EdwinChoyMDMD PhD

PubMed

• 11 citations
  Phase 2 trial of palbociclib and ganitumab in patients with relapsed Ewing sarcoma.
  David S Shulman, Priscilla Merriam, Edwin Choy, Lillian M Guenther, Kerri L Cavanaugh
  Cancer Medicine. 2023-07-01
• 4 citations
  Trimodality Treatment of Extremity Soft Tissue Sarcoma: Where Do We Go Now?
  Sapna Oberoi, Edwin Choy, Yen-Lin Chen, Thomas Scharschmidt, Aaron R Weiss
  Current Treatment Options in Oncology. 2023-04-01
• 114 citations
  Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma.
  I. Frank Ciernik, Andrzej Niemierko, David C. Harmon, Wendy Kobayashi, Yen-Lin Chen
  Cancer. 2011-10-01

Journal Articles

• CRISPR-Cas9-Mediated Silencing of CD44 in Human Highly Metastatic Osteosarcoma Cells  
  Edwin Choy, Francis J Hornicek, Henry Mankin, Cellular Physiology and Biochemistry
• TP53 Mutations Emerge with HDM2 Inhibitor SAR405838 Treatment in De-Differentiated Liposarcoma  
  Mark A Dickson, Edwin Choy, Nature
• Denosumab-treated Giant Cell Tumor of Bone Exhibits Morphologic Overlap With Malignant Giant Cell Tumor of Bone  
  Wojcik J, Rosenberg AE, Bredella MA, Choy E, Nielsen GP, Deshpande V., Am J Surg Pathol., 1/24/2015
• MDR1 siRNA Loaded Hyaluronic Acid-based CD44 Targeted Nanoparticle Systems Circumvent Paclitaxel Resistance in Ovarian Cancer  
  Yang X, Iyer AK, Singh A, Choy E, Hornicek FJ, Amiji MM, Duan Z, Sci Rep., 1/17/2015
• CD44 Is a Direct Target of miR-199a-3p and Contributes to Aggressive Progression in Osteosarcoma  
  Gao Y, Feng Y, Shen JK, Lin M, Choy E, Cote GM, Harmon DC, Mankin HJ, Hornicek FJ, Duan Z., Sci Rep, 1/16/2015
• Phase I Study of Oral Abexinostat, a Histone Deacetylase Inhibitor, in Combination with Doxorubicin in Patients with Metastatic Sarcoma  
  Choy, E., Flamand Y, Balasubramanian S, Butrynski JE, Harmon DC, George S, Cote GM, Wagner AJ, Morgan JA, Sirisawad M, Mani C, Hornicek FJ, Duan Z, Demetri GD, Cancer, 1/15/2015
• NSC23925 Prevents the Emergence of Multidrug Resistance in Ovarian Cancer in Vitro and in Vivo  
  Yang X, Feng Y, Gao Y, Shen J, Choy E, Cote G, Harmon D, Zhang Z, Mankin H, Hornicek FJ, Duan Z, Gynecol Oncol, 1/1/2015
• Inhibition of Vascular Endothelial Growth Factor a and Hypoxiainducible Factor 1Alpha Maximizes the Effects of Radiation in Sarcoma Mouse Models through Destruction of...  
  Lee HJ, Yoon C, Park do J, Kim YJ, Schmidt B, Lee YJ, Tap WD, Eisinger-Mathason TS, Choy E, Kirsch DG, Simon MC, Yoon SS., Int J Radiat Oncol Biol Phys, 1/1/2015
• Cluster of Differentiation 44 Targeted Hyaluronic Acid Based Nanoparticles for MDR1 siRNA Delivery to Overcome Drug Resistance in Ovarian Cancer  
  Yang X, Iyer AK, Singh A, Milane L, Choy E, Hornicek FJ, Amiji MM, Duan Z., Pharm Res, 1/1/2015
• A-770041 Reverses Paclitaxel and Doxorubicin Resistance in Osteosarcoma Cells  
  Duan Z, Zhang J, Ye S, Shen J, Choy E, Cote G, Harmon D, Mankin H, Hua Y, Zhang Y, Gray NS, Hornicek FJ., BMC Cancer., 1/19/2014
• Sarcoma After Five Years of PFS: Lessons from the French Sarcoma Group  
  Choy, E., Cancer, 1/18/2014
• Biosimilar Safety Considerations in Clinical Practice  
  Choy, E., Jacobs, IA, Seminars in Oncology, 1/1/2014
• Prognostic Significance of miRNA-1 (miR-1) Expression in Patients with Chordoma  
  Duan Z, Shen J, Yang X, Yang P, Osaka E, Choy E, Cote G, Harmon D, Zhang Y, Nielsen GP, Spentzos D, Mankin H, Hornicek F., J Orthop Res, 1/1/2014
• Comparison of Performance of Various Tumour Response Criteria in Assessment of Regorafenib Activity in Advanced Gastrointestinal Stromal Tumours after Failure of Imati...  
