Eric J Nestler MD

Director, Friedman Brain Institute; Dean for Academic and Scientific Affairs; Icahn School of Medicine at Mount Sinai

Education & Training

Yale-New Haven Medical CenterResidency, Psychiatry, 1984 - 1987
University of Texas Southwestern Medical CenterResidency, Psychiatry, 1987
Massachusetts General Hospital/McLean HospitalInternship, Transitional Year, 1983 - 1984
Yale School of MedicineClass of 1983

PubMed

2 citations
Astrocytic CREB in Nucleus Accumbens Promotes Susceptibility to Chronic Stress.
Leanne M Holt, Trevonn M Gyles, Eric M Parise, Angelica M Minier-Toribio, Matthew Rivera
Biological Psychiatry. 2025-05-01
1 citations
Cocaine and morphine induce shared and divergent transcriptional regulation in nucleus accumbens D1 and D2 medium spiny neurons.
Caleb J Browne, Philipp Mews, Molly Estill, Xianxiao Zhou, Leanne M Holt
Molecular Psychiatry. 2025-04-05
Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens in male rats.
Freddyson J Martínez-Rivera, Leanne M Holt, Angélica Minier-Toribio, Molly Estill, Szu-Ying Yeh
Nature Communications. 2025-03-25

Journal Articles

The Netrin-1/DCC Guidance Cue Pathway as a Molecular Target in Depression: Translational Evidence
Eric Nestler, MD, Biological Psychiatry
Role of Long Non-Coding RNA Gas5 in Cocaine Action
Eric Nestler, MD, Biological Psychiatry
Effects of the KCNQ Channel Opener Ezogabine on Functional Connectivity of the Ventral Striatum and Clinical Symptoms in Patients with Major Depressive Disorder
Katherine A Collins, Dan V Iosifescu, James W Murrough, Eric J Nestler, Nisha Chadha, Nature
Alpha1 and beta3 Adrenergic Receptor-Mediated Mesolimbic Homeostatic Plasticity Confers Resilience to Social Stress in Susceptible Mice
Eric Nestler, MD, Biological Psychiatry
Methylation in OTX2 and Related Genes, Maltreatment, and Depression in Children
James Hudziak, Joan Kaufman, Eric J Nestler, Joel Gelernter, Robert Althoff, Stewart Mostofsky, Nature
Genome-Wide Transcriptional Profiling of Central Amygdala and Orbitofrontal Cortex During Incubation of Methamphetamine Craving
Eric Nestler, MD, Nature
Cell-Type-Specific Role of ΔFosB in Nucleus Accumbens in Modulating Inter-Male Aggression
Mitra Heshmati, Eric J Nestler, Hossein Aleyasin, The Journal of Neuroscience
Voluntary Wheel Running Promotes Resilience to Chronic Social Defeat Stress in Mice: A Role for Nucleus Accumbens ΔFosB
Eric Nestler, MD, Nature
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The Netrin-1/DCC Guidance Cue Pathway as a Molecular Target in Depression: Translational EvidenceMay 2020
Meeting Report: Can We Make Animal Models of Human Mental Illness?February 2018

New Lipid Nanoparticle Platform Delivers mRNA to the Brain Through the Blood-Brain BarrierFebruary 18th, 2025
Girish N. Nadkarni, MD, MPH, CPH, Named to Leadership Roles in AI and Digital Health at the Icahn School of Medicine at Mount SinaiJanuary 30th, 2025
Mount Sinai Health Announces New Center for AI and Human HealthNovember 25th, 2024
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Transcriptional Mechanisms of Drug AddictionICAHN SCHOOL OF MEDICINE AT MOUNT SINAI2019–2029
Epigenetic Mechanisms of Chronic Stress ActionICAHN SCHOOL OF MEDICINE AT MOUNT SINAI2022–2027
Epigenetic Mechanisms of Chronic Stress ActionICAHN SCHOOL OF MEDICINE AT MOUNT SINAI2022–2027
Glial-mediated synaptic remodeling in drug addictionUNIVERSITY OF PITTSBURGH AT PITTSBURGH2016–2027
NIH FIRST Cohort Cluster Hiring Initiative at Icahn School of Medicine at Mount SinaiICAHN SCHOOL OF MEDICINE AT MOUNT SINAI2021–2026
Small molecule modulators of ΔFosBUNIVERSITY OF TEXAS MED BR GALVESTON2016–2026
Molecular Studies of Cocaine Action in BrainICAHN SCHOOL OF MEDICINE AT MOUNT SINAI1991–2026
Molecular Studies of Cocaine Action in BrainICAHN SCHOOL OF MEDICINE AT MOUNT SINAI1991–2026
Neurotrophic Mechanisms in Cocaine and Opiate ActionICAHN SCHOOL OF MEDICINE AT MOUNT SINAI2000–2025