Edward Joseph Lesnefsky Jr. MD

PubMed

• Skeletal muscle hypertrophy and enhanced mitochondrial bioenergetics following electrical stimulation exercises in spinal cord injury: a randomized clinical trial.
  Ashraf S Gorgey, Refka E Khalil, William Carter, Jeannie Rivers, Qun Chen
  European Journal of Applied Physiology. 2025-04-01
• High-dose metformin treatment to inhibit complex I during early reperfusion protects the aged mouse heart via decreased mitochondrial permeability transition pore open...
  Qun Chen, Jeremy Thompson, Ying Hu, Hao Wang, Lily Slotabec
  The Journal of Pharmacology and Experimental Therapeutics. 2024-12-24
• 1 citations
  Sphingosine kinase 2 (SphK2) depletion alters redox metabolism and enhances inflammation in a diet-induced MASH mouse model.
  Kaitlyn G Jackson, Derrick Zhao, Lianyong Su, Marissa K Lipp, Cameron Toler
  Hepatology Communications. 2024-12-01

Journal Articles

• Aging Decreases Electron Transport Complex III Activity in Heart Interfibrillar Mitochondria By Alteration of the Cytochrome c Binding Site.  
  Lesnefsky E.J., Gudz T.I., Moghaddas S., Migita C.T., Saito M.I., Turkaly P.J., Hoppel C.L, Journal of Molecular and Cellular Cardiology
• Oxidative Phosphorylation And Aging.  
  Lesnefsky E.J., Hoppel C.L, Aging Research Reviews
• Blockade of Electron Transport Protects Against Ischemic Damage to Cardiac Mitochondria.  
  Lesnefsky E.J., Chen Q., Moghaddas S., Hassan M.O., Tandler B., Hoppel C.L, Journal of Biological Chemistry
• Aging Leads to A Defect at the Quinol Oxidation Site of Complex III in Rat Heart Interfibrillar Mitochondria.  
  Moghaddas S., Hoppel C.L., Lesnefsky E.J, Archives of Biochemistry and Biophysics
• Interfibrillar Cardiac Mitochondrial Complex III Defects in the Aging Rat Heart.  
  Hoppel C.L., Moghaddas S., Lesnefsky E.J, Biogerontology
• The IONA study: preparing the myocardium for ischaemia?  
  Lesnefsky E.J, Lancet
• Mitochondrial Dysfunction in Cardiac Disease: Ischemia-Reperfusion, Aging, and Heart Failure.  
  Lesnefsky E.J., Moghaddas S., Tandler, B., Kerner J., Hoppel C.L, Journal of Molecular and Cellular Cardiology
• Race and the Decision to Refer for Coronary Revascularization: Effect of Physician Awareness of Patient Ethnicity.  
  Okelo S., Taylor A.L., Wright J.T., Gordon N., Mohan G., Lesnefsky E, Journal of the American College of Cardiology
• Myocardial Ischemia Selectively Depletes Cardiolipin in Rabbit Heart Subsarcolemmal Mitochondria.  
  Lesnefsky E.J., Slabe T.J., Stoll M.S.K., Hoppel C.L, American Journal of Physiology
• Structure Of Cristae In Cardiac Mitochondria Of Aged Rat.  
  Riva A., Tandler B., Lesnefsky E.J., Conti G., Loffredo F., Vazquez E., Hoppel C.L, Mechanisms of Aging and Development
• Ischemic Injury to Mitochondrial Electron Transport in the Aging Heart: Damage to the Iron- Sulfur Protein Subunit of Electron Transport Complex III.  
  Lesnefsky E.J., Gudz T.I., Migita C.T., Saito M.I., Hassan M.O., Turkaly P.J., Hoppel C.L, Archives of Biochemistry and Biophysics
• Separation and Quantitation of Phospholipids and Lysophospholipids by High Performance Liquid Chromatography.  
  Lesnefsky E.J., Stoll M.S.K., Minkler P.E., Hoppel C.L, Analytical Biochemistry
• Aging Selectively Decreases Oxidative Capacity in Interfibrillar Rat Heart Mitochondria.  