  Shinagare AB, Jagannathan JP, Kurra V, Urban T, Manola J, Choy E, Demetri GD, George S, Ramaiya NH., Eur J Cancer, 1/1/2014
• MRI Surveillance following Treatment of Extremity Soft Tissue Sarcoma  
  Cheney MD, Giraud C, Goldberg SI, Rosenthal DI, Hornicek FJ, Choy E, Mullen JT, Chen YL, Delaney TF., J Surg Oncol., 1/24/2013
• Beta-Catenin Mutation Status and Outcomes in Sporadic Desmoid Tumors  
  Mullen JT, Delaney TF, Rosenberg AE, Le L, Iafrate AJ, Kobayashi W, Szymonifka J, Yeap BY, Chen YL, Harmon DC, Choy E, Yoon SS, Raskin KA, Hornicek FJ, Nielsen GP, Oncologist, 1/19/2013
• Safety and Efficacy of Denosumab for Adults and Skeletally Mature Adolescents with Giant Cell Tumour of Bone: Interim Analysis of an Open-label, Parallel-group, Phase ...  
  Chawla S, Henshaw R, Seeger L, Choy E, Blay JY, Ferrari S, Kroep J, Grimer R, Reichardt P, Rutkowski P, Schuetze S, Skubitz K, Staddon A, Thomas D, Qian Y, Jacobs I., Lancet Oncol., 1/15/2013
• Role of Epigenetic Modulation for the Treatment of Sarcoma  
  Cote, G., Choy, E., Curr Treat Options Oncol., 1/8/2013
• Cyclin-Dependent Kinase 11 (CDK11) is Crucial in the Growth of Liposarcoma Cells  
  Jia B, Choy E, Cote G, Harmon D, Ye S, Kan Q, Mankin H, Hornicek F, Duan Z, Cancer Lett, 1/2/2013
• Update in Treatment and Targets in Ewing Sarcoma  
  Cote GM, Choy E, Hematol Oncol Clin North Am, 1/1/2013
• Neoadjuvant Chemoradiotherapy for Patients with High-risk Extremity and Truncal Sarcomas: A 10-year Single Institution Retrospective Study  
  Hong NJ, Hornicek FJ, Harmon DC, Choy E, Chen YL, Yoon SS, Nielsen GP, Szymonifka J, Yeap BY, Delaney TF, Mullen JT., Eur J Cancer., 1/20/2012
• Targeting Hedgehog-GLI-2 Pathway in Osteosarcoma  
  Yang W, Liu X, Choy E, Mankin H, Hornicek FJ, Duan Z., J Orthop Res, 1/11/2012
• Desmoid Tumor: Analysis of Prognostic Factors and Outcomes in a Surgical Series  
  Mullen JT, Delaney TF, Kobayashi WK, Szymonifka J, Yeap BY, Chen YL, Rosenberg AE, Harmon DC, Choy E, Yoon SS, Raskin KA, Petur Nielsen G, Hornicek FJ., Ann Surg Oncol., 1/1/2012
• Proton-Based Radiotherapy for Unresectable or Incompletely Resected Osteosarcoma  
  Ciernik, I., Niemierko, A., Harmon, D., Kobayashi, W., Chen, Y., Yock, T., Ebb, D., Choy, E., Raskin, K., Liebsch, N., Hornicek, F., and DeLaney, T., Cancer, 1/29/2011
• High Throughput Genotyping in Osteosarcoma Identifies Multiple Mutations in PIK3CA and Other Oncogenes  
  Choy, E., Hornicek, F., MacConnail, L., Harmon, D., Tarik, Z., Garraway, L., Duan, Z., Cancer, 1/17/2011
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Books/Book Chapters

• Harrison's Manual of Oncology 
  Chapter: Section 14: Sarcoma 
  Choy, E., Yoon, S., Delaney, T., and Hornicek, F.Editors: Chabner, B.McGraw-Hill EducationEdition 2nd,2014
• Osteosarcoma: Symptoms, Diagnosis and Treatment 
  Editors: Choy, E.Options Nova Science Publishers, Inc., Hauppauge, NY2014
• Soft Tissue and Bone Sarcoma 
  Editors: Choy, E..MDPI, Basel, Switzerland2014
• The Evidence: 100 Studies Every Medicine Resident Should Know 
  Chapter: Chapter V. Hematology & Oncology 
  Choy, E. and Fogerty, A.Editors: Soverow, J. and McGarrah, R..Massachusetts General Hospital2011
• The MGH Guide to Clinical Cancer Genetics. 
