ElliotMarkEpnerMDPhD Genetics

PubMed

• 39 citations
  Epigenetic therapy overcomes treatment resistance in T cell prolymphocytic leukemia
  Zainul Hasanali, Bikramajit Singh Saroya, August Stuart, Sara Shimko, Juanita J. Evans
  Science Translational Medicine. 2015-06-24
• 101 citations
  A phase II multicenter trial of hyperCVAD MTX/Ara-C and rituximab in patients with previously untreated mantle cell lymphoma; SWOG 0213
  Steven H. Bernstein, Elliot M. Epner, Joseph M. Unger, Michael LeBlanc, Erin Cebula
  Annals of Oncology. 2013-06-01
• 261 citations
  Bortezomib in patients with relapsed or refractory mantle cell lymphoma: updated time-to-event analyses of the multicenter phase 2 PINNACLE study
  Andre Goy, Steven H. Bernstein, Brad S. Kahl, Benjamin Djulbegovic, Michael J. Robertson
  Annals of Oncology. 2008-01-01

Journal Articles

• The Beta-Globin LCR is not Required for an Open Chromatin Structure or Low Level Transcription of the Mouse Beta-Globin Locus.  
  Epner,E, Reik, A, Cimbora, D, Telling, A, Fiering, S, Keller, G, and Groudine, M, Molecular Cell
• The locus control region is necessary for beta-globin gene expression but not for the maintenance of an open chromatin structure in erythroid cells.  
  Reik, A, Telling, A, Zitnik, G, Epner, E and Groudine, M, Mol. Cell Biol
• A Multicenter Phase II Study of Bortezomib in Patients with Relapsed or Refractory Mantle Cell Lymphoma.  
  Fisher,R, Bernstein S, Kahl, B, Djulbegovic, B, Robertson M, De Vos S, Epner, E, Krishnan A, Leonard J, Lonial S, Stadtmauer E, Oconnor O, Shi, H, Boral A, and Goy A, Journal of Clinical Oncology
• Oncogene Addiction/ Substitution In Cyclin D1 Deregulated B Cell Malignancies.  
  Stuart., A Huang, J. Ragland, A, Liu, H, Sharma, K and Elliot Epner, Plos One, in revision
• The Epigenetics of Gastrointestinal Malignanicies.  
  Hasanali Z, Stuart, A, Yee, N, Sharma K, and Epner E, Curr Colorectal Cancer Rep
• What does the human beta-globin locus control region actually control?  
  Epner, E, Kim, C, Groudine, M, Current Biology
• The regulation of Hemoglobin Switching.  
  Fiering, S, Epner, E, Groudine, M, eds. Stamatoyannopoulos, G., Nienhuis, A.W, The Johns Hopkins Univ
• Short-term impact of a robot-assisted laparoscopic prostatectomy 'mini-residency' experience on postgraduate urologists' practice patterns.  
  McDougall EM, Corica FA, Chou DS, Abdelshehid CS, Uribe CA, Stoliar G, Sala LG, Khonsari SS, Eichel L, Boker JR, Ahlering TE, Clayman RV, Int J Med Robot
• Comparison of basic elements of human performance scores between urologists with various extents of experience.  
  McDougall EM, Corica FA, Chou DS, Uribe CA, Abdelshehid CS, Boker JR, Khonsari SS, Eichel L, Lee D, Finley DS, Hogg D, Cadeddu JA, Pearle MS, Clayman RV, J Endourol
• Third Prize: Comparison of radical nephrectomy, laparoscopic microwave thermotherapy, cryotherapy, and radiofrequency ablation for destruction of experimental VX-2 ren...  
  Eichel L, Kim IY, Uribe C, Khonsari S, Basillote J, Steward E, Coad J, Bischof J, Rudie E, Kluge S, McDougall EM, Clayman RV, J Endourol
• Initial impact of a dedicated postgraduate laparoscopic mini-residency on clinical practice patterns.  
  Chou DS, Abdelshehid CS, Uribe CA, Khonsari SS, Eichel L, Boker JR, Shanberg AM, Ahlering TE, Clayman RV, McDougall EM, J Endourol
• Platelet-activating factor and the production of human interferon-gamma.  
  Yousefi S, Vaziri N, Carandang G, Villanueva JL, Khonsari S, Ocariz J, Cesario TC, J Interferon Cytokine Res
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Books/Book Chapters

