EricKarlRichfieldMD

PubMed

• 323 citations
  The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease.
  Mona Thiruchelvam, Eric K. Richfield, Raymond B. Baggs, A W Tank, Deborah A. Cory-Slechta
  The Journal of Neuroscience. 2000-12-15
• 196 citations
  Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype.
  Mona Thiruchelvam, Alison L. McCormack, Eric K. Richfield, Raymond B. Baggs, A. William Tank
  The European Journal of Neuroscience. 2003-08-01
• 214 citations
  Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: environmental risk factors for Parkinson's disease?
  Mona Thiruchelvam, B.J Brockel, Eric K. Richfield, Raymond B. Baggs, Deborah A. Cory-Slechta
  Brain Research. 2000-08-11

Journal Articles

• The distribution of GABAA, GABAB, and benzodiazepine receptors in the forebrain and midbrain of pigeons.  
  Veenman, C. L., Albin, R. L., Richfield, E. K., and Reiner, A, Journal of Comparative Neurology 344:161-189
• Real time epifluorescence stereology and morphology of neurons in the mouse substantia nigra and ventral tegmental area.  
  Prasad, K. and Richfield, E.K, Experimental Neurology 225:328-340
• Neuroprotection against paraquat and maneb induced dopaminergic toxicity in transgenic mice overexpressing superoxide dismutase and glutathione peroxidase.  
  Thiruchelvamm M., Prokopenko. O., Cory-Slechta, D.A., Richfield, E.K., Mirochnitchenko, O, J. Biol. Chem. 280(23): 22530-22539
• Age-related irreversible nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson’s disease phenotype.  
  Thiruchelvam, M., McCormack, A., Richfield, E.K., Baggs, R., Tank, A.W., Di Monte, D.A., and Cory-Slechta, D.A, Eur. J. of Neuroscience 18:589-600
• Selective dithiocarbamates increase synaptosomal dopamine content, brain concentration of paraquat and correlate with potentiation of MPTP and paraquat toxicity.  
  Barlow, B.B., Bennice, L., Thiruchelvam, M.J., Cory-Slechta, D.A., Ballatori, N., and Richfield, E.K, Journal of Neurochemistry 85:1075-86
• Selective loss of preprotachykinin neurons in a phenocopy of Huntington’s disease.  
  Richfield, E.K., Vonsattel, J.P., MacDonald, M.E., Sun, Z., Deng, Y-P.P., Reiner, A, Movement Disorders 17(2):327-332
• Regional decreases in 3H-AMPA and 3H-CNQX binding in response to chronic low-level lead exposure: Reversal vs potentiation by chronic dopamine agonist treatment.  
  McCoy, L., Richfield, E.K. and Cory-Slechta, D.A, Journal of Neurochemistry 69:2466-2476
• Chronic treatment with typical and atypical antipsychotics increase the AMPA-preferring form of the AMPA receptor in rat brain.  
  McCoy, L. and Richfield, E.K, European Journal of Pharmacology 318:41-45
• The relationship of essential tremor to other movement disorders: Report on 678 patients.  
  Koller, W.C., Busenbark, K., Miner, K., and the Essential Tremor Study Group, Annals of Neurology 35:717-723
• Pictet-Spengler condensations in refluxing benzene.  
  Sandrin, J., Richfield. E.K., Hutchins, L., Cook, J.M, Heterocycles 4(6): 1101-1105
• Heterogeneous pattern of dopamine D-1 and D-2 receptors in human ventral striatum.  
  Berendse, H. and Richfield, E.K., Neuroscience Letters 150:75-79
• cortical distribution of D-1 and D-2 receptors in rats, cats, and monkeys.  
  Richfield, E.K., Young, A.B., Penney, J.B, Journal of Comparative Neurology 286:409-426
• Comparison of [14C]-deoxyglucose metabolism and peripheral benzodiazepine receptor binding in rats with C6 glioma.  
  Richfield, E.K., Ciliax, B. J., Starosta-Rubenstein, S. R., McKeever, P.E., Penney, J.B, Young, A.B, Neurology 38:1255-1262
• Neurologic syndrome following bilateral destruction of the head of the caudate nuclei.  
  Richfield, E.K., Twyman, R. and Berent, S, Annals of Neurology 22:768-771
• The distribution of D-1 and D-2 dopamine receptors in the basal ganglia of turtles, pigeons, rats, cats, and monkeys.  
  Richfield, E.K., Young, A.B., Penney, J.B, Journal of Comparative Neurology 262:446-463.
• Properties of D-2 dopamine receptor autoradiography: High percentage of high affinity agonist sites and increased nucleotide sensitivity in tissue sections.  
  Richfield, E.K., Young, A.B., Penney, J.B, Brain Research 383:121-128
• Preferential localization of [3H]-sulpiride binding sites to striatum and ventral striatum in rat brain.  
  Ryan-Jastrow, T., Richfield, E.K., Gnegy, M, Neuroscience Letters 51:47-53
• Review of automated analytical techniques in electromyography.  
  Richfield, E.K., Cohen, B.A., Albers, J.W, IEEE Journal of Biomedical Engineering, Vol. BME-26(7):505-514.
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Books/Book Chapters