  Chapter: The Hap Map Project and Low-Penetrance Cancer Susceptibility Alleles 
  Choy, E. and Altshuler, D.Editors: Chung, D. and Haber, D..Springer, Amherst2010
• The MGH Guide to Clinical Cancer Genetics. 
  Chapter: Cancer Genetics and Targeted Therapy 
  Engelman, J., Shaw, A., Barnes, J., and Choy, E.Editors: Chung, D. and Haber, D..Springer, Amherst2010
• The MGH Ambulatory Care Syllabus 
  Chapter: Dyspepsia: GERD, PUD, and Nonulcer Dyspepsia 
  Choy, E., Kehoe, L., Fleming, N., Wiest, F., Forcione, D.G., Friedman, L.S.Editors: Basch, E., Messersmith, W., Birnbaum, S., and Garza, C..J.P. Lippincott., PhiladelphiaEdition 4th,2001
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Abstracts/Posters

• Programmed Cell Death Ligant 1 Expression in Chordoma
  Feng, Y., Shen, J., Gao, Y., Cote, G., Choy, E., Mankin, H., Hornicek, F., and Duan, Z., ORS (Orthopaedic Research Society) 2015 Annual Meeting, Las Vegas, NV, 1/1/2015
• Expression of PIM1 Kinase in Osteosarcoma and the Clinical Significance
  Feng, Y., Gao, Y., Shen, J., Cote, G., Choy, E., Mankin, H., Hornicek, F., and Duan, Z., ORS (Orthopaedic Research Society) 2015 Annual Meeting, Las Vegas, NV, 1/1/2015
• TP53 Mutations Emerge in Circulating Cell-free DNA Obtained from Patients Undergoing Treatment with the HDM2 Antagonist SAR405838
  Jung, J., Dickson, M., Schwartz, G., Le Cesne, A., Varga, A., Bahleda, R., Wagner, A., Choy, E., de Jonge, M., Light, M., Lee, JS, Mace, S., and Watters, J, Meeting of the American Society of Clinical Oncology, Chicago, IL, 1/1/2015
• Randomized, Open-label, Multicenter, Phase 3 Study of Eribulin versus Dacarbazine in Patients (pts) With Leiomyosarcoma (LMS) And Adipocytic Sarcoma (ADI)
  Schoffski, P., Maki, RG, Italiano, A., Gelderblom, H., Choy, E., Grignani, G., Camargo, V., Bauer, S., Rha, SY, Chawla, S., Blay, JY, Hohenberger, P., D'Adamo, DR, Che..., Meeting of the American Society of Clinical Oncology, Chicago, IL, 1/1/2015
• Preoperative Radiation Therapy Combined with Radical Surgical Resection Is Associated with a Lower Rate of Locoregional Recurrence When Treating Primary Retroperitonea...
  Molina, G., Hull, M., Chen, Y., DeLaney, TF, Bernstein, K., Choy, E., Cote, G., Harmon, DC, Mullen, JT, and Haynes, AB., Meeting of the Connective Tissue Oncology Society, Salt Lake City, UT, 1/1/2015
• Randomized, Open-label, Multicenter, Phase 3 Study of Eribulin versus Dacarbazine in Patients (pts) With Leiomyosarcoma (LMS) And Adipocytic Sarcoma (ADI).
