EdwardJNovotnyJr.MDFACNS, FAES, FAAN(He/Him)

PubMed

• 59 citations
  Frontal lobe tumoral epilepsy: clinical, neurophysiologic features and predictors of surgical outcome.
  Megdad M. Zaatreh, Dennis D. Spencer, James L. Thompson, Hal Blumenfeld, Edward J. Novotny
  Epilepsia. 2002-07-01
• 1065 citations
  De novo mutations in epileptic encephalopathies
  Andrew S. Allen, Samuel F. Berkovic, Patrick Cossette, Norman Delanty, Dennis J. Dlugos
  Nature. 2013-09-12
• 153 citations
  Ultra-rare genetic variation in common epilepsies: a case-control sequencing study.
  Andrew S. Allen, Susannah T. Bellows, Samuel F. Berkovic, Joshua Bridgers, Rosemary Burgess
  The Lancet. Neurology. 2017-02-01

Journal Articles

• Evidence for linkage of migraine in Rolandic epilepsy to known 1q23 FHM2 and novel 17q22 genetic loci  
  Addis L, Chiang T, Clarke T, Hardison H, Kugler S, Mandelbaum DE, Novotny E, Wolf S, Strug LJ, Pal DK, Genes Brain Behav, 1/1/2014
• Lennox-Gastaut syndrome of unknown cause: phenotypic characteristics of patients in the Epilepsy Phenome/Genome Project  
  Widdess-Walsh P, Dlugos D, Fahlstrom R, Joshi S, Shellhaas R, Boro A, Sullivan J, Geller E; EPGP Investigators, Epilepsia, 1/1/2013
• Growth hormone-releasing hormone effects on brain ?-aminobutyric acid levels in mild cognitive impairment and healthy aging  
  Friedman SD, Baker LD, Borson S, Jensen JE, Barsness SM, Craft S, Merriam GR, Otto RK, Novotny EJ, Vitiello MV, JAMA Neurol, 1/1/2013
• Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: initial monotherapy outcomes at 12 months  
  Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Adamson PC; Childhood Absence Epilepsy Study Team, Epilepsia, 1/1/2013
• Tract-Based Spatial Statistical Analysis of Diffusion Tensor Imaging in Pediatric Patients with Mitochondrial Disease: Widespread Reduction in Fractional Anisotropy of...  
  Ishak GE, Poliakov AV, Poliachik SL, Saneto RP, Novotny EJ Jr, McDaniel S, Ojemann JG, Shaw DW, Friedman SD, AJNR, 1/12/2012
• Is postresective intraoperative electrocorticography predictive of seizure outcomes in children?  
  Wray CD, McDaniel SS, Saneto RP, Novotny EJ Jr, Ojemann JG, Neurosurg Pediatr, 1/1/2012
• Randomized trial of adjunctive topiramate therapy in infants with refractory partial seizures  
  Novotny E, Renfroe B, Yardi N, Nordli D, Ness S, Wang S, Weber T, Kurland CL, Yuen E, Eerdekens M, Venkatraman L, Nye JS, Ford L, Neurology, 1/1/2010
• Childhood Absence Epilepsy Study Group Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy  
  Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Capparelli EV, Adamson PC, N Engl J Med, 1/1/2010
• Temporal distributions of seizure occurrence from various epileptogenic regions  
  Durazzo TS, Spencer SS, Duckrow RB, Novotny EJ, Spencer DD, Zaveri HP, Neurology, 1/1/2008
• Evaluating the accuracy of perfusion/metabolism (SPET/PET) ratio in seizure localization  
  Buch K, Blumenfeld H, Spencer S, Novotny E, Zubal IG, Eur J Nucl Med Mol Imaging, 1/16/2007
• Metabolic Brain Imaging by Magnetic Resonance  
  Novotny EJ, Future Neurol, 1/1/2006
• Reference values for long echo time MR spectroscopy in healthy adults  
  Safriel Y, Pol-Rodriguez M, Novotny EJ, Rothman DL, Fulbright RK, AJNR, 1/1/2005
• A novel approach for selective brain cooling: implications for hypercapnia and seizure activity  
  Trubel H, Herman P, Kampmann C, Huth R, Maciejewski PK, Novotny E, Hyder F, Intensive Care Med, 1/1/2004
• Duration of induced seizures during selective pharyngeal brain cooling (German)  