• Receptor autoradiography in Parkinson's disease 
  Chapter: Recent Developments in Parkinson's Disease 
  Penney, J.B., Richfield, E.K., Young, A.BEditors: Fahn, S., Marsden, C.D., Calne, D., Goldstein, M. Macmillan: Florham Park, N.J.
• Anatomical and pharmacological comparisons between dopamine D-1 and D-2 receptors in the mammalian central nervous system 
  Chapter: Progress in Parkinson Research 
  Richfield, E.K., Penney, J.B., and Young, A.BEditors: Hefti, F.F. and Weiner, W.J.Plenum Press, New York
• The mesolimbic motor circuit in Parkinson’s disease and other movement disorders 
  Richfield, E.KEditors: The Mesolimbic Motor Circuit and its Role in Neuropsychiatric Disorders.

Abstracts/Posters

• Complex trait analysis: Approaches to Parkinson’s disease.
  Mhyre, T.R., Chessler, E.J., Thiruchelvam, M., Lungu, C., Copry-Slechta, D.A., Fry, J.D., and Richfield, E.K, NIEHS Neurodegeneration Grantee Meeting
• α-Synuclein pathology in different transgenic mouse models of Parkinson’s disease.
  S. Mueller-Steiner, S. Tep, H. Grajeda, E. Rockenstein, E. Masliah, E. Richfield, D. Games, Lisa McConlogue, and M. Buttini, Society for Neuroscience Abst
• Absence of mouse α-synuclein delays neurotoxicity of mutated human transgenic α-synuclein.
  K. Prasad, Thiruchelvam, L, Kochar, J. and Richfield, E.K, Society for Neuroscience Abst
• Stereological analysis of tyrosine-hydroxylase (TH+) and TH- neurons in the midbrain of 15 strains of mice.
  K. Prasad, E.J. Chesler, E.K. Richfield, Society for Neuroscience Abst
• Proteasomal dysfunction in aged alpha-synuclein transgenic mice.
  E.K. Richfield, M.J. Thiruchelvam, L. Chen, and K. Madura, Society for Neuroscience Abst
• Neuroprotective Effects of Estrogen in a Chronic Animal Model of Parkinson’s Disease.
  Mona Thiruchelvam, Jaspreet Kochar, Deborah A Cory-Slechta, Eric Richfield, James Dykens, Society for Neuroscience Abst
• Overexpression of Cu/Zn Superoxide Dismutase and Glutathione Peroxidase 1 Shows Neuroprotection in an Animal Model of Parkinson’s disease.
  Mona Thiruchelvam, Deborah A Cory-Slechta, Eric K Richfield, Oleg Mirochnitchenko, Society for Neuroscience Abst
• Gene expression changes associated with a developmental pesticide exposure model of Parkinson’s disease.
  M. Thiruchelvam, AI Brooks, EK Richfield & DA Cory-Slechta, SOT
• Complex trait analysis: Approaches to Parkinson’s disease.
  Mhyre, T.R., Chessler, E.J., Thiruchelvam, M., Lungu, C., Copry-Slechta, D.A., Fry, J.D., and Richfield, E.K, NIEHS Neurodegeneration Grantee Meeting
• Thiruchelvam. Paraquat exposure during periods of neurodevelopment and the Parkinson’s disease phenotype.
  B. K. Barlow, J. Kochar, K. Prasad, B. Buckley, O. Mirochnitchenko, E. K. Richfield, M, Society for Neuroscience Abst
• Transcript profiles of microdissected tissue in a mouse model of idiopathic Parkinson’s disease using the Ribo-SPIA™ RNA Amplification process.
  Brooks, A., Richfield, E.K., Thiruchelvam, M.J., Herrler, M., Heath, J.D., Cory-Slechta, D.A., and Kurn, N, Society for Neuroscience Abst