  Schoffski, P., Maki, RG, Italiano, A., Gelderblom, H., Choy, E., Grignani, G., Camargo, V., Bauer, S., Rha, SY, Chawla, S., Blay, JY, Hohenberger, P., D'Adamo, DR, Che..., 23rd Asia Pacific Cancer Conference, Bali, Indonesia, 1/1/2015
• Kin1-141 Identified In A Highthroughput Cell-based Screen reverses Multidrug Resistance In Osteosarcoma
  Ye, S., Choy, E., Mankin, H. Hornicek, F., and Duan, Z., 60th Annual Meeting of the ORS, New Orleans, LA, 1/15/2014
• Outcomes Of Head And Neck Osteosarcoma: 10-year Experience At A Single Institution
  Huang, P., Jacobson, A., Giraud, C., Choy, E., Harmon, D., DeLaney, T., and Chen, Y., 56th Annual Meeting of the American Society for Radiation Oncology (ASTRO), San Francisco, CA., 1/1/2014
• Localized Adult Ewing Sarcoma (ES): Improved Outcomes with Ifosfamide and Etoposide (IE) Added to Cyclophosphamide, Doxorubicin, and Vincristine (CAV) Chemotherapy (CT).
  Pretz, J., Barysauskas, C., Suzanne George; Jason Hornick; Chandrajit Raut, MD; Karen Marcus;Yen-Lin E. Chen, MD; Phillip Devlin; Jeffrey A. Morgan; James Butrynski; F..., Meeting of the Connective Tissue Oncology Society, New York, NY, 1/1/2014
• A Prospective Correlative Trial of Personalized Patient-derived Xenograft (Pdx) Modeling in Patients with Metastatic or Recurrent Sarcoma: Study Design and Rationale.
  Jennifer Isler; Edwin Choy, MD, PhD; Rashmi Chugh; Lara Davis, MD; Robert G. Maki, MD, PhD; Janice Mehnert; Christian F. Meyer, MD, PhD; Sujana Movva; Vinod Ravi, MD; ..., Meeting of the Connective Tissue Oncology Society, New York, NY, 1/1/2014
• Clinical Activity of Cabozantinib in Patients with Sarcoma
  Edwin Choy, MD, PhD; Gregory M. Cote, MD PhD; David Harmon; Rebecca S. Heist., Meeting of the Connective Tissue Oncology Society, New York, NY, 1/1/2014
• Phase I Study of the Parp Inhibitor Olaparib, Given with Temozolomide, in Patients (PTS) With Recurrent And/or Metastatic Ewing Sarcoma (Ews): An Interim Update.
  Edwin Choy, MD, PhD; Suzanne George; Gregory M. Cote, MD, PhD; Andrew J. Wagner; David Harmon; James Butrynski; Jeffrey A. Morgan; George D. Demetri, Meeting of the Connective Tissue Oncology Society, New York, NY, 1/1/2014
• High Dose Proton Beam Boosted Radiation Therapy in the Management of Non-skull Base Chondrosarcomas
  Thomas F. DeLaney; Aashish D. Bhatt, MD; Alex Jacobson; Richard Y. Lee; Christine Giraud; Joseph H. Schwab; Francis J. Hornicek; Petur G. Nielsen; Edwin Choy, MD, PhD;..., Meeting of the Connective Tissue Oncology Society, New York, NY, 1/1/2014
• Phase I Study of Nilotinib Given with Radiation for Patients with High-risk Chordoma.