• Structure and replication of the human beta-globin domain. 
  Chapter: Molecular Mechanisms of Hemoglobin Switching 
  Groudine, M, Forrester, W, Novak, U, Epner, EEditors: Stamatoyannopoulos, G, Neinhuis, A, Liss, A.New York
• Revoltella et. al., Murine erythroleukemia cell differentiation: The relationship of commitment to terminal cell division. Globin mRNA synthesis and cell cycle related effects of inducer. 
  Chapter: Expression of Differentiated Functions in Cancer Cells 
  Marks, P, Chen, Z, Epner, E, Banks, J, Gambari, R, Rifkind, REditors: R. Revoltella.Raven Press, New York
• Chromatin structure and DNA replication patterns in normal and mutant beta-globin gene loci. 
  Chapter: The regulation of Hemoglobin Switching 
  Page 153 - 177Epner, E, Forrester, WC, Kim, C, Telling, A, Enver, T, Brice, M, Papayannopoulou, T, Groudine, MEditors: Stamatoyannopoulos, G., Nienhuis, A.W.The Johns Hopkins Univ, Baltimore and London

Abstracts/Posters

• SGN-30 (Anti-CD30 mAb) Has a Single-Agent Response Rate of 21% in Patients with Refractory or Recurrent Systemic Anaplastic Large Cell Lymphoma (ALCL).
  Andres Forero-Torres, Steven H. Bernstein, Ajay Gopal, Francine Foss, John P. Leonard, Joseph D. Rosenblatt, Nancy L. Bartlett, Bruce D. Cheson, Elliot Epner, Francisc..., Blood American Society of Hematology Annual Meeting
• Desferroxamine: An anti-cyclin D1 agent cytotoxic against cyclin D1 (+) mantle cell lymphoma and multiple myeloma cell lines.
  Epner, E, American Association of Cancer Research
• Long Distance Trans DNA Hypomethylation in Cyclin D1 Deregulated B Cell Malignancies.
  Hui Liu, Jin Wang, Jing Huang, and Elliot M. Epner, Blood American Society of Hematology Annual Meeting
• Cooperative Silencing of Chicken - and ßH- Globin Gene Expression by Chicken ß-Globin Regulatory Elements: Involvement of GATA-1, NF-E2, and RNA Polymerase II.
  Jin Wang, Hui Liu, and Elliot Epner, Blood American Society of Hematology Annual Meeting
• Long Distance Cyclin D1 Activation in B Cell Malignancies: Role of RNA Polymerase II.
  Hui Liu, Jin Wang, Richard T. Maziarz, and Elliot M. Epner, Blood American Society of Hematology Annual Meeting
• Cyclin D1 Deregulation in Mantle Cell Lymphoma: Tethering of the Cyclin D1 Promoter and 3' Immunoglobin Enhancers by CTCF and Nucleophosmin.
  Elliot M. Epner, Hui Liu, Wang Jin, Jing Huang, Craig R. Nichols, and Richard T.Maziarz, Blood American Society of Hematology Annual Meeting
• Transallelic Effects at the Cyclin D1 Loci in Mantle Cell Lymphoma.
  Elliot M. Epner, Liu Hui, Wang Jin, Huang Jing, and Clurman E. Bruce, Blood American Society of Hematology Annual Meeting
• Hematopoietic Cell Transplants (HCT) from HLA-Matched Related (MRD) and Unrelated (URD) Donors for Patients with Hematologic Malignancies Using Low-Dose TBI Conditioning.
  Brenda M. Sandmaier, M.B. Maris, D.G. Maloney, T.A. Gooley, J.A. Shizuru, D.W. Niederwieser, T.R. Chauncey, F. Sahebi, E. Agura, R.T. Maziarz, B. Bruno, M. Pulsipher, ..., Blood American Society of Hematology Annual Meeting
• Mantle Cell Lymphoma: An Epigenetic Disease of Cyclin D1 Deregulation Involving Nucleophosmin, CTCF and Small RNAs.
  Elliot Epner, Huang Jing, Wang Jin, and W.H. Fleming, Blood American Society of Hematology Annual Meeting
• Long distance deregulation of cyclin D1 expression in B cell malignancy is accompanied by local promoter DNA demethylation and histone hyperacetylation.
  Liu H, Wang J, Epner E, American Association of Cancer Research
• Transvection Mediated by the Translocated Cyclin D1 Locus in B Cell Malignancies.
  Elliot Epner, Jing Huang, Hui Liu, Jin Wang, and W.H. Fleming, Blood American Society of Hematology Annual Meeting
• Applying the Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI) in Myeloablative MUD Transplants Predicts NRM and OS Using a Modified 2-Tier Scoring System.
  Tibor Kovacsovics, Byung Park, Brandon Hayes-Lattin, Jose F. Leis, Peter T. Curtin, Gabrielle Meyers, Elliot Epner, and Richard T. Maziarz, Blood American Society of Hematology Annual Meeting