• Exposure to diethyldithiocarbamate (DDC) and iron (Fe): Effects on the nigrostriatal dopaminergic system.
  Thiruchelvam, M., Mayson, S.E., Richfield, E.K., Cory-Slechta, D.A, Society for Neuroscience Abst
• Analyses of locomotor behavior and nigrostriatal nueorchemistry in 15 strains of mice.
  Mhyre, T.R., Chessler, E.J., Thiruchelvam, M., Lungu, C., Copry-Slechta, D.A., Fry, J.D., and Richfield, E.K, Society for Neuroscience Abst.
• Potentiated effects of different classes of neurotoxicants on the nigrostriatal system.
  Richfield E.K., Mhyre, T.R., Barlow, B.K., Thiruchelvam, M., Goodman, B., Stevens, N.M., and Cory-Slechta, D.A, Society for Neuroscience Abst.
• Age-related changes associated with overexpression of wild-type and mutated human alpha-synuclein in transgenic mice.
  Thiruchelvam, M., Cory-Slechta, D.A., Federoff, H.J. and Richfield, E.K, Society for Neuroscience Abst
• Prenatal exposure to maneb increases adult vulnerability to the neurotoxic effects of paraquat: Implications for Parkinson’s disease.
  Barlow, B.K., Thiruchelvam, M., Richfield, E.K., and Cory-Slechta, D.A, Society for Neuroscience Abst.
• Selective Dithiocarbamates increase synaptosomal dopamine content, brain concentration of paraquat and correlate with potentiation of MPTP and paraquat toxicity.
  Richfield E.K., Barlow, B.K., Thiruchelvam, M., and Cory-Slechta, D.A, Society for Neuroscience Abst
• Use of epifluorescence and NeuN in designed based stereology.
  K. Prasad and E K. Richfield, Society for Neuroscience
• Shoot for success.
  Cohen CJ, HIV Plus. 9(2):32-33
• Cytoarchitecture and Transcriptional Profiles of Cerebellar Molecular Layer Heterotopia.
  Z Mangaru, E Hasan, M Sherman, JC. Brumberg, EK. Richfield, LA. Gabel, and RL. Ramos, Society for Neuroscience
• A Grading Scale for the Parkinson’s Disease Phenotype Using the Substantia Nigra.
  K. Prasad and E. K. Richfield, Society for neuroscience
• Regulation of human and mouse -synuclein protein level in vivo by strain, transgene, age, region, and gender.
  E. K. Richfield, A. Sohraby, K. Prasad, S. Mueller-steiner, P. Tanaka, R. Motter, society for neuroscience
• Differential gene expression response to paraquat in brain of two inbred mouse strains.
  L. Yan, E.K. Richfield, and B. Jones, Society for Neuroscience
• Chronic exposure to manganese interacts with striatal dopamine turnover in human alpha-synuclein transgenic mice.
  T.M. Peneder, M. Berger, P. Scholze, G. Heinze, J. Bertl, J. Bauer, E.K. Richfield, O. Hornykiewicz, C. Pifl, Society for Neuroscience
• Behavioural characterisation and MPTP sensitivity of G2019S and D2017A knock-in LRRK2 transgenic mice.
  T.K. Murray, S.N Mitchell, N. Buckner, J. Cooper, E. Browne, C.V. Cella, C.A. DeLong, R. DeMattos, C. Burch, E. Eberle, J.D. Poling, K. Prasad, E.K. Richfield, K.M. Me..., Society for Neuroscience
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Lectures