  Gregory M. Cote, MD, PhD; Yen-Lin E. Chen, MD; Thomas F. DeLaney; David Harmon; Norbert Liebsch; John T. Mullen; Alex B. Haynes; Santiago Lozano-Calderon; Joseph H. Sc..., Meeting of the Connective Tissue Oncology Society, New York, NY, 1/1/2014
• Dissecting the Cdk11 (Cyclin-dependent Kinase 11) Kinase Pathway in Osteosarcoma
  Zhenfeng Duan; Yong Feng; Jianming Zhang; Slim Sassi; Edwin Choy, MD PhD; Gregory M. Cote, MD PhD; David Harmon; Henry Mankin; Francis J. Hornicek, Meeting of the Connective Tissue Oncology Society, New York, NY, 1/1/2014
• Mir-15b Modulates Multidrug Resistance in Human Osteosarcoma Cells in Vitro and in Vivo
  Zhenfeng Duan; Xiaoqian Yang; Yan Gao; Jacson Shen; Yong Feng; Edwin Choy, MD, PhD; Gregory M. Cote, MD, PhD; David Harmon; Henry Mankin; Francis J. Hornicek., Meeting of the Connective Tissue Oncology Society, New York, NY, 1/1/2014
• Polymeric Nanoparticle-based Delivery of Mirna-199a-3p and Let-7a Inhibit Proliferation and Growth of Osteosarcoma Cells
  Zhenfeng Duan; Linlin Zhang; Arun Iyer; Xiaoqian Yang; Edwin Choy, MD, PhD; Gregory M. Cote, MD, PhD; David Harmon; Henry Mankin; Francis J. Hornicek; Mansoor Amiji, Meeting of the Connective Tissue Oncology Society, New York, NY, 1/1/2014
• LB-167: Phase I Dose Escalation Study of Abexinostat and Doxorubicin in Patients with Metastatic Sarcomas.
  Choy, E., Balasubramanian, S., Butrynski, J., Morgan, J., Sinsawad, M., Mani, C., George, S., Wagner, A., Harmon, D., Rubinstein, Y., Duan, Z., Hornicek, F., and Demet..., 104th Annual meeting of the American Association for Clinical Research (AACR), Cancer Research, Washington, D.C., 1/15/2013
• LB-174: Translation of Preclinical Predictive Sensitivity of Ewing Sarcoma to PARP Inhibition: Phase II Study of Olaparib in Adult Patients with Recurrent/metastatic E...
  Choy, E., Butrynski, J., Harmon, D., Morgan, J., George, S., Wagner, A., D'Adamo, D., Cote, G., Rubinstein, Benes, C., Haber, D., Baselga, J., and Demetri, G., 104th Annual meeting of the American Association for Clinical Research (AACR), Cancer Research, Washington, D.C., 1/15/2013
• Denosumab Treatment for Giant Cell Tumor Metastatic to the Lung.
  Choy, E., Staddon, A., Alcindor, T., Ferrari, S., Engellau, J., Rutkowski, P., Feng, A., and Jacobs, I., International Conference of the American Thoracic Society (ATS), Philadelphia, PA, 1/1/2013
• Prolonged Survival and Disease Control in the Academic Phase II Trial of Regorafenib in GIST: Response Based on Genotype
  George, S., Feng, Y., von Mehren, M., Choy, E., Corless, C., Hornick, J., Butrynski, J., Wagner, A., Solomon, S., Morgan, J., Heinrich, M., and Demetri, G, 48th Annual meeting of the American Society for Clinical Oncology (ASCO), Chicago, IL, 1/1/2013
• Efficacy and Safety of Denosumab in Giant Cell Tumour of Bone: Updated Results with Independent Radiographic Assessment of Response
  Thomas, D., Blay, J., Chawla, S., Choy, E., Grimer, R., Ferrari, S., Reichardt, P., Rutkowski, P., Qian, Y., and Jacobs, I., Medical Oncology Group of Australia (MOGA) Annual Scientific Meeting, Melbourne, Australia, 1/1/2013
• Efficacy and Safety of Denosumab in Giant Cell Tumor of Bone
  Grimer, R., Blay, J., Chawla, S., Choy, E., Ferrari, S., Reichardt, P., Rutkowski, P., Thomas, D., Qian, Y., and Jacobs, I., International Society of Limb Salvage 17th General Meeting, Bologna, Italy, 1/1/2013
• Surgical Margin Width and Outcomes in Irradiated Extremity and Truncal Soft Tissue Sarcoma.
