research Resources1999–2002
#217 108 Inhaled Insulin Study With Type 2 DiabeticsNational Center For Research Resources1999–2002
#217 107 Inhaled Insulin Study With Type I DiabeticsNational Center For Research Resources1999–2002
Rhinoviral Challenge On Bioavailability And Tolerance Of Inhaled InsulinNational Center For Research Resources1998–2002
Molecular Correlates Of Metabolic RateNational Center For Research Resources1998–2002
Mechanism Of Insulin And IGF-1 Action On Skeletal Muscle Blood FlowNational Center For Research Resources1997–2002
#217 109 Inhaled Insulin Study With Type 2 DiabeticsNational Center For Research Resources1999–2000
Regulation Of Skeletal Muscle Protein Turnover--Mechanism Of Insulin ActionNational Center For Research Resources1998–1999
Regulation Of Muscle And Adipose Metabolism By InsulinNational Center For Research Resources1998–1999
Diet, Bromocriptine, And T3 In ObesityNational Center For Research Resources1998–1999
Branched Chain Amino Acids And GlucocorticoidsNational Center For Research Resources1997–1999
Comparison Of Insulins Hoe901 To NPH In Subjects With Type II DiabetesNational Center For Research Resources1997
Adaptations To Exercise Training--Effects On Hormonal &Metabolic ParametersNational Center For Research Resources1997
Regulation Of Skeletal Muscle And Adipose Metabolism By Insulin Action ActionNational Center For Research Resources1996–1997
Regulation Of Skeletal Muscle Protein By ExerciseNational Center For Research Resources1993–1997
Safety And Efficacy Of Rhigf-1 For NIDDM TherapyNational Center For Research Resources1996
Meal Frequency And Metabolic Control In Persons With NIDDMNational Center For Research Resources1996
Hormonal Regulation Of Muscle Protein Metabolism In ManNational Center For Research Resources1996
Phase II Dose Study Of Safety And Efficacy Of Rhigf-1 Administered For TherapyNational Center For Research Resources1995
Time Of Adaptations To Exercise Training--Hormonal And Metabolic ParametersNational Center For Research Resources1994–1995
Regulation Of Skeletal Muscle Protein Turnover--Mechanism Of Insulin'S ActionNational Center For Research Resources1993–1995
Regulation Of Skeletal Muscle Protein By EpinephrineNational Center For Research Resources1993–1994
Time Course Of Adaptations To Exercise Training--Hormonal And MetabolicNational Center For Research Resources1993
Regulation Of Skeletal Muscle Protein Metabolism In ManNational Institute Of Diabetes And Digestive And Kidney Diseases1992–1993
Diabetes Endocrinology Research CenterNational Institute Of Diabetes And Digestive And Kidney Diseases1991–1993
In Vivo Heart Protein Turnover In Diabetes And IschemiaNational Heart, Lung, And Blood Institute1988–1990
Regulation Of Skeletal Muscle Protein Metabolism In ManNational Institute Of Diabetes And Digestive And Kidney Diseases1989
NMR Spectroscopic Studies Of Heart Glycogen In VivoNational Heart, Lung, And Blood Institute1985–1987
Pituitary Function In Patients With Pituitary DiseaseNational Center For Research Resources1985
Insulin Resistance In Diabetic KetoacitosisNational Center For Research Resources1985
Pilot Study--Localization Of Amino Acid Transport To Liver Plasma MembraneNat Inst Of Arthritis, Diabetes, Digestive &Kidney Diseases1985