  Fannin S.W., Lesnefsky E.J., Slabe T.S., Hassan M.O., Hoppel C.L, Archives of Biochemistry and Biophysics
• Myocardial Ischemia Damages Cytochrome Oxidase and Cytochrome c in Subsarcolemmal Mitochondria.  
  Lesnefsky E.J., Tandler B., Ye J., Slabe T.S., Turkaly J., Hoppel C.L, American Journal of Physiology
• Oxidative Sensitivity of Thiol Oxidoreductase Enzyme Systems.  
  Starke D., Chen Y., Bapna C., Lesnefsky E.J., Mieyal J.J, Free Radicals Biology and Medicine
• Risk Analysis of Coronary Bypass Surgery After Acute Myocardial Infarction.  
  Lee J.H., Murrell H.K., Strony J., Cmolik B., Nair R., Lesnefsky E., Chavez A., vanHeeckeren D.W., Geha A.S, Surgery
• ATP Catabolism and Adenosine Generation During Ischemia in the Aging Heart.  
  Ramani K., Lust W.D., Whittingham T.S., Lesnefsky E.J, Mechanisms of Aging and Development
• Enhanced Modification Of Cardiolipin During Ischemia In The Aged Heart.  
  Lesnefsky E.J., Minkler P.E., Hoppel C.L, Journal of Molecular and Cellular Cardiology
• Racial Variation in Treatment Recommendations for Coronary Artery Disease in a VA Population.  
  Okelo S.O., Mohan G., Rosenthal G., Lesnefsky E.J., Wright, Jr. J.T., Taylor A.L, Circulation
• In Vivo Evidence for Plaque Fracture Following PTCA: Intracoronary Ultrasound Imaging of Arterial Distensibility.  
  Reddy K.G., Suneja R., Nair R.N., Sheehan H.M., Lesnefsky E.J., Hodgson J.McB, Journal American College of Cardiology
• Intracoronary Plaque Composition in Non-Lesional Segments Differs in Unstable Angina and Stable Angina Patients: Evidence from Intracoronary Ultrasound.  
  Hodgson J.McB., Reddy K.G., Suneja R., Sheehan H.M., Lesnefsky E.J., Nair R.N, Journal American College of Cardiology
• Aged rat heart: Modulation of Age-related Respiratory Defects Decreases Ischemic-reflow Injury.  
  Lesnefsky E.J., Hoppel C.L, Health
• Membrane- Mitochondrial Symbiosis: Caveolin as a Control Point Stress Adaptation.  
  Fridolfsson H.N., Karawaguchi Y., Ali S.S., Panneerselvam M., Balijepalli R.C., Niesman I.R., Finley C., Abdel-alim A.S., Okada H., Moreno A.L., Jennings M., Kidd M.W...., FASEB Journal
• Blockade of Electron Transport Before Ischemia Protects Mitochondria and Decreases Myocardial Injury During Reperfusion in Aged Rat Hearts.  
  Tanaka-Esposito C.C., Chen Q., Lesnefsky E.J, Translational Research
• Blockade of Electron Transport at the Onset of Reperfusion Decreases Cardiac Injury in Aged Hearts by Protecting the Inner Mitochondrial Membrane.  
  Chen Q., Ross T., Hu Y., Lesnefsky E.J, Journal of Aging Research
• Join now to see all

Books/Book Chapters

• Free Radicals in Diagnostic Medicine. 
  Chapter: Tissue Iron Overload and Mechanisms of Iron-Catalyzed Oxidative Injury 
  Lesnefsky E.JEditors: Donald Armstrong, Ph.D.Plenum Press, New York, NY
• Mechanisms of Cardiovascular Aging. 
  Chapter: Mitochondrial Electron Transport And Aging In The Heart 
  Lesnefsky E.J., Tandler B., Moghaddas S., Hassan M.O., Hoppel C.LEditors: Tory Hagan, Ph.D.Elsevier, Amsterdam, The Netherlands
• Muscle Plasticity-Advances in Biochemical and Physiological Research. 
  Chapter: Mitochondria and Cardiac Injury: A Journey From Reperfusion to Ischemia and Back Again 
  Chen Q., Lesnefsky E.JEditors: Jose Magalhaes, Ph.D. and Antonio Ascensal, Ph.D.Research Signpost, Kerala, India