  Ahmad, R., Chen, Y., Hornicek, F., Raskin, K., Choy, E., Harmon, D., Cote, G., Nielsen, G., DeLaney, T., and Mullen, J., Meeting of the Connective Tissue Oncology Society, New York, NY, 1/1/2013
• Genomic Analysis of over 400 Sarcomas
  Cote, G., Shen, J., Choy, E., Wagner, A., Meeting of the Connective Tissue Oncology Society, New York, NY, 1/1/2013
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Lectures

• Presentation of Research Results SNU Sarcoma Symposium 
  Seoul National University Hospital (SNUH), Seoul, South Korea - 1/1/2015
• A 28 Year Old Woman with Back Pain and a Lesion in the Lumbar Spine 
  MGH Cancer Center - 1/1/2015
• Case Presentation and Discussion of a Pelvic Mucoepithelial Carcinoma 
  Botswana-Harvard AIDS Institute - 1/11/2014
• Phase 2 Study of Olaparib and Temozolomide in Ewing Sarcoma 
  Berlin, Germany - 1/1/2014
• Prioritization of Clinical Trials 
  Boston, MA - 1/22/2013
• Using Prosense to Image Residual Tumor Intraoperatively 
  Boston, MA - 1/19/2013
• Current Concepts in Organ Site Research New Therapeutic Targets for Ewing's Sarcoma 
  Washington DC - 1/10/2013
• Timing of Surgery around Adjuvant Treatments 
  Rochester, MN - 1/27/2012
• Case Presentation and Discussion of Leiomyosarcoma 
  Botswana-Harvard AIDS Institute - 1/22/2012
• Case Presentation and Discussion of GIST 
  Botswana-Harvard AIDS Institute - 1/16/2012
• Management of GIST 
  1/1/2012
• Phase I and II Studies Combining an HDAC Inhibitor with Adriamycin for Subjects with Metastatic Sarcoma 
  Chicago, IL - 1/1/2012
• Introduction to Sarcoma Oncology 
  1/1/2011
• Soft Tissue and Bone Sarcomas 
  University of Connecticut Cancer Center - 1/16/2010
• Presentation of Research Results "Genotyping Chordomas" 
  Paris, France - 1/12/2010
• Update in GIST and Sarcomas 
  1/1/2010
• Presentation of Research Results "Genotyping Osteosarcomas" 
  Miami, FL - 1/1/2009
• Presentation of Research Design 
  Chicago, IL - 1/1/2009
• Treating an Incarcerated Patient 
  1/1/2009
• Topics in Sarcoma Oncology 
  1/1/2009
• Introduction to Sarcoma Research 
  MGH Protocols Office - 1/1/2009
• A 23 Year Old Man with Cough, Hoarseness, and Fever 
  MGH Cancer Center - 1/1/2009
• Presentation of Cases Dava Oncology 
  Los Angeles, CA - 1/1/2008
• Advances in Sarcoma Oncology 
  MGH Cancer Center - 1/1/2007
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Other

• Osteogenic Sarcoma Staging. Medscape Reference 
  Choy E
  http://emedicine.medscape.com/article/2007306-overview
  1/21/2013
• Osteogenic Sarcoma Treatment Protocols 
  Choy E
  http://emedicine.medscape.com/article/2006667-overview
  1/21/2013
• Leading the Fight Against Childhood Cancer 
  WGBH Interview with Jordan Weinstein of NPR's Morning Edition
  http://www.wgbh.org/articles/Leading-theFight-Against-Childhood-Cancer-6147
  1/2/2012
• Expert Point of View: Researchers Find Remarkable Heterogeneity in Sarcomas 
  Alice Goodman, ASCO Post
  http://www.ascopost.com/issues/december-15-2011/expert-point-of-view-researchersfind-remarkable-heterogeneity-insarcomas.aspx
  1/15/2011
• Groups Update Guidelines on ESAs in Cancer Patients 
  Elsevier Global Medical News
  http://egmn.idsk.com/stories_us/5_ds_13725772.jsp
  1/27/2010
• Student, Swimmer Wins Biggest Battle Yet. 
  NECN
  http://www.necn.com/Boston/Health/2009/02/12/Student-swimmer-winsbiggest/1234475642.html
  1/12/2009
• Thesis, CAAX Proteins Target Ras to Intracellular Compartments 
  Choy, E, New York University
  New York - 1/1/1999
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