  Trubel H, Herman P, Kampmann C, Novotny E, Hyder F, Biomed Tech (Berl), 1/1/2004
• Levetiracetam efficacy in refractory partial seizures, especially after failed epilepsy surgery  
  Motamedi M, Nguyen DK, Zaatreh M, Singh SP, Westerveld M, Thompson JL, Mattson R, Blumenfeld H, Novotny E, Spencer SS, Epilepsia, 1/1/2003
• Clinical spectrum of succinic semialdehyde dehydrogenase deficiency  
  Pearl PL, Gibson KM, Acosta MT, Vezina LG, Theodore WH, Rogawski MA, Novotny EJ, Gropman A, Conry JA, Berry GT, Tuchman M, Neurology, 1/1/2003
• Selective brain cooling from the pharynx  
  Trubel H, Herman P, Kampmann C, Novotny E, Hyder F, Biomedizinische Technik, 1/1/2003
• Magnetic resonance spectroscopy in epilepsy: Clinical issues  
  Cendes F, Knowlton RC, Novotny E, Min LL, Antel S, Sawrie S, Laxer KD, Arnold D, Epilepsia, 1/1/2002
• Estimating Tissue Deformation between Functional Images Induced by Intracranial Electrode Implantation Using Anatomical MRI  
  Studholme C, Novotny E, Zubal IG, Duncan JS, Neuroimage, 1/1/2001
• Differentiation of glucose transport in human brain gray and white matter  
  de Graaf RA, Pan JW, Telang F, Lee JH, Brown P, Novotny EJ, Hetherington HP, Rothman DL, J Cereb Blood Flow Metab, 1/1/2001
• Differential Increase in Cerebral Cortical Glucose Oxidative Metabolism During Rat Postnatal Development is Greater In Vivo than In Vitro  
  Novotny EJ, Ariyan C, Mason GF, Haddad G, J. O’Reilly J, Behar, K.L, Brain Res, 1/1/2001
• Brain regional development of the activity of -ketoglutarate dehydrogenase complex in the rat  
  Buerstatte CR, Behar KL, Novotny EJ, Lai JCK, Brain Res Dev Brain Res, 1/1/2000
• Cerebral Amino acids and Metabolites in Amino Acylase II deficiency: Alterations with Dietary Therapy  
  Novotny EJ, Hwang J-H, Rothman DL, Matalon R, Molecular and Chemical Neuropathology, 1/1/1999
• Glucose transporter type 1 deficiency: a study of two cases with video-EEG  
  Boles RG, Seashore MR, Mitchell WG, Kollros PR, Mofidi S, Novotny EJ, Eur J Pediatr, 1/1/1999
• Functional magnetic resonance imaging identifies abnormal visual cortical function in patients with occipital lobe epilepsy  
  Masuoka LK, Anderson AW, Gore JC, McCarthy G, Spencer DD, Novotny EJ, Epilepsia, 1/1/1999
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Books/Book Chapters

• Epilepsy. Neurology in Practice. 
  Chapter: What Can Neuroimaging Tell Us? 
  Page 54 - 60Novotny EJEditors: Miller JW and Goodkin HP.Wiley-Blackwell2014
• Diseases of Neurotransmission: from bench to bedside. 
  Chapter: Human SSADH Deficiency – Phenotype and Treatment Strategies. 
  Page 187 - 198Pearl PL, Acost MT, Theodore WH, Novotny EJ, Bennett HD, Jakobs C, Gibson KMEditors: Hoffman GF.SPS Verlagsgesellschaft, Heilbronn2006
• Principles and Practice of Pediatrics. 
  Chapter: Neonatal Seizures. Chapter 36 
  Page 286 - 291Novotny EJEditors: DeAngelis CD, Feigin RD, McMillan JA, Jones MD.J. B. Lippincott, Inc., Philadelphia, PAEdition 4th,2006
• Limbic Seizures in Children 
  Chapter: Mesial temporal sclerosis: electroclinical and pathological correlations and applications to limbic epilepsy in childhood. 
  Page 41 - 54Spencer SS, Novotny E, de Lanerolle N, Kim JEditors: G. Avanzini, A. Beaumanoir & L. Mira.John Libbey & Company, Ltd., London, United Kingdom22001
• Genetic Insights in Paediatric Endocrinology and Metabolism. 
  Chapter: Hypoglycaemia and the child’s brain. 
  Page 31 - 39Novotny EJ, Rothman D, Tamborlane WEditors: O’Rahilly S and Dunger DB.BioScientifica, Ltd., Bristol, United Kingdom1999
• Principles and Practice of Pediatrics. 
  Chapter: Neonatal Seizures. 