Abstracts/Posters

• Influence of Severity of Remote Ischemia on Mortality During Acute Left Anterior Descending Occlusion.
  Lesnefsky E.J., Flanagan T.L., Mahanes M.S., Beller G.A., Gascho J.A, Circulation
• Hydrogen Peroxide Contracts Isolated Vascular Smooth Muscle, Impairs Endothelial Dependent Relaxation, and Blunts Vascular Reactivity.
  VanBenthuysen K.M., Lesnefsky E.J., Morris K., Horwitz L.D., McMurtry I.F, Clinical Research
• Superoxide Dismutase Prevents Myocardial Release of Conjugated Dienes During Early Reperfusion.
  Lesnefsky E.J., VanBenthuysen K., McMurtry I., Fennessey P.M., Travis V.L., Horwitz L.D, Circulation
• Dimethyltheourea but not Dimethylsulfoxide Reduces Canine Myocardial Infarct Size.
  Portz S.J., VanBenthuysen K.M., Lesnefsky E.J., McMurtry I.F., Horwitz L.D, Circulation
• Lidocaine Reduces Canine Infarct Size: Protection from Myocardial Lipid Peroxidation.
  Lesnefsky E.J., VanBenthuysen K., McMurtry I., Johnston R.B., Shikes R.H., Horwitz L.D, Clinical Research
• Ischemic-Reperfused Myocardium Releases Oxidized and Reduced Glutathione in Early Reperfusion: Evidence for Oxidant Injury and Decreased Protection from Oxidant Injury.
  Lesnefsky E.J., Travis V.L., Portz S.J., Parker N.B., Repine J.E., Horwitz L.D, Clinical Research
• Superoxide Dismutase Protects Coronary Arteries from Ischemia-Reperfusion-Induced Endothelial Dysfunction.
  VanBenthuysen K.M., Dauber I.M., McMurtry I.F., Lesnefsky E.J., Portz S.J., Horwitz L.D, Clinical Research
• Lidocaine Reduces Canine Infarct Size: Protection from Myocardial Lipid Peroxidation.
  Lesnefsky E.J., VanBenthuysen K., McMurtry F, Johnston R.B., Shikes R.H., Horwitz L.D, Chest
• Myocardial Release of Glutathione During Early Reperfusion In Vivo.
  Lesnefsky E.J., Repine J.E., Horwitz L.D, Circulation
• Deferoxamine, an Iron Chelator, Reduces Canine Infarct Size.
  Lesnefsky E.J., Dauber I.M., Coller H., Horwitz L.D, Circulation
• Hydrogen Peroxide Decreases Effective Refractory Period in the Isolated Rabbit Heart.
  Lesnefsky E.J., Williams G.R., Horwitz L.D., Reiter M.J, Clinical Research
• Effects of Cough-CPR During Malignant Ventricular Arrhythmias.
  Miller B., Freeman K., Mann D., Lesnefsky E., Schmidt B., Reiter M, Critical Care Medicine
• Atrial Natriuretic Peptide (ANF) Kinetics in Patients With Congestive Heart Failure (CHF).
  Hensen J., Durr J.A., Abraham W.T., Lesnefsky E., Groves B., Lindenfeld J., Ganousis L., Schrier R.W, The American Society of Nephrology
• Glutathione Is Released During Reperfusion From Infarcted But Not From Stunned Myocardium.
  Lesnefsky E., Hogue T.S., Dauber I.M., Horwitz L.D, Journal of the American College of Cardiology
• Reperfusion Therapy With the Iron Chelator Deferoxamine-Hydroxyethyl Starch Does Not Limit Canine Myocardial Infarct Size.
  Lesnefsky E.J., Hedlund B.E., Horwitz L.D, Clinical Research
• Detection of Xanthine Oxidase and Protection by Allopurinol in the Ischemic-Reperfused Rabbit Heart.
  Rubinstein J.D., Terada L.S., Lesnefsky E.J., Horwitz L.D., Repine J.E, Clinical Research
• A Lipid-Soluble Membrane Protective Agent, Trolox C, Attenuates Myocardial Injury From Ischemia-Reperfusion.
  Rubinstein J.D., Lesnefsky E.J., Fennessey P.V., Horwitz L.D, Clinical Research
• Brief Periods of Ischemia-Reperfusion Deplete Non-glutathione Sulfhydryl Groups.
  Lesnefsky E.J., Hogue T.S., Horwitz L.D, Clinical Research
• In Vivo Ischemia-Decreases All Myocardial Sulfhydryl Groups.
  Lesnefsky E.J., Hogue T.S., Horwitz L.D, Clinical Research
• Reperfusion Therapy With Dimethylthiourea Reduces Canine Infarct Size Measured 48 Hours Later.
  Carrea F.P., Lesnefsky E.J., Horwitz L.D, Clinical Research
• Oxygen Radical-Induced Lipid Peroxidation: Adaptation of a Novel Lipid Peroxide Assay to Myocardial Tissue.
  Lesnefsky E.J., Allen K.G.D., Horwitz L.D, Clinical Research
• Differential Myocardial Sulfhydryl Depletion Occurs During Reperfusion Following Brief Vs. Prolonged Ischemia In Vivo.
  Lesnefsky E.J., Dauber I.M., Horwitz L.D, Circulation
• Leukocytes Cause Microvascular, But Little Epicardial Coronary Endothelial Injury Due to Ischemia and Reperfusion.
  Sheridan F.M., Dauber I.M., Lesnefsky E.J., Coller H.S., Peach J.L., Hogue T.S., Horwitz L.D, Circulation
• U74006F Decreases Necrosis and Enhances Functional Recovery After Ischemia/Reperfusion in Isolated Rabbit Hearts.
  Carrea F.P., Lesnefsky, E.J., Horwitz L.D, Journal American College of Cardiology
• Streptokinase and T-PA Treatment Reduces Superoxide Anion (O2-.) Generation by Human Neutrophils In Vitro.
  Lindenfeld J., Stringer K.A., Lesnefsky E.J., Repine J.E, linical Research
• Join now to see all

