Dr. Lesnefsky is on Doximity
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Office
1250 E Marshall Street
Internal Medicine
Richmond, VA 23298Phone+1 804-828-9198Fax+1 804-828-0395
Education & Training
- University of ColoradoFellowship, Cardiovascular Disease, 1984 - 1987
- University of Virginia Medical CenterResidency, Internal Medicine, 1983 - 1984
- University of Virginia Medical CenterInternship, Internal Medicine, 1981 - 1982
- University of Wisconsin School of Medicine & Public HealthClass of 1981
- University of Notre DameBS, Chemistry, Highest Honors, 1977
Certifications & Licensure
- OH State Medical License 1990 - 2026
- VA State Medical License 2008 - 2026
- CO State Medical License 1985 - 1991
- American Board of Internal Medicine Internal Medicine
- American Board of Internal Medicine Cardiovascular Disease
Awards, Honors, & Recognition
- Aging Selectively Decreases Oxidative Capacity in Interfibrillar Rat Mitochondria Pepper Older Americans Independence Center, Case Western Reserve University, 1994
- Midwest Section AFCR Award for Excellence in Research in Cardiovascular Disease 1990
- First Place in the Fellowship Research Category Colorado ACP Associates Program 1986
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Publications & Presentations
PubMed
- Skeletal muscle hypertrophy and enhanced mitochondrial bioenergetics following electrical stimulation exercises in spinal cord injury: a randomized clinical trial.Ashraf S Gorgey, Refka E Khalil, William Carter, Jeannie Rivers, Qun Chen
European Journal of Applied Physiology. 2025-04-01 - High-dose metformin treatment to inhibit complex I during early reperfusion protects the aged mouse heart via decreased mitochondrial permeability transition pore open...Qun Chen, Jeremy Thompson, Ying Hu, Hao Wang, Lily Slotabec
The Journal of Pharmacology and Experimental Therapeutics. 2024-12-24 - 1 citationsSphingosine kinase 2 (SphK2) depletion alters redox metabolism and enhances inflammation in a diet-induced MASH mouse model.Kaitlyn G Jackson, Derrick Zhao, Lianyong Su, Marissa K Lipp, Cameron Toler
Hepatology Communications. 2024-12-01
Journal Articles
- Aging Decreases Electron Transport Complex III Activity in Heart Interfibrillar Mitochondria By Alteration of the Cytochrome c Binding Site.Lesnefsky E.J., Gudz T.I., Moghaddas S., Migita C.T., Saito M.I., Turkaly P.J., Hoppel C.L, Journal of Molecular and Cellular Cardiology
- Oxidative Phosphorylation And Aging.Lesnefsky E.J., Hoppel C.L, Aging Research Reviews
- Blockade of Electron Transport Protects Against Ischemic Damage to Cardiac Mitochondria.Lesnefsky E.J., Chen Q., Moghaddas S., Hassan M.O., Tandler B., Hoppel C.L, Journal of Biological Chemistry
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Books/Book Chapters
Abstracts/Posters
- Influence of Severity of Remote Ischemia on Mortality During Acute Left Anterior Descending Occlusion.Lesnefsky E.J., Flanagan T.L., Mahanes M.S., Beller G.A., Gascho J.A, Circulation
- Hydrogen Peroxide Contracts Isolated Vascular Smooth Muscle, Impairs Endothelial Dependent Relaxation, and Blunts Vascular Reactivity.VanBenthuysen K.M., Lesnefsky E.J., Morris K., Horwitz L.D., McMurtry I.F, Clinical Research
- Superoxide Dismutase Prevents Myocardial Release of Conjugated Dienes During Early Reperfusion.Lesnefsky E.J., VanBenthuysen K., McMurtry I., Fennessey P.M., Travis V.L., Horwitz L.D, Circulation
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Other
- Oxidative Phospylation Provides A Valuable Tool For Identifying The Aging Mitochondrial Phenotype.Kypriotakis G., Vazquez E., Lesnefsky E., Hoppel C, 12th Congress of the International Association of Biomedical Gerontology
http://www.eie.gr/nhrf/institutes/ibrb/spetses-2007/poster_abstracts.pdf - Protection of mitochondrial respiration prevents permeability transition pore opening during reperfusion.Chen Q., Lesnefsky E.J, Basic Cardiovascular Sciences Meeting, Palm Springs, CA
http://www.americanheart.org/presenter.jhtml?identifier=3074181 - Activation of mitochondrial calpain during cardiac ischemia-reperfusion.Chen Q., Paillard M., Gomez L., Ross T., Hu Y., Lesnefsky E.J, Basic Cardiovascular Sciences Meeting
http://www.americanheart.org/presenter.jhtml?identifier=3074181
Palm Springs, CA - Join now to see all
Press Mentions
- Ischemia and Reperfusion Injury to Mitochondria and Cardiac Function in Donation After Circulatory Death Hearts- an Experimental StudyDecember 28th, 2020
- Dietary Inorganic Nitrate May Reduce Heart Dysfunction Caused by Powerful Anti-Cancer DrugMay 31st, 2011
Grant Support
- Metformin Therapy for Ischemic Insult and Reperfusion Injury in AgingVIRGINIA COMMONWEALTH UNIVERSITY2021–2025
- Mitochondrial Dysfunction in the Aged Heart: Role of Endoplasmic Reticulum StressVA VETERANS ADMINISTRATION HOSPITAL2012–2025
- Complex III Augments Oxidants Damage In Ischemic Aged HeartNational Institute On Aging2004–2008
- Animal / Physiology CoreNational Institute On Aging2004–2008
- Core--PhysiologyNational Institute On Aging1998–2001
- Antioxidants And Reperfusion Injury In Aging HeartNational Institute On Aging1998–2001
- Mitochondrial Focus Of Reperfusion Injury In Aging HeartNational Institute On Aging1997–1999
- Mitochondria Increase Oxidative Injury In Aging HeartNational Institute On Aging1995–1999
- Aging, Cardiac Mitochondria, And Ischemic InjuryNational Institute On Aging1994–1996
Professional Memberships
- Fellow
- Fellow
- Fellow
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