  Page 240 - 245Novotny EJEditors: Oski FA, DeAngelis CD, Feigin RD, McMillan JA, Warshaw JB.J. B. Lippincott, Inc., Philadelphia, PAEdition 2nd,1999
• The Clinical Evaluation of a Food Additive: Assessment of Aspartame. 
  Chapter: Evaluation of Seizures. 
  Page 205 - 216Anderson GM, Novotny EJ, Shaywitz BAEditors: Tschanz C, Butchko HH, Stargel WW, Kotsonis FN.CRC Press, New York, NY1996
• Tissue Oxygen Deprivation: From Molecular to Integrated function. 
  Chapter: Cerebral Blood Flow and Metabolism in Hypoxia. 
  Page 653 - 668Novotny EJEditors: Haddad GG, Lister G, L’Enfant C.Marcel Dekker, New York, NY1996
• Case Studies in Pediatric Intensive Care. 
  Chapter: Case 4. 
  Page 21 - 28Kain Z, Novotny EJ, Lister GEditors: Rogers 888MC, Helfaer MA.Williams and Wilkens, Baltimore, MD1993
• Frontiers in Cerebral Vascular Biology: Transport and its Regulation. 
  Chapter: Non-invasive Measurements of the Cerebral Steady State Glucose Concentration and Transport in Humans by 13C Nuclear Magnetic Resonance. 
  Page 35 - 40Gruetter R, Novotny EJ, Boulware SD, Rothman DL, Mason GF, Shulman GI, Tamborlane WV, Shulman RGEditors: Drewes LR, Betz AL.Plenum Press, New York, NY1993
• Surgical Treatment of Epilepsies. 
  Chapter: Experimental Technologies. Chapter 23 
  Page 291 - 308Laxer KD, Rowley HA, Novotny EJ, Gates JR, Sato S, Sutherling W, Elger CE, Ebersole JS, Stefan HEditors: Engel J.Raven Press, New York, NY1993
• Handbook of Clinical Neurology, Vol 15; Diseases of the Motor System. 
  Chapter: Hereditary Secondary Dystonias. Chapter 20 
  Page 339 - 349Novotny EJEditors: Vinken PJ, Gruyn GW, Klawans HL, de Jong JMBV.Elsevier Science Publishers B.V., Amsterdam1991
• Fetal and Neonatal Brain Injury: Mechanisms, Management, and the Risk of Malpractice. 
  Chapter: Hypoxic-Ischemic Encephalopathy. Chapter 10 
  Page 113 - 122Novotny EJEditors: Stevenson, DK and Sunshine, P.B. C. Decker, Inc., Philadelphia, PA1989
• Achievements and Perspectives of Mitochondrial Research Vol. II: Biogenesis. 
  Chapter: Maternally Inherited Diseases in Man. 
  Page 427 - 436Wallace DC, Singh, Hopkins LC, Novotny EJEditors: Quagliariello E et al.Elsevier Science Publishers, Amsterdam1985
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Abstracts/Posters

• Outcome Following Focal Epilepsy Surgery in Very Young Intact Children.
  H. Shurtleff, T. Firman, M. Warner, R. P. Saneto, J. Kuratani, R. Ellenbogen, E. Novotny, J. Ojemann, Epilepsia, 1/1/2011
• Functional connectivity MRI reveals disrupted interhemispheric connectivity in children with diffuse, but lateralized, epilepsy.
  J. G. Ojemann, A. Poliakov, S. Poliachik, , S. McDaniel, R. Saneto, J. Kuratani, K. Weaver, , C. Wray, H. Shurtleff, M. Warner, D. Shaw, E. J. Novotny Jr, Epilepsia, 1/1/2011
• EEG and fMRI correlates of ictal task performance during childhood absence seizures.
  J. Guo, X. Bai, M. Negishi, N. Danielson, X. Han, J. Gonzalez, E. Loftfield, M. Wang, H. Mistry, R. Berman, C. Vega, M. Spann, E. Novotny, R. T. Constable, H. Blumenfeld, Epilepsia, 1/1/2011
• Localization of Tissue Removed During Epilepsy Surgery.
  S.L. Poliachik, A.V. Poliakov, Laura Jansen, Sharon McDaniel, Carter Wray, Russ Saneto, John Kuratani, Ojemann J.G., Novotny E.J. Jr, Epilepsia, 1/1/2011
• Multimodality localization of sensorimotor cortex in pediatric epilepsy surgery.