Other

• Oxidative Phospylation Provides A Valuable Tool For Identifying The Aging Mitochondrial Phenotype. 
  Kypriotakis G., Vazquez E., Lesnefsky E., Hoppel C, 12th Congress of the International Association of Biomedical Gerontology
  http://www.eie.gr/nhrf/institutes/ibrb/spetses-2007/poster_abstracts.pdf
• Protection of mitochondrial respiration prevents permeability transition pore opening during reperfusion. 
  Chen Q., Lesnefsky E.J, Basic Cardiovascular Sciences Meeting, Palm Springs, CA
  http://www.americanheart.org/presenter.jhtml?identifier=3074181
• Activation of mitochondrial calpain during cardiac ischemia-reperfusion. 
  Chen Q., Paillard M., Gomez L., Ross T., Hu Y., Lesnefsky E.J, Basic Cardiovascular Sciences Meeting
  http://www.americanheart.org/presenter.jhtml?identifier=3074181
  Palm Springs, CA
• Failure to Precondition SK2-KO Mice: Not Without RISK. 
  Gomez L, Paillard M, Allegood JC, Hait NC, Price M, Chen Q, Milstien S, Spiegel S, and Lesnefsky EJ, Basic Cardiovascular Sciences Meeting
  http://www.americanheart.org/presenter.jhtml?identifier=3074181
  Palm Springs, CA
• Join now to see all