• Transvection Mediated by the Translocated Cyclin D1 Gene in Mantle Cell Lymphoma.
  Elliot M. Epner, Hui Liu, Jing Wang, and Mathew Thayer, Blood American Society of Hematology Annual Meeting
• A Multi Center Trial of hyperCVAD+Rituxan in Patients with Newly Diagnosed Mantle Cell Lymphoma.
  Elliot M. Epner, Joseph Unger, Thomas Miller, Lisa Rimzsa, Catherine Spier, Michael Leblanc, and Richard Fisher, Blood American Society of Hematology Annual Meeting
• Fleming. CTCF and Nucleophosmin Participate in Long Distance Cyclin D1 Deregulation in Mantle Cell Lymphoma.
  Elliot M. Epner, Jing Huang, Hui Liu, Jin Wang, Shugiang Liang, and William H, Blood American Society of Hematology Annual Meeting
• Hematopoietic Stem Cell Transplantation following Reduced Intensity Conditioning for High Risk Patients with Paroxysmal Nocturnal Hemoglobinuria.
  Agata Mikolajewska, Haifa Kathrin Al-Ali, Nadezda Basara, Elliot Epner, Ernst Holler, Laura Johnston, Dietger Niederwieser, and Thoralf Lange, Blood American Society of Hematology Annual Meeting
• Targeting the epigenome in B-cell malignancies: A phase I/II study of vorinostat (SAHA), cladribine (2-CdA), and rituximab (R) in B-cell malignancies.
  Stephen E Spurgeon, Craig Y. Okada, Gundula Palmbach, Nan Subbiah, Jing Huang, John D. Phillips, Elliot M. Epner, American Society of Clinical Oncology Annual Meeting
• Cladribine plus rituximab for the initial treatment of mantle cell lymphoma.
  Talia Pindyck, Stephen E.F. Spurgeon, Marc M. Loriaux, Craig Okada, Yiyi Chen, Zunqiu Chen, Elana Mater, Elliot M. Epner, merican Society of Clinical Oncology Annual Meeting
• Cyclin D1 Gene Expression is not required for in vitro growth or in vivo tumorigenicity of mantle cell lymphoma lines.
  Wang J, Rangland A, Lui H, Grogan T, Epner E, American Association of Cancer Research
• Desferroxamine: An anti-cyclin D1 agent cytoxic against cyclin D1 (+) mantle cell lymphoma and multiple myeloma cell lines.
  Epner E, Wright H, DeAngelis K, Wang J, Liu H, Clurman B, American Society of Hematology
• Immunoablative Transplantation for Lymphoid Malignancies.
  Briggs A, Safah H, List A, Epner E, Weiner R, Rink J, Miller A, American Society of Bone Marrow Transplant
• Linezolid Use in Patients Prior to or During Stem Cell Transplantation for Vancomycin Resistant Enterococcus Infections: An Effective Nontoxic Therapy.
  Epner E, Shapiro T, Graham M, American Society of Hematology
• Gene Targeting Mediated Ablation Of IgH Deregulated Genes in Human B Cell Lines Reveals that Cyclin D3 can Substitute for Cyclin D1 in Mantle Cell Lymphoma and Multipl...
  Ragland A Liu H, Liu X, Epner E, American Society of Hematology
• Gene Targeting Studies of Cyclin D1 Deregulation in U266 Multiple Myeloma Cells.
  Liu X, Lowe M, Ragland A, Brenneman J, Liu H, and Epner E, American Society of Hematology
• Cyclin D1 Gene Expression Is not Required for In Vitro Growth or In Vivo Tumorigenicity of Mantle Cell Lymphoma Cell Lines.
  Lowe M, Ragland A, Brenneman J, Liu H, Liu X, Stadheim C, List A, Grogan T, Clurman B and Epner E, American Society of Hematology
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Lectures

• Traumatic Brain Injury. 
  University of CA, Irvine Department
• Rehabilitation Issues in Parkinson’s Disease. 
  Huntington Parkinson’s Support Group
• Bladder Function and Dysfunction. 
  Casa Colina Centers for Rehabilitation Stroke Symposium
• Regarding pain and treatment options for pain 
  La Fetra Senior Center, Glendora Community Services, Glendora, CA
• Traumatic Brain Injury Recovery. 
  Ontario, CA
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Other

• Recombination-proficient avian/mammalian microcell hybrids. 
  Epner E
• Targeting nucleophosmin in mantle cell lymphoma. 
  Epner E
• Therapeutic drug combinations for the treatment of B Cell Malignancies. 
  Epner E
• Therapeutic drug combinations using epigenetic and monoclonal antibody therapy in human malignancies. 
  Epner E
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