  T. M. Blakely, C. Wray, S. L. Poliachik, A. Poliakov, , S. M. McDaniel, E. J. Novotny, J. G. Ojemann, Epilepsia, 1/1/2011
• Cluster analysis applied to fMRI data in typical childhood absence seizures.
  Bai X, Killory B, Guo J, Vestal M, Berman R, Negishi M, Novotny E, Constable R and Blumenfeld H, Epilepsia, 1/1/2010
• Ictal BOLD changes and behavioral performance variability in childhood absence epilepsy.
  Danielson N, Guo J, Killory B, Bai X, Negishi M, Vestal M, Berman R, Vega C, Spann M, Novotny E, Constable R and Blumenfeld H, Epilepsia, 1/1/2010
• Absence seizures impair attention and network connectivity in children.
  Killory B, Bai X, Negishi M, Vega C, Spann M, Vestal M, Berman R, Danielson N, Guo J, Foote S, Novotny E, Constable R and Blumenfeld H, Epilepsia, 1/1/2010
• Laterality of the EEG-fMRI seeded functional connectivity as a predictor of the surgical outcome of epilepsy.
  Negishi M, Martuzzi R, Novotny E, Spencer D and Constable R, Epilepsia, 1/1/2010
• Diffusion Tensor Imaging (DTI) shows motor fibers may be intimately related to cortical dysplasia.
  Ojemann J, Poliakov A, Shaw D, Saneto R, Kuratani J and Novotny E, Epilepsia, 1/1/2010
• A randomized, double-blind, placebo-controlled, fixed dose-ranging study to assess the efficacy, safety, and tolerability of topiramate oral liquid and sprinkle formul...
  Novotny E, Renfroe B, Yardi N, Nordli D, Ness S, Wang S, Weber T, Yuen E, Eerdekens M, Ford L, Annals of Neurology, 1/1/2008
• FMRI timecourse and correlation analysis in typical childhood absence seizures.
  Bai XX , Berman R, Negishi M, Novotny EJ, Constable T, Blumenfeld H, Epilepsia, 1/1/2008
• Eeg-bold (blood oxygen-level dependent) and eeg-cbv (cerebral blood volume) measurements of IED'S.
  Negishi M, Qiu M, Novotny E J, Spencer SS, Spencer D, Constable T, Epilepsia, 1/1/2008
• Evaluating epileptic networks in surgical planning by simultaneous eeg-fmri and functional connectivity.
  Rajeevan N, Negishi M, Novotny EJ, Blumenfeld H, Spencer D , Spencer SS, Constable T, Epilepsia, 1/1/2008
• Nicotine increases GABA synthesis in human brain, seen with 13C MRS in vivo.
  Mason, G. F., Boumezbeur, F., Sanacora, G., Guidone, E., Watzl, J., Gomez, R., Novotny, E., Weinzimer, S., Shulman, G. I., Krystal, J. H., Rothman, D. L., O'Malley, S, Alcoholism-Clinical and Experimental Research, 1/1/2007
• Combined EEG and fMRI in presurgical evaluation of pediatric epilepsy.
  Novotny, E; Negishi, M; Fertig, E, et al, Annals of Neurology, 1/1/2007
• Resting state FMRI for revealing hemispheric asymmetry in language, memory, and epileptogenic networks in epilepsy.
  Constable RT, Rajeevan N, Negishi M., Fertig E., Huh L., Novotny E., Blumenfeld H., Spencer D. D., Spencer S. S., Epilepsia, 1/1/2007
• Comparison of inter-ictal spike correlated FMRI and ictal difference SPECT localization of epilepsy.
  Negishi M., Fertig E., Teisseyre T. Z, Huh L., Novotny E., Blumenfeld H., Spencer D. D., Spencer, S. S., Constable RT, Epilepsia, 1/1/2007
• Serial ictal F-18FDG-PET imaging in Rasmussen's encephalitis.
  Shetty-Alva N, Novotny EJ, Shetty T, Kuo PH, Neurology, 1/14/2006
• Combined EEG, FMRI, and cognitive testing during typical childhood absence seizures at 3T.
  Berman, Rachel), Negishi, Michiro, Spann, Marissa, Enev, Miro, Constable, R. Todd, Novotny, Edward J., Blumenfeld, Hal, Epilepsia, 1/1/2006
• BOLD MR signal changes in response to cognitive activity are present in cortical regions exhibiting disrupted Cr/NAA ratio.