• Physiologic and Pathologic Effects of Human –Synuclein Transgenic Mice, Nineteenth International Neurotoxicology Conference: Parkinson’s disease, Environment, and Genes. 
  Colorado Springs, CO
• Mouse Models for Translation Research in Parkinson’s disease. 
  Multiple locations, 2008
• Parkinson's disease Phenotype in Man and Mouse. 
  Pathology Grand Rounds, UMDNJ, Newark, NJ
• Alpha-Synuclein: From risk factor to model, mechanism, and targeted neuroprotection in Parkinson's disease, Elan Pharmaceuticals. 
  South San Francisco, CA
• Alpha-Synuclein: From risk factor to model, mechanism, and targeted neuroprotection in Parkinson's disease. 
  University of Florida, Gainesville, FL
• The Parkinson's disease Phenotype: Risk Factors, Models, and Mechanisms. 
  Sun Health Research Institute, Sun City, AZ.
• Heritability and Correlations of Locomotor Behaviors and Neurochemistry in Inbred Strains of Mice. 
  New Paradigms for Exploring Gene-Environment-Behavior Relationships, NIEHS, Research Park Triangle,
• Pesticides, Transporters and the Parkinson’s Disease Phenotype: You Are What You Ate? 
  Neurology Grand Rounds, University of California, Davis, Sacramento, CA.
• Transgenic Human –Synuclein Transgenic Mice. 
  Pathology Grand Rounds, University of California, Davis, Sacramento, CA.
• Mechanisms of Dithiocarbamates and Paraquat in Neurotoxicant Parkinsonism. 
  Twentieth International Neurotoxicology Conference: Little Rock, AR.
• Mechanisms of Dithiocarbamates and Paraquat in Neurotoxicant Parkinsonism. 
  Environmental Medicine Grant Rounds, University of Rochester, Rochester, NY
• Physiologic and Pathologic Effects of Human –Synuclein Transgenic Mice. 
  Massachusetts General Hospital Neuroscience Seminar Series, Boston, MA.
• Anatomical and pharmacological comparisons between dopamine D-1 and D-2 receptors in the mammalian central nervous system. 
  First National Parkinson Foundation Meeting on Parkinson Research, Miami, FL.
• Molecular Neuropathology of Huntington’s Disease. 
  Genentech, Inc., San Francisco, CA
• Zinc and the central nervous system. 
  Neurology Resident basic science seminar series, University of Rochester.
• Zinc and the dopamine transporter. 
  Pharmacology seminar series, University of Rochester
• Delirium and dementia. 
  Geriatric medicine review course, University of Rochester
• Pharmacology and Anatomy of the Dopamine Uptake Complex. 
  Neurobiology and Anatomy Seminar, University of Tennessee, Memphis.
• The Human Ventral Striatum in Neurology and Psychiatry. 
  Neurology Grand Rounds, University of Tennessee, Memphis
• Tardive Syndromes. 
  Geriatric Grand Rounds, Monroe Community Hospital
• Anatomy and Pharmacology of the Human Ventral Striatum. 
  Neurology Grand Rounds, University of Rochester.
• Glutamate, aspartate, and excitotoxins in neurologic disorders. 
  Neurology Resident basic science seminar series, University of Rochester.
• Dopamine receptors in neurologic disorders. 
  Neurology Resident basic science seminar series, University of Rochester.
• Distribution of dopamine terminals and receptors in primate cerebral cortex. 
  Neuroscience seminar series, University of Michigan
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