  Constable, R. Todd, Hetherington, Hoby P., Arora, Jagritia, Schafer, Robin, Novotny, Edward J., Papademetris, Xenios, Duncan, James S., Spencer, Dennis D, Epilepsia, 1/1/2006
• Circadian patterns of intracranial seizures arising from various epileptogenic regions.
  Durazzo, Tyler S., Duckrow, Robert B., Novotny, Edward J., Spencer, Susan S., Zaveri, Hitten P, Epilepsia, 1/1/2006
• Interictal activity recorded intracranially during wakefulness and sleep differentiates patients with medial temporal and temporal neocortical onset of seizures.
  Goncharova, Irina I., Zaveri, Hitten P., Novotny, Edward J., Duckrow, Robert B., Spencer, Susan S, Epilepsia, 1/1/2006
• Spectral analysis of interictal fMRI data.
  Negishi, Michiro, Blumenfeld, Hal, Novotny, Edward J., Fertig, Evan, Spencer, Dennis D., Spencer, Susan S., Constable, R. Todd, Epilepsia, 1/1/2006
• Correlation Of Magnetic Resonance Spectroscopic Imaging And Intracranial Eeg Recording In Lateralization Of Epilepsy
  E.J. Novotny, E. Scharff, H. Zaveri, H. Blumenfeld, X. Papademetris, S.S. Spencer, D.D. Spencer, R.B. Duckrow, H.P. Hetherington, J. Duncan, Abstract Viewer/Itinerary Planner; Society for Neuroscience, Washington, DC, 1/1/2005
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Lectures

• Pediatric Epilepsy: What the Clinician Wants. 
  Toronto, Canada - 1/31/2015
• Neuroimaging in Epilepsy 
  Vancouver, British Columbia, Canada - 1/1/2014
• Corticography in Pediatric Tumors –How can it Help? 
  Cleveland Clinic - 1/23/2013
• Molecular Diagnostic Studies of Epilepsy: Impact on Clinical Management 
  University of Washington - 1/10/2013
• Six Degrees of Separation in Epilepsy 
  University of British Columbia - 1/9/2013
• Epilepsy Syndromes 
  University of Washington - 1/4/2011
• Neuroimaging in Pediatric Epilepsy 
  University of California San Diego - 1/29/2008
• Shifting the Focus on Epilepsy 
  Cornell–Weill School of Medicine, New York, NY - 1/22/2006
• Epilepsy Surgery in Childhood 
  Cornell–Weill School of Medicine, New York, NY - 1/21/2006
• Childhood Epilepsy in Autistic Spectrum Disorders 
  Fairfield University - 1/12/2006
• Unfocusing in on Epilepsy 
  1/1/2005
• MRS in Pediatric Neurological Disorders 
  Osaka, Japan - 1/21/2002
• Advances in Pediatric Epileptology 
  Dokkyo University, Tochigi, Japan - 1/19/2002
• Magnetic Resonance Spectroscopy of neurotransmitters in the developing nervous system. 
  Baltimore, MD - 1/17/2002
• Developmental Brain Metabolism by C13 MRS 
  Tokyo University, Tokyo, Japan - 1/15/2002
• Developmental Neuroimaging 
  Children’s Hospital of Boston/Longwood Neurology, Boston, MA - 1/11/2002
• Neuroimaging Insights on Normal Development and Neurologic Disease: Principles and Applications “MR Spectroscopy” 
  Washington, DC - 1/10/2002
• MRS in Pediatric Epilepsy 
  Cleveland, OH - 1/1/2002
• Neurological manifestation of Mitochondrial Disorders 
  NH - 1/27/2001
• Ketogenic diet Workshop 
  Seattle, WA - 1/1/2001
• International Conference on Developmental Cerebral Blood Flow and Metabolism 
  Hershey, PA - 1/8/2000
• Hypoglycemia and the Brain. 
  1/7/2000
• NIRS as a Cerebral Function Monitor in the neonate. 
  Washington, DC - 1/5/2000
• Second International Conference on Neuroimaging in Epilepsy 
  Birmingham, AL - 1/1/2000
• Brain Imaging Techniques in Children with Epilepsy 
  Orlando, FL - 1/3/1999
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Other

• MRS Studies of the role of the glutamate neurotransmitter cycle in the cerebral cortex response to hypoglycemia. 
  Rothman DL, Novotny EJ
  http://www.jdrf.org/research/workshop090800.pdf
  1/1/2001
• Relation of hypoglycemia to epileptogenesis. 
  Novotny EJ, Rothman DL, Tamborlane WV
  http://www.jdrf.org/research/workshop090800.pdf.
  1/1/2001